BINDSの支援を受けた研究成果（論文）
Jun Nakayama, Hiroko Matsunaga, Koji Arikawa, Takuya Yoda, Masahito Hosokawa, Haruko Takeyama, Yusuke Yamamoto, Kentaro Semba (2021)
Identification of two cancer stem cell-like populations in triple-negative breast cancer xenografts bioRxiv.
465257- DOI:10.1101/2021.10.21.465257
Shuhei Ueda, Masahito Hosokawa, Koji Arikawa, Kiyofumi Takahashi, Mao Fujiwara, Manami Kakita, Taro Fukada, Hiroaki Koyama, Shin-Ichiro Horigane, Keiichi Itoi, Masaki Kakeyama, Hiroko Matsunaga, Haruko Takeyama, Haruhiko Bito, Sayaka Takemoto-Kimura (2021)
Distinctive Regulation of Emotional Behaviors and Fear-Related Gene Expression Responses in Two Extended Amygdala Subnuclei With Similar Molecular Profiles Frontiers in Molecular Neuroscience.
14
741895- DOI:10.3389/fnmol.2021.741895 PMID:34539345
Jun-ichi Kishikawa, Atsuko Nakanishi, Atsuki Nakano, Shiori Saeki, Aya Furuta, Takayuki Kato, Kaoru Mitusoka, Ken Yokoyama (2022)
Structural snapshots of V/A-ATPase reveal the rotary catalytic mechanism of rotary ATPases Nature communications.
13
1213- DOI:10.1038/s41467-022-28832-5 PMID:35260556
Cesar Aguirre, Kensuke Ikenaka, Masatomo So, Takahiro Maruno, Keiichi Yamaguchi, Kichitaro Nakajima, Chi-Jing Choong, Kei Nabekura, Goichi Beck, Kentaro Tomii, Yu Yamamori, Junko Doi, Tomoyasu Matsubara, Maho Morishima, Keita Kakuda, Makoto Hideshima, Yasuyoshi Kimura, Seiichi Nagano, Kousuke Baba, Shigeo Murayama, Hirotsugu Ogi, Yoshitaka Nagai, Yasushi Kawata, Susumu Uchiyama, Yohei Miyanoiri, Yuji Goto, Hideki Mochizuki (2022)
Conformational change in the monomeric alpha-synuclein imparts fibril polymorphs biorxev.
DOI:10.1101/2022.02.10.479831
Kunio Nakata, Naoyuki Miyazaki, Hiroki Yamaguchi, Mika Hirose, Tatsuki Kashiwagi, Nidamarthi H V Kutumbarao, Osamu Miyashita, Florence Tama, Hiroshi Miyano, Toshimi Mizukoshi, Kenji Iwasaki (2021)
High-resolution structure of phosphoketolase from Bifidobacterium longum
determined by cryo-EM single-particle analysis Journal of Structural Biology.
DOI:10.1016/j.jsb.2022.107842 PMID:35181457
Toshihiko Sugiki, Young-Ho Lee, Nesreen Alsanousi, Kaito Murata, Izuru Kawamura, Toshimichi Fujiwara, Kentaro Hanada, Chojiro Kojima (2021)
A hybrid strategy combining solution NMR spectroscopy and isothermal titration
calorimetry to characterize protein-nanodisc interaction Analytical Biochemistry.
639
114521- DOI:10.1016/j.ab.2021.114521 PMID:34906540
Koji Kato, Ryo Nagao, Yoshifumi Ueno, Makio Yokono, Takehiro Suzuki, Tian-Yi Jiang, Naoshi Dohmae, Fusamichi Akita, Seiji Akimoto, Naoyuki Miyazaki, and Jian-Ren Shen (2022)
Structural insights into an evolutionary turning-point of photosystem I 1 from prokaryotes to eukaryotes biorxev.
DOI:10.1101/2022.01.03.474851
Inaba, K., Ebihara, K., Senda, M., Yoshino, R., Sakuma, C., Koiwai, K., Takaya, D., Watanabe, C., Watanabe, A., Kawashima, Y., Fukuzawa, K., Imamura, R., Kojima, H., Okabe, T., Ue?ura, N., Kasai, S., Kanuka, H., Nishimura, T., Watanabe, K., Inoue, H., Fujikawa, Y., HOnma, T., Hirokawa, T., Senda, T. And Niwa, R.* (2022)
Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti. BMC Biology.
20
43-62 DOI:10.1186/s12915-022-01233-2 PMID:35172816
Kano Suzuki, Mara del Carmen Marin, Masae Konno, Reza Bagherzadeh, *Takeshi Murata, and *Keiichi Inoue (2022)
Structural characterization of proton-pumping rhodopsin lacking a cytoplasmic proton donor residue by X-ray crystallography J. Biol. Chem..
in press
DOI:10.1016/j.jbc.2022.101722
Takeshi Haraguchi, Masanori Tamanaha, Kano Suzuki, Kohei Yoshimura, Takuma Imi, Motoki Tominaga, Hidetoshi Sakayama, Tomoaki Nishiyama, *Takeshi Murata, and *Kohji Ito (2022)
Discovery of the fastest myosin, its amino acid sequence, and structural features Proc. Natl. Acad. Sci. U. S. A..
119
e212096211- DOI:10.1073/pnas.2120962119
Arif Md. Rashedul Kabir, Tasrina Munmun, Tomohiko Hayashi, Satoshi Yasuda, Atsushi P. Kimura, Masahiro Kinoshita, Takeshi Murata, Kazuki Sada and *Akira Kakugo (2022)
Controlling the rigidity of kinesin-propelled microtubules in an in vitro gliding assay using the deep-sea osmolyte trimethylamine N-oxide ACS Omega.
7
3796-3803 DOI:10.1021/acsomega.1c06699
Atsuhiro Tomita, Takashi Daiho, Tsukasa Kusakizako, Keitaro Yamashita, Satoshi Ogasawara, Takeshi Murata, *Tomohiro Nishizawa, *Osamu Nureki (2021)
Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2 Mol. Cell.
81
4799-4809 DOI:10.1016/j.molcel.2021.11.001
S. Horikoshi, W. Saburi, J. Yu, H. Matsuura, J. R K. Cairns, M.Yao, H. Mori (2021)
Substrate specificity of glycoside hydrolase family 1 β-glucosidase AtBGlu42 from Arabidopsis thaliana and its molecular mechanism Bioscience, Biotechnology, and Biochemistry. (2021).
86
:2,
231-245 DOI:10.1093/bbb/zbab200
T. Tagami, M. Chen, Y. Furunaga, A. Kikuchi, J.Sadahiro, W. Lang, M.Okuyama, Y. Tanaka, T. Iwasaki, M. Yao and A. Kimura. (2021)
State-Targeting Stabilization of Adenosine A2A Receptor by Fusing a Custom-Made De Novo Designed α-Helical Protein; The FEBS Journal..
289
1118-1134 DOI:10.1111/febs.16237
Daisuke Takahashi, Eri Matsunaga, Tomohiro Yamashita, Jose M.M. Caaveiro,
Yoshito Abe, Tadashi Ueda (2022)
Compound screening identified gossypetin and isoquercitrin as novel inhibitors for
amyloid fibril formations of Vλ6 proteins associated with AL amyloidosis Biochemical and Biophysical Research Communications.
DOI:10.1016/j.bbrc.2022.01.066 PMID:35108650
Nishiyama K, Nishimura A, Shimoda K, Tanaka T, Kato Y, Shibata T, Tanaka H, Kurose H, Azuma Y-T, Ihara H, Kumagai K, Akaike T, Eaton P, Uchida K, Nishida M (2022)
Redox-dependent internalization of purinergic P2Y6 receptor limits colitis progression. Science Signaling.
15
:716,
DOI:10.1126/scisignal.abj0644 PMID:35015570
Yi Yang, Adam Csakai, Shuangshuang Jiang, Christina Smith, Hiromi Tanji, Jian Huang, Torey Jones, Kentaro Sakaniwa, Lindsey Broadwell, Chengrui Shi, Subada Soti, Umeharu Ohto, Yaohui Fang, Shu Shen, Fei Deng, Toshiyuki Shimizu & Hang Yin (2021)
Tetrasubstituted imidazoles as incognito Toll-like receptor 8 antagonists Nat Commun.
12
:1,
4351- DOI:10.1038/s41467-021-24536-4 PMID:34272380
Toma-Fukai S. and Shimizu, T (2021)
Structural Diversity of Ubiquitin E3 Ligase Molecules.
26
:21,
6682- DOI:10.3390/molecules26216682 PMID:34771091
鎌田 祥太郎, 石井 功 (2021)
X線結晶構造解析により明らかとなったPPARαとリガンドの結合様式 Yakugaku Zasshi.
141
:11,
1267-1274 DOI:10.1248/yakushi.21-00138 PMID:34719550
Kouhei Kunichika, Ryosuke Nakamura, Takashi Fujishiro, Yasuhiro Takahashi (2021)
The Structure of the Dimeric State of IscU Harboring Two Adjacent [2Fe-2S] Clusters Provides Mechanistic Insights into Cluster Conversion to [4Fe-4S] Biochemistry.
60
:20,
1569-1572 DOI:10.1021/acs.biochem.1c00112 PMID:33938220
Manatsu Morikawa, Nivedita U Jerath, Tadayuki Ogawa, Momo Morikawa, Yosuke Tanaka, Michael E Shy, Stephan Zuchner, Nobutaka Hirokawa (2022)
A neuropathy-associated kinesin KIF1A mutation hyper-stabilizes the motor-neck interaction during the ATPase cycle EMBO journal.
DOI:10.15252/embj.2021108899
Linh, N.T, Arimura, T, Tominaga, K., Kigoshi, H, and Isoda, H. (2021)
Syntheses and aggregation properties of new squalene receptors bearing open chain ligands. Supramolecular Chemistry.
DOI:10.1080/10610278.2021.1970161
Sato, S, Takizawa, Y, Hoshikawa, F, Dacher, M, Tanaka, H, Tachiwana, H, Kujirai, T, Iikura, Y, Ho, C.H, Adachi, N, Patwal, I, Flaus, A, and Kurumizaka, H. (2021)
Cryo-EM structure of the nucleosome core particle containing Giardia lamblia histones. Nucleic Acids Res..
49
8934-8946 DOI:10.1093/nar/gkab644
Ikegaya M., Moriya, T., Adachi N., Kawasaki, M., Park E. Y., Miyazaki, T. (2022)
Structural basis of the strict specificity of a bacterial GH31 a-1,3-glucodiase for nigerooligosaccharides. J. Biol. Chem..
DOI:10.1016/j.jbc.2022.101827
Kawano, Y, Hikita, M, Matsugaki, N, Yamamoto, M, and Senda, T (2022)
A crystal-processing machine using a deep-ultraviolet laser: application to long-wavelength native SAD experiments Acta Cryst.
F78
88-95 DOI:10.1107/S2053230X2101339X PMID:35102898
Ko Sato, Amarjeet Kumar, Keisuke Hamada, Chikako Okada, Asako Oguni, Ayumi Machiyama, Shun Sakuraba, Tomohiro Nishizawa, Osamu Nureki, Hidetoshi Kono, Kazuhiro Ogata, Toru Sengoku (2021)
Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2. Nat Commun.
12
:6605,
DOI:10.1038/s41467-021-26913-5 PMID:34782608
Seiya Hirai, Kosuke Tomimatsu, Atsuko Miyawaki-Kuwakado, Yoshimasa Takizawa, Tetsuro Komatsu, Taro Tachibana, Yutaro Fukushima, Yasuko Takeda, Lumi Negishi, Tomoya Kujirai, Masako Koyama, Yasuyuki Ohkawa, Hitoshi Kurumizaka (2021)
Unusual nucleosome formation and transcriptome
influence by the histone H3mm18 variant
Nucleic Acids Research.
50
:1,
72-91 DOI:10.1093/nar/gkab1137 PMID:34929737
Koichiro E Kishi, Yoon Seok Kim, Masahiro Fukuda, Masatoshi Inoue, Tsukasa Kusakizako, Peter Y Wang, Charu Ramakrishnan, Eamon F X Byrne, Elina Thadhani, Joseph M Paggi, Toshiki E Matsui, Keitaro Yamashita, Takashi Nagata, Masae Konno, Sean Quirin, Maisie Lo, Tyler Benster, Tomoko Uemura, Kehong Liu, Mikihiro Shibata, Norimichi Nomura, So Iwata, Osamu Nureki, Ron O Dror, Keiichi Inoue, Karl Deisseroth, Hideaki E Kato (2022)
Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine Cell.
185
:4,
672-689 DOI:10.1016/j.cell.2022.01.007 PMID:35114111
Caner Akıl, Samson Ali, Linh T. Tran, Jeremie Gaillard, Wenfei Li, Kenichi Hayashida, Mika Hirose, Takayuki Kato, Atsunori Oshima, Kosuke Fujishima, Laurent Blanchoin, Akihiro Narita & Robert C. Robinsonn (2022)
Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution Science Advances.
8
eabm2225- DOI:10.1126/sciadv.abm2225
Kazuya Sumi, Kenji Tago, Yosuke Nakazawa, Kyoko Takahashi, Tomoyuki Ohe Tadahiko Mashino, Megumi Funakoshi-Tago (2022)
Novel Mechanism by a Bis-Pyridinium Fullerene Derivative to Induce Apoptosis by Enhancing the MEK-ERK Pathway in a Reactive Oxygen Species-Independent Manner in BCR-ABL-Positive Chronic Myeloid Leukemia-Derived K562 Cells Int J Mol Sci.
23
:2,
749- DOI:10.3390/ijms23020749 PMID:35054935
Hitomi Sudo, Atsushi B. Tsuji, Aya Sugyo, Mika K. Kaneko, Yukinari Kato, Kotaro Nagatsu, Hisashi Suzuki, and Tatsuya Higashi (2021)
Preclinical evaluation of podoplanin-targeted al-pha-radioimmunotherapy with the novel antibody NZ-16 for malignant mesothelioma Cells.
10
:10,
2503- DOI:10.3390/cells10102503 PMID:34685483
Kei Watari, Satoru Konnai, Tomohiro Okagawa, Naoya Maekawa, Yamato Sajiki, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi (2021)
Enhancement of interleukin-2 production by bovine
peripheral blood mononuclear cells treated with the
combination of anti-programmed death-ligand 1 and cytotoxic
T lymphocyte antigen 4 chimeric monoclonal antibodies Journal of Veterinary Medical Science.
84
:1,
6-15 DOI:10.1292/jvms.21-0552 PMID:34789592
Tomoya Fujita, Takeshi Yokoyama, Mikako Shirouzu, Hideki Taguchi, Takuhiro Ito, Shintaro Iwasaki (2022)
The landscape of translational stall sites in bacteria revealed by monosome and disome profiling RNA.
28
:3,
290-302 DOI:10.1261/rna.078188.120 PMID:34906996
Yutaka Suto, Tatiana Ascencio, Tomoya Nobuta, Noriyuki Yamagiwa,Yoko Onizuka,
Mayumi Ishii, Kayoko Kanemitsu, and Junko Nakajima-Shimada (2021)
Synthesis and Evaluation of Quinone Derivatives for Activity against
Trypanosome cruzi Chemical and Pharmaceutical Bulletin.
69
:12,
1195-1199 DOI:10.1248/cpb.c21-00732 PMID:34853286
Yasunobu Hoshino, Daisuke Noto, Shuhei Sano, Yuji Tomizawa, Kazumasa Yokoyama, Nobutaka Hattori, Sachiko Miyake (2022)
Dysregulated B cell differentiation
towards antibody?secreting cells
in neuromyelitis optica spectrum disorder Journal of Neuroinflammation.
19
:1,
6- DOI:10.1186/s12974-021-02375-w PMID:34991631
Maki Kuzuya, Hidemi Hirano, Kenichi Hayashida, Masakatsu Watanabe, Kazumi Kobayashi, Tohru Terada, Md. Iqbal Mahmood, Florence Tama, Kazutoshi Tani, Yoshinori Fujiyoshi, and Atsunori Oshima (2022)
Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids Science Signaling.
15
:720,
eabg6941- DOI:10.1126/scisignal.abg6941 PMID:35133866
Nouran Ghanem, Natsuki Kanagami, Takashi Matsui, Kein Takeda, Jun Kaneko, Yasuyuki Shiraishi, Christian A Choe, Tomomi Uchikubo-Kamo, Mikako Shirouzu, Tsubasa Hashimoto, Tomohisa Ogawa, Tomoaki Matsuura, Po-Ssu Huang, Takeshi Yokoyama, Yoshikazu Tanaka (2022)
Chimeric mutants of staphylococcal hemolysin, which act as both one-component and two-component hemolysin, created by grafting the stem domain FEBS Journal.
DOI:10.1111/febs.16354 PMID:35030303
Toshiaki Hosaka, Takashi Nomura, Minoru Kubo, Takanori Nakane, Luo Fangjia, Shun-Ichi Sekine, Takuhiro Ito, Kazutaka Murayama, Kentaro Ihara, Haruhiko Ehara, Kazuhiro Kashiwagi, Kazushige Katsura, Ryogo Akasaka, Tamao Hisano, Tomoyuki Tanaka, Rie Tanaka, Toshi Arima, Ayumi Yamashita, Michihiro Sugahara, Hisashi Naitow, Yoshinori Matsuura, Susumu Yoshizawa, Kensuke Tono, Shigeki Owada, Osamu Nureki, Tomomi Kimura-Someya, So Iwata, Eriko Nango, Mikako Shirouzu (2022)
Conformational alterations in unidirectional ion transport of a light-driven chloride pump revealed using X-ray free electron lasers Proceedings of the National Academy of Sciences of the United States of America .
119
:9,
e2117433119- DOI:10.1073/pnas.2117433119 PMID:35197289
Yasuhiro Fukuda, Marin Yokomine, Daisuke Kuroda, Kouhei Tsumoto, Jumpei Morimoto, Shinsuke Sando (2021)
Peptoid-based reprogrammable template for cell-permeable inhibitors of protein-protein interactions Chemical Science.
12
:40,
13292-13300 DOI:10.1039/d1sc01560e PMID:34777747
Shintaro Mise, Akinobu Matsumoto, Keisuke Shimada, Toshiaki Hosaka, Masatomo Takahashi, Kazuya Ichihara, Hideyuki Shimizu, Chisa Shiraishi, Daisuke Saito, Mikita Suyama, Tomoharu Yasuda, Toru Ide, Yoshihiro Izumi, Takeshi Bamba, Tomomi Kimura-Someya, Mikako Shirouzu, Haruhiko Miyata, Masahito Ikawa, Keiichi I Nakayama (2022)
Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis Nature Communications.
13
:1,
1071- DOI:10.1038/s41467-022-28677-y PMID:35228556
Motohiro Sekiya,Kenta Kainoh,Takehito Sugasawa,Ryunosuke Yoshino,Takatsugu Hirokawa,Hiroaki Tokiwa,Shogo Nakano,Satoru Nagatoishi,Kouhei Tsumoto,Yoshinori Takeuchi,Takafumi Miyamoto,Takashi Matsuzaka,Hitoshi Shimano (2021)
The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis Nature Communications.
12
:1,
6315- DOI:10.1038/s41467-021-26638-5 PMID:34728642
Shun Kageyama, Sigurdur Runar Gudmundsson, Yu-Shin Sou, Yoshinobu Ichimura, Naoki Tamura, Saiko Kazuno, Takashi Ueno, Yoshiki Miura, Daisuke Noshiro, Manabu Abe, Tsunehiro Mizushima, Nobuaki Miura, Shujiro Okuda, Hozumi Motohashi, Jin-A Lee, Kenji Sakimura, Tomoyuki Ohe, Nobuo N. Noda, Satoshi Waguri, Eeva-Liisa Eskelinen, Masaaki Komatsu (2021)
p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response Nat Commun.
12
:1,
16- DOI:10.1038/s41467-020-20185-1 PMID:33397898
Dai Shimizu, Kenzui Taniue, Yusuke Matsui, Hiroshi Haeno, Hiromitsu Araki, Fumihito Miura, Mitsuko Fukunaga, Kenji Shiraishi, Yuji Miyamoto, Seiichi Tsukamoto, Aya Komine, Yuta Kobayashi, Akihiro Kitagawa, Yukihiro Yoshikawa, Kuniaki Sato, Tomoko Saito, Shuhei Ito, Takaaki Masuda, Atsushi Niida, Makoto Suzuki, Hideo Baba, Takashi Ito, Nobuyoshi Akimitsu, Yasuhiro Kodera, Koshi Mimori (2021)
Pan-cancer methylome analysis for cancer diagnosis and classification of cancer cell of origin Cancer Gene Therapy.
DOI:10.1038/s41417-021-00401-w PMID:34744163
Keigo Hirai, Hiroko Yamashita, Shusuke Tomoshige, Yugo Mishima, Tatsuya Niwa, Kenji Ohgane,
Mayumi Ishii, Kayoko Kanamitsu, Yui Ikemi, Shinsaku Nakagawa, Hideki Taguchi, Shinichi Sato,
Yuichi Hashimoto, and Minoru Ishikawa (2022)
Conversion of a PROTAC Mutant Huntingtin Degrader into Small-
Molecule Hydrophobic Tags Focusing on Drug-like Properties ACS Medicinal Chemistry Letters.
13
:3,
396-402 DOI:10.1021/acsmedchemlett.1c00500 PMID:35300080
Miyuki Kumazawa, Manabu Tejima, Miwa Fukuda, Shota Takeda, Kenji Suzuki, Yukiko Mizumoto, Kakeru Sato, Minoru Waki, Hiroyuki Miyachi, Akira Asai, Osamu Takikawa, Tomoko Hashimoto, Osamu Ohno, Kenji Matsuno (2021)
Discovery of Carbono(di)thioates as Indoleamine 2,3-Dioxygenase 1 Inhibitors. ACS Med Chem Lett. .
12
:2,
211-216 DOI:10.1021/acsmedchemlett.0c00527 PMID:33603967
Satoshi Yasuda, Tomoki Akiyama, Keiichi Kojima, Tetsuya Ueta, Tomohiko Hayashi, Satoshi Ogasawara, Satoru Nagatoishi, Kouhei Tsumoto, Naoki Kunishima, Yuki Sudo, Masahiro Kinoshita, Takeshi Murata (2022)
Development of an Outward Proton Pumping Rhodopsin with a New Record in Thermostability by Means of Amino Acid Mutations The Journal of Physical Chemistry B.
126
:5,
1004-1015 DOI:10.1021/acs.jpcb.1c08684 PMID:35089040
Toma Kashima, Kouki Okumura, Akihiro Ishiwata, Machika Kaieda, Tohru Terada, Takatoshi Arakawa, Chihaya Yamada, Kentaro Shimizu, Katsunori Tanaka, Motomitsu Kitaoka, Yukishige Ito, Kiyotaka Fujita, Shinya Fushinobu (2021)
Identification of a difructose dianhydride I synthase/hydrolase from oral bacterium
establishes a novel glycoside hydrolase family The Journal of biological chemistry.
297
:5,
101324- DOI:10.1016/j.jbc.2021.101324 PMID:34688653
Ayako Furukawa, Masatoshi Wakamori, Yasuhiro Arimura, Hideaki Ohtomo, Yasuo Tsunaka, Hitoshi Kurumizaka, Takashi Umehara, Yoshifumi Nishimura (2022)
Characteristic H3 N-tail dynamics in the nucleosome core particle, nucleosome, and chromatosome iScience.
25
:3,
103937- DOI:10.1016/j.isci.2022.103937 PMID:35265811
Evgeniia Borisova, Ken Nishimura, Yuri An, Miho Takami, Jingyue Li, Dan Song, Mami Matsuo-Takasaki, Dorian Luijkx, Shiho Aizawa, Akihiro Kuno, Eiji Sugihara, Taka-aki Sato, Fumiaki Yumoto, Tohru Terada, Koji Hisatake, Yohei Hayashi (2022)
Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency iScience.
25
103525- DOI:10.1016/j.isci.2021.103525 PMID:35106457
Keisuke Hagihara, Kazuto Nunomura, Bangzhong Lin, Megumi Fumimoto, Junko Watanabe, Yasuharu Mizuhara (2022)
Gosha-jinki-Gan (GJG) shows anti-aging effects through suppression of TNF-α production by Chikusetsusaponin V Gene.
815
146178- DOI:10.1016/j.gene.2021.146178 PMID:34995733
Masaya Matsuda, Yoshiyuki Tanaka, Hayato Shimora, Naoki Takemoto, Miku Nomura, Ryogo Terakawa, Kennosuke Hashimoto, Harumi Sakae, Akira Kanda, Hiroshi Iwai, Kazuyuki Kitatani, Takeshi Nabe (2021)
Pathogenic changes in group 2 innate lymphoid cells (ILC2s) in a
steroid-insensitive asthma model of mice European Journal of Pharmacology.
916
174732- DOI:10.1016/j.ejphar.2021.174732 PMID:34971621
Kazuya Sumi, Kenji Tago, Yosuke Nakazawa, Kyoko Takahashi, Tomoyuki Ohe Tadahiko Mashino, Megumi Funakoshi-Tago (2022)
A bis-pyridinium fullerene derivative induces apoptosis through the generation of ROS in BCR-ABL-positive leukemia cells Eur J Pharmacol.
916
174714- DOI:10.1016/j.ejphar.2021.174714 PMID:34953803
Ichiro Takasaki, Ai Watanabe, Takuya Okada, Daisuke Kanayama, Ryota Nagashima, Miyu Shudo, Ayaka Shimodaira, Kazuto Nunomura, Bangzhong Lin, Yurie Watanabe, Hiroaki Gouda, Atsuro Miyata, Takashi Kurihara, Naoki Toyooka (2022)
Design and synthesis of pyrido[2,3-d]pyrimidine derivatives for a novel PAC1 receptor antagonist European Journal of Medicinal Chemistry.
231
114160- DOI:10.1016/j.ejmech.2022.114160 PMID:35124531
Tomoko Yamaguchi, Fumiaki Makino, Tomoko Miyata, Tohru Minamino, Takayuki Kato, Keiichi Namba (2021)
Structure of the molecular bushing of the bacterial flagellar motor. Nature Communications.
12
:1,
4469- DOI:10.1038/s41467-021-24715-3 PMID:34294704
Yoshiaki Kawano, Masahide Hikita, Naohiro Matsugaki, Masaki Yamamoto and Toshiya Senda (2021)
Crystal processing machine using a deep-ultraviolet laser-application to long-wavelength native SAD experiments Acta Crystallographica Sectioun F .
DOI:submitted
Tomohiro Yamashita, Sawako Kamikaseda, Aya Tanaka, Hidetoshi Tozaki-Saitoh, Jose M. M. Caaveiro, Kazuhide Inoue, Makoto Tsuda (2021)
New Inhibitory Effects of Cilnidipine on Microglial P2X7 Receptors and IL-1β Release: An Involvement in its Alleviating Effect on Neuropathic Pain Cells.
10
434- DOI:10.3390/cells100204345
Takuo Minato,?Takamasa Teramoto,?Naruhiko Adachi,?Nguyen Khac Hung,?Kaho Yamada,?Masato Kawasaki,?Masato Akutsu,Toshio Moriya,?Toshiya Senda,?Seiji Ogo,?Yoshimitsu Kakuta, Ki-Seok Yoon? (2021)
Non-conventional octameric structure of C-phycocyanin Communications Biology.
4
:1,
1238- DOI:10.1038/s42003-021-02767-x PMID:34716405
Takahiro Mori,?Takuto Kumano,?Haibing He,?Satomi Watanabe,?Miki Senda,?Toshio Moriya,?Naruhiko Adachi,?Sanae Hori,?Yuzu Terashita,?Masato Kawasaki,?Yoshiteru Hashimoto,?Takayoshi Awakawa,?Toshiya Senda,?Ikuro Abe,?Michihiko Kobayashi? (2021)
C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes Nature Communications.
12
:1,
6294- DOI:10.1038/s41467-021-26585-1 PMID:34728636
Kazutoshi Tani,?Kenji V P Nagashima, Ryo Kanno,?Saki Kawamura,?Riku Kikuchi,?Malgorzata Hall,?Long-Jiang Yu,?Yukihiro Kimura,?Michael T Madigan,?Akira Mizoguchi,?Bruno M Humbel,?Zheng-Yu Wang-Otomo (2021)
A previously unrecognized membrane protein in the Rhodobacter sphaeroides LH1-RC photocomplex Nature Communications.
12
:1,
6300- DOI:10.1038/s41467-021-26561-9 PMID:34728609
Yuya Monoe, Kentaro Jingushi, Akitaka Kawase, Takayuki Hirono, Ryo Hirose, Yoshino Nakatsuji, Kaori Kitae, Yuko Ueda, Hiroaki Hase, Yuichi Abe, Jun Adachi, Takeshi Tomonaga, Kazutake Tsujikawa (2021)
Pharmacological Inhibition of miR-130 Family Suppresses Bladder Tumor Growth by Targeting Various Oncogenic Pathways via PTPN1 International Journal of Molecular Sciences.
9
:22,
4751- DOI:10.3390/ijms22094751 PMID:33947152
Yuichi Aki, Yuta Katsumata, Hirofumi Kakihara, Koichi Nonaka, Kenshu Fujiwara (2021)
4-(2,5-Dimethyl-1H-pyrrol-1-yl)-N-(2,5- dioxopyrrolidin-1-yl) benzamide improves monoclonal antibody production in a Chinese hamster ovary cell culture PLoS One.
4
:16,
e0250416- DOI:10.1371/journal.pone.0250416 PMID:33886677
Takeshi Nara , Yukari Nakagawa , Keiko Tsuganezawa , Hitomi Yuki , Katsuhiko Sekimata , Hiroo Koyama , Naoko Ogawa , Teruki Honma , Mikako Shirouzu , Takehiro Fukami , Yuichi Matsuo , Daniel Ken Inaoka , Kiyoshi Kita , Akiko Tanaka (2021)
The ubiquinone synthesis pathway is a promising drug target for Chagas disease. PLoS One.
2
:16,
e0243855- DOI:10.1371/journal.pone.0243855 PMID:33539347
Yusuke Sasano, Aoto Yamaichi, Ryota Sasaki, Shota Nagasawa, Yoshiharu Iwabuchi (2021)
Expansion of Substrate Scope for Nitroxyl Radical/Copper-Catalyzed
Aerobic Oxidation of Primary Alcohols: A Guideline for Catalyst
Selection Chemical & pharmaceutical bulletin.
:69,
488-497 DOI:10.1248/cpb.c21-00043 PMID:33952858
Akihiro Honda, Shotaro Kamata, Chihiro Satta, Yui Machida, Kie Uchii, Kazuki Terasawa, Ayane Nemoto, Takuji Oyama, Isao Ishii (2021)
Structural Basis for Anti-non-alcoholic Fatty Liver Disease and Diabetic Dyslipidemia Drug Saroglitazar as a PPAR α/γ Dual Agonist Biological and Pharmaceutical Bulletin.
9
:44,
1210-1219 DOI:10.1248/bpb.b21-00232 PMID:34471049
Yuki Takada, Ruken Yaman-Deveci, Takayuki Shirakawa, Jafar Sharif, Shin-Ichi Tomizawa, Fumihito Miura, Takashi Ito, Michio Ono, Kuniko Nakajima, Yoko Koseki, Fuyuko Shiotani, Kei-Ichiro Ishiguro, Kazuyuki Ohbo, Haruhiko Koseki (2021)
Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairing Development.
10
:148,
dev194605- DOI:10.1242/dev.194605 PMID:33998651
Riku Kawanabe, Kohei Yoshihara, Izuho Hatada, Makoto Tsuda (2021)
Activation of spinal dorsal horn astrocytes
by noxious stimuli involves descending
noradrenergic signaling Molecular brain.
1
:14,
79- DOI:10.1186/s13041-021-00788-5 PMID:33971918
Kaori Saito, Qi Zhang, Haeun Yang, Kotoko Yamatani, Tomohiko Ai, Vivian Ruvolo, Natalia Baran, Tianyu Cai, Helen Ma, Rodrigo Jacamo, Vinitha Kuruvilla, Junichi Imoto, Sonoko Kinjo, Kazuho Ikeo, Kaori Moriya, Koya Suzuki, Takashi Miida, Yong-Mi Kim, Christopher P Vellano, Michael Andreeff, Joseph R Marszalek, Yoko Tabe, Marina Konopleva (2021)
Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition Blood Advances.
20
:5,
4233-4255 DOI:10.1182/bloodadvances.2020003661 PMID:34507353
Takuma Toyonaga, Takayuki Kato, Akihiro Kawamoto, Noriyuki Kodera, Tasuku Hamaguchi, Yuhei O Tahara, Toshio Ando, Keiichi Namba, Makoto Miyata (2021)
Chained structure of dimeric F1-like ATPase in Mycoplasma mobile gliding machinery. mBio.
4
:12,
e0141421- DOI:10.1128/MBIO.01414-21 PMID:34281395
Atsushi Kawai, Yasuyuki Yamamoto, Takuto Nogimori, Kohei Takeshita, Takuya Yamamoto, Yasuo Yoshioka (2021)
The Potential of Neuraminidase as an Antigen for Nasal Vaccines To Increase Cross-Protection against Influenza Viruses Journal of Virology.
20
:95,
e01180-21- DOI:10.1128/JVI.01180-21 PMID:34379511
Koya Sakuma, Naohiro Kobayashi, Toshihiko Sugiki, Toshio Nagashima, Toshimichi Fujiwara, Kano Suzuki, Naoya Kobayashi, Takeshi Murata, Takahiro Kosugi, Rie Koga, Nobuyasu Koga (2021)
Design of complicated all-ﾎｱ protein structures bioRxiv.
DOI:10.1101/2021.07.14.449347
Junya Obata, Norifumi Kawakami, Akihisa Tsutsumi, Erika Nasu, Kenji Miyamoto, Masahide Kikkawa, Ryoichi Arai (2021)
Icosahedral 60-meric porous structure of designed supramolecular protein nanoparticle TIP60 Chemical Communications.
79
:57,
10226-10229 DOI:10.1039/d1cc03114g PMID:34523636
Akihiro Nakamura, Yoshiyuki Suzuki, Yasumitsu Sakamoto, Saori Roppongi, Chisato Kushibiki, Natsuri Yonezawa, Masato Takahashi, Yosuke Shida, Hiroaki Gouda, Takamasa Nonaka, Nobutada Tanaka, Wataru Ogasawara (2021)
Structural basis for an exceptionally strong preference for asparagine residue at the S2 subsite of Stenotrophomonas maltophilia dipeptidyl peptidase 7 Scientific Reports.
1
:11,
7929- DOI:10.1038/s41598-021-86965-x PMID:33846449
Koki Makabe, Takeshi Yokoyama, Shiro Uehara, Tomomi Uchikubo窶銭amo, Mikako Shirouzu, Kouki Kimura, Kouhei Tsumoto, Ryutaro Asano, Yoshikazu Tanaka, Izumi Kumagai (2021)
Anti-EGFR antibody 528 binds to domain III of EGFR at a site shifted from the cetuximab epitope Scientific Reports.
1
:11,
5790- DOI:10.1038/s41598-021-84171-3 PMID:33707468
Nagakumar Bharatham, Purnendu Bhowmik, Maho Aoki, Ui Okada, Sreevalli Sharma, Eiki Yamashita, Anirudh P. Shanbhag, Sreenath Rajagopal, Teby Thomas, Maitrayee Sarma, Riya Narjari, Savitha Nagaraj, Vasanthi Ramachandran, Nainesh Katagihallimath, Santanu Datta, Satoshi Murakami (2021)
Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae Nature Communications.
1
:12,
5400- DOI:10.1038/s41467-021-25679-0 PMID:34518546
Ryo Tashiro,Takaaki Sato,Haruyuki Atomi,Kunio Miki,Masahiro Fujihashi (2021)
Altering the Phosphorylation Position of Pyrophosphate-Dependent myo-Inositol-1-Kinase Based on Its Crystal Structure ACS Chemical Biology.
5
:16,
794-799 DOI:10.1021/acschembio.0c00733 PMID:33877806
Naruhiko Adachi, Takahide Yamaguchi, Toshio Moriya, Masato Kawasaki, Kotaro Koiwai, Akira Shinoda, Yusuke Yamada, Fumiaki Yumoto, Takamitsu Kohzuma, Toshiya Senda (2021)
2.85 and 2.99A resolution structures of 110 kDa nitrite reductase determined by 200 kV cryogenic electron microscopy Journal of structural biology.
3
:213,
107768- DOI:10.1016/j.jsb.2021.107768 PMID:34217801
Chieko Inoue, Ryosuke Negoro, Kazuo Takayama, Hiroyuki Mizuguchi, Fuminori Sakurai (2022)
Asymmetric profiles of infection and innate immunological responses in human iPS cellderived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus Virus Research.
296
198334- DOI:10.1016/j.virusres.2021.198334 PMID:33581186
Andriy Kryshtafovych,John Moult,Wendy M Billings,Dennis Della Corte,Krzysztof Fidelis,Sohee Kwon,Kliment Olechnovic,Chaok Seok,Ceslovas Venclovas,Jonghun Won (2021)
Modeling SARS-CoV2 proteins in the CASP-commons experiment Proteins.
DOI:10.1002/prot.26231 PMID:34462960
Rie Uesugi, Shunsuke Ishii, Akira Matsuura, Eisuke Itakura (0000)
Labeling and Measuring Stressed Mitochondria Using a PINK1-Based Ratiometric Fluorescent Sensor Journal of Biological Chemistry.
:2021,
DOI:10.1016/j.jbc.2021.101279 PMID:34624312
Toshihiro Kobayashi,Aracely Castillo-Venzor,Chris A Penfold,Michael Morgan,Naoaki Mizuno,Walfred W C Tang,Yasuyuki Osada,Masao Hirao,Fumika Yoshida,Hideyuki Sato,Hiromitsu Nakauchi,Masumi Hirabayashi,M Azim Surani (2021)
Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cell Cell Reports.
37
:2,
109812- DOI:10.1016/j.celrep.2021.109812 PMID:34644585
Yoshiaki Kawano, Masahide Hikita, Naohiro Matsugaki, Masaki Yamamoto and Toshiya Senda (2021)
Crystal processing machine using a deep-ultraviolet laser:application to long-wavelength native SAD experiments Acta Crystallographica Sectioun F .
R. Kato, M. Hiraki, Y. Yamada, M. Tanabe and
T. Senda (2021)
Improvement of Automated Crystallization and Monitoring
System in PF PF Highlights 2020.
52-53 DOI:https://www2.kek.jp/imss/pf/science/publ/pfhl/2020/
Masahito Ohue, Yutaka Akiyama (2021)
MEGADOCK-GUI: a GUI-based complete
cross-docking tool for exploring protein-protein
interactions In Proceedings of The 27th International Conference on Parallel & Distributed Processing Techniques and Applications (PDPTA’21).
DOI:https://arxiv.org/pdf/2105.03617.pdf
Masahito Ohue, Hiroki Watanabe, Yutaka Akiyama (2021)
MEGADOCK-Web-Mito: human mitochondrial protein-protein interaction prediction database. In Proceedings of The 27th International Conference on Parallel & Distributed Processing Techniques and Applications (PDPTA’21).
DOI:https://arxiv.org/abs/2105.00445
加藤龍一 (2021)
高エネ機構における結晶化条件探索の自動化 日本結晶学会誌.
63
212-215 DOI:10.5940/jcrsj.63.212
Yamato Sajiki, Satoru Konnai, Zimeng Cai, Kensuke Takada, Tomohiro Okagawa, Naoya Maekawa, Sotaro Fujisawa, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi (2021)
Enhanced Immunotherapeutic Efficacy of Anti-PD-L1 Antibody in Combination with an EP4 Antagonist. Immunohorizons.
4
:12,
837-850 DOI:10.4049/immunohorizons.2000089 PMID:33443026
Kenta Hayami, Yuichi Kuboki, Katsumi Ohta, Bangzhong Lin, Megumi Fumimoto, Kazuto Nunomura, Jun-Ichi Haruta , Kenichi Murai, Hiromichi Fujioka, Akira Asai, and Mitsuhiro Arisawa (2021)
Design, Synthesis, Physical Properties and Indoleamine 2, 3-Dioxygenase 1 Inhibitory Activity of Substitued Indole Derivatives with N-H, N-Metohymethyl, or N-Mehylthiomethyl Group toward Fragment-Based Drug Discovery Heterocycles.
103
511-525 DOI:10.3987/COM-20-S(K)35
Masatoshi Kanayama, Rintaro Oyama, Masataka Mori, Akihiro Taira, Shinji Shinohara, Taiji Kuwata, Masaru Takenaka, Kazue Yoneda, Koji Kuroda, Takashi Ohnaga, Yukinari Kato, Fumihiro Tanaka (2021)
Novel circulating tumor cell-detection chip combining conventional podoplanin and EGFR antibodies for all histological malignant pleural mesothelioma. Oncology Letters.
22
:1,
522- DOI:10.3892/ol.2021.12783 PMID:34025789
Manabu Igarashi , Takatsugu Hirokawa , Yoshihiro Takadate , Ayato Takada (2021)
Structural Insights into the Interaction of Filovirus Glycoproteins with the Endosomal Receptor Niemann-Pick C1: A Computational Study Viruses.
13
913- DOI:10.3390/v13050913 PMID:34069246
Kei Moritsugu (2021)
Multiscale Enhanced Sampling Using Machine Learning Life.
11
1076- DOI:10.3390/life11101076 PMID:34685447
Toshihiko Matsuo , Shihui Liu, Tetsuya Uchida, Satomi Onoue, Shinsaku Nakagawa, Mayumi Ishii and Kayoko Kanamitsu (2021)
Photoelectric Dye, NK-5962, as a Potential Drug for Preventing
Retinal Neurons from Apoptosis: Pharmacokinetic Studies
Based on Review of the Evidence Life .
11
:6,
591- DOI:10.3390/life11060591 PMID:34205684
Takatsugu Kosugi, Masahito Ohue (2021)
Quantitative estimate index for early-stage screening of compounds targeting protein-protein interactions. International Journal of Molecular Sciences.
22
10925- DOI:10.3390/ijms222010925 PMID:34681589
Effi Haque , Magdalena Smiech , Kamila Luczynska , Marie France Bouchard , Robert Viger , Hidetoshi Kono , Mariusz Pierzchala , Hiroaki Taniguchi (2021)
NRF2 DLG domain mutations identified in Japanese liver can-cer patients affect the transcriptional activity in HCC cell lines International Journal of Molecular Sciences.
22
5296- DOI:10.3390/ijms22105296 PMID:34069882
Kento Fujiwara, Masaki Kitaura, Ayaka Tsunei, Hotaka Kusabuka, Erika Ogaki, Naoki Okada (2021)
Structure of the Signal Transduction Domain in Second-Generation CAR Regulates the Input Efficiency of CAR Signals. International Journal of Molecular Sciences.
22
:5,
2476- DOI:10.3390/ijms22052476 PMID:33804441
Yasuka Matsunaga , Shun Hasei , Takeshi Yamamotoya , Hiroaki Honda , Akifumi Kushiyama , Hideyuki Sakoda , Midori Fujishiro , Hiraku Ono , Hisanaka Ito , Takayoshi Okabe , Tomoichiro Asano , Yusuke Nakatsu (2021)
Pathological Role of Pin1 in the Development of DSS-Induced Colitis. Cells.
10
1230- DOI:10.3390/cells10051230 PMID:34067858
Koji Kitamura, Keisuke Nimura (2021)
Regulation of RNA splicing: Aberrant splicing regulation and therapeutic targets in cancer Cells.
10
923- DOI:10.3390/cells10040923 PMID:33923658
Natsuki Osaka, Yoshihisa Hirota, Doshun Ito, Yoshiki Ikeda, Ryo Kamata, Yuki Fujii, Venkat R Chirasani, Sharon L Campbell, Koh Takeuchi, Toshiya Senda, Atsuo T Sasaki (2021)
Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification Frontiers molecular biosciences.
8
707439- DOI:10.3389/fmolb.2021.707439 PMID:34307463
Shunya Sugita, Masahito Ohue
(2021)
Drug-target affinity prediction using applicability
domain based on data density In Proceedings of The 18th IEEE International Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB 2021).
DOI:10.26434/chemrxiv.14498688.v1
Takatsugu Kosugi, Masahito Ohue (2021)
Quantitative estimate of protein-protein interaction targeting drug-likeness Analytical Chemistry.
DOI:10.26434/chemrxiv.14489769.v1
Taishi Onodera, Shunsuke Kita, Yu Adachi, Saya Moriayma, Akihiko Sato, Takao Nomura, Takeshi Inoue, Takashi Tadokoro, Yuki Anraku, Kohei Yumoto, Cong Tian, Hideo Fukuhara, Michihito Sasaki, Yasuko Orba, Nozomi Shiwa, Naoko Iwata, Noriyo Nagata, Tateki Suzuki, Jiei Sasaki, Tsuyoshi Sekizuka, Keisuke Tonouchi, Shuetsu Fukushi, Hiroyuki Satofuka, Yasuhiro Kazuki, Lin Sun, Mitsuo Oshimura, Tomohiro Kurosaki, Makoto Kuroda, Tadaki Suzuki, Hirofumi Sawa, Takao Hashiguchi, Katsumi Maenaka, Yoshimasa Takahashi, (2021)
Broad Neutralization Activity of SARS-CoV-2 Antibody is Achieved by Coordinated Recognition of Virus Vulnerable Site Cell press.
DOI:10.2139/ssrn.3817803
Haon Futamata, Masahiro Fukuda, Rie Umeda, Keitaro Yamashita, Satoe Takahashi, Takafumi Shikakura, Shigehiko Hayashi, Kazuaki Homma, Tomohiro Nishizawa, Osamu Nureki (2021)
Cryo-EM structures reveal the electromotility
mechanism of prestin, the cochlear amplifier nature portfolio.
DOI:10.21203/rs.3.rs-927386/v1
Makiko Kosugi, Masato Kawasaki, Yutaka Shibata, Kojiro Hara, Shinichi Takaichi, Toshio Moriya, Naruhiko Adachi, Yasuhiro Kamei, Yasuhiro Kashino, Sakae Kudoh, Hiroyuki Koike, Toshiya Senda (2021)
Uphill energy transfer mechanism for
photosynthesis in the Antarctic alga resezarch square.
DOI:10.21203/rs.3.rs-701485/v1
Satoshi Abe,Kazuhisa Honma, Akane Okada,Kanako Kazuki,Hiroshi Tanaka, Takeshi Endo, Kayoko Morimoto, Takashi Moriwaki, Shusei Hamamichi,Yuji Nakayama,Teruhiko Suzuki, Shoko Takehara, Mitsuo Oshimura, Yasuhiro Kazuki (2021)
Construction of Stable Mouse Artificial Chromosome from Native Mouse Chromosome 10 for Generation of Transchromosomic Mice Research square.
11
:1,
20050- DOI:10.21203/rs.3.rs-675300/v1
Ryoya Nakagawa, Soh Ishiguro, Sae Okazaki, Hideto Mori, Mamoru Tanaka, Hiroyuki Aburatani, Nozomu Yachie, Hiroshi Nishimasu, Osamu Nureki (2021)
Engineered Campylobacter jejuni Cas9 variant with
enhanced activity nature portfolio.
DOI:10.21203/rs.3.rs-512474/v1
Yuxia Zhang, Satoshi Watanabe, Akihisa Tsutsumi, Hiroshi Kadokura, Masahide Kikkawa, Kenji Inaba (2021)
Cryo-EM analysis provides new mechanistic insight into ATP binding to Ca 2+ -ATPase SERCA2b The EMBO Journal.
40
:19,
e108482- DOI:10.15252/embj.2021108482 PMID:34459010
Fei Jin, Minxuan Sun, Takashi Fujii, Yurika Yamada, Jin Wang, Andres D Maturana, Miki Wada, Shichen Su, Jinbiao Ma, Hironori Takeda, Tsukasa Kusakizako, Atsuhiro Tomita, Yoshiko Nakada-Nakura, Kehong Liu, Tomoko Uemura, Yayoi Nomura, Norimichi Nomura, Koichi Ito, Osamu Nureki, Keiichi Namba, So Iwata, Ye Yu, Motoyuki Hattori (2021)
The structure of MgtE in the absence of
magnesium provides new insights into
channel gating PLOS Biology.
19
:4,
e3001231- DOI:10.1371/journal.pbio.3001231 PMID:33905418
Tomonori Kameda, Hideyuki Nakashima, Takumi Takizawa, Fumihito Miura, Takashi Ito, Kinichi Nakashima, Takuya Imamura (2021)
Neuronal activation modulates enhancer activity of genes for excitatory synaptogenesis through de novo DNA methylation Journal of Reproduction and Development.
67
:6,
369-379 DOI:10.1262/jrd.2021-106 PMID:34615840
Aoze Su, Yuko Tabata, Kiyono Aoki, Akane Sada, Rieko Ohki, Satoru Nagatoishi, Kouhei Tsumoto, Siyuan Wang, Yuko Otani, Tomohiko Ohwada (2021)
Elaboration of non-naturally occurring helical tripeptides as p53-MDM2/MDMX interaction inhibitors Chemical & pharmaceutical bulletin.
69
681-692 DOI:10.1248/cpb.c21-00238 PMID:33952867
Yukiko Karuo, Riona Shiraki, Ayaka Yoshida, Ryo Tsunokawa, Mayuko Nakahara-Yamada, Atsushi Tarui, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote, Hitoshi Nishimura (2021)
Identification and Synthesis of DDI-6, a Quinolinol Analog Capable of Activating Both Caenorhabditis elegans and Mouse Spermatozoa Chemical and Pharmaceutical Bulletin.
69
557-563 DOI:10.1248/cpb.c21-00127 PMID:34078802
Kotaro Kasai,Yuma Horii,Takanori Hironaka,Kyosuke Mae,Tomoyuki Ueno,Akiomi Nagasaka,Michio Nakaya (2021)
Increased Expression of Heparan Sulfate 6-O-Sulfotransferase-2 Promotes Collagen Production in Cardiac Myofibroblasts BPB Reports.
4
85-91 DOI:10.1248/bpbreports.4.3_85
Shigehiro Ohdo (2021)
Chrono-Drug Discovery and Development Based on
Circadian Rhythm of Molecular, Cellular and Organ Level Biological & pharmaceutical bulletin.
44
747-761 DOI:10.1248/bpb.b21-00277 PMID:34078807
Daichi Egawa,Taku Ogiso,Kimina Nishikata,Keiko YamamotoToshimasa Itoh (2021)
Structural Insights into the Loss-of-Function R288H Mutant of Human PPARγ Biological and Pharmaceutical Bulletin.
44
:9,
1196-1201 DOI:10.1248/bpb.b21-00253 PMID:34471047
Phuong Thuy Viet Nguyen, Truong Van Dat, Shusaku Mizukami, Duy Le Hoang Nguyen,
Farhana Mosaddeque, Son Ngoc Kim, Duy Hoang Bao Nguyen, Oanh Thi Dinh, Tu Linh Vo, Giang Le
Tra Nguyen, Cuong Quoc Duong, Satoshi Mizuta, Dao Ngoc Hien Tam, M. Phuong Truong,
Nguyen Tien Huy and Kenji Hirayama (2021)
2D-quantitative structure-activity
relationships model using PLS method
for anti-malarial activities of anti-haemozoin
compounds Malar J.
20
264- DOI:10.1186/s12936-021-03775-2 PMID:34116665
Yoshihisa Hirakawa, Miki Senda, Kodai Fukuda, Hong Yang Yu, Masaki Ishida, Masafumi Taira, Kazushi Kinbara, Toshiya Senda (2021)
Characterization of a novel type of carbonic
anhydrase that acts without metal cofactors BMC Biology.
19
:1,
105- DOI:10.1186/s12915-021-01039-8 PMID:34006275
Shuhei Kanagaki,Takahiro Suezawa,Keita Moriguchi,Kazuhisa Nakao,Masayasu Toyomoto,Yuki Yamamoto,Koji Murakami,Masatoshi Hagiwara,Shimpei Gotoh (2021)
Hydroxypropyl Cyclodextrin Improves Amiodarone-Induced Aberrant Lipid Homeostasis of Alveolar Cells American Journal of Respiratory Cell and Molecular Biology.
64
504-514 DOI:10.1165/rcmb.2020-0119OC PMID:33493427
Shogo Nakajima, Koichi Watashi, Takanobu Kato, Masamichi Muramatsu, Takaji Wakita, Noriko Tamura, Shin-Ichiro Hattori, Kenji Maeda, Hiroaki Mitsuya, Yoshiaki Yasutake, Tetsuya Toyoda (2021)
Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations Journal of Virology.
95
:16,
e0240120- DOI:10.1128/JVI.02401-20 PMID:34076480
Stephanie L Neville, Jennie Sjohamn, Jacinta A Watts, Hugo MacDermott-Opeskin, Stephen J Fairweather, Katherine Ganio, Alex Carey Hulyer, Aaron P McGrath, Andrew J Hayes, Tess R Malcolm, Mark R Davies, Norimichi Nomura, So Iwata, Megan L OMara, Megan J Maher, Christopher A McDevitt (2021)
The structural basis of bacterial manganese import Science Advances.
7
:32,
eabg3980- DOI:10.1126/sciadv.abg3980 PMID:34362732
Mutsuko Kukimoto-Niino, Kazushige Katsura, Rahul Kaushik, Haruhiko Ehara, Takeshi Yokoyama, Tomomi Uchikubo-Kamo, Reiko Nakagawa, Chiemi Mishima-Tsumagari, Mayumi Yonemochi, Mariko Ikeda, Kazuharu Hanada, Kam Y J Zhang, Mikako Shirouzu (2021)
Cryo-EM structure of the human
ELMO1-DOCK5-Rac1 complex Science Advances.
7
:30,
eabg3147- DOI:10.1126/sciadv.abg3147 PMID:34290093
Laura Bracun, Atsushi Yamagata, Bern M Christianson, Tohru Terada, Daniel P Canniffe, Mikako Shirouzu, Lu-Ning Liu (2021)
Cryo-EM structure of the photosynthetic RC-LH1-PufX
supercomplex at 2.8-A resolution Science Advances.
7
:25,
eabf8864- DOI:10.1126/sciadv.abf8864 PMID:34134992
Kiyoshi Yoshioka, Hiroshi Nagahisa, Fumihito Miura, Hiromitsu Araki, Yasutomi Kamei, Yasuo Kitajima, Daiki Seko, Jumpei Nogami, Yoshifumi Tsuchiya, Narihiro Okazaki, Akihiko Yonekura, Seigo Ohba, Yoshinori Sumita, Ko Chiba, Kosei Ito, Izumi Asahina, Yoshihiro Ogawa, Takashi Ito, Yasuyuki Ohkawa, Yusuke Ono (2021)
Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle Science Advances.
7
:24,
eabd7924- DOI:10.1126/sciadv.abd7924 PMID:34108202
Aya Shiba-Ishii (2021)
Significance of stratifin in early progression of lung
adenocarcinoma and its potential therapeutic relevance International Journal of Surgical Pathology.
71
655-665 DOI:10.1111/pin.13147 PMID:34324245
Rieko Imae, Naoyuki Kuwabara, Hiroshi Manya, Tomohiro Tanaka, Masato Tsuyuguchi, Mamoru Mizuno, Tamao Endo, Ryuichi Kato (2021)
The structure of POMGNT2 provides new insights into the mechanism to determine the functional O-mannosylation site on α-dystroglycan. Genes to Cells .
26
:7,
485-494 DOI:10.1111/gtc.12853 PMID:33893702
Evdokia-Anastasia Giannopoulou, Miki Senda, Maharani Pertiwi Koentjoro, Naruhiko Adachi, Naoto Ogawa, Toshiya Senda (2021)
Crystal structure of the full-length LysR-type transcription regulator CbnR in complex with promoter DNA The FEBS Journal.
288
:15,
4560-4575 DOI:10.1111/febs.15764 PMID:33576566
Isabel Sebastian,Nobuhiko Okura,Bruno M Humbel,Jun Xu,Idam Hermawan,Chiaki Matsuura,Malgorzata Hall,Chitoshi Takayama,Tetsu Yamashiro,Shuichi Nakamura,Claudia Toma
(2021)
Disassembly of the apical junctional complex during the transmigration of Leptospira interrogans across polarized renal proximal tubule epithelial cells cellular microbiology.
23
:9,
e13343.- DOI:10.1111/cmi.13343 PMID:33864347
Mina Noura , Ken Morita , Hiroki Kiyose , Yukiko Okuno , Hidemasa Matsuo, Asami Koyama , Yoko Nishinaka-Arai , Yasuhiko Kamikubo , Souichi Adachi (2021)
Albendazole induces the terminal differentiation of acute
myeloid leukaemia cells to monocytes by stimulating the
Kruppel-like factor 4-dihydropyrimidinase-like 2A
(KLF4-DPYSL2A) axis British Journal of Haematology.
194
598-603 DOI:10.1111/bjh.17557 PMID:34227104
Risako Tamura-Sakaguchi, Rie Aruga, Mika Hirose, Toru Ekimoto, Takuya Miyake, Yohei Hizukuri, Rika Oi, Mika K Kaneko, Yukinari Kato, Yoshinori Akiyama, Mitsunori Ikeguchi, Kenji Iwasaki, Terukazu Nogi (2021)
Moving toward generalizable NZ-1 labeling for 3D structure determination with optimized epitope-tag insertion Acta Crystallographica Section D.
77
645-662 DOI:10.1107/S2059798321002527 PMID:33960020
Takeshi Murakawa, Mamoru Suzuki, Toshi Arima, Michihiro Sugahara, Tomoyuki Tanaka, Rie Tanaka, So Iwata, Eriko Nango, Kensuke Tono, Hideyuki Hayashi, Kenji Fukui, Takato Yano, Katsuyuki Tanizawa, Toshihide Okajima (2021)
Microcrystal preparation for serial femtosecond X-ray crystallography of bacterial copper amine oxidase Acta Crystallographica Section F, Structural bilogy of commuinications.
77
356-363 DOI:10.1107/S2053230X21008967 PMID:34605440
Keijun Kakihara, Kengo Asamizu, Kei Moritsugu, Masahide Kubo, Tetsuya Kitaguchi, Akinori Endo, Akinori Kidera, Mitsunori Ikeguchi, Akira Kato, Masayuki Komada, Toshiaki Fukushima (2021)
The molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain bioRxiv.
DOI:10.1101/2021.05.31.446389
Sato K, Kumar A, Hamada K, Okada C, Oguni A, Machida A, Sakuraba S, Nishizawa T, Nureki O, Kono H, et al. (2021)
Structural mechanism regulating normal and oncogenic methylation of nucleosomal histone H3K36 by NSD2 DOI:10.1101/2020.12.05.413278
Shohei Nosaki, Mika K Kaneko, Fuminori Tsuruta, Hideki Yoshida, Yukinari Kato, Kenji Miura (2021)
Prevention of necrosis caused by transient expression in Nicotiana benthamiana by application of ascorbic acid Plant Physiol.
186
:2,
832-835 DOI:10.1093/plphys/kiab102 PMID:33638348
Masahiko Okuda, Tetsufumi Suwa, Hidefumi Suzuki, Yuki Yamaguchi, Yoshifumi Nishimura (2021)
Three human RNA polymerases interact with TFIIH via a common RPB6 subunit Nucleic Acids Research.
50
:1,
1-16 DOI:10.1093/nar/gkab612 PMID:34268577
Satoru Ishihara, Yohei Sasagawa, Takeru Kameda, Hayato Yamashita, Mana Umeda, Naoe Kotomura, Masayuki Abe, Yohei Shimono, Itoshi Nikaido (2021)
Local states of chromatin compaction at transcription start sites control transcription levels Nucleic Acids Research.
49
:14,
8007-8023 DOI:10.1093/nar/gkab587 PMID:34233004
Keisuke Oki, Takeshi Yamagami, Mariko Nagata, Kouta Mayanagi, Tsuyoshi Shirai, Naruhiko Adachi, Tomoyuki Numata, Sonoko Ishino,Yoshizumi Ishino (2021)
DNA polymerase D temporarily connects primase to the CMG-like helicase before interacting with proliferating cell nuclear antigen Nucleic Acids Research.
49
4599-4612 DOI:10.1093/nar/gkab243 PMID:33849056
Yoshihiro Kobashigawa, Toshiya Ohara, Kosuke Morita, Yuya Toyota, Teruya Nakamura, Shunsuke Kotani, Takao Arimori, Soichiro Yamauchi, Chenjiang Liu, Masaya Kitazaki, Yukari Wakeyama-Miyazaki, Yoshiaki Suwa, Makiyo Uchida-Kamekura, Natsuki Fukuda, Takashi Sato, Makoto Nakajima, Junichi Takagi, Yuriko Yamagata, Hiroshi Morioka (2021)
Molecular recognition of a single-chain Fv antibody specific for GA-pyridine, an advanced glycation end-product (AGE), elucidated using biophysical techniques and synthetic antigen analogues The Journal of Biochemistry.
170
:3,
379-387 DOI:10.1093/jb/mvab056 PMID:34185078
Jianan Li , Keisuke Yanagisawa , Yasushi Yoshikawa, Masahito Ohue and Yutaka Akiyama (2021)
Plasma protein binding prediction focusing on
residue-level features and circularity of cyclic peptides by deep learning Bioinformatics.
DOI:10.1093/bioinformatics/btab726 PMID:34849593
Tomonari Muramatsu and Masaru Tanokura (2021)
A novel method of literature mining to identify
candidate COVID-19 drugs Bioinformatics Advances.
1
vbab013- DOI:10.1093/bioadv/vbab013
Hana Inoue, Takashi Murayama, Takuya Kobayashi, Masato Konishi, Utako Yokoyama (2021)
The zinc-binding motif of TRPM7 acts as an oxidative stress sensor to regulate its channel activity Journal of General Physiology.
153
:6,
e202012708- DOI:10.1085/jgp.202012708 PMID:33999118
Taito Kashio, Keisuke Shirakura, Mayumi Kinoshita, Maaya Morita, Ryosuke Ishiba, Kosuke Muraoka, Tomoaki Kanbara, Masato Tanaka, Risa Funatsu, Nobumasa Hino, Shohei Koyama, Ryo Suzuki, Yasuo Yoshioka, Taiki Aoshi, Takefumi Doi, Yoshiaki Okada (2021)
HDAC inhibitor, MS-275, increases vascular permeability by suppressing Robo4 expression in endothelial cells Tissue Barriers.
9
:3,
1911195- DOI:10.1080/21688370.2021.1911195 PMID:33955828
Takuto Kumano, Sanae Hori, Satomi Watanabe, Yuzu Terashita, Hong Yang Yu, Yoshiteru Hashimoto, Toshiya Senda, Miki Senda, Michihiko Kobayashi (2021)
FAD-dependent C-glycoside-metabolizing Enzymes in Microorganisms: Screening, Characterization and Crystal Structure Analysis Proceedings of the National Academy of Sciences of the United States of America.
118
:40,
e2106580118- DOI:10.1073/pnas.2106580118 PMID:34583991
Junki Hirano , Sachiyo Yoshio , Yusuke Sakai , Li Songling , Tatsuya Suzuki , Yumi Itoh , He Zhang , David Virya Chen , Saori Haga , Hiroko Oomori , Takahiro Kodama , Yusuke Maeda , Yoshihiro Ono , Yu Takahashi, Daron M Standley , Masahiro Yamamoto , Kohji Moriishi , Kyoji Moriya , Tatsuya Kanto , Tetsuo Takehara , Kazuhiko Koike , Yoshiharu Matsuura , Toru Okamoto (2021)
Hepatitis C virus modulates signal peptide peptidase to alter host protein processing Proc Natl Acad Sci U S A .
118
:22,
e2026184118- DOI:10.1073/pnas.2026184118 PMID:34035171
Takayuki Nagae, Masashi Unno, Taiki Koizumi, Yohei Miyanoiri, Tomotsumi Fujisawa, Kento Masui, Takanari Kamo, Kei Wada, Toshihiko Eki, Yutaka Ito, Yuu Hirose, Masaki Mishima (2021)
Structural basis of the protochromic green/red photocycle of the chromatic acclimation sensor RcaE Proceedings of the National Academy of Sciences of the United States of America.
118
:20,
e2024583118- DOI:10.1073/pnas.2024583118 PMID:33972439
Naoki Kamo,Tomoya Kujirai,Hitoshi Kurumizaka,Hiroshi Murakami,Gosuke Hayashi and Akimitsu Okamoto (2021)
Organoruthenium-catalyzed chemical protein synthesis to elucidate the functions of epigenetic modifications on heterochromatin factors. Chemical Science.
12
:16,
5926-5937 DOI:10.1039/D1SC00731A
Yue Ma , Yuki Wakabayashi , Naruyuki Watatani , Ryota Saito , Takatsugu Hirokawa , Masayuki Tera , Kazuo Nagasawa (2021)
Vinylnaphthalene-bearing hexaoxazole as a fluorescence turn-on type G-quadruplex ligand Organic and Biomolecular Chemistry.
19
8035-8040 DOI:10.1039/d1ob01500a PMID:34492672
Hikari Tanaka,Kanoh Kondo,Kyota Fujita,Hidenori Homma,Kazuhiko Tagawa,Xiaocen Jin,Meihua Jin,Yuki Yoshioka,Sumire Takayama,Hitomi Masuda,Rie Tokuyama,Yukoh Nakazaki,Takashi Saito,Takaomi Saido,Shigeo Murayama,Teikichi Ikura,Nobutoshi Ito,Yu Yamamori,Kentaro Tomii,Marco E Bianchi,Hitoshi Okazawa (2021)
HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology 4
1175- DOI:10.1038/s42003-021-02671-4 PMID:34635772
Kazutaka Katoh , Daron M Standley (2021)
Emerging SARS-CoV-2 variants follow a historical pattern recorded in outgroups infecting non-human hosts. Communications Biology.
4
:1,
1134- DOI:10.1038/s42003-021-02663-4 PMID:34552191
Mirai Tanigawa, Katsuyoshi Yamamoto, Satoru Nagatoishi, Koji Nagata, Daisuke Noshiro, Nobuo N Noda, Kouhei Tsumoto, Tatsuya Maeda (2021)
A glutamine sensor that directly activates TORC1 Nature Commun.
4
1093- DOI:10.1038/s42003-021-02625-w PMID:34535752
Akinobu Senoo, Sho Ito, Satoru Nagatoishi, Yutaro Saito, Go Ueno, Daisuke Kuroda, Kouhei Yoshida, Takumi Tashima, Shota Kudo, Shinsuke Sando & Kouhei Tsumoto (2021)
Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion Communications Biology.
4
:1,
1041- DOI:10.1038/s42003-021-02575-3 PMID:34493804
Yuya Taguchi, Takahiro Yamasaki, Marie Ishikawa, Yuki Kawasaki, Ryuji Yukimura, Maki Mitani, Kunio Hirata, Daisuke Kohda (2021)
The structure of an archaeal oligosaccharyltransferase provides insight into the strict exclusion of proline from the N-glycosylation sequon
Communications Biology.
4
:1,
941- DOI:10.1038/s42003-021-02473-8 PMID:34354228
Seiya Oura, Taichi Noda, Naoko Morimura, Seiji Hitoshi, Hiroshi Nishimasu, Yoshitaka Nagai, Osamu Nureki, Masahito Ikawa (2021)
Precise CAG repeat contraction in a Huntington's Disease mouse model is enabled by gene editing with SpCas9-NG Comminications biology.
4
:1,
771- DOI:10.1038/s42003-021-02304-w PMID:34163001
Miho Watanabe-Takahashi, Masakazu Tamada, Miki Senda, Masahiro Hibino, Eiko Shimizu, Akiko Okuta, Atsuo Miyazawa, Toshiya Senda, Kiyotaka Nishikawa (2021)
Identification of a peptide motif that potently inhibits two functionally distinct subunits of Shiga toxin Communications biology.
4
:1,
538- DOI:10.1038/s42003-021-02068-3 PMID:33972673
Naoya Maekawa, Satoru Konnai, Maki Nishimura, Yumiko Kagawa, Satoshi Takagi, Kenji Hosoya, Hiroshi Ohta, Sangho Kim, Tomohiro Okagawa, Yusuke Izumi, Tatsuya Deguchi, Yukinari Kato, Satoshi Yamamoto, Keiichi Yamamoto, Mikihiro Toda, Chie Nakajima, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi (2021)
PD-L1 immunohistochemistry for canine cancers and clinical benefit of anti-PD-L1 antibody in dogs with pulmonary metastatic oral malignant melanoma NPJ Precision oncology.
5
:1,
10- DOI:10.1038/s41698-021-00147-6 PMID:33580183
Takeshi Yamamotoya, Yusuke Nakatsu, Machi Kanna, Shun Hasei, Yukino Ohata, Jeffrey Encinas, Hisanaka Ito, Takayoshi Okabe, Tomoichiro Asano, Takemasa Sakaguchi (2021)
Prolyl isomerase Pin1 plays an essential role in SARS-CoV-2 proliferation, indicating its possibility as a novel therapeutic target. Scietific Reports.
11
18581- DOI:10.1038/s41598-021-97972-3 PMID:34535740
Keiko Fukasawa , Mari Gotoh , Akiharu Uwamizu , Takatsugu Hirokawa , Masaki Ishikawa , Yoshibumi Shimizu , Shinji Yamamoto , Kensuke Iwasa , Keisuke Yoshikawa , Junken Aoki , Kimiko Murakami-Murofushi (2021)
2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition Scientific Reports.
11
17360- DOI:10.1038/s41598-021-96931-2 PMID:34462512
Halilibrahim Ciftci, Hiroshi Tateishi, Kotaro Koiwai, Ryoko Koga, Kensaku Anraku, Kazuaki Monde, Cagdas Dag, Ebru Destan , Busra Yuksel, Esra Ayan, Gunseli Yildirim, Merve Yigin, F Betul Ertem, Alaleh Shafiei, Omur Guven, Sabri O Besler, Raymond G Sierra, Chun Hong Yoon, Zhen Su, Mengling Liang, Burcin Acar, Turkan Haliloglu, Masami Otsuka, Fumiaki Yumoto, Mikako Fujita, Toshiya Senda, Hasan DeMirci (2021)
Structural insight into host plasma membrane association and assembly of HIV-1 matrix protein Scientific Reports.
11
:1,
15819- DOI:10.1038/s41598-021-95236-8 PMID:34349176
Yuta Yamamura, Kengo Furuichi, Yasuhiro Murakawa, Shigeki Hirabayashi, Masahito Yoshihara, Keisuke Sako, Shinji Kitajima, Tadashi Toyama, Yasunori Iwata, Norihiko Sakai, Kazuyoshi Hosomichi, Philip M Murphy, Atsushi Tajima, Keisuke Okita, Kenji Osafune, Shuichi Kaneko, Takashi Wada (2021)
Identification of candidate PAX2-regulated genes implicated in human kidney development Scientific Reports.
11
:1,
9123- DOI:10.1038/s41598-021-88743-1 PMID:33907292
Yosuke Ito, Yasuhisa Terao, Shohei Noma, Michihira Tagami, Emiko Yoshida, Yoshihide Hayashizaki, Masayoshi Itoh, Hideya Kawaji (2021)
Nanopore sequencing reveals TACC２ locus complexity and diversity of isoforms
transcribed from an intronic promoter Scientific Reports.
11
:1,
9355- DOI:10.1038/s41598-021-88018-9 PMID:33931666
Takaharu Sakuragi, Ryuta Kanai, Akihisa Tsutsumi, Hirotaka Narita, Eriko Onishi, Kohei Nishino, Takuya Miyazaki, Takeshi Baba, Hidetaka Kosako, Atsushi Nakagawa, Masahide Kikkawa, Chikashi Toyoshima, Shigekazu Nagata (2021)
The tertiary structure of the human Xkr8-Basigin complex that scrambles phospholipids at plasma membranes Nature Structural & Molecular Biology.
28
:10,
825-834 DOI:10.1038/s41594-021-00665-8 PMID:34625749
Hiroyuki H Okamoto, Hirotake Miyauchi, Asuka Inoue, Francesco Raimondi, Hirokazu Tsujimoto, Tsukasa Kusakizako, Wataru Shihoya, Keitaro Yamashita, Ryoji Suno, Norimichi Nomura, Takuya Kobayashi, So Iwata, Tomohiro Nishizawa, Osamu Nureki (2021)
Cryo-EM structure of the human MT 1-G i signaling complex nature structural & molecular biology.
28
:8,
694-701 DOI:10.1038/s41594-021-00634-1 PMID:34354246
Nathan Singh , Noelle V Frey , Boris Engels , David M Barrett , Olga Shestova , Pranali Ravikumar , Katherine D Cummins , Yong Gu Lee , Raymone Pajarillo , Inkook Chun , Amy Shyu , Steven L Highfill , Andrew Price , Linlin Zhao , Liaomin Peng , Brian Granda , Melissa Ramones , Xueqing Maggie Lu , David A Christian , Jessica Perazzelli , Simon F Lacey , Nathan H Roy , Janis K Burkhardt , Florent Colomb , Mohammad Damra , Mohamed Abdel-Mohsen , Ting Liu , Dongfang Liu , Daron M Standley , Regina M Young , Jennifer L Brogdon , Stephan A Grupp , Carl H June , Shannon L Maude , Saar Gill , Marco Ruella (2021)
Antigen-independent activation enhances the efficacy of 41BB co-stimulated CD22 CAR T cells. Nature Medicine.
27
:5,
842-850 DOI:10.1038/s41591-021-01326-5 PMID:33888899
Yoshiaki Kise, Go Kasuya, Hiroyuki H. Okamoto, Daichi Yamanouchi, Kan Kobayashi, Tsukasa Kusakizako, Tomohiro Nishizawa, Koichi Nakajo & Osamu Nurek (2021)
Structural basis of gating modulation of Kv4 channel complexes Nature.
599
:7883,
158-164 DOI:10.1038/s41586-021-03935-z PMID:34552243
Masahiko Ajiro, Tomonari Awaya, Young Jin Kim, Kei Iida, Masatsugu Denawa, Nobuo Tanaka, Ryo Kurosawa, Shingo Matsushima, Saiko Shibata, Tetsunori Sakamoto, Lorenz Studer, Adrian R Krainer, Masatoshi Hagiwara (2021)
Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia. Nature Communications.
12
4507- DOI:10.1038/s41467-021-24705-5 PMID:34301951
Toshiko Yamazawa , Takuya Kobayashi , Nagomi Kurebayashi , Masato Konishi , Satoru Noguchi , Takayoshi Inoue , Yukiko U Inoue , Ichizo Nishino , Shuichi Mori , Hiroto Iinuma , Noriaki Manaka , Hiroyuki Kagechika, Arkady Uryash , Jose Adams , Jose R Lopez , Xiaochen Liu , Christine Diggle , Paul D Allen , Sho Kakizawa , Keigo Ikeda , Bangzhong Lin , Yui Ikemi , Kazuto Nunomura , Shinsaku Nakagawa , Takashi Sakurai , Takashi Murayama (2021)
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke Nature Communications.
12
:1,
4293- DOI:10.1038/s41467-021-24644-1 PMID:34257294
Yusuke Higuchi, Tatsuya Suzuki , Takao Arimori , Nariko Ikemura , Emiko Mihara , Yuhei Kirita , Eriko Ohgitani , Osam Mazda , Daisuke Motooka , Shota Nakamura , Yusuke Sakai , Yumi Itoh , Fuminori Sugihara , Yoshiharu Matsuura , Satoaki Matoba , Toru Okamoto , Junichi Takagi , Atsushi Hoshino (2021)
Engineered ACE2 receptor therapy overcomes
mutational escape of SARS-CoV-2 Nature Communications.
12
:1,
3802- DOI:10.1038/s41467-021-24013-y PMID:34155214
Yuya Yoshida, Naoya Matsunaga, Takaharu Nakao, Kengo Hamamura, Hideaki Kondo,Tomomi Ide, Hiroyuki Tsutsui, Akito Tsuruta, Masayuki Kurogi, Michio Nakaya, Hitoshi Kurose, Satoru Koyanagi & Shigehiro Ohdo (2021)
Alteration of circadian machinery in monocytes
underlies chronic kidney disease-associated cardiac
inflammation and fibrosis Nature communications.
12
2783- DOI:10.1038/s41467-021-23050-x PMID:33986294
Makoto Saito, Yasushi Itoh, Fumihiko Yasui, Tsubasa Munakata, Daisuke Yamane, Makoto Ozawa, Risa Ito, Takayuki Katoh, Hirohito Ishigaki, Misako Nakayama, Shintaro Shichinohe, Kenzaburo Yamaji, Naoki Yamamoto, Ai Ikejiri, Tomoko Honda, Takahiro Sanada, Yoshihiro Sakoda, Hiroshi Kida, Thi Quynh Mai Le, Yoshihiro Kawaoka, Kazumasa Ogasawara, Kyoko Tsukiyama-Kohara, Hiroaki Suga, Michinori Kohara (2021)
Macrocyclic peptides exhibit antiviral effects
against influenza virus HA and prevent pneumonia
in animal models Nature communications.
12
2654- DOI:10.1038/s41467-021-22964-w PMID:33976181
Akihiro Eguchi, Ayaka Ueki, Junya Hoshiyama, Keiko Kuwata, Yoko Chikaoka, Takeshi Kawamura, Satoru Nagatoishi, Kouhei Tsumoto, Ryosuke Ueki, and Shinsuke Sando (2021)
A DNA Aptamer That Inhibits the Aberrant Signaling of Fibroblast Growth Factor Receptor in Cancer Cells JACS Au.
1
578-585 DOI:10.1021/jacsau.0c00121 PMID:34467321
Mitsuyasu Kawaguchi, Eriko Sekimoto, Yuhei Ohta, Naoya Ieda, Takashi Murakami,
and Hidehiko Nakagawa (2021)
Synthesis of Fluorescent Probes Targeting Tumor-Suppressor
Protein FHIT and Identification of Apoptosis-Inducing FHIT
Inhibitors Journal of Medicinal Chemistry.
64
9567-9576 DOI:10.1021/acs.jmedchem.1c00874 PMID:34160227
Sho Konno, Kiyotaka Kobayashi, Miki Senda, Yuta Funai, Yuta Seki, Ikumi Tamai, Laura Schakel, Kyousuke Sakata, Thanigaimalai Pillaiyar, Akihiro Taguchi, Atsuhiko Taniguchi, Michael Gutschow, Christa E Muller, Koh Takeuchi, Mikako Hirohama, Atsushi Kawaguchi, Masaki Kojima, Toshiya Senda, Yoshiyuki Shirasaka, Wataru Kamitani, Yoshio Hayashi (2021)
3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as
Anti-SARS-CoV-2 Agents Journal of Medicinal Chemistry.
DOI:10.1021/acs.jmedchem.1c00665 PMID:34313428
Masatake Sugita , Satoshi Sugiyama , Takuya Fujie , Yasushi Yoshikawa , Keisuke Yanagisawa , Masahito Ohue , Yutaka Akiyama (2021)
Large-Scale Membrane Permeability Prediction of Cyclic Peptides
Crossing a Lipid Bilayer Based on Enhanced Sampling Molecular
Dynamics Simulations Journal of Chemical Information and Modeling.
61
3681-3695 DOI:10.1021/acs.jcim.1c00380 PMID:34236179
Chun-Ming Zhang, Yoshihiro Imoto, Takaaki Hikima, Tsuyoshi Inoue (2021)
Structural flexibility of the tetanus neurotoxin revealed by crystallographic and solution scattering analyses Journal of Structural Biology.
5
100045- DOI:10.1016/j.yjsbx.2021.100045 PMID:33598655
Zhikuan Zhang, Hideki Shigematsu, Toshiyuki Shimizu, Umeharu Ohto (2021)
Improving particle quality in cryo-EM analysis using a PEGylation method. Structure.
29
:10,
1192-1199 DOI:10.1016/j.str.2021.05.004 PMID:34048698
Nobuaki Yasuo, Takashi Ishida, Masakazu Sekijima (2021)
Computer aided drug discovery review for infectious diseases
with case study of anti-Chagas project Parasitology International.
83
DOI:10.1016/j.parint.2021.102366 PMID:33915269
Akiko Sagara, Kohei Nakata, Tomohiro Yamashita, Weiyu Guan, Pingshan Zhong, Sokichi Matsumoto, Sho Endo, Chika Iwamoto, Koji Shindo, Naoki Ikenaga, Taiki Moriyama, Kenoki Ohuchida, Kazuhiro Mizumoto, Masafumi Nakamura (2021)
New high-throughput screening detects compounds that suppress pancreatic stellate cell activation and attenuate pancreatic cancer growth Pancreatology.
S1424-3903
:21,
141- DOI:10.1016/j.pan.2021.04.002 PMID:33965328
Chisae Nagiri, Kazuhiro Kobayashi, Atsuhiro Tomita, Masahiko Kato, Kan Kobayashi, Keitaro Yamashita, Tomohiro Nishizawa, Asuka Inoue, Wataru Shihoya, Osamu Nureki (2021)
Cryo-EM structure of the β3-adrenergic receptor reveals the molecular basis of subtype selectivity molecular cell.
81
:15,
3205-3215 DOI:10.1016/j.molcel.2021.06.024 PMID:34314699
Takayuki Kimura, Nobuaki Yasuo, Masakazu Sekijima, Brooke Lustig (2021)
Statistical potentials for RNA-protein interactions optimized by CMA-ES Journal of Molecular Graphics and Modelling.
110
108044- DOI:10.1016/j.jmgm.2021.108044 PMID:34736056
Hideaki Ohtomo, Jun-ichi Kurita, Shun Sakuraba, Zhenhai Li, Yasuhiro Arimura, Masatoshi Wakamori, Yasuo Tsunaka, Takashi Umehara, Hitoshi Kurumizaka, Hidetoshi Kono, Yoshifumi Nishimura (2021)
The N-terminal tails of histones H2A and H2B adopt two distinct conformations in the nucleosome with contact and reduced contact to DNA. Journal of Molecular Biology.
433
167110- DOI:10.1016/j.jmb.2021.167110 PMID:34153285
Kosuke Shido , Kaname Kojima , Matsuyuki Shirota , Kenshi Yamasak , Ikuko N Motoike , Atsushi Hozawa , Soichi Ogishima , Naoko Minegishi , Kozo Tanno , Fumiki Katsuoka, Gen Tamiya , Setsuya Aiba, Masayuki Yamamoto , Kengo Kinoshita (2021)
GWAS Identified IL4R and the Major Histocompatibility Complex Region as the Associated Loci of Total Serum IgE Levels in 9,260 Japanese Individuals Journal of Investigative Dermatology.
S0022-202X
1151-9- DOI:10.1016/j.jid.2021.02.762 PMID:33864772
Chiharu Anada, Keisuke Ikeda, Ayako Egawa, Toshimichi Fujiwara, Hiroyuki Nakao, Minoru Nakano (2021)
Temperature- and Composition-Dependent Conformational Transitions of Amphipathic Peptide-Phospholipid Nanodiscs Journal of Colloid and Interface Science.
588
522-530 DOI:10.1016/j.jcis.2020.12.090 PMID:33429348
Tensho Ten, Satoru Nagatoishi, Ryo Maeda, Masaru Hoshino, Yoshiaki Nakayama, Motoharu Seiki, Takeharu Sakamoto, Kouhei Tsumoto (2021)
Structural and thermodynamical insights into the binding and inhibition of FIH-1 by the N-terminal disordered region of Mint3 Journal of Biological Chemistry.
DOI:10.1016/j.jbc.2021.101304 PMID:34655613
Takamasa Teramoto, Takeshi Koyasu, Naruhiko Adachi, Masato Kawasaki, Toshio Moriya, Tomoyuki Numata, Toshiya Senda, Yoshimitsu Kakuta (2021)
Minimal protein-only RNase P structure reveals insights into tRNA precursor
recognition and catalysis The Journal of Biological Chemistry.
297
:3,
101028- DOI:10.1016/j.jbc.2021.101028 PMID:34339732
Yasuhisa Kamikaseda, Takehito Uruno, Kazufumi Kunimura, Akihito Harada, Kuniko Saiki, Kounosuke Oisaki, Daiji Sakata, Takeshi Nakahara, Makiko Kido-Nakahara, Motomu Kanai, Seiji Nakamura, Yasuyuki Ohkawa, Masutaka Furue, Yoshinori Fukui (2021)
Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound The Journal of Allergy and Clinical Immunology.
148
633-638 DOI:10.1016/j.jaci.2021.03.029 PMID:33819507
Yasuhiro Isogai, Hiroshi Imamura, Setsu Nakae, Tomonari Sumi, Ken-ichi Takahashi,Tsuyoshi Shirai (2021)
Common and unique strategies of myoglobin evolution for deep sea adaptation of
diving mammals iScience.
24
102920- DOI:10.1016/j.isci.2021.102920 PMID:34430810
Takafumi Nakae, Masanori Obana, Takahiro Maeda, Akari Ikeda, Hiroshi Miyazaki, Shota Tanaka, Makiko Maeda, Kunihiko Yamashita, Kazuhiro Terai, Satoshi Obika, Yasushi Fujio (2021)
Gene Transfer by Pyro-Drive Jet Injector is a Novel Therapeutic Approach for Muscle Diseases Gene.
788
145664- DOI:10.1016/j.gene.2021.145664 PMID:33887371
Mingming Chen, Miwako Asanuma, Mari Takahashi, Yuichi Shichino, Mari Mito, Koichi Fujiwara, Hironori Saito, Stephen N Floor, Nicholas T Ingolia, Mikiko Sodeoka, Kosuke Dodo, Takuhiro Ito, Shintaro Iwasaki (2021)
Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A Cell Chemical Biology.
28
:4,
475-486 DOI:10.1016/j.chembiol.2020.11.008 PMID:33296667
Kouichi Yanagi, Toru Komatsu, Shusuke Ogihara, Takayoshi Okabe, Hirotatsu Kojima, Tetsuo Nagano, Tasuku Ueno, Kenjiro Hanaoka, Yasuteru Urano (2021)
Establishment of live-cell-based coupled assay
system for identification of compounds to modulate
metabolic activities of cells Cell Reports.
36
109311- DOI:10.1016/j.celrep.2021.109311 PMID:34233188
Yafei Liu , Wai Tuck Soh , Jun-Ichi Kishikawa , Mika Hirose , Emi E Nakayama , Songling Li , Miwa Sasai , Tatsuya Suzuki , Asa Tada , Akemi Arakawa , Sumiko Matsuoka , Kanako Akamatsu , Makoto Matsuda , Chikako Ono , Shiho Torii , Kazuki Kishida , Hui Jin , Wataru Nakai , Noriko Arase , Atsushi Nakagawa , Maki Matsumoto , Yukoh Nakazaki , Yasuhiro Shindo , Masako Kohyama , Keisuke Tomii , Koichiro Ohmura , Shiro Ohshima , Toru Okamoto , Masahiro Yamamoto , Hironori Nakagami , Yoshiharu Matsuura , Atsushi Nakagawa , Takayuki Kato , Masato Okada , Daron M Standley , Tatsuo Shioda , Hisashi Arase (2021)
An infectivity-enhancing site on the SARS-CoV-2 spike protein is targeted by COVID-19 antibodies. Cell .
184
:13,
3452-3466 DOI:10.1016/j.cell.2021.05.032 PMID:34139176
Hirofumi Yamamoto, Naoki Sakai, Satoshi Ohte, Tomohiro Sato, Katsuhiko Sekimata, Takehisa Matsumoto, Kana Nakamura, Hisami Watanabe, Chiemi Mishima-Tsumagari, Akiko Tanaka, Yoshinobu Hashizume, Teruki Honma, Takenobu Katagiri, Kohei Miyazono, Hiroshi Tomoda, Mikako Shirouzu, Hiroo Koyama (2021)
Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva Bioorganic & Medicinal Chemistry Letters.
38
127858- DOI:10.1016/j.bmcl.2021.127858 PMID:33609658
Hiroyuki Miyachi, Kayoko Kanamitsu, Mayumi Ishii, Eri, Watanabe, Akira Katsuyama, Satoko Otsuguro, Fumika Yakushiji, Mizuki Watanabe, Kouhei Matsui, Yukina Sato, Satoshi Shuto, Takashi Tadokoro, Shunsuke Kita, Takanori Matsumaru, Akira Matsuda, Tomoyasu Hirose, Masato Iwatsuki, Yasuteru Shigeta, Tetsuo Nagano, Hirotatsu Kojima, Satoshi Ichikawa, Toshiaki Sunazuka, Katsumi Maenaka (2021)
Structure, solubility, and permeability relationships in a diverse middle molecule library Bioorganic & Medicinal Chemistry Letters.
37
127847- DOI:10.1016/j.bmcl.2021.127847 PMID:33571648
Satomi Kori, Yuki Shibahashi, Toru Ekimoto, Atsuya Nishiyama, Sae
Yoshimi, Kosuke Yamaguchi, Satoru Nagatoishi, Masateru Ohta, Kouhei
Tsumoto, Makoto Nakanishi, Pierre-Antoine Defossez, Mitsunori Ikeguchi,
Kyohei Arita (2021)
Structure-based screening combined with computational and biochemical
analyses identified the inhibitor targeting the binding of DNA Ligase 1 to
UHRF1 Bioorganic & Medicinal Chemistry.
52
116500- DOI:10.1016/j.bmc.2021.116500 PMID:34801826
Ryota Kitakami , Kishin Inui , Yusuke Nakagawa , Yurika Sawai , Wakana Katayama , Takeshi Yokoyama , Takuya Okada , Kayoko Kanamitsu , Shinsaku Nakagawa , Naoki Toyooka , Mineyuki Mizuguchi (2021)
Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis Bioorganic & Medicinal Chemistry Letters.
44
:15,
116292- DOI:10.1016/j.bmc.2021.116292 PMID:34225167
Yui Kuroda, Miki Nonaka, Yuji Kamikubo, Haruo Ogawa, Takashi Murayama, Nagomi Kurebayashi, Hakushun Sakairi, Kanako Miyano, Akane Komatsu, Tetsushi Dodo, Kyoko Nakano-Ito, Keisuke Yamaguchi, Takashi Sakurai, Masako Iseki, Masakazu Hayashida, Yasuhito Uezono (2021)
Inhibition of endothelin A receptor by a novel, selective receptor antagonist
enhances morphine-induced analgesia: Possible functional interaction of
dimerized endothelin A and μ-opioid receptors Biomedicine & Pharmacotherapy.
141
111800- DOI:10.1016/j.biopha.2021.111800 PMID:34175819
Keigo Tanaka, Naoki Dozono, Hiroyuki Neyama, Jun Nagai, Ryoko Tsukahara,
Kazuki Nagayasu, Shuji Kaneko, Hiroshi Ueda (2021)
Secreted PLA2-III is a possible therapeutic target to treat neuropathic
pain Biochemical and Biophysical Research Communications.
568
167-173 DOI:10.1016/j.bbrc.2021.06.058 PMID:34237486
Koji Katsumata,Yuichi Ichikawa,Tomohiro Fuse,Hitoshi Kurumizaka,Akio Yanagida,Takeshi Urano,Hiroaki KatoMitsuhiro Shimizu (2021)
Sequence-dependent nucleosome formation in trinucleotide repeats evaluated by in vivo chemical mapping Biochemical and Biophysical Research Communications.
556
179-184 DOI:10.1016/j.bbrc.2021.03.155 PMID:33839413
Satoshi Saijoh, Mao Nakamura-Shima, Rie Shibuya-Takahashi, Ryo Ito, Akira Sugawara, Tomoko Yamazaki, Takayuki Imai, Yukinori Asada, Kazuto Matsuura, Wataru Iwai, Yuta Wakui, Makoto Abue, Sadafumi Kawamura, Yu Katayose, Haruna Fujimori, Mai Mochizuki, Jun Yasuda, Kazunori Yamaguchi, Kazuo Sugamura, Kennichi Satoh, Yukio Katori, Keiichi Tamai (2021)
Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein Biochemical and Biophysical Research Communications.
537
132-139 DOI:10.1016/j.bbrc.2020.11.022 PMID:33412384
Keisuke Murakami, Satoru Nagatoishi, Keisuke Kasahara, Hirokazu Nagai, Yoshiyuki
Sasajima, Ryo Sasaki, Kouhei Tsumoto (2021)
Electrostatic-triggered exothermic antibody adsorption to the cellulose nanoparticles Analytical Biochemistr.
632
114337- DOI:10.1016/j.ab.2021.114337 PMID:34391727
Takeru Ebihara, Akitsu Masuda, Daisuke Takahashi, Masato Hino, Hiroaki Mon, Kohei Kakino, Tsuguru Fujii, Ryosuke Fujita, Tadashi Ueda, Jae Man Lee, Takahiro Kusakabe (2021)
Production of scFv, Fab, and IgG of CR3022 Antibodies Against
SARS-CoV-2 Using Silkworm-Baculovirus Expression System Molecular Biotechnology.
63
1223-1234 DOI:10.1007/s12033-021-00373-0 PMID:34304364
Hiroki Igarashi, Nobuaki Yasuo, Masakazu Sekijima (2021)
Leave-One-Element-Out Cross-Validation for Band Gap Prediction of Halide Double Perovskites Advances in Parallel & Distributed Processing, and Applications .
759-768 DOI:10.1007/978-3-030-69984-0_55
Naoki Sato, Takeshi Obayashi. (2021)
Lipid pathway databases with a focus on algae. Methods in Molecular Biology.
2295
455-468 DOI:10.1007/978-1-0716-1362-7_26 PMID:34047993
Martin C Frith, Satomi Mitsuhashi, Kazutaka Katoh (2021)
lamassemble: Multiple alignment and consensus sequence of long reads. Methods in molecular biology.
2231
135-145 DOI:10.1007/978-1-0716-1036-7_9 PMID:33289891
Ryo Kawakami, Miki Matsui, Ayumu Konno, Ryosuke Kaneko, Shreya Shrestha, Suman Shrestha, Hiroaki Sunaga, Hirofumi Hanaoka, Sawako Goto, Michihiro Hosojima, Hideyuki Kabasawa, Masaru Obokata, Norimichi Koitabashi, Hiroki Matsui, Tsutomu Sasaki, Akihiko Saito, Motoko Yanagita, Hirokazu Hirai, Masahiko Kurabayashi, Tatsuya Iso (2021)
Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is
synergistically enhanced by concurrent liver injury The Journal of pathology.
DOI:10.1002/path.5775 PMID:34370295
Otgontuya Ganbaatar, Satoru Konnai, Tomohiro Okagawa, Yutaro Nojima, Naoya Maekawa, Yoshiki Ichikawa, Atsushi Kobayashi, Tomoyuki Shibahara, Yojiro Yanagawa, Hidetoshi Higuchi, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi (2021)
Programmed death-ligand 1 expression in swine chronic infections and enhancement of interleukin-2 production via programmed death-1/programmed death-ligand 1 blockade. Immunity, Inflammation and disease.
9
:4,
1573-1583 DOI:10.1002/iid3.510 PMID:34414683
Xue-ni Hou, Naotaka Sekiyama, Yasuko Ohtani, Feng Yang, Yohei Miyanoiri, Kenn-ichi Akagi, Xun-Cheng Su, Hidehito Tochio (2021)
Conformational space sampled by domain reorientation of linear diubiquitin reflected in its binding mode for target proteins Chemphyschem..
22
:14,
1505-1517 DOI:10.1002/cphc.202100187 PMID:33928740
Daisuke Okuno, Noriho Sakamoto, Mohammed S O Tagod, Yoshiko Akiyama, Sakiko Moriyama, Takuto Miyamura, Atsuko Hara, Takashi Kido, Hiroshi Ishimoto, Yuji Ishimatsu, Takashi Tanaka, Jun Ishihara, Kohsuke Takeda, Yoshimasa Tanaka, Hiroshi Mukae (2021)
Screening of inhibitors targeting heat shock protein 47 involved in the development of idiopathic pulmonary fibrosis. ChemMedChem.
16
2515-2523 DOI:10.1002/cmdc.202100064 PMID:33890415
Megumi Nishinaga, Hiroshi Sugimoto, Yudai Nishitani, Seina Nagai, Satoru Nagatoishi, Norifumi Muraki, Takehiko Tosha, Kouhei Tsumoto, Shigetoshi Aono, Yoshitsugu Shiro, Hitomi Sawai (2021)
Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival Communications Biology.
4
:1,
467- DOI:10.1038/s42003-021-01987-5 PMID:33850260
