成果

創薬等先端技術支援基盤プラットフォーム(BINDS)の実施者による研究支援と研究高度化の成果として輩出されたデータベース、 ツール、論文および特許を紹介します。

開発されたデータベースやツール

ケミカルシーズ・リード 探索ユニット

インシリコユニット

プラットフォーム機能最適化ユニット

BINDS支援技術に関する研究成果(論文)

Yoh Matsuki, Shinji Nakamura, Fumio Hobo, Yuki Endo, Hiroki Takahashi, Hiroto Suematsu, Toshimichi Fujiwara (2022)  Cryogenic Signal Amplification Combined with Helium-Temperature MAS DNP toward Ultimate NMR Sensitivity at High Field Conditions Journal of Magnetic Resonance. 335 107139- DOI:10.1016/j.jmr.2021.107139
Toru Kawakami, Eri Sasakura, Yohei Miyanoiri, Hironobu Hojo (2022)  Relative configuration of Cys-Pro ester peptides in thioester formation JOURNAL OF PEPTIDE SCIENCE. e3406- DOI:10.1002/psc.3406 PMID:35043501 
山田悠介 (2021)  Photon Factoryのタンパク質X線結晶構造解析ビームラインにおける全自動測定とリモート実験. 日本結晶学会誌. 63 208-211 DOI:10.5940/jcrsj.63.208
Masaya Mitsumoto, Kanna Sugaya, Kazuki Kazama, Ryosuke Nakano, Takahiro Kosugi, *Takeshi Murata and *Nobuyasu Koga (2021)  Structural snapshot of a glycoside hydrolase family 8 endo-β-1, 4-glucanase capturing the state after cleavage of the scissile bond Int. J. Mol. Sci.. 22 12906- DOI:10.3390/ijms222312906
T. Fujiwara, A. Fujishima, Y. Nakamura, K. Tajima and M. Yao (2022)  Structural snapshot of a glycoside hydrolase family 8 endo-β-1, 4-glucanase capturing the state after cleavage of the scissile bond Acta Cryst. Section D. 78 :2,  228-237 DOI:10.1107/S2059798321012882
K. Tajima, T. Imai, T.Yui, M. Yao, and I.Saxena (2021)  Cellulose-synthesizing machinery in bacteria Cellulose. 1 DOI:10.1007/s10570-021-04225-7
Tetsu Ikeda, Haruka Ochiishi, Mana Yoshida, Ryo Yazaki, Takashi Ohshima (2021)  Catalytic Dehydrogenative β-Alkylation of Amino Acid Schiff Bases with Hydrocarbon Organic Letters. 24 :1,  369-373 DOI:10.1021/acs.orglett.1c04042 PMID:34918939 
Sawako Uchiyama, Kohei Yoshihara, Riku Kawanabe, Izuho Hatada, Keisuke Koga, Makoto Tsuda (2022)  Stress-induced antinociception to noxious heat requires α1A-adrenaline receptors of spinal inhibitory neurons in mice Molecular Brain. 15 :1,  6- DOI:10.1186/s13041-021-00895-3 PMID:34980215 
Satoru Koyanagi, Naoki Kusunose, Sai Yasukochi, Shigehiro Ohdo (2021)  Basis for diurnal exacerbation of neuropathic pain hypersensitivity and its application for drug development Journal of Biochemistry. DOI:10.1093/jb/mvab143 PMID:34967399 
Chinatsu Shinozaki, Keita Kohno, Mitsunori Shiroishi, Daisuke Takahashi, Yu Yoshikawa, Yoshito Abe, Kenji Hamase, Makoto Nakakido, Kohei Tsumoto, Kazuhide Inoue, Makoto Tsuda & Tadashi Ueda (2022)  Improvement of the affinity of an anti-rat P2X4 receptor antibody by introducing electrostatic interactions Scientific Reports. 12 :1,  131- DOI:10.1038/s41598-021-03784-w PMID:34996944 
Xiaomei Sun, Yuxin Ye, Naofumi Sakurai, Koji Kato, Jian Yu, Keizo Yuasa, Akihiko Tsuji, Min Yao (2021)  Structural insights into the phlorotannin binding of EHEP and akuBGL for producing biofuel from brown algae Acta Crystallographica Section A.
Karman Virk, Kento Yonezawa, Komal Choukate, Lucky Singh, Nobutaka Shimizu, Barnali Chaudhuri (2022)  K-edge anomalous SAXS for protein solution structure modeling. Acta Crystallogr. Sect. D-Biol. Crystallogr. 78 :2,  204-211 DOI:10.1107/S205979832101247X PMID:35102886 
安達成彦 (2021)  KEKの共同利用型クライオ電子顕微鏡の利用方法 日本結晶学会誌. 63 267-272 DOI:10.5940/jcrsj.63.267
安達成彦 (2022)  高エネルギー加速器研究機構における共同利用型クライオ電子顕微鏡の現状と課題 生物物理. 62 e108899-
Rachel M Johnson, Xin Zhang, Sarah J Piper, Theodore J Nettleton, Teresa H Vandekolk, Christopher J Langmead, Radostin Danev, Patrick M Sexton, Denise Wootten (2021)  Structural and functional diversity among agonist-bound states of the GLP-1 receptor. Nat Chem Biol?. 12 :578,  84-90 DOI:10.1101/2021.02.24.432589 PMID:34547628 
Giuseppe Deganutti, Yi-Lynn Liang, Xin Zhang, Maryam Khoshouei, Lachlan Clydesdale, Matthew J Belousoff, Hari Venugopal, Tin T Truong, Alisa Glukhova, Andrew N Keller, Karen J Gregory, Katie Leach, Arthur Christopoulos, Radostin Danev, Christopher A Reynolds, Peishen Zhao, Patrick M Sexton, Denise Wootten (2022)  Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nat Commun?. 13 :92,  DOI:10.1038/s41467-021-27760-0 PMID:35013280 
Mieko Arisawa, Taro Mizuno, Kanako Nozawa-Kumada, Kaori Itto-Nakama, Miyu Furuta, Saori Tanii  (2021)  Rhodium-Catalyzed Synthesis of Unsymmetric Di(heteroaryl)ureas Involving an Equilibrium Shift Organic Letters. 23 9382-9286 DOI:10.1021/acs.orglett.1c03485
Mieko Arisawa, Miyu Yoshida, Kohei Fukumoto, Tsukasa Sawato, Masahiko Yamaguchi, Masaki Matsubara, and Kiyoshi Kanie (2021)  Three-state Structural Switching and Selective Molecular Interactions of Cylindrical Concentric Monodomain Liquid Crystal Elastomer ChemistrySelect . 6 12604-12609 DOI:10.1002/slct.202103490
Mieko Arisawa, Rina Iwamoto, and Masahiko Yamaguchi (2021)  Unstable and Stable Thermal Hysteresis Under Thermal Triangle Waves ChemistrySelect . 6 4461-4465 DOI:10.1002/slct.202100089
Shota Nagasawa, Yusuke Sasano, and Yoshiharu Iwabuchi  (2022)  The Utility of Oxoammonium Species in Organic Synthesis: Beyond Alcohol Oxidation Heterocycles. 105 DOI:10.3987/REV-21-SR(R)2
Shota Nagasawa, Masaki Hosaka, and Yoshiharu Iwabuchi  (2021)  ortho-C-H Acetoxylation of Cubane Enabling Access to Cubane Analogues of Pharmaceutically Relevant Scaffolds Organic Letters. 23 :22,  8717-8721 DOI:10.1021/acs.orglett.1c03144
Yuko Wakahara, Takahiro Noro, Juri Sakata, Hirofumi Ueda, Hidetoshi Tokuyama (2022)  Construction of Tetrahydroquinolines with Spirocyclic Structures at the 4-Position Heterocycles. DOI:10.3987/COM-22-S(R)16
Kosuke Okada, Hirofumi Ueda, Hidetoshi Tokuyama (2022)  Total synthesis of (±)-vinoxine: construction of the bridged pyrido[1,2-a]indole skeleton via Tf2O-mediated Bischler-Napieralski reaction and stereoselective radical cyclization Organic and Biomolecular Chemistry. DOI:10.1039/D2OB00274D
Katsuya Saito, Kazuki Kurasawa, Chiaki Takino, Shigefumi Kuwahara, Masaru Enomoto  (2021)  Asymmetric total synthesis of (-)-rossinone A Tetrahedron Letters. 84 : ,  No.153456- DOI:10.1016/j.tetlet.2021.153456
Masanori Shigeno, Kazuya Hanasaka, Itsuki Tohara, Koki Izumi, Hiroyuki Yamakoshi, Eunsang Kwon, Kanako Nozawa-Kumada, and Yoshinori Kondo (2022)  Direct C-H Carboxylation Forming Polyfunctionalized Aromatic Carboxylic Acids by Combined Br?nsted Bases Organic Letters. 24 :3,  809-814 DOI:10.1021/acs.orglett.1c03866
Masanori Shigeno, Yoshiteru Shishido, Kazutoshi Hayashi, Kanako Nozawa-Kumada, and Yoshinori Kondo (2021)  KO-t-Bu Catalyzed Thiolation of β-(Hetero)arylethyl Ethers via MeOH Elimination/hydrothiolation European Journal of Organic Chemistry. 2021 :28,  3932-3935 DOI:10.1002/ejoc.202100597
Hanayo Nakanishi, Kenichi Hayashida, Tomohiro Nishizawa, Atsunori Oshima, Kazuhiro Abe (2022)  Cryo-EM of the ATP11C flippase reconstituted in Nanodiscs shows a distended phospholipid bilayer inner membrane around transmembrane helix 2 Journal of Biological Chemistry. 298 101498- DOI:10.1016/j.jbc.2021.101498 PMID:34922944 
Atsushi Hasegawa, Yuki Hayasaka, Masanobu Morita, Yuta Takenaka, Yuna Hosaka, Ikuo Hirano, Masayuki Yamamoto, Ritsuko Shimizu (2022)  Heterozygous variants in GATA2 contribute to DCML deficiency in mice by disrupting tandem protein binding Communications Biology.
Hiroaki Tachiwana,Mariko Dacher,Kazumitsu Maehara,Akihito Harada,Yosuke Seto,Ryohei Katayama,Yasuyuki Ohkawa,Hiroshi Kimura,Hitoshi Kurumizaka,Noriko Saitoh (2021)  Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay Elife. 10 10:e66290- DOI:10.7554/eLife.66290. PMID:33970102 
Hiroyuki Miyachi (2021)  Structural Biology-Based Exploration of Subtype-Selective Agonists for Peroxisome Proliferator-Activated Receptors Int J Mol Sci. . 22 :17,  9223- DOI:10.3390/ijms22179223. PMID:34502131 
Guanjie Li, Tomokazu Ohishi, Mika K Kaneko, Junko Takei, Takuya Mizuno, Manabu Kawada, Masaki Saito, Hiroyuki Suzuki, Yukinari Kato (2021)  Defucosylated Mouse?Dog Chimeric Anti-EGFR Antibody Exerts Antitumor Activities in Mouse Xenograft Models of Canine Tumors Cells. 10 :12,  3599- DOI:10.3390/cells10123599 PMID:34944112 
Ayana Yoshihara, Haru Kawasaki, Hiroyuki Masuno, Koki Takada, Nobutaka Numoto, Nobutoshi Ito, Naoya Hirata, Yasunari Kanda, Michiyasu Ishizawa, Makoto Makishima, Hiroyuki Kagechika, Aya Tanatani (2022)  Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists Biomolecules. 12 :1,  130- DOI:10.3390/biom12010130 PMID:35053278 
Hitoshi kurumizaka (2022)  Structural studies of functional nucleosome complexes with transacting factors Proceedings of the Japan Academy Series B, physical and biological sciences. 98 :1,  1-14 DOI:10.2183/pjab.98.001 PMID:35013027 
Hiroyuki Suzuki1, Mika K. Kaneko and Yukinari Kato (2022)  Roles of Podoplanin in Malignant Progression of Tumor medicine & pharmacology. DOI:10.20944/preprints202201.0280.v1
Kazumitsu Maehara, Kosuke Tomimatsu, Akihito Harada, Kaori Tanaka, Shoko Sato, Megumi Fukuoka, Seiji Okada, Tetsuya Handa, Hitoshi Kurumizaka, Noriko Saitoh, Hiroshi Kimura, Yasuyuki Ohkawa  (2021)  Modeling population size independent tissue epigenomes by ChIL-seq with single thin sections Molecular Systems Biology. 17 :11,  e10323- DOI:10.15252/msb.202110323 PMID:34730297 
Shun Sakuraba, Qilin Xie, Kota Kasahara, Junichi Iwakiri, Hidetoshi Kono (2022)  Extended ensemble simulations of a SARSCoV- 2 nsp1-5’-UTR complex PLOS Computational Biology. 18 :1,  e1009804- DOI:10.1371/journal.pcbi.1009804 PMID:35045069 
Jumpei Taguchi,Kota Kimura,Kazunobu Igawa,Katsuhiko Tomooka and Takamitsu Hosoya (2022)  3-Azidoarynes: Generation and Regioselective Reactions Chemistry Letters. 51 :2,  94-98 DOI:10.1246/cl.210632
Satoru Ide, Asuka Sasaki, Yusuke Kawamoto, Toshikazu Bando, Hiroshi Sugiyama, Kazuhiro Maeshima (2021)  Telomere-Specific Chromatin Capture using a Pyrrole?Imidazole Polyamide Probe for the Identification of Proteins and Non-Coding RNAs Epigenetics & Chromatin. 14 :1,  46- DOI:10.1186/s13072-021-00421-8 PMID:34627342 
Osamu Hisano, Takashi Ito, Fumihito Miura (2021)  Pan-cancer methylome analysis for cancer diagnosis and classification of cancer cell of origin BMC Biology. 19 :1,  225- DOI:10.1186/s12915-021-01160-8 PMID:34649537 
Tatsuya Masuda, Shintaro Maeda, Sae Shimada, Naoya Sakuramoto, Ken Morita, Asami Koyama, Kensho Suzuki, Yoshihide Mitsuda, Hidemasa Matsuo, Hirohito Kubota, Itaru Kato, Kuniaki Tanaka, Junko Takita, Masahiro Hirata, Tatsuki R Kataoka, Tatsutoshi Nakahata, Souichi Adachi, Hideyo Hirai, Shuichi Mizuta, Kazuhito Naka, Yoichi Imai, Shinya Kimura, Hiroshi Sugiyama, Yasuhiko Kamikubo (2022)  RUNX1 Transactivates BCR-ABL1 Expression in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Cancer Science. 113 :2,  529-539 DOI:10.1111/cas.15239 PMID:34902205 
Takuji Oyama, Kazuki Takiguchi, Hiroyuki Miyachi (2022)  Crystal structures of the ligand-binding domain of human peroxisome proliferator-activated receptor δ in complexes with phenylpropanoic acid derivatives and a pyridine carboxylic acid derivative. Acta Crystallogr F Struct Biol Commun. 78 :2,  81-87 DOI:10.1107/S2053230X22000449 PMID:35102897 
Xiaojuan Zhang, Mika Nomoto, Marta Garcia-Leon, Naoki Takahashi, Mariko Kato1, Kei Yura, Masaaki Umeda, Vicente Rubio, Yasuomi Tada, Tsuyoshi Furumoto, Takashi Aoyama, Tomohiko Tsuge (2022)  CFI 25 Subunit of Cleavage Factor I is Important for Maintaining the Diversity of 3' UTR Lengths in Arabidopsis thaliana (L.) Heynh. Plant Cell Physiol. DOI:10.1093/pcp/pcac002 PMID:35016226 
Keiichi Namba & Fumiaki Makino. (2022)  Recent progress and future perspective of electron cryomicroscopy for structural life sciences. Microscopy . 71 :S1,  i3-i14 DOI:10.1093/jmicro/dfab049 PMID:35275178 
Naoki Horikoshi, Hitoshi Kurumizaka (2022)  Structural insight into replicative helicase loading in Escherichia coli The Journal of Biochemistry. mvac023- DOI:10.1093/jb/mvac023 PMID:35238386 
Tomohiro Tanaka, Tomokazu Ohishi, Masaki Saito, Manabu Kawada, Mika K. Kaneko, and Yukinari Kato (2022)  TrMab-6 Exerts Antitumor Activity in Mouse Xenograft Models of Breast Cancers Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 41 :1,  32-38 DOI:10.1089/mab.2021.0056 PMID:35225665 
Guanjie Li, Hiroyuki Suzuki, Junko Takei, Masaki Saito, Nohara Goto, Kazuyuki Uchida, Takayuki Nakagawa, Hiroyuki Harada, Tomohiro Tanaka, Teizo Asano, Mika K. Kaneko, and Yukinari Kato  (2022)  Immunohistochemical Analysis using Monoclonal Antibody PMab-269 against Steller Sea Lion Podoplanin Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 41 :1,  39-44 DOI:10.1089/mab.2021.0055 PMID:35225666 
Hiroyuki Suzuki, Teizo Asano, Tomohiro Tanaka, Mika K. Kaneko, and Yukinari Kato (2022)  Epitope Mapping of the Anti-CD20 Monoclonal Antibodies (C20Mab-11 and 2H7) using HisMAP method Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 41 :1,  20-26 DOI:10.1089/mab.2021.0051 PMID:35225660 
Masaki Saito, Yasuhiro Harigae, Guanjie Li, Teizo Asano, Tomohiro Tanaka, Hiroyuki Suzuki, Mika K. Kaneko, and Yukinari Kato (2022)  C3Mab-2: An Anti-Mouse CCR3 Monoclonal Antibody for Immunocytochemistry Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 41 :1,  45-49 DOI:10.1089/mab.2021.0050 PMID:35225661 
Hiroki Kawabata, Hiroyuki Suzuki, Junko Takei, Mika K. Kaneko, and Yukinari Kato (2022)  Epitope Mapping of an Anti-CD10 Monoclonal Antibody (MME/1870) using Enzyme-Linked Immunosorbent Assay Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 41 :1,  15-19 DOI:10.1089/mab.2021.0046 PMID:35225664 
Teizo Asano, Hiroyuki Suzuki, Mika K. Kaneko, and Yukinari Kato (2022)  Epitope Mapping of Rituximab using HisMAP Method Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. :1,  8-14 DOI:10.1089/mab.2021.0044 PMID:35225667 
Junko Takei, Hiroyuki Suzuki, Teizo Asano, Guanjie Li, Masaki Saito, Mika K. Kaneko, and Yukinari Kato (2021)  Epitope Mapping of an Anti-CD20 Monoclonal Antibody (C20Mab-60) using Enzyme-Linked Immunosorbent Assay Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :6,  250-254 DOI:10.1089/mab.2021.0042 PMID:34958272 
Junko Takei, Teizo Asano, Guanjie Li, Masaki Saito, Hiroyuki Suzuki, Mika K Kaneko, Yukinari Kato  (2021)  Epitope Mapping of an Anti-Human CCR9 Monoclonal Antibody (C9Mab-1) Using Enzyme-Linked Immunosorbent Assay Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :6,  239-242 DOI:10.1089/mab.2021.0037 PMID:34958276 
Ren Nanamiya, Junko Takei, Tomokazu Ohishi, Teizo Asano, Tomohiro Tanaka, Masato Sano, Takuro Nakamura, Miyuki Yanaka, Saori Handa, Nami Tateyama, Yasuhiro Harigae, Masaki Saito, Hiroyuki Suzuki, Manabu Kawada, Mika K. Kaneko, and Yukinari Kato (2022)  Defucosylated Anti-EGFR Monoclonal Antibody (134-mG2a-f) Exerts Antitumor Activities in Mouse Xenograft Models of Canine Osteosarcoma Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 41 :1,  1-7 DOI:10.1089/mab.2021.0036 PMID:35225663 
Teizo Asano, Junko Takei, Yoshikazu Furusawa, Masaki Saito, Hiroyuki Suzuki, Mika K. Kaneko, and Yukinari Kato (2021)  Epitope Mapping of an Anti-CD20 Monoclonal Antibody (C20Mab-60) using the HisMAP Method Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :6,  243-249 DOI:10.1089/mab.2021.0035 PMID:34958277 
Tomoyuki Nakano, Toshiaki Tanaka, Fumio Sakane, Mika K Kaneko, Yukinari Kato, Kaoru Goto (2021)  Immunocytochemical Analysis of DGKη in Cultured Cells Using a Monoclonal Antibody DhMab-4 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :6,  261-265 DOI:10.1089/mab.2021.0034 PMID:34958278 
Teizo Asano, Hiroyuki Suzuki, Mika K Kaneko, Yukinari Kato (2021)  Epitope Mapping of a Cancer-Specific Anti-Podocalyxin Monoclonal Antibody (PcMab-60) Using Enzyme-Linked Immunosorbent Assay and Surface Plasmon Resonance Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :5,  227-232 DOI:10.1089/mab.2021.0030 PMID:34678093 
Teizo Asano, Junko Takei, Hiroyuki Suzuki, Mika K. Kaneko, and Yukinari Kato (2021)  Epitope Mapping of an Anti-HER2 Monoclonal Antibody (H2Mab-181) Using Enzyme-Linked Immunosorbent Assay Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :6,  255-260 DOI:10.1089/mab.2021.0029 PMID:34958275 
Junko Takei, Teizo Asano, Hiroyuki Suzuki, Mika K. Kaneko, and Yukinari Kato (2021)  Epitope Mapping of the Anti-CD44 Monoclonal Antibody (C?44?Mab-46) Using Alanine-Scanning Mutagenesis and Surface Plasmon Resonance Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :5,  219-226 DOI:10.1089/mab.2021.0028 PMID:34678095 
Hinano Takemura, Gaku Orimoto, Akihiro Kobayashi, Takamitsu Hosoya, Suguru Yoshida (2022)  Modular synthesis of triazoles from 2-azidoacrylamides having a nucleophilic amino group Organic & Biomolecular Chemistry. DOI:10.1039/d2ob00151a PMID:35201255 
Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nami Ohashi, Wataru Nomura, Hirokazu Tamamura (2021)  Fluorescence resonance energy transfer-based screening for protein kinase C ligands using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones Organic & Biomolecular Chemistry. 19 :38,  8264-8271 DOI:10.1039/d1ob00814e PMID:34338277 
Akira Uruno, Daisuke Saigusa, Takafumi Suzuki, Akane Yumoto, Tomohiro Nakamura, Naomi Matsukawa, Takahiro Yamazaki, Ristumi Saito, Keiko Taguchi, Mikiko Suzuki, Norio Suzuki, Akihito Otsuki, Fumiki Katsuoka, Eiji Hishinuma, Risa Okada, Seizo Koshiba, Yoshihisa Tomioka, Ritsuko Shimizu, Masaki Shirakawa, Thomas W Kensler, Dai Shiba, Masayuki Yamamoto (2021)  Nrf2 plays a critical role in the metabolic response during and after spaceflight Communications Biology. 4 :1,  1381- DOI:10.1038/s42003-021-02904-6 PMID:34887485 
Mitsuhiro Yamada, Ikuko N Motoike, Kaname Kojima, Nobuo Fuse, Atsushi Hozawa, Shinichi Kuriyama, Fumiki Katsuoka, Shu Tadaka, Matsuyuki Shirota, Miyuki Sakurai, Tomohiro Nakamura, Yohei Hamanaka, Kichiya Suzuki, Junichi Sugawara, Soichi Ogishima, Akira Uruno, Eiichi N Kodama, Naoya Fujino, Tadahisa Numakura, Tomohiro Ichikawa, Ayumi Mitsune, Takashi Ohe, Kengo Kinoshita, Masakazu Ichinose, Hisatoshi Sugiura, Masayuki Yamamoto  (2021)  Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator Communications Biology. 4 :1,  1288- DOI:10.1038/s42003-021-02813-8 PMID:34782693 
Masahiro Nakano, Yukihiko Sugita, Noriyuki Kodera, Sho Miyamoto, Yukiko Muramoto, Matthias Wolf, Takeshi Noda (2021)  Ultrastructure of influenza virus ribonucleoprotein complexes during viral RNA synthesis Communications Biology . 4 :858,  DOI:10.1038/s42003-021-02388-4 PMID:34244608 
Kayo Takahashi, Takamitsu Hosoya, Kayo Onoe, Tomoko Mori, Shusaku Tazawa, Aya Mawatari, Yasuhiro Wada, Yumiko Watanabe, Hisashi Doi, Yasuyoshi Watanabe (2021)  PET imaging of brain aromatase in humans and rhesus monkeys by 11 C-labeled cetrozole analogs Scientific Reports. 11 :1,  23623- DOI:10.1038/s41598-021-03063-8 PMID:34880350 
Zhenmei Xu, Tatsuya Ikuta, Kouki Kawakami, Ryoji Kise, Yu Qian, Ruixue Xia, Ming-Xia Sun, Anqi Zhang, Changyou Guo, Xue-Hui Cai, Zhiwei Huang, Asuka Inoue, Yuanzheng He (2021)  Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism Nature Chemical Biology. DOI:10.1038/s41589-021-00930-3 PMID:34937912 
Kouki Kawakami, Masataka Yanagawa, Suzune Hiratsuka, Misaki Yoshida, Yuki Ono, Michio Hiroshima, Masahiro Ueda, Junken Aoki, Yasushi Sako, Asuka Inoue (2022)  Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias Nature Commun.. 13 :1,  487- DOI:10.1038/s41467-022-28056-7 PMID:35078997 
Kazuhiro Kashiwagi,Yuichi Shichino,Tatsuya Osaki,Ayako Sakamoto,Madoka Nishimoto,Mari Takahashi,Mari Mito,Friedemann Weber,Yoshiho Ikeuchi,Shintaro Iwasaki,Takuhiro Ito (2021)  eIF2B-capturing viral protein NSs suppresses the integrated stress response Nature Communications. 12 :1,  7102- DOI:10.1038/s41467-021-27337-x PMID:34876589 
Yuki Sakata, Suguru Yoshida, Takamitsu Hosoya (2021)  Synthesis of Azidoanilines by the Buchwald-Hartwig Amination The Journal of Organic Chemistry. 86 :21,  15674-15688 DOI:10.1021/acs.joc.1c02251 PMID:34694814 
Kosuke Ohsawa, Junya Kubota, Shota Ochiai, Takayuki Doi (2021)  Stereoselective Synthesis of 1-Aminocyclopropanecarboxylic Acid Carnosadines via Inter-intramolecular Double Alkylation with Optically Active 2-Methylaziridine Derivatives Journal of the Organic Chemistry. 86 :10,  7304-7313 DOI:10.1021/acs.joc.1c00680 PMID:33974420 
Satoshi Mizuta, Hiroki Otaki, Takeshi Ishikawa, Juliann Nzembi Makau, Tomoko Yamaguchi, Takuya Fujimoto, Nobuyuki Takakura, Nobuki Sakauchi, Shuji Kitamura, Hikaru Nono, Ryota Nishi, Yoshimasa Tanaka, Kohsuke Takeda, Noriyuki Nishida, Ken Watanabe (2021)  Lead Optimization of Influenza Virus RNA Polymerase Inhibitors Targeting PA-PB1 Interaction Medicinal Chemistry. DOI:10.1021/acs.jmedchem.1c01527 PMID:34905383 
Chikako Shibazaki,Okishi Mashita,Kyoko Takahashi,Shigeo Nakamura,Tadahiko Mashino,Tomoyuki Ohe (2021)  Development of a Fluorescent-Labeled Trapping Reagent to Detect Reactive Acyl Glucuronides Chemical Research in Toxicology. 34 :11,  2343-2352 DOI:10.1021/acs.chemrestox.1c00236 PMID:34705453 
Tensho Ten, Satoru Nagatoishi, Ryo Maeda, Masaru Hoshino, Yoshiaki Nakayama, Motoharu Seiki, Takeharu Sakamoto, Kouhei Tsumoto (2021)  Structural and thermodynamical insights into the binding and inhibition of FIH-1 by the N-terminal disordered region of Mint3 Journal of Biological Chemistry. DOI:10.1016/j.jbc.2021.101304 PMID:34655613 
Wen Ann Wee, Hiroshi Sugiyama, Soyoung Park (2021)  Photoswitchable Single-Stranded DNA-Peptide Coacervate Formation as a Dynamic System for Reaction Control iScience. 24 :12,  103455- DOI:10.1016/j.isci.2021.103455 PMID:34877509 
Yasuhiro Tateishi, Chikako Shibazaki, Kyoko Takahashi, Shigeo Nakamura, Yasuhiro Kazuki, Tadahiko Mashino, Tomoyuki Ohe (2022)  Synthesis and evaluation of tofacitinib analogs designed to mitigate metabolic activation Drug Metabolism and Pharmacokinetics. 43 1000439- DOI:10.1016/j.dmpk.2021.100439 PMID:35139477 
Mami Yoshizawa, Tomomi Aoyama, Itoh, and Hiroyuki Miyachi (2022)  Arylalkynyl amide-type peroxisome proliferator-activated receptor g (PPARg)-selective antagonists covalently bind to Toshimasa the PPARg ligand binding domain with a unique binding mode Bioorganic & Medicinal Chemistry Letters. :64,  128676- DOI:10.1016/j.bmcl.2022.128676 PMID:35301139 
Keita Iio, Noriki Kutsumura, Yasuyuki Nagumo, Tsuyoshi Saitoh, Akihisa Tokuda, Kao Hashimoto, Naoshi Yamamoto, Ryoji Kise, Asuka Inoue, Hirokazu Mizoguchi, Hiroshi Nagase (2022)  Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands Bioorg Med Chem Lett. 56 128485- DOI:10.1016/j.bmcl.2021.128485 PMID:34861349 
Shinya Fujii, Takahiro Miura, Tsuyoshi Oikawa, Xian-Yang Qin, Soichi Kojima, Hiroyuki Kagechika (2021)  Design, synthesis and antitumor activity of phthalazine-1,4-dione-based menaquinone analogs Bioorganic & Medicinal Chemistry Letters. 43 128065- DOI:10.1016/j.bmcl.2021.128065 PMID:33915257 
Kohei Tsuji, Takuya Kobayakawa, Kiju Konno, Ami Masuda, Kohei Takahashi, Nami Ohashi, Kazuhisa Yoshimura, Takeo Kuwata, Shuzo Matsushita, Shigeyoshi Harada, Hirokazu Tamamura (2022)  Exploratory studies on soluble small molecule CD4 mimics as HIV entry inhibitors Bioorganic & Medicinal Chemistry. 56 116616- DOI:10.1016/j.bmc.2022.116616 PMID:35063895 
TakuNakai, Daisuke Saigusa, Yuma Iwamura, Yotaro Matsumoto, Keiko Umeda, Koichiro Kato, Hayato Yamaki, Yoshihisa Tomioka, Ikuo Hirano, Seizo Koshiba, Masayuki Yamamoto, Norio Suzuki (2022)  Esterification promotes the intracellular accumulation of roxadustat, an activator of hypoxia-inducible factors, to extend its effective duration Biochemical Pharmacology. 197 114939- DOI:10.1016/j.bcp.2022.114939 PMID:35114188 
Takeaki Shibata, Kouki Kawakami, Hiroki Kawana, Junken Aoki, Asuka Inoue (2022)  Phenotypic evaluation of constitutive GPCR/G-protein signaling in zebrafish embryos and larvae Biochemical and Biophysical Research Communications. :602,  70-76 DOI:10.1016/j.bbrc.2022.02.098 PMID:35255436 
Tomohide Nishikawa, Reiko Watanabe, Yotaro Kitano, Akane Yamamichi, Kazuya Motomura, Fumiharu Ohka, Kosuke Aoki, Masaki Hirano, Akira Kato, Junya Yamaguchi, Sachi Maeda, Yuji Kibe, Ryuta Saito, Toshihiko Wakabayashi, Yukinari Kato, Shuta Sato, Tomoyoshi Ogino, Atsushi Natsume, and Ichiro Ito (2022)  Reliability of IDH1-R132H and ATRX and/or p53 immunohistochemistry for molecular subclassification of Grade 2/3 gliomas Brain Tumor Pathology. 39 :1,  14-24 DOI:10.1007/s10014-021-00418-x PMID:34826036 
Shinya Fujii, Eriko Kikuchi, Honoka Suzuyama, Yuko Watanabe, Mari Ishigami-Yuasa, Hiroyuki Masuno, Takayasu Mori, Kiyoshi Isobe, Shinichi Uchida, Hiroyuki Kagechika (2021)  Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents ChemMedChem. 16 :18,  2817-2822 DOI:10.1002/cmdc.202100273 PMID:34109743 
Yuki Hirose, Tomo Ohno, Sefan Asamitsu, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama (2022)  Strong and Specific Recognition of CAG/CTG Repeat DNA (5’-dWGCWGCW-3’) by a Cyclic Pyrrole?Imidazole Polyamide ChemBioChem. 23 :2,  e202100533- DOI:10.1002/cbic.202100533 PMID:34796607 
Atsushi Hijikata, Clara Shionyu-Mitsuyama, Setsu Nakae, Masafumi Shionyu, Motonori Ota, Shigehiko Kanaya, Takatsugu Hirokawa, Shogo Nakajima, Koichi Watashi , Tsuyoshi Shirai  (2022)  Evaluating cepharanthine analogues as natural drugs against SARS-CoV-2 polyamine export by human ATP13A2 FEBS Open Bio. 12 :1,  285-294 DOI:10.1002/2211-5463.13337 PMID:34850606 
Tohru Minamino, Yusuke V Morimoto, Miki Kinoshita, Keiichi Namba (2021)  Multiple roles of flagellar export chaperones for efficient and robust flagellar filament formation in Salmonella. Frontiers in Microbiology. 12 :1,  756044- DOI:10.3389/fmicb.2021.756044 PMID:34691007 
Yumi Inoue, Miki Kinoshita, Mamoru Kida, Norihiro Takekawa, Keiichi Namba, Katsumi Imada, Tohru Minamino  (2021)  The FlhA linker mediates flagellar protein export switching during flagellar assembly. Communications biology. 4 :1,  646- DOI:10.1038/s42003-021-02177-z PMID:34059784 
Miki Kinoshita, Keiichi Namba, Tohru Minamino (2021)  A positive charge region of Salmonella FliI is required for ATPase formation and efficient flagellar protein export. Communications biology. 4 :1,  464- DOI:10.1038/s42003-021-01980-y PMID:33846530 
Tomonori Hayami,?Narutoshi Kamiya,?Kota Kasahara,?Takeshi Kawabata,?Jun-Ichi Kurita,?Yoshifumi Fukunishi,?Yoshifumi Nishimura,?Haruki Nakamura,?Junichi Higo (2021)  Difference of binding modes among three ligands to a receptor mSin3B corresponding to their inhibitory activities Scientific reports. 11 :1,  6178- DOI:10.1038/s41598-021-85612-9 PMID:33731831 
Osamu Hisano, Takashi Ito, Fumihito Miura (2021)  Short single-stranded DNAs with putative non-canonical structures comprise a new class of plasma cell-free DNA BMC Biology. 19 :1,  225-225 DOI:10.1186/s12915-021-01160-8 PMID:34649537 
Yoshikazu Furuta, Fumihito Miura, Takahiro Ichise, Shouta M. M. Nakayama, Yoshinori Ikenaka, Tuvshinzaya Zorigt, Mai Tsujinouchi, Mayumi Ishizuka, Takashi Ito, Hideaki Higashi (2022)  A GCDGC-specific DNA (cytosine-5) methyltransferase that methylates the GCWGC sequence on both strands and the GCSGC sequence on one strand PLOS ONE. 17 :3,  e0265225-e0265225 DOI:10.1371/journal.pone.0265225 PMID:35312710 
Si-Si Liu, Fei Jin, Yi-Shi Liu, Yoshiko Murakami, Yukihiko Sugita, Takayuki Kato, Xiao-Dong Gao, Taroh Kinoshita, Motoyuki Hattori, Morihisa Fujita (2021)  Functional Analysis of the GPI Transamidase Complex by Screening for Amino Acid Mutations in Each Subunit molecules. 26 :18,  5462- DOI:10.3390/molecules26185462 PMID:34576938 
Jesse I Mobbs,Matthew J Belousoff,Kaleeckal G Harikumar,Sarah J Piper,Xiaomeng Xu,Sebastian G B Furness,Hari Venugopal,Arthur Christopoulos,Radostin Danev,Denise Wootten,David M Thal,Laurence J Miller,Patrick M Sexton (2021)  Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity PLoS Biology. 19 :6,  e3001295- DOI:10.1371/journal.pbio.3001295 PMID:34086670 
Satoshi Matsuyama, Munmun Pervin, Minto Nakagawa, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate (2021)  Properties of macrophages and lymphocytes appearing in rat renal fibrosis followed by repeated injection of cisplatin The Journal of Veterinary Medical Science. 83 :9,  1435-1442 DOI:10.1292/jvms.21-0341 PMID:34305076 
Toshio Kasamatsu, Airi Kitazawa, Sumie Tajima, Masahiro Kaneko, Kei-ichi Sugiyama, Masami Yamada, Manabu Yasui, Kenichi Masumura, Katsuyoshi Horibata, and Masamitsu Honma (2021)  Development of a new quantitative structure-activity relationship model for predicting Ames mutagenicity of food flavor chemicals using StarDrop-Auto-Modeller Genes and Environment. 43 :1,  16- DOI:10.1186/s41021-021-00182-6 PMID:33931133 
Takashi Imada, Takeshi Shimi, Ai Kaiho, Yasushi Saeki, Hiroshi Kimura  (2021)  RNA polymerase II condensate formation and association with Cajal and histone locus bodies in living human cells Gens to cells. 26 :5,  298-312 DOI:10.1111/gtc.12840 PMID:33608942 
Andrea Cellini, Weixiao Yuan Wahlgren, Leocadie Henry, Suraj Pandey, Swagatha Ghosh, Leticia Castillon, Elin Claesson, Heikki Takala, Joachim K?bel, Amke Nimmrich, Valentyna Kuznetsova, Eriko Nango, So Iwata, Shigeki Owada, Emina A Stojkovi?, Marius Schmidt, Janne A Ihalainen, Sebastian Westenhoff (2021)  The three-dimensional structure of Drosophila melanogaster (6-4) photolyase at room temperature Acta Crystallographica Section D, Structural bilogy.. 77 1001-1009 DOI:10.1107/S2059798321005830 PMID:34342273 
Shintaro Minami, Naohiro Kobayashi, Toshihiko Sugiki, Toshio Nagashima, Toshimichi Fujiwara, Rie Koga, George Chikenji, Nobuyasu Koga (2021)  Exploration of novel αβ-protein folds through de novo design bioRxiv. - DOI:10.1101/2021.08.06.455475
Radostin Danev, Haruaki Yanagisawa, Masahide Kikkawa (2021)  Cryo-EM performance testing of hardware and data acquisition strategies microscopy. 70 :6,  487-497 DOI:10.1093/jmicro/dfab016 PMID:33969878 
Radostin Danev, Matthew Belousoff, Yi-Lynn Liang, Xin Zhang, Fabian Eisenstein, Denise Wootten, Patrick M Sexton  (2021)  Routine sub-2.5-cryo-EM structure determination of GPCRs Nature Communications. 12 :1,  4333- DOI:10.1038/s41467-021-24650-3 PMID:34267200 
Akihiro Kawamoto, Tomoko Miyata, Fumiaki Makino, Miki Kinoshita, Tohru Minamino, Katsumi Imada, Takayuki Kato, Keiichi Namba (2021)  Native flagellar MS ring is formed by 34 subunits with 23-fold and 11-fold subsymmetries Nature Communications. 12 :1,  4223- DOI:10.1038/s41467-021-24507-9 PMID:34244518 
David Drew, Rachel A North, Kumar Nagarathinam, Mikio Tanabe (2021)  Structures and general transport mechanisms by the major facilitator superfamily (MFS) Chemical reviews. 121 :9,  5289-5335 DOI:10.1021/acs.chemrev.0c00983 PMID:33886296 
Takahiro Kogaki, Ikumi Ohshio, Hasumi Ura, Souta Iyama, Kaori Kitae, Morie Toshiya, Fujii Shintarou, Sato Shohei, Toshiyuki Nagata, Aya Harada Takeda, Masaya Aoki, Kazuhiro Ueda, Kentaro Minami, Masatatsu Yamamoto, Kohichi Kawahara, Tatsuhiko Furukawa, Masami Sato, Yuko Ueda, Kentaro Jingushi, Zenzaburo Tozuka, Daisuke Saigusa, Hiroaki Hase, Kazutake Tsujikawa (2021)  Development of a highly sensitive method for the quantitative analysis of modified nucleosides using UHPLC-UniSpray-MS/MS Journal of Pharmaceutical and Biomedical Analysis. 197 113943- DOI:10.1016/j.jpba.2021.113943 PMID:33601155 
Keisuke Tachibana , Yosuke Hashimoto , Keisuke Shirakura , Yoshiaki Okada , Ryuichi Hirayama, Yumi Iwashita , Itsuki Nishino , Yukio Ago , Hiroyuki Takeda , Hiroki Kuniyasu , Masuo Kondoh (2021)  Safety and efficacy of an anti-claudin-5 monoclonal antibody to increase blood-brain barrier permeability for drug delivery to the brain in a non-human primate Journal of Controlled Release. 336 105-111 DOI:10.1016/j.jconrel.2021.06.009 PMID:34118338 
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Kenji Kawai, Masafumi Yamamoto, Hidetaka Kamimura, Yuichi Iida, Mitsuo Oshimura, Yasuhiro Kazuki, Hiroshi Yamazaki, Hayato Hikita, Tetsuo Takehara, Hiroshi Suemizu (2021)  An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals Drug Metabolism and Pharmacokinetics. - DOI:10.1016/j.dmpk.2021.100410 PMID:34839181 
Xin Zhang, Matthew J Belousoff, Yi-Lynn Liang, Radostin Danev, Patrick M Sexton, Denise Wootten  (2021)  Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes Cell Reports. 36 :2,  109374- DOI:10.1016/j.celrep.2021.109374 PMID:34260945 
Kyoko Furuita, Marina Hiraoka, Kentaro Hanada, Toshimichi Fujiwara, Chojiro Kojima (2021)  Sequence requirements of the FFAT-like motif for specific binding to VAP-A are revealed by NMR FEBS Letters. 595 :17,  2248-2256 DOI:10.1002/1873-3468.14166 PMID:34312846 
Yoshiaki Miyake , Masanori Obana , Takafumi Nakae , Ayaha Yamamoto , Shota Tanaka , Makiko Maeda , Yoshiaki Okada , Yasushi Fujio (2021)  PKNOX2 regulates myofibroblast functions and tubular cell survival during kidney fibrosis Biochemical and Biophysical Research Communications. :571,  88-95 DOI:10.1016/j.bbrc.2021.07.067 PMID:34311199 
Jumpei Yokota , Tomoki Yamashita , Tatsuya Inui , Ryuga Nomoto , Wataru Kishimoto , Hiroshi Nakase , Hiroyuki Mizuguchi (2021)  Comparison of culture media for human intestinal organoids from the viewpoint of pharmacokinetic studies Biochemical and Biophysical Research Communications. 566 115-122 DOI:10.1016/j.bbrc.2021.06.007 PMID:34119823 
Takayuki Katoh, Yuki Goto, Hiroaki Suga (0000)  In Vitro Selection of Thioether-Closed Macrocyclic Peptide Ligands by Means of the RaPID System Methods in Molecular Biology. 247-259 DOI:10.1007/978-1-0716-1689-5_13 PMID:34596852 
Hirofumi Ohashi, Koichi Watashi, Wakana Saso, Kaho Shionoya, Shoya Iwanami, Takatsugu Hirokawa, Tsuyoshi Shirai, Shigehiko Kanaya, Yusuke Ito , Kwang Su Kim, Takao Nomura, Tateki Suzuki, Kazane Nishioka, Shuji Ando, Keisuke Ejima, Yoshiki Koizumi, Tomohiro Tanaka, Shin Aoki, Kouji Kuramochi, Tadaki Suzuki, Takao Hashiguchi, Katsumi Maenaka, Tetsuro Matano, Masamichi Muramatsu, Masayuki Saijo, Kazuyuki Aihara, Shingo Iwami, Makoto Takeda, Jane A McKeating, Takaji Wakita (2021)  Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment iScience. 24 :4,  102367- DOI:10.1016/j.isci.2021.102367 PMID:33817567 
Mayuka Higo, Hiroki Kojima, Masato Iwatsuki, Tomotaka Tanabe, Takashi Yaguchi, Toru Okuda, Taiga Kasuya, Kenichi Nonaka (2021)  Lecanicillium aphanocladii isolated from Tengu-no-Mugimeshi found in Mount Kurohime, Nagano Prefecture, central Japan Microbial Resources and Systematics. 37 DOI:ISSN:1342-4041
Hirotatsu Kojima (2021)  Supporting drug discovery research in Japan by Drug Discovery Initiative at the University of Tokyo Burger’s Medicinal Chemistry, Drug Discovery and Development 8th Ed., Wiley, Abraham, D.J., Myers M. ed.. 3 179-187 DOI:ISBN: 978-1-119-53030-5
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Teizo Asano, Tomokazu Ohishi, Junko Takei, Takuro Nakamura, Ren Nanamiya, Hideki Hosono, Tomohiro Tanaka, Masato Sano, Hiroyuki Harada, Manabu Kawada, Mika K Kaneko, Yukinari Kato  (2021)  Anti-HER3 monoclonal antibody exerts antitumor activity in a mouse model of colorectal adenocarcinoma Oncology Reports. 46 :2,  173- DOI:10.3892/or.2021.8124 PMID:34184091 
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Takuya Kobayashi, Nagomi Kurebayashi, Takashi Murayama (2021)  The ryanodine receptor as a sensor for intracellular environments in muscles. International Journal of Molecular Sciences. 22 :19,  10795- DOI:10.3390/ijms221910795 PMID:34639137 
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Takuji Oyama, Shotaro Kamata, Isao Ishii, and Hiroyuki Miyachi (2021)  Crystal Structures of the Human Peroxisome Proliferator-Activated Receptor (PPAR)α Ligand-Binding Domain in Complexes with a Series of Phenylpropanoic Acid Derivatives Generated by a Ligand-Exchange Soaking Method Biological and Pharmaceutical Bulletin. 44 :9,  1202-1209 DOI:10.1248/bpb.b21-00220 PMID:34471048 
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Tracy M Josephs, Matthew J Belousoff, Yi-Lynn Liang, Sarah J Piper, Jianjun Cao, Daniel J Garama, Katie Leach, Karen J Gregory, Arthur Christopoulos, Debbie L Hay, Radostin Danev, Denise Wootten, Patrick M Sexton (2021)  Structure and dynamics of the CGRP receptor in apo and peptide-bound forms Science. 372 :6538,  eabf7258- DOI:10.1126/science.abf7258 PMID:33602864 
Dmitry Ghilarov, Satomi Inaba-Inoue, Piotr Stepien, Feng Qu, Elizabeth Michalczyk, Zuzanna Pakosz, Norimichi Nomura, Satoshi Ogasawara, Graham Charles Walker, Sylvie Rebuffat, So Iwata, Jonathan Gardiner Heddle, Konstantinos Beis (2021)  Molecular mechanism of SbmA, a promiscuous transporter exploited by antimicrobial peptides Science Advances. 7 :37,  eabj5363- DOI:10.1126/sciadv.abj5363 PMID:34516884 
Stephanie Schumacher, Dirk Dedden, Roberto Vazquez Nunez, Kyoko Matoba, Junichi Takagi, Christian Biertumpfel, Naoko Mizuno (2021)  Structural insights into the integrin α5β1 opening by fibronectin ligand. Science Advances. 7 :19,  eabe9716- DOI:10.1126/sciadv.abe9716 PMID:33962943 
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Natsu Nakajima, Tomoatsu Hayashi, Katsunori Fujiki, Katsuhiko Shirahige, Tetsu Akiyama, Tatsuya Akutsu, Ryuichiro Nakato (2021)  Codependency and mutual exclusivity for gene community detection from sparse single-cell transcriptome data Nucleic Acids research. 49 :18,  e104- DOI:10.1093/nar/gkab601 PMID:34291282 
Yuichiro Mita, Risa Uchida, Sayuri Yasuhara, Kohei Kishi, Takayuki Hoshi, Yoshitaka Matsuo, Tadashi Yokooji, Yoshino Shirakawa, Takashi Toyama, Yasuomi Urano, Toshifumi Inada, Noriko Noguchi, Yoshiro Saito (2021)  Identification of a Novel Endogenous Long Non-coding RNA that Inhibits Selenoprotein P Translation. Nucleic Acids Research. 49 6893-6907 DOI:10.1093/nar/gkab498 PMID:34142161 
Katsuyuki Sakai, Yufu Unten, Aoi Kimishima, Kenichi Nonaka, Takumi Chinen, Kazunari Sakai, Takeo Usui, Kazuro Shiomi, Masato Iwatsuki, Masatoshi Murai, Hideto Miyoshi, Yukihiro Asami, Satoshi Omura (2021)  Traminines A and B, produced by Fusarium concentricum, inhibit oxidative phosphorylation in Saccharomyces cerevisiae mitochondria Journal of Industrial Microbiology and Biotechnology. 74 DOI:10.1093/jimb/kuab051 PMID:34343309 
Nobuhiro Sato, Rina Yogo, Saeko Yanaka, Anne Martel, Lionel Porcar, Ken Morishima, Rintaro Inoue, Taiki Tominaga, Takao Arimori, Junichi Takagi, Masaaki Sugiyama, Koichi Kato (2021)  A feasibility study of inverse contrast-matching small-angle neutron scattering method combined with size exclusion chromatography using antibody interactions as model systems. The Journal of Biochemistry. 169 :6,  701-708 DOI:10.1093/jb/mvab012 PMID:33585933 
Chie Motono, Shunsuke Yanagida, Miwa Sato, Takatsugu Hirokawa (2021)  MDContactCom: a tool to identify differences of protein molecular dynamics from two MD simulation trajectories in terms of interresidue contacts Bioinformatics. DOI:10.1093/bioinformatics/btab538 PMID:34289011 
Nami Tateyama, Teizo Asano, Tomokazu Ohishi, Junko Takei, Hideki Hosono, Ren Nanamiya, Tomohiro Tanaka, Masato Sano, Masaki Saito, Manabu Kawada, Mika K. Kaneko, and Yukinari Kato (2021)  An Anti-HER2 Monoclonal Antibody H2Mab-41 Exerts Antitumor Activities in Mouse Xenograft Model Using Dog HER2-Overexpressed Cells Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :4,  184-190 DOI:10.1089/mab.2021.0025 PMID:34424760 
Teizo Asano, Mika K Kaneko, Yukinari Kato (2021)  Development of a Novel Epitope Mapping System: RIEDL Insertion for Epitope Mapping Method. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :4,  162-167 DOI:10.1089/mab.2021.0023 PMID:34424761 
Nami Tateyama, Ren Nanamiya, Tomokazu Ohishi, Junko Takei, Takuro Nakamura, Miyuki Yanaka, Hideki Hosono, Masaki Saito, Teizo Asano, Tomohiro Tanaka, Masato Sano, Manabu Kawada, Mika K Kaneko, Yukinari Kato (2021)  Defucosylated Anti-Epidermal Growth Factor Receptor Monoclonal Antibody 134-mG2a-f Exerts Antitumor Activities in Mouse Xenograft Models of Dog Epidermal Growth Factor Receptor-Overexpressed Cells Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :4,  177-183 DOI:10.1089/mab.2021.0022 PMID:34424762 
Junko Takei, Teizo Asano, Tomohiro Tanaka, Masato Sano, Hideki Hosono, Ren Nanamiya, Nami Tateyama, Masaki Saito, Hiroyoshi Suzuki, Hiroyuki Harada, Mika K Kaneko, Yukinari Kato (2021)  Development of a Novel Anti-HER2 Monoclonal Antibody H2Mab-181 for Gastric Cancer Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :4,  168-176 DOI:10.1089/mab.2021.0021 PMID:34424764 
Tomohiro Tanaka, Teizo Asano, Masato Sano, Junko Takei, Hideki Hosono, Ren Nanamiya, Nami Tateyama, Mika K Kaneko, Yukinari Kato (2021)  Epitope Mapping of the Anti-California Sea Lion Podoplanin Monoclonal Antibody PMab-269 Using Alanine-Scanning Mutagenesis and ELISA Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :4,  196-200 DOI:10.1089/mab.2021.0017 PMID:34283661 
Ren Nanamiya, Junko Takei, Teizo Asano, Masato Sano, Tomohiro Tanaka, Hideki Hosono, Hiroyuki Harada, Yusuke Sakai, Takuya Mizuno, Hiroyoshi Suzuki, Mika K Kaneko, Yukinari Kato (2021)  Ferret Podoplanin Is Detected by PMab-241 in Immunohistochemistry. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :3,  134-140 DOI:10.1089/mab.2021.0016 PMID:34161160 
Hideki Hosono, Teizo Asano, Junko Takei, Masato Sano, Tomohiro Tanaka, Mika K. Kaneko, and Yukinari Kato (2021)  Development of an Anti-Elephant Podoplanin Monoclonal Antibody PMab-265 for Flow Cytometry Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :3,  141-145 DOI:10.1089/mab.2021.0015 PMID:34042502 
Masato Sano, Mika K Kaneko, Teizo Aasano, Yukinari Kato (2021)  Epitope Mapping of an Antihuman EGFR Monoclonal Antibody (EMab-134) Using the REMAP Method Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :4,  191-195 DOI:10.1089/mab.2021.0014 PMID:34283639 
Teizo Asano, Mika K Kaneko, Junko Takei, Nami Tateyama, Yukinari Kato (2021)  Epitope Mapping of the Anti-CD44 Monoclonal Antibody (C 44 Mab-46) Using the REMAP Method Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :4,  156-161 DOI:10.1089/mab.2021.0012 PMID:34283655 
Tomohiro Tanaka, Teizo Asano, Masato Sano, Junko Takei, Hideki Hosono, Ren Nanamiya, Takuro Nakamura, Miyuki Yanaka, Hiroyuki Harada, Masato Fukui, Hiroyoshi Suzuki, Kazuyuki Uchida,Takayuki Nakagawa, Yukinari Kato, and Mika K. Kaneko (2021)  Development of Monoclonal Antibody PMab-269 Against California Sea Lion Podoplanin Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 40 :3,  124-133 DOI:10.1089/mab.2021.0011 PMID:34042540 
Ren Nanamiya, Masato Sano, Teizo Asano, Miyuki Yanaka, Takuro Nakamura, Masaki Saito, Tomohiro Tanaka, Hideki Hosono, Nami Tateyama, Mika K Kaneko, Yukinari Kato (2021)  Epitope Mapping of an Anti-Human Epidermal Growth Factor Receptor Monoclonal Antibody (EMab-51) Using the RIEDL Insertion for Epitope Mapping Method Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 40 :4,  149-155 DOI:10.1089/mab.2021.0010 PMID:34424763 
Teizo Asano,Ren Nanamiya,Junko Takei,Takuro Nakamura,Miyuki Yanaka,Hideki Hosono,Tomohiro Tanaka,Masato Sano,Mika K Kaneko,Yukinari Kato (2021)  Development of Anti-Mouse CC Chemokine Receptor 3 Monoclonal Antibodies for Flow Cytometry Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 40 :3,  107-112 DOI:10.1089/mab.2021.0009 PMID:33877898 
Teizo Asano, Ren Nanamiya, Tomohiro Tanaka, Mika K Kaneko, Yukinari Kato (2021)  Development of Antihuman Killer Cell Lectin-Like Receptor Subfamily G Member 1 Monoclonal Antibodies for Flow Cytometry Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 40 :2,  76-80 DOI:10.1089/mab.2021.0008 PMID:33900816 
Ren Nanamiya, Junko Takei, Teizo Asano, Tomohiro Tanaka, Masato Sano, Takuro Nakamura, Miyuki Yanaka, Hideki Hosono, Mika K Kaneko, Yukinari Kato (2021)  Development of Anti-Human CC Chemokine Receptor 9 Monoclonal Antibodies for Flow Cytometry Monoclon Antib Immunodiagn Immunother. 40 :3,  101-106 DOI:10.1089/mab.2021.0007 PMID:34161159 
Junko Takei, Teizo Asano, Ren Nanamiya, Takuro Nakamura, Miyuki Yanaka, Hideki Hosono, Tomohiro Tanaka, Masato Sano, Mika K. Kaneko, Hiroyuki Harada, and Yukinari Kato (2021)  Development of Anti-human T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) Monoclonal Antibodies for Flow Cytometry Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 40 :2,  71-75 DOI:10.1089/mab.2021.0006 PMID:33900817 
Tomohiro Tanaka, Ren Nanamiya, Junko Takei, Takuro Nakamura, Miyuki Yanaka, Hideki Hosono, Masato Sano, Teizo Asano, Mika K Kaneko, Yukinari Kato (2021)  Development of Anti-Mouse CC Chemokine Receptor 8 Monoclonal Antibodies for Flow Cytometry. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 40 :2,  65-70 DOI:10.1089/mab.2021.0005 PMID:33900818 
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki, Hiroshi Suemizu  (2021)  UDP-glucuronosyltransferase 1A4-mediated N2- glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised livers Xenobiotica. 51 :10,  1146-1154 DOI:10.1080/00498254.2021.1972492 PMID:34423713 
Ryuta Kanai, Flemming Cornelius,eHaruo Ogawa, Kanna Motoyama, Bente Vilsen,eChikashi Toyoshima (2021)  Binding of cardiotonic steroids to Na+,K+-ATPase in the E2P state Proceedings of the National Academy of Sciences of the United States of America. 118 :1,  e2020438118- DOI:10.1073/pnas.2020438118 PMID:33318128 
Atsushi Kimishima, Hayato Saito, Violeta Petrova, Masayoshi Arai (2021)  Asymmetric Formal Synthesis of Trichodermamides B and C Synlett. 32 1865-1868 DOI:10.1055/s-0040-1720383
Ohno, Shohei, Miyoshi, Makoto, Murai, Kenichi, Arisawa, Mitsuhiro  (2021)  Non-directed β- or γ-C(sp3)-H Functionalization of Saturated Nitrogen-containing. Heterocycles. Synthesis in press. 53 2947-2960 DOI:10.1055/a-1483-4575
Kohei Suzuki,a Kota Katayama Yuji Sumii,Tomoya Nakagita,Ryoji Suno,Hirokazu Tsujimoto, So Iwata,Takuya Kobayashi, Norio Shibata and Hideki Kandori (2021)  Vibrational analysis of acetylcholine binding to the M2 receptor RSC Advances. 11 :21,  12559-12567 DOI:10.1039/d1ra01030a
Yuki Wada, Toshiki Akiyama, Kazuo Harada,Tetsuo Honma Hiroshi Naka, Susumu Saito and Mitsuiro Arisawa (2021)  Preparation of a platinum nanoparticle catalyst located near photocatalyst titanium oxide and its catalytic activity to convert benzyl alcohols to the corresponding ethers RSC Advances. 11 22230-22237 DOI:10.1039/d1ra00988e
Masatoshi Shibuya, Takayuki Orihashi, Yamei Li, Yoshihiko Yamamoto (2021)  N-Hydroxyphthalimide-catalyzed chemoselective intermolecular benzylic C-H amination of unprotected arylalkanols Chemical Communications. 57 8742-8745 DOI:10.1039/d1cc03466a PMID:34374398 
Kanako Nozawa-Kumada , Yuta Matsuzawa , Kanako Ono , Masanori Shigeno , Yoshinori Kondo (2021)  Copper-catalyzed aerobic double functionalization of benzylic C(sp3)-H bonds for the synthesis of 3-hydroxyisoindolinones Chemical Communications. 57 8604-8607 DOI:10.1039/d1cc02870g PMID:34368822 
Takahiro Aimi, Tomohiro Meguro, Akihiro Kobayashi, Takamitsu Hosoya, and Suguru Yoshida (2021)  Nucleophilic transformations of azido-containing carbonyl compounds via protection of azido group Chemical communications. 57 :49,  6062-6065 DOI:10.1039/D1CC01143J PMID:34036976 
Watanabe C, Okiyama Y, Tanaka S, Fukuzawa K, Honma T. (2021)  Molecular Recognition of SARS-CoV-2 Spike Glycoprotein: Quantum Chemical Hot Spot and Epitope Analyses. Chemical Science. 12 4722-4739 DOI:10.1039/D0SC06528E
Joseph M Rogers, Mickal Nawatha, Betsegaw Lemma, Ganga B Vamisetti, Ido Livneh, Uri Barash, Israel Vlodavsky, Aaron Ciechanover, David Fushman, Hiroaki Suga, Ashraf Brik  (2021)  In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides RSC Chemical Biology. 2 513-522 DOI:10.1039/d0cb00179a PMID:34179781 
Mari Hashimoto, Yoriko Saito, Ryo Nakagawa, Ikuko Ogahara, Shinsuke Takagi, Sadaaki Takata, Hanae Amitani, Mikiko Endo, Hitomi Yuki, Jordan A. Ramilowski, Jessica Severin, Ri-ichiroh Manabe, Takashi Watanabe, Kokoro Ozaki, Akiko Kaneko, Hiroshi Kajita, Saera Fujiki, Kaori Sato, Teruki Honma, Naoyuki Uchida, Takehiro Fukami, Yasushi Okazaki, Osamu Ohara, Leonard D. Shultz, Makoto Yamada, Shuichi Taniguchi, Paresh Vyas, Michiel de Hoon, Yukihide Momozawa & Fumihiko Ishikawa (2021)  Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia. Nature Cancer. 2 340-356 DOI:10.1038/s43018-021-00177-w PMID:35121960 
Kota Katayama, Kohei Suzuki, Ryoji Suno, Ryoji Kise, Hirokazu Tsujimoto, So Iwata, Asuka Inoue, Takuya Kobayashi, Hideki Kandori (2021)  Vibrational spectroscopy analysis of ligand efficacy in M2R. Communication Biology. DOI:10.1038/s42003-021-02836-1 PMID:34815515 
Yuta Horie, Takafumi Suzuki, Jin Inoue, Tatsuro Iso, Geoffrey Wells, Terry W. Moore, Tsunehiro Mizushima, Albena T. Dinkova-Kostova, Takuma Kasai, Takashi Kamei, Seizo Koshiba, Masayuki Yamamoto (2021)  Molecular basis for the disruption of Keap1-Nrf2 interaction via Hinge & Latch mechanism Communication Biology. 4 576- DOI:10.1038/s42003-021-02100-6 PMID:33990683 
Md Altaf-Ul-Amin 1, Kazuhisa Hirose , Joao V Nani , Lucas C Porta , Ljubica Tasic , Shaikh Farhad Hossain , Ming Huang , Naoaki Ono , Mirian A F Hayashi , Shigehiko Kanaya (2021)  A system biology approach based on metabolic biomarkers and protein-protein interactions for identifying athways underlying schizophrenia and bipolar disorder Scietific Reports. 11 14450- DOI:10.1038/s41598-021-93653-3 PMID:34262063 
Moe Ichikawa, Hiroki Akamine, Michika Murata, Sumito Ito, Kazuo Takayama, Hiroyuki Mizuguchi (2021)  Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system Scientific Reports. 11 11670- DOI:10.1038/s41598-021-91160-z PMID:34083621 
Melissa M Matthews, Tae Gyun Kim, Satoshi Shibata, Noriko Shibata, Christian Butcher, Jaekyung Hyun, Keon Young Kim, Theodore Robb, Siang Sheng Jheng, Masashi Narita, Tomoari Mori, Mary Collins, Matthias Wolf  (2021)  COVID-19 serological survey using micro blood sampling Scientific Reports. 11 :1,  9475- DOI:10.1038/s41598-021-88850-z PMID:33947894 
Kentaro Jingushi, Masaya Aoki, Kazuhiro Ueda, Takahiro Kogaki, Masaya Tanimoto, Yuya Monoe, Masayuki Ando, Takuya Matsumoto, Kentaro Minami, Yuko Ueda, Kaori Kitae, Hiroaki Hase, Toshiyuki Nagata, Aya Harada-Takeda, Masatatsu Yamamoto, Kohichi Kawahara, Kazuhiro Tabata, Tatsuhiko Furukawa, Masami Sato, Kazutake Tsujikawa (2021)  ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer scientific Reports. 11 :1,  8677- DOI:10.1038/s41598-021-87763-1 PMID:33883577 
Christopher J Draper-Joyce, Rebecca Bhola, Jinan Wang, Apurba Bhattarai, Anh T N Nguyen, India Cowie-Kent, Kelly O'Sullivan, Ling Yeong Chia, Hariprasad Venugopal, Celine Valant, David M Thal, Denise Wootten, Nicolas Panel, Jens Carlsson, Macdonald J Christie, Paul J White, Peter Scammells, Lauren T May, Patrick M Sexton, Radostin Danev, Yinglong Miao, Alisa Glukhova, Wendy L Imlach, Arthur Christopoulos  (2021)  Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia Nature. 597 :7877,  571-576 DOI:10.1038/s41586-021-03897-2 PMID:34497422 
Kazuhiro Abe, Kenta Yamamoto, Katsumasa Irie, Tomohiro Nishizawa, Atsunori Oshima  (2021)  Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations Nature Communications. 12 :1,  5709- DOI:10.1038/s41467-021-26024-1 PMID:34588453 
Agata Butryn, Philipp S Simon, Pierre Aller, Philip Hinchliffe, Ramzi N Massad, Gabriel Leen, Catherine L Tooke, Isabel Bogacz, In-Sik Kim, Asmit Bhowmick, Aaron S Brewster, Nicholas E Devenish, Jurgen Brem, Jos J A G Kamps, Pauline A Lang, Patrick Rabe, Danny Axford, John H Beale, Bradley Davy, Ali Ebrahim, Julien Orlans, Selina L S Storm, Tiankun Zhou, Shigeki Owada, Rie Tanaka, Kensuke Tono, Gwyndaf Evans, Robin L Owen, Frances A Houle, Nicholas K Sauter, Christopher J Schofield, James Spencer, Vittal K Yachandra, Junko Yano, Jan F Kern, Allen M Orville  (2021)  An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography Nature Communications. 12 :1,  4461- DOI:10.1038/s41467-021-24757-7 PMID:34294694 
Arimori T, Miyazaki N, Mihara E, Takizawa M, Taniguchi Y, Cabanas C, Sekiguchi K, Takagi J (2021)  Structural mechanism of laminin recognition byintegrin Nature Communications. 12 :1,  4012- DOI:10.1038/s41467-021-24184-8 PMID:34188035 
Kazunari Sakai, Masato Iwatsuki, Taichi Kaneta, Aoi Kimishima, Yukihiro Asami, Toshiaki Sunazuka, Rokuro Masuma, Kenichi Nonaka (2021)  Sesquicillin F, a new insecticidal meroterpenoid produced by Mariannaea macrochlamydospora FKI-4735 The Journal of Antibiotics. 74 817-820 DOI:10.1038/s41429-021-00456-9 PMID:34334788 
Hiroaki Ikeda,Hideaki Kakeya (2021)  Targeting hypoxia-inducible factor 1 (HIF-1) signaling with natural products toward cancer chemotherapy The Journal of Antibiotics. 74 687-695 DOI:10.1038/s41429-021-00451-0 PMID:34331027 
Aki Ishiyama, Rei Hokari, Kenichi Nonaka, Takuya Chiba, Hiromi Miura, Kazuhiko Otoguro, Masato Iwatsuki (2021)  Diatretol, an α, α'-dioxo-diketopiperazine, is a potent in vitro and in vivo antimalarial The journal of antibiotics. 74 266-268 DOI:10.1038/s41429-020-00390-2 PMID:33446930 
Takashi Ikawa, Yuta Yamamoto, Akito Heguri, Yutaka Fukumoto, Tomonari Murakami, Akira Takagi, Yuto Masuda, Kenzo Yahata, Hiroshi Aoyama, Yasuteru Shigeta, Hiroaki Tokiwa, Shuji Akai  (2021)  Could London Dispersion Force Control Regioselective (2 + 2) Cyclodimerizations of Benzynes YES: Application to the Synthesis of Helical Biphenylenes Journal of the American Chemical Society. 143 10853-10859 DOI:10.1021/jacs.1c05434 PMID:34197100 
Yuta Sato, Naoko Oyobe, Takao Ogawa, Sayo Suzuki, Hiroshi Aoyama, Tomonori Nakamura, Hiromichi Fujioka, Satoshi Shuto, and Mitsuhiro Arisawa (2021)  Design, Synthesis, and Monoamine Oxidase Inhibitory Activity of (+)-Cinchonaminone and Its Simplified Derivatives ACS medicinal chemistry letters. 12 1464-1469 DOI:10.1021/acsmedchemlett.1c00310 PMID:34531955 
Takeshi Yasui, Rine Tatsumi, and Yoshihiko Yamamoto (2021)  Highly Enantioselective [2+2+2] Cycloaddition of Enediynes Enabled by Cobalt/Organophotoredox Cooperative Catalysis ACS Catalysis. 11 9479-9484 DOI:10.1021/acscatal.1c02410
Masanori Shigeno,Masaya Imamatsu,Yusuke Kai,Moe Kiriyama,Shintaro Ishida,Kanako Nozawa-Kumada,Yoshinori Kondo (2021)  Construction of 1,2,3-Benzodiazaborole by Electrophilic Borylation of Azobenzene and Nucleophilic Dialkylative Cyclization Organic Letters. 23 8023-8027 DOI:10.1021/acs.orglett.1c03033 PMID:34613748 
Takefumi Kuranaga, Miho Tamura, Hiroaki Ikeda, Sakahiro Terada, Yusuke Nakagawa, and Hideaki Kakeya (2021)  Identification and Total Synthesis of an Unstable Anticancer Macrolide Presaccharothriolide Z Produced by Saccharothrix sp.A1506 A1506 Organic Letters. 23 7106-7111 DOI:10.1021/acs.orglett.1c02506 PMID:34436915 
Kanako Nozawa-Kumada, Koto Noguchi, Tomoya Akada, Masanori Shigeno, and Yoshinori Kondo (2021)  Regio- and Stereoselective Hydroiodination of Internal Alkynes with Ex Situ-Generated HI Organic Letters. 23 6659-6663 DOI:10.1021/acs.orglett.1c02218 PMID:34474572 
Tomohiro Kikuchi, Keiji Yamada, Takeshi Yasui, Yoshihiko Yamamoto (2021)  Synthesis of Benzo-Fused Cyclic Ketones via Metal-Free Ring Expansion of Cyclopropanols Enabled by Proton-Coupled Electron Transfer Organic Letters. 23 4710-4714 DOI:10.1021/acs.orglett.1c01436 PMID:34060855 
Takehiro Nishimura, Teppei Kawahara, Noritaka Kagaya, Yusuke Ogura, Hirosato Takikawa, Hikaru Suenaga, Masaatsu Adachi, Takatsugu Hirokawa, Takayuki Doi, Kazuo Shin-Ya (2021)  JBIR-155, a Specific Class D β-Lactamase Inhibitor of Microbial Origin Organic letters. 23 4415-4419 DOI:10.1021/acs.orglett.1c01352 PMID:34029112 
Minori Suzuki, Kazuya Kanemoto, Yu Nakamura, Takamitsu Hosoya, Suguru Yoshida (2021)  Palladium-Catalyzed Sulfinylation of Aryl- and Alkenylborons with Sulfinate Esters Organic Letters. 23 :9,  3796-3737 DOI:10.1021/acs.orglett.1c01292 PMID:33908784 
Jiawei Qiu, Makoto Sako, Tomoyuki Tanaka, Tsuyoshi Matsuzaki, Tsunayoshi Takehara, Takeyuki Suzuki, Shohei Ohno, Kenichi Murai, and Mitsuhiro Arisawa (2021)  Iridium-Catalyzed Isomerization/Cycloisomerization/Aromatization of N-Allyl-N-sulfonyl-o-(λ1-silylethynyl)aniline Derivatives to Give Substituted Indole Derivatives Organic Letters. 23 4284-4288 DOI:10.1021/acs.orglett.1c01231 PMID:34032456 
Tetsuya Kadota, Masanao Sawa, Yuta Kondo, Hiroyuki Morimoto, Takashi Ohshima (2021)  Catalytic Enantioselective Strecker Reaction of Isatin-Derived N-Unsubstituted Ketimines Organic Letters. 23 4553-4558 DOI:10.1021/acs.orglett.1c01194 PMID:34029103 
Yuki Wada, Tsunayoshi Takehara, Takeyuki Suzuki, Satoshi Aoki, Takayuki Hibi, Makoto Sako, Hirofumi Tsujino, Yasuo Tsutsumi, and Mitsuhiro Arisawa (2021)  Carbon-Carbon Bond Formation between N-Heterocyclic Carbene Ligand on Ruthenium Carbene Catalysts and 1,4-Naphthoquinone via Intramolecular Carbon(sp3)-Hydrogen Bond Activation Organometallics. 40 2901-2908 DOI:10.1021/acs.organomet.1c00350
Kazuki Watanabe , Chiduru Watanabe , Teruki Honma , Yu-Shi Tian , Yusuke Kawashima , Norihito Kawashita , Tatsuya Takagi , Kaori Fukuzawa  (2021)  Intermolecular Interaction Analyses on SARS-CoV-2 Receptor Binding Domain and Human Angiotensin-Converting Enzyme 2 Receptor-Blocking Antibody/peptide Using Fragment Molecular Orbital Calculation. The Journal of Physical Chemistry Letters. 12 4059-4066 DOI:10.1021/acs.jpclett.1c00663 PMID:33881894 
Miku Kimura, Tomoyo Mohri, Masaru Enomoto, Yasuhiro Meguro, Yusuke Ogura, and Shigefumi Kuwahara (2021)  Seven-Step Total Synthesis of Sporothriolide The Journal of Organic Chemistry. 86 12475-12479 DOI:10.1021/acs.joc.1c01663 PMID:34423986 
Kenji Watanabe, Nodoka Terao, Takashi Niwa, and Takamitsu Hosoya (2021)  Direct 3-Acylation of Indolizines by Carboxylic Acids for the Practical Synthesis of Red Light-Releasable Caged Carboxylic Acids The Journal of Organic Chemistry. 86 :17,  11822-11834 DOI:10.1021/acs.joc.1c01244 PMID:34279948 
Shota Nagasawa, Shogo Fujiki, Yusuke Sasano, Yoshiharu Iwabuchi (2021)  Chromium-Salen Complex/Nitroxyl Radical Cooperative Catalysis: A Combination for Aerobic Intramolecular Dearomative Coupling of Phenols The Journal of organic chemistry. 86 6952-6968 DOI:10.1021/acs.joc.1c00438 PMID:33890777 
Misa Sayama, Akiharu Uwamizu, Masaya Ikubo, Luying Chen, Ge Yan, Yuko Otani, Asuka Inoue, Junken Aoki, Tomohiko Ohwada (2021)  Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine Journal of Medicinal Chemistry. 64 10059-10101 DOI:10.1021/acs.jmedchem.1c00347 PMID:34233115 
Kei Moritsugu, Norifumi Yamamoto, Yasushige Yonezawa, Shin-ichi Tate, and Hiroshi Fujisaki (2021)  Path ensembles for Pin1-catalyzed cis-trans isomerization of a substrate calculated by weighted ensemble simulations Journal of Chemical Theory and Computation. 17 2522-2529 DOI:10.1021/acs.jctc.0c01280 PMID:33769826 
Kaori Fukuzawa, Koichiro Kato, Chiduru Watanabe, Yusuke Kawashima, Yuma Handa, Ami Yamamoto, Kazuki Watanabe, Tatsuya, Kikuko Kamisaka, Daisuke Takaya,Teruki Honma (2021)  Special feature of COVID-19 in FMODB: Fragment molecular orbital calculations and interaction energy analysis of SARS-CoV-2 related proteins ChemRxiv. 61 4594-4612 DOI:10.1021/acs.jcim.1c00694 PMID:34506132 
Toru Ekimoto, Takafumi Kudo, Tsutomu Yamane, Mitsunori Ikeguchi (2021)  Mechanism of Vitamin D Receptor Ligand-Binding Domain Regulation Studied by gREST Simulations Journal of Chemical Information and Modeling. 61 3625-3637 DOI:10.1021/acs.jcim.1c00534 PMID:34189910 
Kei Takedomi , Masateru Ohta , Toru Ekimoto , Mitsunori Ikeguchi (2021)  Effect of Water Molecules on the Activating S810L Mutation of the Mineralocorticoid Receptor Journal of Chemical Information and Modeling. 61 3583-3592 DOI:10.1021/acs.jcim.1c00389 PMID:34228431 
Keisuke Yanagisawa, Yoshitaka Moriwaki, Tohru Terada, Kentaro Shimizu (2021)  EXPRORER: Rational Cosolvent Set Construction Method for Cosolvent Molecular Dynamics Using Large-Scale Computation Journal of chemical information and modeling. 61 :6,  2744-2753 DOI:10.1021/acs.jcim.1c00134 PMID:34061535 
Kei Moritsugu, Koh Takeuchi, Narutoshi Kamiya, Junichi Higo, Isao Yasumatsu, Yoshifumi Fukunishi and Ikuo Fukuda (2021)  Flexibility and Cell Permeability of Cyclic Ras-Inhibitor Peptides Revealed by the Coupled Nose-Hoover Equation Journal of Chemical Information and Modeling. 61 1921-1930 DOI:10.1021/acs.jcim.0c01427 PMID:33835817 
Daisuke Takaya, Chiduru Watanabe, Shunpei Nagase, Kikuko Kamisaka, Yoshio Okiyama, Hirotomo Moriwaki, Hitomi Yuki, Tomohiro Sato, Noriyuki Kurita, Yoichiro Yagi, Tatsuya Takagi, Norihito Kawashita, Kenichiro Takaba, Tomonaga Ozawa, Midori Takimoto-Kamimura, Shigenori Tanaka, Kaori Fukuzawa, Teruki Honma  (2021)  FMODB: The World's First Database of Quantum Mechanical Calculations for Biomacromolecules Based on the Fragment Molecular Orbital Method. Journal of Chemical Information and Modeling . 61 777-794 DOI:10.1021/acs.jcim.0c01062 PMID:33511845 
Kazutoshi Tani, Ryo Kanno, Xuan-Cheng Ji, Malgorzata Hall, Long-Jiang Yu, Yukihiro Kimura, Michael T Madigan, Akira Mizoguchi, Bruno M Humbel, Zheng-Yu Wang-Otomo (2021)  Cryo-EM Structure of the Photosynthetic LH1-RC Complex from Rhodospirillum rubrum Biochemistry. 60 :32,  2483-2491 DOI:10.1021/acs.biochem.1c00360 PMID:34323477 
Waka Sakamoto,Nanako Azegami,Tsuyoshi Konuma,Satoko Akashi (2021)  Single-Cell Native Mass Spectrometry of Human Erythrocytes Analytical Chemistry. 93 :17,  6583-6588 DOI:10.1021/acs.analchem.1c00588 PMID:33871982 
Yuki Goto, Hiroaki Suga (2021)  The RaPID Platform for the Discovery of Pseudo-Natural Macrocyclic Peptides Accounts of chemical research. 54 :18,  3604-3617 DOI:10.1021/acs.accounts.1c00391 PMID:34505781 
Yohei Kawai, Ai Kawana-Tachikawa, Shuichi Kitayama, Tatsuki Ueda, Shoji Miki, Akira Watanabe, Shin Kaneko (2021)  Generation of highly proliferative rejuvenated cytotoxic T cell clones through pluripotency reprogramming for adoptive immunotherapy Molecular therapy. 29 :10,  3027-3041 DOI:10.1016/j.ymthe.2021.05.016 PMID:34023508 
Takahiro Noro, Juri Sakata, and Hidetoshi Tokuyama (2021)  Synthetic Studies on Discorhabdin V: Construction of the A-F Hexacyclic Framework Tetrahedron Letter. 81 153333-153336 DOI:10.1016/j.tetlet.2021.153333
Shinji Tanaka, Sho Yoshinaka, Kiyoshi Kawamura, Mikio Morita, Masato Kitamura (2021)  Systematic asymmetric analog synthesis of fluspidine, a σ1 receptor ligand, to improve ligand affinity Tetrahedron Letters. DOI:10.1016/j.tetlet.2021.153250
Shu Takahashia, Aoi Kimishima, Tomoyasu Hirose, Takeshi Yamada, Akihiro Sugawara, Tatsuya Shirahata, Yoshihiko Noguchi, Masato Iwatsuki, Rei Hokari, AkiI shiyama, Yoshinori Kobayashi, Toshiaki Sunazuka (2021)  Unified enantioselective total synthesis of 3,6-dioxygenated diketopiperazine natural products, diatretol and lepistamides A, B and C Tetrahedron Letters. 67 152895- DOI:10.1016/j.tetlet.2021.152895
Minami Otsubo, KousukeS akimoto, Hiromichi Egami, Yoshitaka Hamashima (2021)  Dearomative enantio- and diastereoselective difluorination of resorcinol derivatives Tetrahedron. 96 132355- DOI:10.1016/j.tet.2021.132355
Xin Zhang,Rachel M Johnson,eva Drulyte,Lingbo Yu,Abhay Kotecha,Radostin Danev,Denise Wootten,Patrick M Sexton,Matthew J Belousoff (2021)  Evolving cryo-EM structural approaches for GPCR drug discovery Structure. 29 :9,  963-974 DOI:10.1016/j.str.2021.04.008 PMID:33957078 
Zukang Feng, John D. Westbrook, Raul Sala, Oliver S. Samart, Gerald Bricogne, Masaak Matsubara, Issaku Yamada, Shinichiro Tsuchiya, Kiyoko F. Aoki-Kinoshita, Jefferey C. Hoch, Genji Kurisu, Sameer Velankar, Stephen K. Burley, Jasmine Y. Young (2021)  Enhanced validation of small-molecule ligands and carbohydrates in the Protein Data Bank Structure. 29 393-400 DOI:10.1016/j.str.2021.02.004 PMID:33657417 
Kaori Fukuzawa, Shigenori Tanaka (2021)  Fragment molecular orbital calculations for biomolecules Current Opinion in Structural Biology. 72 127-134 DOI:10.1016/j.sbi.2021.08.010 PMID:34656048 
Akihito Harada, Hiroshi Kimura, Yasuyuki Ohkawa  (2021)  Recent advance in single-cell epigenomics Current Opinion in Structural Biology. 71 :116,  122- DOI:10.1016/j.sbi.2021.06.010 PMID:34303078 
Wataru Kagawa and Hitoshi Kurumizaka (2021)  Structural basis for DNA sequence recognition by pioneer factors in nucleosomes Current opinion in Structural Biology. 71 59-64 DOI:10.1016/j.sbi.2021.05.011 PMID:34218163 
Amarjeet Kumar , Justin Chan , Masahiko Taguchi , Hidetoshi Kono (2021)  Interplay between nucleosomes and transacting factors around promoter Current Opinion in Structural Biology. 71 7-15 DOI:10.1016/j.sbi.2021.04.008 PMID:34111671 
Tomoki Yamashita, Tatsuya Inui, Jumpei Yokota, Kentaro Kawakami, Gaku Morinaga, Masahito Takatani, Daisuke Hirayama, Ryuga Nomoto, Kohei Ito, Yunhai Cui, Stephanie Ruez, Kazuo Harada, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi (2021)  Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research Molecular Therapy: Methods & Clinical Development. 22 263-278 DOI:10.1016/j.omtm.2021.05.005 PMID:34485610 
Emma Rose McGlone, Yusman Manchanda, Ben Jones, Phil Pickford, Asuka Inoue, David Carling, Stephen R Bloom, Tricia Tan, Alejandra Tomas (2021)  Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling. Molecular Metabolism. 53 DOI:10.1016/j.molmet.2021.101296 PMID:34271220 
Shubhi Pandey , Punita Kumari , Mithu Baidya , Ryoji Kise , Yubo Cao , Hemlata Dwivedi-Agnihotri , Ramanuj Banerjee , Xaria X Li , Cedric S Cui , John D Lee , Kouki Kawakami , Jagannath Maharana , Ashutosh Ranjan , Madhu Chaturvedi , Gagan Deep Jhingan , Stephane A Laporte , Trent M Woodruff , Asuka Inoue , Arun K Shukla (2021)  Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors. Mol Cell. 81 4605-4621 DOI:10.1016/j.molcel.2021.09.007 PMID:34582793 
Keito Hiragi, Kazuya Nishio, Shu Moriyama, Tasuku Hamaguchi, Akira Mizoguchi, Koji Yonekura, Kazutoshi Tani, Tsunehiro Mizushima (2021)  Structural insights into the targeting specificity of ubiquitin ligase for S. cerevisiae isocitrate lyase but not C. albicans isocitrate lyase Jounral of Structural Biology. 213 :3,  107748- DOI:10.1016/j.jsb.2021.107748 PMID:34033899 
Kensuke Misawa,Yoshiya Sugai,Taketoshi Fujimori,Takatsugu Hirokawa (2021)  Structural insights from an in silico molecular docking simulation of complement component 3a receptor 1 with an antagonist Journal of Molecular Graphics and Modelling. 106 107914- DOI:10.1016/j.jmgm.2021.107914 PMID:33932736 
Akinori Kidera, Kei Moritsugu, Toru Ekimoto, Mitsunori Ikeguchi (2021)  Allosteric regulation of 3CL protease of SARS-CoV-2 and SARS-CoV observed in the crystal structure ensemble Journal of Molecular Biology. 433 167324- DOI:10.1016/j.jmb.2021.167324 PMID:34717972 
Hideki Itoh, Takashi Murayama, Nagomi Kurebayashi, Seiko Ohno, Takuya Kobayashi, Yusuke Fujii, MasayaWatanabe, Haruo Ogawa, Toshihisa Anzai, Minoru Horie (2021)  Sudden death after inappropriate shocks of implantable cardioverter defibrillator in a catecholaminergic polymorphic ventricular tachycardia case with a novel RyR2 mutation Journal of Electrocardiology. 69 111-118 DOI:10.1016/j.jelectrocard.2021.09.015 PMID:34656916 
Katsuya Ohbuchi,Takatsugu Hirokawa (2021)  Protein druggability assessment for natural products using in silico simulation: A case study with estrogen receptor and the flavonoid genistein Gene. 791 145726- DOI:10.1016/j.gene.2021.145726 PMID:34010704 
Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki, Hiroshi Suemizu (2021)  Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes Drug Metabolism and Pharmacokinetics. 41 100419- DOI:10.1016/j.dmpk.2021.100419 PMID:34624627 
Chikako Shibazaki,Tomoyuki Ohe,Kyoko Takahashi,Shigeo,Nakamura,Tadahiko Mashino (2021)  Development of fluorescent-labeled trapping reagents based on cysteine to detect soft and hard electrophilic reactive metabolites Drug Metabolism and Pharmacokinetics. 39 100386- DOI:10.1016/j.dmpk.2021.100386 PMID:34091122 
Yu Yamamori, Kentaro Tomii (2021)  An ensemble reweighting method for combining the information of experiments and simulations Chemical Physics Letters. 779 :1月2日,  138821- DOI:10.1016/j.cplett.2021.138821
Takuya Hidaka, Kaori Hashiya, Toshikazu Bando, Ganesh N Pandian, Hiroshi Sugiyama (2021)  Targeted elimination of mutated mitochondrial DNA by a multi-functional conjugate capable of sequence-specific adenine alkylation Cell Chemical Biology. S2451-9456 00365-2- DOI:10.1016/j.chembiol.2021.08.003 PMID:34450110 
Toi Kobayashi, Takumi Yasuno, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino, Tomoyuki Ohe (2021)  Novel pyridinium-type fullerene derivatives as multitargeting inhibitors of HIV-1 reverse transcriptase, HIV-1 protease, and HCV NS5B polymerase Bioorganic & Medicinal Chemistry Letters. 49 128267- DOI:10.1016/j.bmcl.2021.128267 PMID:34271071 
Kentaro Inoue, Hiromitsu Araki, Fumihito Miura, Takashi Ito (2021)  Transcriptome dynamics during cholesterol-induced transdifferentiation of human coronary artery smooth muscle cells: A Gene Ontology-centric clustering approach Biochemistry Biophysics Reports. 27 101061- DOI:10.1016/j.bbrep.2021.101061 PMID:34258396 
Yusuke Sayama, Mika K Kaneko, Junko Takei, Hideki Hosono, Masato Sano, Teizo Asano, Yukinari Kato  (2021)  Establishment of a novel anti-TROP2 monoclonal antibody TrMab-29 for immunohistochemical analysis. Biochemistry and Biophysics Reports. 25 100902- DOI:10.1016/j.bbrep.2020.100902 PMID:33490649 
Edurne Rujas, Daniel P. Leaman, Sara Insausti, Pablo Carravilla, Miguel Garcia-Porras, Eneko Largo, Izaskun Morillo, Ruben Sanchez-Eugenia, Lei Zhang, Hong Cui, Ibon Iloro, Felix Elortza, Jean-Philippe Julien, Christian Eggeling, Michael B. Zwick, Jose M.M. Caaveiro, Jose L. Nieva (2021)  Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile iScience. 24 102987- DOI:10.1016/ j.isci.2021.102987 PMID:34505005 
John Rozewicki, Songling Li, Kazutaka Katoh, Daron M Standley (2021)  Analysis of Protein Intermolecular Interactions with MAFFT-DASH. Methods in molecular biology. 2231 163-177 DOI:10.1007/978-1-0716-1036-7_11 PMID:33289893 
Gert-Jan Bekker, Masashi Yokochi, Hirofumi Suzuki, Yasuyo Ikegawa, Takeshi Iwata, Takahiro Kudo, Kei Yura, Toshimichi Fujiwara, Takeshi Kawabata, Genji Kurisu (2021)  Protein Data Bank Japan: Celebrating our 20th anniversary during a global pandemic as the Asian hub of 3D macromolecular structural data Protein science. DOI:10.1002/pro.4211 PMID:34664328 
Masatomo So, Yuto Kimura, Keiichi Yamaguchi, Toshihiko Sugiki, Toshimichi Fujiwara, Cesar Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Yasushi Kawata, Yuji Goto (2021)  Polyphenol-solubility alters amyloid fibril formation of α-synuclein Protein Science. 30 :8,  1701-1713 DOI:10.1002/pro.4130 PMID:34046949 
Tadayoshi Kanao, Naruki Hase, Hisayuki Nakayama, Kyoya Yoshida, Kazumi Nishiura, Megumi Kosaka, Kazuo Kamimura, Yu Hirano, Taro Tamada  (2021)  Reaction mechanism of tetrathionate hydrolysis based on the crystal structure of tetrathionate hydrolase from Acidithiobacillus ferrooxidans Protein Science. 30 :2,  328-338 DOI:10.1002/pro.3984 PMID:33103311 
Hirohito Kubota, Tatsuya Masuda, Mina Noura, Kana Furuichi, Hidemasa Matsuo, Masahiro Hirata, Tatsuki R. Kataoka, Hidefumi Hiramatsu, Takahiro Yasumi, Tatsutoshi Nakahata, Yoichi Imai, Junko Takita, Souichi Adachi, Hiroshi Sugiyama, Yasuhiko Kamikubo (2021)  RUNX inhibitor suppresses graft-versus-host disease through targeting RUNX-NFATC2 axis British Journal of Haematology. DOI:10.1002/jha2.230
Tatsuhiko Ozawa, Eiji Kobayashi, Hiroshi Hamana, Tomoko Nakamura, Fulian Lyu, Atsushi Hayashi, Atsushi Muraguchi, Hiroyuki Kishi (2021)  Rapid and efficient generation of T-cell receptor-like antibodies using chip-based single-cell analysis European Journal of Immunology. 51 :7,  1850-1853 DOI:10.1002/eji.202049083 PMID:33728647 
Naoto Sugisawa, Hiroki Sugisawa, Yuma Otake, Roman V. Krems, Hiroyuki Nakamura, Shinichiro Fuse (2021)  Rapid and Mild One-Flow Synthetic Approach to Unsymmetrical Sulfamides Guided by Bayesian Optimization Chemistry Methods. DOI:10.1002/cmtd.202100053
Masahiro Kanaida, Aoi Kimishima, Shuhei Eguchi, Masato Iwatsuki, Yoshihiro Watanabe, Masako Honsho, Tomoyasu Hirose, Yoshihiko Noguchi, Kenichi Nonaka, Goh Sennari, Hidehito Matsui, Chikara Kaito, Hideaki Hanaki, Yukihiro Asami, Toshiaki Sunazuka  (2021)  Total Syntheses and Chemical Biology Studies of Hymeglusin and Fusarilactone A, Novel Circumventors of β-Lactam Drug Resistance in Methicillin-Resistant Staphylococcus aureus ChemMedChem. 16 2106-2111 DOI:10.1002/cmdc.202100219 PMID:33783142 
Daisuke Fujiwara, Kousuke Mihara, Ryo Takayama, Yusuke Nakamura, Mitsuhiro Ueda, Takeshi Tsumuraya, Ikuo Fujii (2021)  Chemical Modification of Phage-Displayed Helix-Loop-Helix Peptides to Construct Kinase-Focused Libraries ChemBioChem. DOI:10.1002/cbic.202100450 PMID:34605137 
Takeshi Yasui, Yuya Nakazato, Koutarou Kurisaki, and Yoshihiko Yamamoto (2021)  Enantioselective Construction of 5-6-5 Tricyclic Lactone Framework Bearing a Quaternary Bridgehead Carbon via Rh-Catalyzed Asymmetric [2+2+2] Cycloaddition of Enediynes Advanced Synthesis & Catalysis. 363 4182-4189 DOI:10.1002/adsc.202100513
Takuya Naito, Kentaro Jingushi, Koji Ueda, Kazutake Tsujikawa (2021)  Azurocidin is loaded into small extracellular vesicles via its N-linked glycosylation and promotes intravasation of renal cell carcinoma cells The FEBS Letters. 595 2522-2532 DOI:10.1002/1873-3468.14183 PMID:34418081 
Atsushi Hijikata,Clara Shionyu-Mitsuyama,Setsu Nakae,Masafumi Shionyu,Motonori Ota,Shigehiko Kanaya,Tsuyoshi Shirai (2021)  Knowledge‐based structural models of SARS‐CoV‐2 proteins and their complexes with potential drugs. FEBS Letters. 594 1960-1973 DOI:10.1002/1873-3468.13806 PMID:32379896 

BINDSの支援を受けた研究成果(論文)

Jun Nakayama, Hiroko Matsunaga, Koji Arikawa, Takuya Yoda, Masahito Hosokawa, Haruko Takeyama, Yusuke Yamamoto, Kentaro Semba (2021)  Identification of two cancer stem cell-like populations in triple-negative breast cancer xenografts bioRxiv. 465257- DOI:10.1101/2021.10.21.465257
Shuhei Ueda, Masahito Hosokawa, Koji Arikawa, Kiyofumi Takahashi, Mao Fujiwara, Manami Kakita, Taro Fukada, Hiroaki Koyama, Shin-Ichiro Horigane, Keiichi Itoi, Masaki Kakeyama, Hiroko Matsunaga, Haruko Takeyama, Haruhiko Bito, Sayaka Takemoto-Kimura (2021)  Distinctive Regulation of Emotional Behaviors and Fear-Related Gene Expression Responses in Two Extended Amygdala Subnuclei With Similar Molecular Profiles Frontiers in Molecular Neuroscience. 14 741895- DOI:10.3389/fnmol.2021.741895 PMID:34539345 
Jun-ichi Kishikawa, Atsuko Nakanishi, Atsuki Nakano, Shiori Saeki, Aya Furuta, Takayuki Kato, Kaoru Mitusoka, Ken Yokoyama (2022)  Structural snapshots of V/A-ATPase reveal the rotary catalytic mechanism of rotary ATPases Nature communications. 13 1213- DOI:10.1038/s41467-022-28832-5 PMID:35260556 
Cesar Aguirre, Kensuke Ikenaka, Masatomo So, Takahiro Maruno, Keiichi Yamaguchi, Kichitaro Nakajima, Chi-Jing Choong, Kei Nabekura, Goichi Beck, Kentaro Tomii, Yu Yamamori, Junko Doi, Tomoyasu Matsubara, Maho Morishima, Keita Kakuda, Makoto Hideshima, Yasuyoshi Kimura, Seiichi Nagano, Kousuke Baba, Shigeo Murayama, Hirotsugu Ogi, Yoshitaka Nagai, Yasushi Kawata, Susumu Uchiyama, Yohei Miyanoiri, Yuji Goto, Hideki Mochizuki (2022)  Conformational change in the monomeric alpha-synuclein imparts fibril polymorphs biorxev. DOI:10.1101/2022.02.10.479831
Kunio Nakata, Naoyuki Miyazaki, Hiroki Yamaguchi, Mika Hirose, Tatsuki Kashiwagi, Nidamarthi H V Kutumbarao, Osamu Miyashita, Florence Tama, Hiroshi Miyano, Toshimi Mizukoshi, Kenji Iwasaki  (2021)  High-resolution structure of phosphoketolase from Bifidobacterium longum determined by cryo-EM single-particle analysis Journal of Structural Biology. DOI:10.1016/j.jsb.2022.107842 PMID:35181457 
Toshihiko Sugiki, Young-Ho Lee, Nesreen Alsanousi, Kaito Murata, Izuru Kawamura, Toshimichi Fujiwara, Kentaro Hanada, Chojiro Kojima (2021)  A hybrid strategy combining solution NMR spectroscopy and isothermal titration calorimetry to characterize protein-nanodisc interaction Analytical Biochemistry. 639 114521- DOI:10.1016/j.ab.2021.114521 PMID:34906540 
Koji Kato, Ryo Nagao, Yoshifumi Ueno, Makio Yokono, Takehiro Suzuki, Tian-Yi Jiang, Naoshi Dohmae, Fusamichi Akita, Seiji Akimoto, Naoyuki Miyazaki, and Jian-Ren Shen (2022)  Structural insights into an evolutionary turning-point of photosystem I 1 from prokaryotes to eukaryotes biorxev. DOI:10.1101/2022.01.03.474851
Inaba, K., Ebihara, K., Senda, M., Yoshino, R., Sakuma, C., Koiwai, K., Takaya, D., Watanabe, C., Watanabe, A., Kawashima, Y., Fukuzawa, K., Imamura, R., Kojima, H., Okabe, T., Ue?ura, N., Kasai, S., Kanuka, H., Nishimura, T., Watanabe, K., Inoue, H., Fujikawa, Y., HOnma, T., Hirokawa, T., Senda, T. And Niwa, R.* (2022)  Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti. BMC Biology. 20 43-62 DOI:10.1186/s12915-022-01233-2 PMID:35172816 
Kano Suzuki, Mara del Carmen Marin, Masae Konno, Reza Bagherzadeh, *Takeshi Murata, and *Keiichi Inoue (2022)  Structural characterization of proton-pumping rhodopsin lacking a cytoplasmic proton donor residue by X-ray crystallography J. Biol. Chem.. in press DOI:10.1016/j.jbc.2022.101722
Takeshi Haraguchi, Masanori Tamanaha, Kano Suzuki, Kohei Yoshimura, Takuma Imi, Motoki Tominaga, Hidetoshi Sakayama, Tomoaki Nishiyama, *Takeshi Murata, and *Kohji Ito (2022)  Discovery of the fastest myosin, its amino acid sequence, and structural features Proc. Natl. Acad. Sci. U. S. A.. 119 e212096211- DOI:10.1073/pnas.2120962119
Arif Md. Rashedul Kabir, Tasrina Munmun, Tomohiko Hayashi, Satoshi Yasuda, Atsushi P. Kimura, Masahiro Kinoshita, Takeshi Murata, Kazuki Sada and *Akira Kakugo (2022)  Controlling the rigidity of kinesin-propelled microtubules in an in vitro gliding assay using the deep-sea osmolyte trimethylamine N-oxide ACS Omega. 7 3796-3803 DOI:10.1021/acsomega.1c06699
Atsuhiro Tomita, Takashi Daiho, Tsukasa Kusakizako, Keitaro Yamashita, Satoshi Ogasawara, Takeshi Murata, *Tomohiro Nishizawa, *Osamu Nureki (2021)  Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2 Mol. Cell. 81 4799-4809 DOI:10.1016/j.molcel.2021.11.001
S. Horikoshi, W. Saburi, J. Yu, H. Matsuura, J. R K. Cairns, M.Yao, H. Mori (2021)  Substrate specificity of glycoside hydrolase family 1 β-glucosidase AtBGlu42 from Arabidopsis thaliana and its molecular mechanism Bioscience, Biotechnology, and Biochemistry. (2021). 86 :2,  231-245 DOI:10.1093/bbb/zbab200
T. Tagami, M. Chen, Y. Furunaga, A. Kikuchi, J.Sadahiro, W. Lang, M.Okuyama, Y. Tanaka, T. Iwasaki, M. Yao and A. Kimura. (2021)  State-Targeting Stabilization of Adenosine A2A Receptor by Fusing a Custom-Made De Novo Designed α-Helical Protein; The FEBS Journal.. 289 1118-1134 DOI:10.1111/febs.16237
Daisuke Takahashi, Eri Matsunaga, Tomohiro Yamashita, Jose M.M. Caaveiro, Yoshito Abe, Tadashi Ueda (2022)  Compound screening identified gossypetin and isoquercitrin as novel inhibitors for amyloid fibril formations of Vλ6 proteins associated with AL amyloidosis Biochemical and Biophysical Research Communications. DOI:10.1016/j.bbrc.2022.01.066 PMID:35108650 
Nishiyama K, Nishimura A, Shimoda K, Tanaka T, Kato Y, Shibata T, Tanaka H, Kurose H, Azuma Y-T, Ihara H, Kumagai K, Akaike T, Eaton P, Uchida K, Nishida M (2022)  Redox-dependent internalization of purinergic P2Y6 receptor limits colitis progression. Science Signaling. 15 :716,  DOI:10.1126/scisignal.abj0644 PMID:35015570 
Yi Yang, Adam Csakai, Shuangshuang Jiang, Christina Smith, Hiromi Tanji, Jian Huang, Torey Jones, Kentaro Sakaniwa, Lindsey Broadwell, Chengrui Shi, Subada Soti, Umeharu Ohto, Yaohui Fang, Shu Shen, Fei Deng, Toshiyuki Shimizu & Hang Yin (2021)  Tetrasubstituted imidazoles as incognito Toll-like receptor 8 antagonists Nat Commun. 12 :1,  4351- DOI:10.1038/s41467-021-24536-4 PMID:34272380 
Toma-Fukai S. and Shimizu, T (2021)  Structural Diversity of Ubiquitin E3 Ligase Molecules. 26 :21,  6682- DOI:10.3390/molecules26216682 PMID:34771091 
鎌田 祥太郎, 石井 功 (2021)  X線結晶構造解析により明らかとなったPPARαとリガンドの結合様式 Yakugaku Zasshi. 141 :11,  1267-1274 DOI:10.1248/yakushi.21-00138 PMID:34719550 
Kouhei Kunichika, Ryosuke Nakamura, Takashi Fujishiro, Yasuhiro Takahashi (2021)  The Structure of the Dimeric State of IscU Harboring Two Adjacent [2Fe-2S] Clusters Provides Mechanistic Insights into Cluster Conversion to [4Fe-4S] Biochemistry. 60 :20,  1569-1572 DOI:10.1021/acs.biochem.1c00112 PMID:33938220 
Manatsu Morikawa, Nivedita U Jerath, Tadayuki Ogawa, Momo Morikawa, Yosuke Tanaka, Michael E Shy, Stephan Zuchner, Nobutaka Hirokawa (2022)  A neuropathy-associated kinesin KIF1A mutation hyper-stabilizes the motor-neck interaction during the ATPase cycle EMBO journal. DOI:10.15252/embj.2021108899
Linh, N.T, Arimura, T, Tominaga, K., Kigoshi, H, and Isoda, H. (2021)  Syntheses and aggregation properties of new squalene receptors bearing open chain ligands. Supramolecular Chemistry. DOI:10.1080/10610278.2021.1970161
Sato, S, Takizawa, Y, Hoshikawa, F, Dacher, M, Tanaka, H, Tachiwana, H, Kujirai, T, Iikura, Y, Ho, C.H, Adachi, N, Patwal, I, Flaus, A, and Kurumizaka, H. (2021)  Cryo-EM structure of the nucleosome core particle containing Giardia lamblia histones. Nucleic Acids Res.. 49 8934-8946 DOI:10.1093/nar/gkab644
Ikegaya M., Moriya, T., Adachi N., Kawasaki, M., Park E. Y., Miyazaki, T. (2022)  Structural basis of the strict specificity of a bacterial GH31 a-1,3-glucodiase for nigerooligosaccharides. J. Biol. Chem.. DOI:10.1016/j.jbc.2022.101827
Kawano, Y, Hikita, M, Matsugaki, N, Yamamoto, M, and Senda, T (2022)  A crystal-processing machine using a deep-ultraviolet laser: application to long-wavelength native SAD experiments Acta Cryst. F78 88-95 DOI:10.1107/S2053230X2101339X PMID:35102898 
Ko Sato, Amarjeet Kumar, Keisuke Hamada, Chikako Okada, Asako Oguni, Ayumi Machiyama, Shun Sakuraba, Tomohiro Nishizawa, Osamu Nureki, Hidetoshi Kono, Kazuhiro Ogata, Toru Sengoku (2021)  Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2. Nat Commun. 12 :6605,  DOI:10.1038/s41467-021-26913-5 PMID:34782608 
Seiya Hirai, Kosuke Tomimatsu, Atsuko Miyawaki-Kuwakado, Yoshimasa Takizawa, Tetsuro Komatsu, Taro Tachibana, Yutaro Fukushima, Yasuko Takeda, Lumi Negishi, Tomoya Kujirai, Masako Koyama, Yasuyuki Ohkawa, Hitoshi Kurumizaka (2021)  Unusual nucleosome formation and transcriptome influence by the histone H3mm18 variant Nucleic Acids Research. 50 :1,  72-91 DOI:10.1093/nar/gkab1137 PMID:34929737 
Koichiro E Kishi, Yoon Seok Kim, Masahiro Fukuda, Masatoshi Inoue, Tsukasa Kusakizako, Peter Y Wang, Charu Ramakrishnan, Eamon F X Byrne, Elina Thadhani, Joseph M Paggi, Toshiki E Matsui, Keitaro Yamashita, Takashi Nagata, Masae Konno, Sean Quirin, Maisie Lo, Tyler Benster, Tomoko Uemura, Kehong Liu, Mikihiro Shibata, Norimichi Nomura, So Iwata, Osamu Nureki, Ron O Dror, Keiichi Inoue, Karl Deisseroth, Hideaki E Kato (2022)  Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine Cell. 185 :4,  672-689 DOI:10.1016/j.cell.2022.01.007 PMID:35114111 
Caner Akıl, Samson Ali, Linh T. Tran, Jeremie Gaillard, Wenfei Li, Kenichi Hayashida, Mika Hirose, Takayuki Kato, Atsunori Oshima, Kosuke Fujishima, Laurent Blanchoin, Akihiro Narita & Robert C. Robinsonn (2022)  Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution Science Advances. 8 eabm2225- DOI:10.1126/sciadv.abm2225
Kazuya Sumi, Kenji Tago, Yosuke Nakazawa, Kyoko Takahashi, Tomoyuki Ohe Tadahiko Mashino, Megumi Funakoshi-Tago (2022)  Novel Mechanism by a Bis-Pyridinium Fullerene Derivative to Induce Apoptosis by Enhancing the MEK-ERK Pathway in a Reactive Oxygen Species-Independent Manner in BCR-ABL-Positive Chronic Myeloid Leukemia-Derived K562 Cells Int J Mol Sci. 23 :2,  749- DOI:10.3390/ijms23020749 PMID:35054935 
Hitomi Sudo, Atsushi B. Tsuji, Aya Sugyo, Mika K. Kaneko, Yukinari Kato, Kotaro Nagatsu, Hisashi Suzuki, and Tatsuya Higashi (2021)  Preclinical evaluation of podoplanin-targeted al-pha-radioimmunotherapy with the novel antibody NZ-16 for malignant mesothelioma Cells. 10 :10,  2503- DOI:10.3390/cells10102503 PMID:34685483 
Kei Watari, Satoru Konnai, Tomohiro Okagawa, Naoya Maekawa, Yamato Sajiki, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi  (2021)  Enhancement of interleukin-2 production by bovine peripheral blood mononuclear cells treated with the combination of anti-programmed death-ligand 1 and cytotoxic T lymphocyte antigen 4 chimeric monoclonal antibodies Journal of Veterinary Medical Science. 84 :1,  6-15 DOI:10.1292/jvms.21-0552 PMID:34789592 
Tomoya Fujita, Takeshi Yokoyama, Mikako Shirouzu, Hideki Taguchi, Takuhiro Ito, Shintaro Iwasaki  (2022)  The landscape of translational stall sites in bacteria revealed by monosome and disome profiling RNA. 28 :3,  290-302 DOI:10.1261/rna.078188.120 PMID:34906996 
Yutaka Suto, Tatiana Ascencio, Tomoya Nobuta, Noriyuki Yamagiwa,Yoko Onizuka, Mayumi Ishii, Kayoko Kanemitsu, and Junko Nakajima-Shimada (2021)  Synthesis and Evaluation of Quinone Derivatives for Activity against Trypanosome cruzi Chemical and Pharmaceutical Bulletin. 69 :12,  1195-1199 DOI:10.1248/cpb.c21-00732 PMID:34853286 
Yasunobu Hoshino, Daisuke Noto, Shuhei Sano, Yuji Tomizawa, Kazumasa Yokoyama, Nobutaka Hattori, Sachiko Miyake (2022)  Dysregulated B cell differentiation towards antibody?secreting cells in neuromyelitis optica spectrum disorder Journal of Neuroinflammation. 19 :1,  6- DOI:10.1186/s12974-021-02375-w PMID:34991631 
Maki Kuzuya, Hidemi Hirano, Kenichi Hayashida, Masakatsu Watanabe, Kazumi Kobayashi, Tohru Terada, Md. Iqbal Mahmood, Florence Tama, Kazutoshi Tani, Yoshinori Fujiyoshi, and Atsunori Oshima (2022)  Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids Science Signaling. 15 :720,  eabg6941- DOI:10.1126/scisignal.abg6941 PMID:35133866 
Nouran Ghanem, Natsuki Kanagami, Takashi Matsui, Kein Takeda, Jun Kaneko, Yasuyuki Shiraishi, Christian A Choe, Tomomi Uchikubo-Kamo, Mikako Shirouzu, Tsubasa Hashimoto, Tomohisa Ogawa, Tomoaki Matsuura, Po-Ssu Huang, Takeshi Yokoyama, Yoshikazu Tanaka (2022)  Chimeric mutants of staphylococcal hemolysin, which act as both one-component and two-component hemolysin, created by grafting the stem domain FEBS Journal. DOI:10.1111/febs.16354 PMID:35030303 
Toshiaki Hosaka, Takashi Nomura, Minoru Kubo, Takanori Nakane, Luo Fangjia, Shun-Ichi Sekine, Takuhiro Ito, Kazutaka Murayama, Kentaro Ihara, Haruhiko Ehara, Kazuhiro Kashiwagi, Kazushige Katsura, Ryogo Akasaka, Tamao Hisano, Tomoyuki Tanaka, Rie Tanaka, Toshi Arima, Ayumi Yamashita, Michihiro Sugahara, Hisashi Naitow, Yoshinori Matsuura, Susumu Yoshizawa, Kensuke Tono, Shigeki Owada, Osamu Nureki, Tomomi Kimura-Someya, So Iwata, Eriko Nango, Mikako Shirouzu (2022)  Conformational alterations in unidirectional ion transport of a light-driven chloride pump revealed using X-ray free electron lasers Proceedings of the National Academy of Sciences of the United States of America . 119 :9,  e2117433119- DOI:10.1073/pnas.2117433119 PMID:35197289 
Yasuhiro Fukuda, Marin Yokomine, Daisuke Kuroda, Kouhei Tsumoto, Jumpei Morimoto, Shinsuke Sando (2021)  Peptoid-based reprogrammable template for cell-permeable inhibitors of protein-protein interactions Chemical Science. 12 :40,  13292-13300 DOI:10.1039/d1sc01560e PMID:34777747 
Shintaro Mise, Akinobu Matsumoto, Keisuke Shimada, Toshiaki Hosaka, Masatomo Takahashi, Kazuya Ichihara, Hideyuki Shimizu, Chisa Shiraishi, Daisuke Saito, Mikita Suyama, Tomoharu Yasuda, Toru Ide, Yoshihiro Izumi, Takeshi Bamba, Tomomi Kimura-Someya, Mikako Shirouzu, Haruhiko Miyata, Masahito Ikawa, Keiichi I Nakayama (2022)  Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis Nature Communications. 13 :1,  1071- DOI:10.1038/s41467-022-28677-y PMID:35228556 
Motohiro Sekiya,Kenta Kainoh,Takehito Sugasawa,Ryunosuke Yoshino,Takatsugu Hirokawa,Hiroaki Tokiwa,Shogo Nakano,Satoru Nagatoishi,Kouhei Tsumoto,Yoshinori Takeuchi,Takafumi Miyamoto,Takashi Matsuzaka,Hitoshi Shimano (2021)  The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis Nature Communications. 12 :1,  6315- DOI:10.1038/s41467-021-26638-5 PMID:34728642 
Shun Kageyama, Sigurdur Runar Gudmundsson, Yu-Shin Sou, Yoshinobu Ichimura, Naoki Tamura, Saiko Kazuno, Takashi Ueno, Yoshiki Miura, Daisuke Noshiro, Manabu Abe, Tsunehiro Mizushima, Nobuaki Miura, Shujiro Okuda, Hozumi Motohashi, Jin-A Lee, Kenji Sakimura, Tomoyuki Ohe, Nobuo N. Noda, Satoshi Waguri, Eeva-Liisa Eskelinen, Masaaki Komatsu  (2021)  p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response Nat Commun. 12 :1,  16- DOI:10.1038/s41467-020-20185-1 PMID:33397898 
Dai Shimizu, Kenzui Taniue, Yusuke Matsui, Hiroshi Haeno, Hiromitsu Araki, Fumihito Miura, Mitsuko Fukunaga, Kenji Shiraishi, Yuji Miyamoto, Seiichi Tsukamoto, Aya Komine, Yuta Kobayashi, Akihiro Kitagawa, Yukihiro Yoshikawa, Kuniaki Sato, Tomoko Saito, Shuhei Ito, Takaaki Masuda, Atsushi Niida, Makoto Suzuki, Hideo Baba, Takashi Ito, Nobuyoshi Akimitsu, Yasuhiro Kodera, Koshi Mimori  (2021)  Pan-cancer methylome analysis for cancer diagnosis and classification of cancer cell of origin Cancer Gene Therapy. DOI:10.1038/s41417-021-00401-w PMID:34744163 
Keigo Hirai, Hiroko Yamashita, Shusuke Tomoshige, Yugo Mishima, Tatsuya Niwa, Kenji Ohgane, Mayumi Ishii, Kayoko Kanamitsu, Yui Ikemi, Shinsaku Nakagawa, Hideki Taguchi, Shinichi Sato, Yuichi Hashimoto, and Minoru Ishikawa (2022)  Conversion of a PROTAC Mutant Huntingtin Degrader into Small- Molecule Hydrophobic Tags Focusing on Drug-like Properties ACS Medicinal Chemistry Letters. 13 :3,  396-402 DOI:10.1021/acsmedchemlett.1c00500 PMID:35300080 
Miyuki Kumazawa, Manabu Tejima, Miwa Fukuda, Shota Takeda, Kenji Suzuki, Yukiko Mizumoto, Kakeru Sato, Minoru Waki, Hiroyuki Miyachi, Akira Asai, Osamu Takikawa, Tomoko Hashimoto, Osamu Ohno, Kenji Matsuno (2021)  Discovery of Carbono(di)thioates as Indoleamine 2,3-Dioxygenase 1 Inhibitors. ACS Med Chem Lett. . 12 :2,  211-216 DOI:10.1021/acsmedchemlett.0c00527 PMID:33603967 
Satoshi Yasuda, Tomoki Akiyama, Keiichi Kojima, Tetsuya Ueta, Tomohiko Hayashi, Satoshi Ogasawara, Satoru Nagatoishi, Kouhei Tsumoto, Naoki Kunishima, Yuki Sudo, Masahiro Kinoshita, Takeshi Murata (2022)  Development of an Outward Proton Pumping Rhodopsin with a New Record in Thermostability by Means of Amino Acid Mutations The Journal of Physical Chemistry B. 126 :5,  1004-1015 DOI:10.1021/acs.jpcb.1c08684 PMID:35089040 
Toma Kashima, Kouki Okumura, Akihiro Ishiwata, Machika Kaieda, Tohru Terada, Takatoshi Arakawa, Chihaya Yamada, Kentaro Shimizu, Katsunori Tanaka, Motomitsu Kitaoka, Yukishige Ito, Kiyotaka Fujita, Shinya Fushinobu (2021)  Identification of a difructose dianhydride I synthase/hydrolase from oral bacterium establishes a novel glycoside hydrolase family The Journal of biological chemistry. 297 :5,  101324- DOI:10.1016/j.jbc.2021.101324 PMID:34688653 
Ayako Furukawa, Masatoshi Wakamori, Yasuhiro Arimura, Hideaki Ohtomo, Yasuo Tsunaka, Hitoshi Kurumizaka, Takashi Umehara, Yoshifumi Nishimura (2022)  Characteristic H3 N-tail dynamics in the nucleosome core particle, nucleosome, and chromatosome iScience. 25 :3,  103937- DOI:10.1016/j.isci.2022.103937 PMID:35265811 
Evgeniia Borisova, Ken Nishimura, Yuri An, Miho Takami, Jingyue Li, Dan Song, Mami Matsuo-Takasaki, Dorian Luijkx, Shiho Aizawa, Akihiro Kuno, Eiji Sugihara, Taka-aki Sato, Fumiaki Yumoto, Tohru Terada, Koji Hisatake, Yohei Hayashi (2022)  Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency iScience. 25 103525- DOI:10.1016/j.isci.2021.103525 PMID:35106457 
Keisuke Hagihara, Kazuto Nunomura, Bangzhong Lin, Megumi Fumimoto, Junko Watanabe, Yasuharu Mizuhara (2022)  Gosha-jinki-Gan (GJG) shows anti-aging effects through suppression of TNF-α production by Chikusetsusaponin V Gene. 815 146178- DOI:10.1016/j.gene.2021.146178 PMID:34995733 
Masaya Matsuda, Yoshiyuki Tanaka, Hayato Shimora, Naoki Takemoto, Miku Nomura, Ryogo Terakawa, Kennosuke Hashimoto, Harumi Sakae, Akira Kanda, Hiroshi Iwai, Kazuyuki Kitatani, Takeshi Nabe (2021)  Pathogenic changes in group 2 innate lymphoid cells (ILC2s) in a steroid-insensitive asthma model of mice European Journal of Pharmacology. 916 174732- DOI:10.1016/j.ejphar.2021.174732 PMID:34971621 
Kazuya Sumi, Kenji Tago, Yosuke Nakazawa, Kyoko Takahashi, Tomoyuki Ohe Tadahiko Mashino, Megumi Funakoshi-Tago (2022)  A bis-pyridinium fullerene derivative induces apoptosis through the generation of ROS in BCR-ABL-positive leukemia cells Eur J Pharmacol. 916 174714- DOI:10.1016/j.ejphar.2021.174714 PMID:34953803 
Ichiro Takasaki, Ai Watanabe, Takuya Okada, Daisuke Kanayama, Ryota Nagashima, Miyu Shudo, Ayaka Shimodaira, Kazuto Nunomura, Bangzhong Lin, Yurie Watanabe, Hiroaki Gouda, Atsuro Miyata, Takashi Kurihara, Naoki Toyooka (2022)  Design and synthesis of pyrido[2,3-d]pyrimidine derivatives for a novel PAC1 receptor antagonist European Journal of Medicinal Chemistry. 231 114160- DOI:10.1016/j.ejmech.2022.114160 PMID:35124531 
Hayama Tsutsumi,Yoshitaka Moriwaki,Tohru Terada,Kentaro Shimizu,Kazuo Shin-Ya,Yohei Katsuyama,Yasuo Ohnishi (2021)  Structural and Molecular Basis of the Catalytic Mechanism of Geranyl Pyrophosphate C-6 Methyltransferase: Creation of an Unprecedented Farnesyl Pyrophosphate C-6 Methyltransferase Angewandte Chemie - International Edition. DOI:10.1002/anie.202111217 PMID:34626048 
Tomoko Yamaguchi, Fumiaki Makino, Tomoko Miyata, Tohru Minamino, Takayuki Kato, Keiichi Namba (2021)  Structure of the molecular bushing of the bacterial flagellar motor. Nature Communications. 12 :1,  4469- DOI:10.1038/s41467-021-24715-3 PMID:34294704 
Yoshiaki Kawano, Masahide Hikita, Naohiro Matsugaki, Masaki Yamamoto and Toshiya Senda (2021)  Crystal processing machine using a deep-ultraviolet laser-application to long-wavelength native SAD experiments Acta Crystallographica Sectioun F . DOI:submitted
Tomohiro Yamashita, Sawako Kamikaseda, Aya Tanaka, Hidetoshi Tozaki-Saitoh, Jose M. M. Caaveiro, Kazuhide Inoue, Makoto Tsuda (2021)  New Inhibitory Effects of Cilnidipine on Microglial P2X7 Receptors and IL-1β Release: An Involvement in its Alleviating Effect on Neuropathic Pain Cells. 10 434- DOI:10.3390/cells100204345
Takuo Minato,?Takamasa Teramoto,?Naruhiko Adachi,?Nguyen Khac Hung,?Kaho Yamada,?Masato Kawasaki,?Masato Akutsu,Toshio Moriya,?Toshiya Senda,?Seiji Ogo,?Yoshimitsu Kakuta, Ki-Seok Yoon? (2021)  Non-conventional octameric structure of C-phycocyanin Communications Biology. 4 :1,  1238- DOI:10.1038/s42003-021-02767-x PMID:34716405 
Takahiro Mori,?Takuto Kumano,?Haibing He,?Satomi Watanabe,?Miki Senda,?Toshio Moriya,?Naruhiko Adachi,?Sanae Hori,?Yuzu Terashita,?Masato Kawasaki,?Yoshiteru Hashimoto,?Takayoshi Awakawa,?Toshiya Senda,?Ikuro Abe,?Michihiko Kobayashi? (2021)  C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes Nature Communications. 12 :1,  6294- DOI:10.1038/s41467-021-26585-1 PMID:34728636 
Kazutoshi Tani,?Kenji V P Nagashima, Ryo Kanno,?Saki Kawamura,?Riku Kikuchi,?Malgorzata Hall,?Long-Jiang Yu,?Yukihiro Kimura,?Michael T Madigan,?Akira Mizoguchi,?Bruno M Humbel,?Zheng-Yu Wang-Otomo (2021)  A previously unrecognized membrane protein in the Rhodobacter sphaeroides LH1-RC photocomplex Nature Communications. 12 :1,  6300- DOI:10.1038/s41467-021-26561-9 PMID:34728609 
Yuya Monoe, Kentaro Jingushi, Akitaka Kawase, Takayuki Hirono, Ryo Hirose, Yoshino Nakatsuji, Kaori Kitae, Yuko Ueda, Hiroaki Hase, Yuichi Abe, Jun Adachi, Takeshi Tomonaga, Kazutake Tsujikawa (2021)  Pharmacological Inhibition of miR-130 Family Suppresses Bladder Tumor Growth by Targeting Various Oncogenic Pathways via PTPN1 International Journal of Molecular Sciences. 9 :22,  4751- DOI:10.3390/ijms22094751 PMID:33947152 
Yuichi Aki, Yuta Katsumata, Hirofumi Kakihara, Koichi Nonaka, Kenshu Fujiwara (2021)  4-(2,5-Dimethyl-1H-pyrrol-1-yl)-N-(2,5- dioxopyrrolidin-1-yl) benzamide improves monoclonal antibody production in a Chinese hamster ovary cell culture PLoS One. 4 :16,  e0250416- DOI:10.1371/journal.pone.0250416 PMID:33886677 
Takeshi Nara , Yukari Nakagawa , Keiko Tsuganezawa , Hitomi Yuki , Katsuhiko Sekimata , Hiroo Koyama , Naoko Ogawa , Teruki Honma , Mikako Shirouzu , Takehiro Fukami , Yuichi Matsuo , Daniel Ken Inaoka , Kiyoshi Kita , Akiko Tanaka  (2021)  The ubiquinone synthesis pathway is a promising drug target for Chagas disease. PLoS One. 2 :16,  e0243855- DOI:10.1371/journal.pone.0243855 PMID:33539347 
Yusuke Sasano, Aoto Yamaichi, Ryota Sasaki, Shota Nagasawa, Yoshiharu Iwabuchi (2021)  Expansion of Substrate Scope for Nitroxyl Radical/Copper-Catalyzed Aerobic Oxidation of Primary Alcohols: A Guideline for Catalyst Selection Chemical & pharmaceutical bulletin. :69,  488-497 DOI:10.1248/cpb.c21-00043 PMID:33952858 
Akihiro Honda, Shotaro Kamata, Chihiro Satta, Yui Machida, Kie Uchii, Kazuki Terasawa, Ayane Nemoto, Takuji Oyama, Isao Ishii (2021)  Structural Basis for Anti-non-alcoholic Fatty Liver Disease and Diabetic Dyslipidemia Drug Saroglitazar as a PPAR α/γ Dual Agonist Biological and Pharmaceutical Bulletin. 9 :44,  1210-1219 DOI:10.1248/bpb.b21-00232 PMID:34471049 
Yuki Takada, Ruken Yaman-Deveci, Takayuki Shirakawa, Jafar Sharif, Shin-Ichi Tomizawa, Fumihito Miura, Takashi Ito, Michio Ono, Kuniko Nakajima, Yoko Koseki, Fuyuko Shiotani, Kei-Ichiro Ishiguro, Kazuyuki Ohbo, Haruhiko Koseki (2021)  Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairing Development. 10 :148,  dev194605- DOI:10.1242/dev.194605 PMID:33998651 
Riku Kawanabe, Kohei Yoshihara, Izuho Hatada, Makoto Tsuda (2021)  Activation of spinal dorsal horn astrocytes by noxious stimuli involves descending noradrenergic signaling Molecular brain. 1 :14,  79- DOI:10.1186/s13041-021-00788-5 PMID:33971918 
Kaori Saito, Qi Zhang, Haeun Yang, Kotoko Yamatani, Tomohiko Ai, Vivian Ruvolo, Natalia Baran, Tianyu Cai, Helen Ma, Rodrigo Jacamo, Vinitha Kuruvilla, Junichi Imoto, Sonoko Kinjo, Kazuho Ikeo, Kaori Moriya, Koya Suzuki, Takashi Miida, Yong-Mi Kim, Christopher P Vellano, Michael Andreeff, Joseph R Marszalek, Yoko Tabe, Marina Konopleva (2021)  Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition Blood Advances. 20 :5,  4233-4255 DOI:10.1182/bloodadvances.2020003661 PMID:34507353 
Takuma Toyonaga, Takayuki Kato, Akihiro Kawamoto, Noriyuki Kodera, Tasuku Hamaguchi, Yuhei O Tahara, Toshio Ando, Keiichi Namba, Makoto Miyata (2021)  Chained structure of dimeric F1-like ATPase in Mycoplasma mobile gliding machinery. mBio. 4 :12,  e0141421- DOI:10.1128/MBIO.01414-21 PMID:34281395 
Atsushi Kawai, Yasuyuki Yamamoto, Takuto Nogimori, Kohei Takeshita, Takuya Yamamoto, Yasuo Yoshioka (2021)  The Potential of Neuraminidase as an Antigen for Nasal Vaccines To Increase Cross-Protection against Influenza Viruses Journal of Virology. 20 :95,  e01180-21- DOI:10.1128/JVI.01180-21 PMID:34379511 
Koya Sakuma, Naohiro Kobayashi, Toshihiko Sugiki, Toshio Nagashima, Toshimichi Fujiwara, Kano Suzuki, Naoya Kobayashi, Takeshi Murata, Takahiro Kosugi, Rie Koga, Nobuyasu Koga (2021)  Design of complicated all-ホア protein structures bioRxiv. DOI:10.1101/2021.07.14.449347
Junya Obata, Norifumi Kawakami, Akihisa Tsutsumi, Erika Nasu, Kenji Miyamoto, Masahide Kikkawa, Ryoichi Arai  (2021)  Icosahedral 60-meric porous structure of designed supramolecular protein nanoparticle TIP60 Chemical Communications. 79 :57,  10226-10229 DOI:10.1039/d1cc03114g PMID:34523636 
Akihiro Nakamura, Yoshiyuki Suzuki, Yasumitsu Sakamoto, Saori Roppongi, Chisato Kushibiki, Natsuri Yonezawa, Masato Takahashi, Yosuke Shida, Hiroaki Gouda, Takamasa Nonaka, Nobutada Tanaka, Wataru Ogasawara (2021)  Structural basis for an exceptionally strong preference for asparagine residue at the S2 subsite of Stenotrophomonas maltophilia dipeptidyl peptidase 7 Scientific Reports. 1 :11,  7929- DOI:10.1038/s41598-021-86965-x PMID:33846449 
Koki Makabe, Takeshi Yokoyama, Shiro Uehara, Tomomi Uchikubo窶銭amo, Mikako Shirouzu, Kouki Kimura, Kouhei Tsumoto, Ryutaro Asano, Yoshikazu Tanaka, Izumi Kumagai (2021)  Anti-EGFR antibody 528 binds to domain III of EGFR at a site shifted from the cetuximab epitope Scientific Reports. 1 :11,  5790- DOI:10.1038/s41598-021-84171-3 PMID:33707468 
Nagakumar Bharatham, Purnendu Bhowmik, Maho Aoki, Ui Okada, Sreevalli Sharma, Eiki Yamashita, Anirudh P. Shanbhag, Sreenath Rajagopal, Teby Thomas, Maitrayee Sarma, Riya Narjari, Savitha Nagaraj, Vasanthi Ramachandran, Nainesh Katagihallimath, Santanu Datta, Satoshi Murakami (2021)  Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae Nature Communications. 1 :12,  5400- DOI:10.1038/s41467-021-25679-0 PMID:34518546 
Ryo Tashiro,Takaaki Sato,Haruyuki Atomi,Kunio Miki,Masahiro Fujihashi (2021)  Altering the Phosphorylation Position of Pyrophosphate-Dependent myo-Inositol-1-Kinase Based on Its Crystal Structure ACS Chemical Biology. 5 :16,  794-799 DOI:10.1021/acschembio.0c00733 PMID:33877806 
Naruhiko Adachi, Takahide Yamaguchi, Toshio Moriya, Masato Kawasaki, Kotaro Koiwai, Akira Shinoda, Yusuke Yamada, Fumiaki Yumoto, Takamitsu Kohzuma, Toshiya Senda (2021)  2.85 and 2.99A resolution structures of 110 kDa nitrite reductase determined by 200 kV cryogenic electron microscopy Journal of structural biology. 3 :213,  107768- DOI:10.1016/j.jsb.2021.107768 PMID:34217801 
Chieko Inoue, Ryosuke Negoro, Kazuo Takayama, Hiroyuki Mizuguchi, Fuminori Sakurai (2022)  Asymmetric profiles of infection and innate immunological responses in human iPS cellderived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus Virus Research. 296 198334- DOI:10.1016/j.virusres.2021.198334 PMID:33581186 
Andriy Kryshtafovych,John Moult,Wendy M Billings,Dennis Della Corte,Krzysztof Fidelis,Sohee Kwon,Kliment Olechnovic,Chaok Seok,Ceslovas Venclovas,Jonghun Won (2021)  Modeling SARS-CoV2 proteins in the CASP-commons experiment Proteins. DOI:10.1002/prot.26231 PMID:34462960 
Rie Uesugi, Shunsuke Ishii, Akira Matsuura, Eisuke Itakura (0000)  Labeling and Measuring Stressed Mitochondria Using a PINK1-Based Ratiometric Fluorescent Sensor Journal of Biological Chemistry. :2021,  DOI:10.1016/j.jbc.2021.101279 PMID:34624312  
Toshihiro Kobayashi,Aracely Castillo-Venzor,Chris A Penfold,Michael Morgan,Naoaki Mizuno,Walfred W C Tang,Yasuyuki Osada,Masao Hirao,Fumika Yoshida,Hideyuki Sato,Hiromitsu Nakauchi,Masumi Hirabayashi,M Azim Surani (2021)  Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cell Cell Reports. 37 :2,  109812- DOI:10.1016/j.celrep.2021.109812 PMID:34644585  
Yoshiaki Kawano, Masahide Hikita, Naohiro Matsugaki, Masaki Yamamoto and Toshiya Senda (2021)  Crystal processing machine using a deep-ultraviolet laser:application to long-wavelength native SAD experiments Acta Crystallographica Sectioun F .
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Masahito Ohue, Yutaka Akiyama (2021)  MEGADOCK-GUI: a GUI-based complete cross-docking tool for exploring protein-protein interactions In Proceedings of The 27th International Conference on Parallel & Distributed Processing Techniques and Applications (PDPTA’21). DOI:https://arxiv.org/pdf/2105.03617.pdf
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Yamato Sajiki, Satoru Konnai, Zimeng Cai, Kensuke Takada, Tomohiro Okagawa, Naoya Maekawa, Sotaro Fujisawa, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi (2021)  Enhanced Immunotherapeutic Efficacy of Anti-PD-L1 Antibody in Combination with an EP4 Antagonist. Immunohorizons. 4 :12,  837-850 DOI:10.4049/immunohorizons.2000089 PMID:33443026 
Kenta Hayami, Yuichi Kuboki, Katsumi Ohta, Bangzhong Lin, Megumi Fumimoto, Kazuto Nunomura, Jun-Ichi Haruta , Kenichi Murai, Hiromichi Fujioka, Akira Asai, and Mitsuhiro Arisawa (2021)  Design, Synthesis, Physical Properties and Indoleamine 2, 3-Dioxygenase 1 Inhibitory Activity of Substitued Indole Derivatives with N-H, N-Metohymethyl, or N-Mehylthiomethyl Group toward Fragment-Based Drug Discovery Heterocycles. 103 511-525 DOI:10.3987/COM-20-S(K)35
Masatoshi Kanayama, Rintaro Oyama, Masataka Mori, Akihiro Taira, Shinji Shinohara, Taiji Kuwata, Masaru Takenaka, Kazue Yoneda, Koji Kuroda, Takashi Ohnaga, Yukinari Kato, Fumihiro Tanaka (2021)  Novel circulating tumor cell-detection chip combining conventional podoplanin and EGFR antibodies for all histological malignant pleural mesothelioma. Oncology Letters. 22 :1,  522- DOI:10.3892/ol.2021.12783 PMID:34025789 
Manabu Igarashi , Takatsugu Hirokawa , Yoshihiro Takadate , Ayato Takada (2021)  Structural Insights into the Interaction of Filovirus Glycoproteins with the Endosomal Receptor Niemann-Pick C1: A Computational Study Viruses. 13 913- DOI:10.3390/v13050913 PMID:34069246 
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Toshihiko Matsuo , Shihui Liu, Tetsuya Uchida, Satomi Onoue, Shinsaku Nakagawa, Mayumi Ishii and Kayoko Kanamitsu  (2021)  Photoelectric Dye, NK-5962, as a Potential Drug for Preventing Retinal Neurons from Apoptosis: Pharmacokinetic Studies Based on Review of the Evidence Life . 11 :6,  591- DOI:10.3390/life11060591 PMID:34205684 
Takatsugu Kosugi, Masahito Ohue (2021)  Quantitative estimate index for early-stage screening of compounds targeting protein-protein interactions. International Journal of Molecular Sciences. 22 10925- DOI:10.3390/ijms222010925 PMID:34681589 
Effi Haque , Magdalena Smiech , Kamila Luczynska , Marie France Bouchard , Robert Viger , Hidetoshi Kono , Mariusz Pierzchala , Hiroaki Taniguchi (2021)  NRF2 DLG domain mutations identified in Japanese liver can-cer patients affect the transcriptional activity in HCC cell lines International Journal of Molecular Sciences. 22 5296- DOI:10.3390/ijms22105296 PMID:34069882 
Kento Fujiwara, Masaki Kitaura, Ayaka Tsunei, Hotaka Kusabuka, Erika Ogaki, Naoki Okada (2021)  Structure of the Signal Transduction Domain in Second-Generation CAR Regulates the Input Efficiency of CAR Signals. International Journal of Molecular Sciences. 22 :5,  2476- DOI:10.3390/ijms22052476 PMID:33804441 
Yasuka Matsunaga , Shun Hasei , Takeshi Yamamotoya , Hiroaki Honda , Akifumi Kushiyama , Hideyuki Sakoda , Midori Fujishiro , Hiraku Ono , Hisanaka Ito , Takayoshi Okabe , Tomoichiro Asano , Yusuke Nakatsu (2021)  Pathological Role of Pin1 in the Development of DSS-Induced Colitis. Cells. 10 1230- DOI:10.3390/cells10051230 PMID:34067858 
Koji Kitamura, Keisuke Nimura (2021)  Regulation of RNA splicing: Aberrant splicing regulation and therapeutic targets in cancer Cells. 10 923- DOI:10.3390/cells10040923 PMID:33923658 
Natsuki Osaka, Yoshihisa Hirota, Doshun Ito, Yoshiki Ikeda, Ryo Kamata, Yuki Fujii, Venkat R Chirasani, Sharon L Campbell, Koh Takeuchi, Toshiya Senda, Atsuo T Sasaki (2021)  Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification Frontiers molecular biosciences. 8 707439- DOI:10.3389/fmolb.2021.707439 PMID:34307463 
Shunya Sugita, Masahito Ohue  (2021)  Drug-target affinity prediction using applicability domain based on data density In Proceedings of The 18th IEEE International Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB 2021). DOI:10.26434/chemrxiv.14498688.v1
Takatsugu Kosugi, Masahito Ohue (2021)  Quantitative estimate of protein-protein interaction targeting drug-likeness Analytical Chemistry. DOI:10.26434/chemrxiv.14489769.v1
Taishi Onodera, Shunsuke Kita, Yu Adachi, Saya Moriayma, Akihiko Sato, Takao Nomura, Takeshi Inoue, Takashi Tadokoro, Yuki Anraku, Kohei Yumoto, Cong Tian, Hideo Fukuhara, Michihito Sasaki, Yasuko Orba, Nozomi Shiwa, Naoko Iwata, Noriyo Nagata, Tateki Suzuki, Jiei Sasaki, Tsuyoshi Sekizuka, Keisuke Tonouchi, Shuetsu Fukushi, Hiroyuki Satofuka, Yasuhiro Kazuki, Lin Sun, Mitsuo Oshimura, Tomohiro Kurosaki, Makoto Kuroda, Tadaki Suzuki, Hirofumi Sawa, Takao Hashiguchi, Katsumi Maenaka, Yoshimasa Takahashi,  (2021)  Broad Neutralization Activity of SARS-CoV-2 Antibody is Achieved by Coordinated Recognition of Virus Vulnerable Site Cell press. DOI:10.2139/ssrn.3817803
Haon Futamata, Masahiro Fukuda, Rie Umeda, Keitaro Yamashita, Satoe Takahashi, Takafumi Shikakura, Shigehiko Hayashi, Kazuaki Homma, Tomohiro Nishizawa, Osamu Nureki (2021)  Cryo-EM structures reveal the electromotility mechanism of prestin, the cochlear amplifier nature portfolio. DOI:10.21203/rs.3.rs-927386/v1
Makiko Kosugi, Masato Kawasaki, Yutaka Shibata, Kojiro Hara, Shinichi Takaichi, Toshio Moriya, Naruhiko Adachi, Yasuhiro Kamei, Yasuhiro Kashino, Sakae Kudoh, Hiroyuki Koike, Toshiya Senda (2021)  Uphill energy transfer mechanism for photosynthesis in the Antarctic alga resezarch square. DOI:10.21203/rs.3.rs-701485/v1
Satoshi Abe,Kazuhisa Honma, Akane Okada,Kanako Kazuki,Hiroshi Tanaka, Takeshi Endo, Kayoko Morimoto, Takashi Moriwaki, Shusei Hamamichi,Yuji Nakayama,Teruhiko Suzuki, Shoko Takehara, Mitsuo Oshimura, Yasuhiro Kazuki (2021)  Construction of Stable Mouse Artificial Chromosome from Native Mouse Chromosome 10 for Generation of Transchromosomic Mice Research square. 11 :1,  20050- DOI:10.21203/rs.3.rs-675300/v1
Ryoya Nakagawa, Soh Ishiguro, Sae Okazaki, Hideto Mori, Mamoru Tanaka, Hiroyuki Aburatani, Nozomu Yachie, Hiroshi Nishimasu, Osamu Nureki (2021)  Engineered Campylobacter jejuni Cas9 variant with enhanced activity nature portfolio. DOI:10.21203/rs.3.rs-512474/v1
Yuxia Zhang, Satoshi Watanabe, Akihisa Tsutsumi, Hiroshi Kadokura, Masahide Kikkawa, Kenji Inaba  (2021)  Cryo-EM analysis provides new mechanistic insight into ATP binding to Ca 2+ -ATPase SERCA2b The EMBO Journal. 40 :19,  e108482- DOI:10.15252/embj.2021108482 PMID:34459010 
Fei Jin, Minxuan Sun, Takashi Fujii, Yurika Yamada, Jin Wang, Andres D Maturana, Miki Wada, Shichen Su, Jinbiao Ma, Hironori Takeda, Tsukasa Kusakizako, Atsuhiro Tomita, Yoshiko Nakada-Nakura, Kehong Liu, Tomoko Uemura, Yayoi Nomura, Norimichi Nomura, Koichi Ito, Osamu Nureki, Keiichi Namba, So Iwata, Ye Yu, Motoyuki Hattori (2021)  The structure of MgtE in the absence of magnesium provides new insights into channel gating PLOS Biology. 19 :4,  e3001231- DOI:10.1371/journal.pbio.3001231 PMID:33905418 
Tomonori Kameda, Hideyuki Nakashima, Takumi Takizawa, Fumihito Miura, Takashi Ito, Kinichi Nakashima, Takuya Imamura (2021)  Neuronal activation modulates enhancer activity of genes for excitatory synaptogenesis through de novo DNA methylation Journal of Reproduction and Development. 67 :6,  369-379 DOI:10.1262/jrd.2021-106 PMID:34615840 
Aoze Su, Yuko Tabata, Kiyono Aoki, Akane Sada, Rieko Ohki, Satoru Nagatoishi, Kouhei Tsumoto, Siyuan Wang, Yuko Otani, Tomohiko Ohwada (2021)  Elaboration of non-naturally occurring helical tripeptides as p53-MDM2/MDMX interaction inhibitors Chemical & pharmaceutical bulletin. 69 681-692 DOI:10.1248/cpb.c21-00238 PMID:33952867 
Yukiko Karuo, Riona Shiraki, Ayaka Yoshida, Ryo Tsunokawa, Mayuko Nakahara-Yamada, Atsushi Tarui, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote, Hitoshi Nishimura (2021)  Identification and Synthesis of DDI-6, a Quinolinol Analog Capable of Activating Both Caenorhabditis elegans and Mouse Spermatozoa Chemical and Pharmaceutical Bulletin. 69 557-563 DOI:10.1248/cpb.c21-00127 PMID:34078802 
Kotaro Kasai,Yuma Horii,Takanori Hironaka,Kyosuke Mae,Tomoyuki Ueno,Akiomi Nagasaka,Michio Nakaya (2021)  Increased Expression of Heparan Sulfate 6-O-Sulfotransferase-2 Promotes Collagen Production in Cardiac Myofibroblasts BPB Reports. 4 85-91 DOI:10.1248/bpbreports.4.3_85
Shigehiro Ohdo (2021)  Chrono-Drug Discovery and Development Based on Circadian Rhythm of Molecular, Cellular and Organ Level Biological & pharmaceutical bulletin. 44 747-761 DOI:10.1248/bpb.b21-00277 PMID:34078807 
Daichi Egawa,Taku Ogiso,Kimina Nishikata,Keiko YamamotoToshimasa Itoh (2021)  Structural Insights into the Loss-of-Function R288H Mutant of Human PPARγ Biological and Pharmaceutical Bulletin. 44 :9,  1196-1201 DOI:10.1248/bpb.b21-00253 PMID:34471047 
Phuong Thuy Viet Nguyen, Truong Van Dat, Shusaku Mizukami, Duy Le Hoang Nguyen, Farhana Mosaddeque, Son Ngoc Kim, Duy Hoang Bao Nguyen, Oanh Thi Dinh, Tu Linh Vo, Giang Le Tra Nguyen, Cuong Quoc Duong, Satoshi Mizuta, Dao Ngoc Hien Tam, M. Phuong Truong, Nguyen Tien Huy and Kenji Hirayama (2021)  2D-quantitative structure-activity relationships model using PLS method for anti-malarial activities of anti-haemozoin compounds Malar J. 20 264- DOI:10.1186/s12936-021-03775-2 PMID:34116665 
Yoshihisa Hirakawa, Miki Senda, Kodai Fukuda, Hong Yang Yu, Masaki Ishida, Masafumi Taira, Kazushi Kinbara, Toshiya Senda (2021)  Characterization of a novel type of carbonic anhydrase that acts without metal cofactors BMC Biology. 19 :1,  105- DOI:10.1186/s12915-021-01039-8 PMID:34006275 
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Stephanie L Neville, Jennie Sjohamn, Jacinta A Watts, Hugo MacDermott-Opeskin, Stephen J Fairweather, Katherine Ganio, Alex Carey Hulyer, Aaron P McGrath, Andrew J Hayes, Tess R Malcolm, Mark R Davies, Norimichi Nomura, So Iwata, Megan L OMara, Megan J Maher, Christopher A McDevitt (2021)  The structural basis of bacterial manganese import Science Advances. 7 :32,  eabg3980- DOI:10.1126/sciadv.abg3980 PMID:34362732 
Mutsuko Kukimoto-Niino, Kazushige Katsura, Rahul Kaushik, Haruhiko Ehara, Takeshi Yokoyama, Tomomi Uchikubo-Kamo, Reiko Nakagawa, Chiemi Mishima-Tsumagari, Mayumi Yonemochi, Mariko Ikeda, Kazuharu Hanada, Kam Y J Zhang, Mikako Shirouzu (2021)  Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex Science Advances. 7 :30,  eabg3147- DOI:10.1126/sciadv.abg3147 PMID:34290093 
Laura Bracun, Atsushi Yamagata, Bern M Christianson, Tohru Terada, Daniel P Canniffe, Mikako Shirouzu, Lu-Ning Liu (2021)  Cryo-EM structure of the photosynthetic RC-LH1-PufX supercomplex at 2.8-A resolution Science Advances. 7 :25,  eabf8864- DOI:10.1126/sciadv.abf8864 PMID:34134992 
Kiyoshi Yoshioka, Hiroshi Nagahisa, Fumihito Miura, Hiromitsu Araki, Yasutomi Kamei, Yasuo Kitajima, Daiki Seko, Jumpei Nogami, Yoshifumi Tsuchiya, Narihiro Okazaki, Akihiko Yonekura, Seigo Ohba, Yoshinori Sumita, Ko Chiba, Kosei Ito, Izumi Asahina, Yoshihiro Ogawa, Takashi Ito, Yasuyuki Ohkawa, Yusuke Ono (2021)  Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle Science Advances. 7 :24,  eabd7924- DOI:10.1126/sciadv.abd7924 PMID:34108202 
Aya Shiba-Ishii (2021)  Significance of stratifin in early progression of lung adenocarcinoma and its potential therapeutic relevance International Journal of Surgical Pathology. 71 655-665 DOI:10.1111/pin.13147 PMID:34324245 
Rieko Imae, Naoyuki Kuwabara, Hiroshi Manya, Tomohiro Tanaka, Masato Tsuyuguchi, Mamoru Mizuno, Tamao Endo, Ryuichi Kato (2021)  The structure of POMGNT2 provides new insights into the mechanism to determine the functional O-mannosylation site on α-dystroglycan. Genes to Cells . 26 :7,  485-494 DOI:10.1111/gtc.12853 PMID:33893702 
Evdokia-Anastasia Giannopoulou, Miki Senda, Maharani Pertiwi Koentjoro, Naruhiko Adachi, Naoto Ogawa, Toshiya Senda (2021)  Crystal structure of the full-length LysR-type transcription regulator CbnR in complex with promoter DNA The FEBS Journal. 288 :15,  4560-4575 DOI:10.1111/febs.15764 PMID:33576566 
Isabel Sebastian,Nobuhiko Okura,Bruno M Humbel,Jun Xu,Idam Hermawan,Chiaki Matsuura,Malgorzata Hall,Chitoshi Takayama,Tetsu Yamashiro,Shuichi Nakamura,Claudia Toma  (2021)  Disassembly of the apical junctional complex during the transmigration of Leptospira interrogans across polarized renal proximal tubule epithelial cells cellular microbiology. 23 :9,  e13343.- DOI:10.1111/cmi.13343 PMID:33864347 
Mina Noura , Ken Morita , Hiroki Kiyose , Yukiko Okuno , Hidemasa Matsuo, Asami Koyama , Yoko Nishinaka-Arai , Yasuhiko Kamikubo , Souichi Adachi  (2021)  Albendazole induces the terminal differentiation of acute myeloid leukaemia cells to monocytes by stimulating the Kruppel-like factor 4-dihydropyrimidinase-like 2A (KLF4-DPYSL2A) axis British Journal of Haematology. 194 598-603 DOI:10.1111/bjh.17557 PMID:34227104 
Risako Tamura-Sakaguchi, Rie Aruga, Mika Hirose, Toru Ekimoto, Takuya Miyake, Yohei Hizukuri, Rika Oi, Mika K Kaneko, Yukinari Kato, Yoshinori Akiyama, Mitsunori Ikeguchi, Kenji Iwasaki, Terukazu Nogi (2021)  Moving toward generalizable NZ-1 labeling for 3D structure determination with optimized epitope-tag insertion Acta Crystallographica Section D. 77 645-662 DOI:10.1107/S2059798321002527 PMID:33960020 
Takeshi Murakawa, Mamoru Suzuki, Toshi Arima, Michihiro Sugahara, Tomoyuki Tanaka, Rie Tanaka, So Iwata, Eriko Nango, Kensuke Tono, Hideyuki Hayashi, Kenji Fukui, Takato Yano, Katsuyuki Tanizawa, Toshihide Okajima (2021)  Microcrystal preparation for serial femtosecond X-ray crystallography of bacterial copper amine oxidase Acta Crystallographica Section F, Structural bilogy of commuinications. 77 356-363 DOI:10.1107/S2053230X21008967 PMID:34605440 
Keijun Kakihara, Kengo Asamizu, Kei Moritsugu, Masahide Kubo, Tetsuya Kitaguchi, Akinori Endo, Akinori Kidera, Mitsunori Ikeguchi, Akira Kato, Masayuki Komada, Toshiaki Fukushima (2021)  The molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain bioRxiv. DOI:10.1101/2021.05.31.446389
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Shohei Nosaki, Mika K Kaneko, Fuminori Tsuruta, Hideki Yoshida, Yukinari Kato, Kenji Miura (2021)  Prevention of necrosis caused by transient expression in Nicotiana benthamiana by application of ascorbic acid Plant Physiol. 186 :2,  832-835 DOI:10.1093/plphys/kiab102 PMID:33638348 
Masahiko Okuda, Tetsufumi Suwa, Hidefumi Suzuki, Yuki Yamaguchi, Yoshifumi Nishimura (2021)  Three human RNA polymerases interact with TFIIH via a common RPB6 subunit Nucleic Acids Research. 50 :1,  1-16 DOI:10.1093/nar/gkab612 PMID:34268577 
Satoru Ishihara, Yohei Sasagawa, Takeru Kameda, Hayato Yamashita, Mana Umeda, Naoe Kotomura, Masayuki Abe, Yohei Shimono, Itoshi Nikaido (2021)  Local states of chromatin compaction at transcription start sites control transcription levels Nucleic Acids Research. 49 :14,  8007-8023 DOI:10.1093/nar/gkab587 PMID:34233004 
Keisuke Oki, Takeshi Yamagami, Mariko Nagata, Kouta Mayanagi, Tsuyoshi Shirai, Naruhiko Adachi, Tomoyuki Numata, Sonoko Ishino,Yoshizumi Ishino (2021)  DNA polymerase D temporarily connects primase to the CMG-like helicase before interacting with proliferating cell nuclear antigen Nucleic Acids Research. 49 4599-4612 DOI:10.1093/nar/gkab243 PMID:33849056 
Yoshihiro Kobashigawa, Toshiya Ohara, Kosuke Morita, Yuya Toyota, Teruya Nakamura, Shunsuke Kotani, Takao Arimori, Soichiro Yamauchi, Chenjiang Liu, Masaya Kitazaki, Yukari Wakeyama-Miyazaki, Yoshiaki Suwa, Makiyo Uchida-Kamekura, Natsuki Fukuda, Takashi Sato, Makoto Nakajima, Junichi Takagi, Yuriko Yamagata, Hiroshi Morioka (2021)  Molecular recognition of a single-chain Fv antibody specific for GA-pyridine, an advanced glycation end-product (AGE), elucidated using biophysical techniques and synthetic antigen analogues The Journal of Biochemistry. 170 :3,  379-387 DOI:10.1093/jb/mvab056 PMID:34185078 
Jianan Li , Keisuke Yanagisawa , Yasushi Yoshikawa, Masahito Ohue and Yutaka Akiyama (2021)  Plasma protein binding prediction focusing on residue-level features and circularity of cyclic peptides by deep learning Bioinformatics. DOI:10.1093/bioinformatics/btab726 PMID:34849593 
Tomonari Muramatsu and Masaru Tanokura (2021)  A novel method of literature mining to identify candidate COVID-19 drugs Bioinformatics Advances. 1 vbab013- DOI:10.1093/bioadv/vbab013
Hana Inoue, Takashi Murayama, Takuya Kobayashi, Masato Konishi, Utako Yokoyama (2021)  The zinc-binding motif of TRPM7 acts as an oxidative stress sensor to regulate its channel activity Journal of General Physiology. 153 :6,  e202012708- DOI:10.1085/jgp.202012708 PMID:33999118 
Taito Kashio, Keisuke Shirakura, Mayumi Kinoshita, Maaya Morita, Ryosuke Ishiba, Kosuke Muraoka, Tomoaki Kanbara, Masato Tanaka, Risa Funatsu, Nobumasa Hino, Shohei Koyama, Ryo Suzuki, Yasuo Yoshioka, Taiki Aoshi, Takefumi Doi, Yoshiaki Okada (2021)  HDAC inhibitor, MS-275, increases vascular permeability by suppressing Robo4 expression in endothelial cells Tissue Barriers. 9 :3,  1911195- DOI:10.1080/21688370.2021.1911195 PMID:33955828 
Takuto Kumano, Sanae Hori, Satomi Watanabe, Yuzu Terashita, Hong Yang Yu, Yoshiteru Hashimoto, Toshiya Senda, Miki Senda, Michihiko Kobayashi (2021)  FAD-dependent C-glycoside-metabolizing Enzymes in Microorganisms: Screening, Characterization and Crystal Structure Analysis Proceedings of the National Academy of Sciences of the United States of America. 118 :40,  e2106580118- DOI:10.1073/pnas.2106580118 PMID:34583991 
Junki Hirano , Sachiyo Yoshio , Yusuke Sakai , Li Songling , Tatsuya Suzuki , Yumi Itoh , He Zhang , David Virya Chen , Saori Haga , Hiroko Oomori , Takahiro Kodama , Yusuke Maeda , Yoshihiro Ono , Yu Takahashi, Daron M Standley , Masahiro Yamamoto , Kohji Moriishi , Kyoji Moriya , Tatsuya Kanto , Tetsuo Takehara , Kazuhiko Koike , Yoshiharu Matsuura , Toru Okamoto (2021)  Hepatitis C virus modulates signal peptide peptidase to alter host protein processing Proc Natl Acad Sci U S A . 118 :22,  e2026184118- DOI:10.1073/pnas.2026184118 PMID:34035171 
Takayuki Nagae, Masashi Unno, Taiki Koizumi, Yohei Miyanoiri, Tomotsumi Fujisawa, Kento Masui, Takanari Kamo, Kei Wada, Toshihiko Eki, Yutaka Ito, Yuu Hirose, Masaki Mishima (2021)  Structural basis of the protochromic green/red photocycle of the chromatic acclimation sensor RcaE Proceedings of the National Academy of Sciences of the United States of America. 118 :20,  e2024583118- DOI:10.1073/pnas.2024583118 PMID:33972439 
Naoki Kamo,Tomoya Kujirai,Hitoshi Kurumizaka,Hiroshi Murakami,Gosuke Hayashi and Akimitsu Okamoto  (2021)  Organoruthenium-catalyzed chemical protein synthesis to elucidate the functions of epigenetic modifications on heterochromatin factors. Chemical Science. 12 :16,  5926-5937 DOI:10.1039/D1SC00731A
Yue Ma , Yuki Wakabayashi , Naruyuki Watatani , Ryota Saito , Takatsugu Hirokawa , Masayuki Tera , Kazuo Nagasawa  (2021)  Vinylnaphthalene-bearing hexaoxazole as a fluorescence turn-on type G-quadruplex ligand Organic and Biomolecular Chemistry. 19 8035-8040 DOI:10.1039/d1ob01500a PMID:34492672 
Hikari Tanaka,Kanoh Kondo,Kyota Fujita,Hidenori Homma,Kazuhiko Tagawa,Xiaocen Jin,Meihua Jin,Yuki Yoshioka,Sumire Takayama,Hitomi Masuda,Rie Tokuyama,Yukoh Nakazaki,Takashi Saito,Takaomi Saido,Shigeo Murayama,Teikichi Ikura,Nobutoshi Ito,Yu Yamamori,Kentaro Tomii,Marco E Bianchi,Hitoshi Okazawa (2021)  HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology 4 1175- DOI:10.1038/s42003-021-02671-4 PMID:34635772 
Kazutaka Katoh , Daron M Standley (2021)  Emerging SARS-CoV-2 variants follow a historical pattern recorded in outgroups infecting non-human hosts. Communications Biology. 4 :1,  1134- DOI:10.1038/s42003-021-02663-4 PMID:34552191 
Mirai Tanigawa, Katsuyoshi Yamamoto, Satoru Nagatoishi, Koji Nagata, Daisuke Noshiro, Nobuo N Noda, Kouhei Tsumoto, Tatsuya Maeda (2021)  A glutamine sensor that directly activates TORC1 Nature Commun. 4 1093- DOI:10.1038/s42003-021-02625-w PMID:34535752 
Akinobu Senoo, Sho Ito, Satoru Nagatoishi, Yutaro Saito, Go Ueno, Daisuke Kuroda, Kouhei Yoshida, Takumi Tashima, Shota Kudo, Shinsuke Sando & Kouhei Tsumoto (2021)  Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion Communications Biology. 4 :1,  1041- DOI:10.1038/s42003-021-02575-3 PMID:34493804 
Yuya Taguchi, Takahiro Yamasaki, Marie Ishikawa, Yuki Kawasaki, Ryuji Yukimura, Maki Mitani, Kunio Hirata, Daisuke Kohda (2021)  The structure of an archaeal oligosaccharyltransferase provides insight into the strict exclusion of proline from the N-glycosylation sequon Communications Biology. 4 :1,  941- DOI:10.1038/s42003-021-02473-8 PMID:34354228 
Seiya Oura, Taichi Noda, Naoko Morimura, Seiji Hitoshi, Hiroshi Nishimasu, Yoshitaka Nagai, Osamu Nureki, Masahito Ikawa (2021)  Precise CAG repeat contraction in a Huntington's Disease mouse model is enabled by gene editing with SpCas9-NG Comminications biology. 4 :1,  771- DOI:10.1038/s42003-021-02304-w PMID:34163001 
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