成果

創薬等先端技術支援基盤プラットフォーム(BINDS)の実施者による研究支援と研究高度化の成果として輩出されたデータベース、 ツール、論文および特許を紹介します。

開発されたデータベースやツール

ケミカルシーズ・リード 探索ユニット

インシリコユニット

プラットフォーム機能最適化ユニット

BINDS支援技術に関する研究成果(論文)

Miki Yamazaki, Masahito Hosokawa , Koji Arikawa, Kiyofumi Takahashi, Chikako Sakanashi, Takuya Yoda, Hiroko Matsunaga, Haruko Takeyama (2020)  Efective microtissue RNA extraction coupled with Smart-seq2 for reproducible and robust spatial transcriptome analysis Scientific Reports. 10 :1,  7083- DOI:10.1038/s41598-020-63495-6 PMID:32341421 
Yamaguchi T, Sumida TS, Nomura S, Satoh M, Higo T, Ito M, Ko T, Fujita K, Sweet ME, Sanbe A, Yoshimi K, Manabe I, Sasaoka T, Taylor MRG, Toko H, Takimoto E, Naito AT, Komuro I. (2020)  Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure. Nat Commun.. 11 :1,  4364-オンライン DOI:10.1038/s41467-020-18128-x PMID:32868781 
Izumi-Nakaseko H, Chiba K, Hagiwara-Nagasawa M, Satsuka A, Goto A, Nunoi Y, Kambayashi R, Matsumoto A, Takei Y, Kanda Y, Naito AT, Sugiyama A. (2020)  Optimizing the Direction and Order of the Motion Unveiled the Ability of Conventional Monolayers of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Show Frequency-Dependent Enhancement of Contraction and Relaxation Motion. Front Cell Dev Biol.. 8 542562-オンライン DOI:10.3389/fcell.2020.542562 PMID:33015053 
Yuta Kohro, Tsuyoshi Matsuda, Kohei Yoshihara, Keita Kohno, Keisuke Kog, Ryuichi Katsuragi, Takaaki Oka, Ryoichi Tashima, Sho Muneta, Takuya Yamane, Shota Okada, Kazuya Momokino, Aogu Furusho, Kenji Hamase, Takumi Oti, Hirotaka Sakamoto, Kenichiro Hayashida, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada, Hidetoshi Tozaki-Saitoh, Katsuhiko Mikoshiba, Verdon Taylor, Kazuhide Inoue, Makoto Tsuda (2020)  Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity Nature Neuroscience. 23 :11,  1376-1387 DOI:10.1038/s41593-020-00713-4 PMID:33020652 
Ryoichi Tashima, Keisuke Koga, Yu Yoshikawa, Misuzu Sekine, Moeka Watanabe, Hidetoshi Tozaki-Saitoh, Hidemasa Furue, Toshiharu Yasaka, Makoto Tsuda (2021)  A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior Proc Natl Acad Sci U S A. 118 :3,  e2021220118- DOI:10.1073/pnas.2021220118 PMID:33431693 
Haruki Nakamura, Masahide Kikkawa, Takeshi Murata (2021)  Technical development and sharing of high-resolution cryo-electron microscopes Biophysics and Physicobiology . 18 265-266 DOI:10.2142/biophysico.bppb-v18.030 PMID:34909362 
Sayaka Ishii, Katsuya Saito, Shigefumi Kuwahara, Masaru Enomoto  (2020)  Synthesis of (S)-ktedonoketone Tetrahedron Letters. 61 :22,  No.151915- DOI:10.1016/j.tetlet.2020.151915
Hitomi Koga, Mai Negishi, Marie Kinoshita,?Shinya Fujii,?Shuichi Mori,?Mari Ishigami-Yuasa,?Emiko Kawachi, Hiroyuki Kagechika, Aya Tanatani (2020)  Development of Androgen-Antagonistic Coumarinamides with a Unique Aromatic Folded Pharmacophore International Journal of Molecular Sciences. 21 :15,  5584- DOI:10.3390/ijms21155584 PMID:32759847 
Mari Ishigami-Yuasa, Hiroyuki Kagechika (2020)  Chemical Screening of Nuclear Receptor Modulators International Journal of Molecular Sciences. 21 :15,  5512- DOI:10.3390/ijms21155512 PMID:32752136 
Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Masayuki Fujino, Masaki Kurakami, Sayaka Boku, Miyuki Nakayama, Moemi Kaneko, Nami Ohashi, Osamu Kotani, Tsutomu Murakami, Hironori Sato, Hirokazu Tamamura (2021)  Small-Molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins Biomolecules. 11 :2,  208- DOI:10.3390/biom11020208 PMID:33546092 
Koki Makabe, Ruka Hirota, Yoshihito Shiono, Yoshikazu Tanaka, Takuya Koseki (2021)  Aspergillus oryzae Rutinosidase: Biochemical and Structural Investigation. Applied and environmental microbiology. 87 :3,  e02438-20- DOI:10.1128/AEM.02438-20 PMID:33218993 
Minghao Chen, Masato Ishizaka, Shun Narai, Masaki Horitani, Naoki Shigi, Min Yao, Yoshikazu Tanaka (2020)  The [4Fe-4S] cluster of sulfurtransferase TtuA desulfurizes TtuB during tRNA modification in Thermus thermophilus. Communications biology. 3 :1,  168-168 DOI:10.1038/s42003-020-0895-3 PMID:32265486 
Hisashi Yoshida, Sam-Yong Park, Gyosuke Sakashita, Yuko Nariai, Kanako Kuwasako, Yutaka Muto, Takeshi Urano, Eiji Obayashi (2020)  Elucidation of the aberrant 3' splice site selection by cancer-associated mutations on the U2AF1 nature communications. 11 :1,  4744- DOI:10.1038/s41467-020-18559-6. PMID:32958768 
Kosuke Ohsawa, Shota Ochiai, Junya Kubota, Takayuki Doi (2021)  Gold-Catalyzed Amide/Carbamate-Linked N,O-Acetal Formation with Bulky Amides and Alcohols Journal of the Organic Chemistry. 86 :1,  1281-1291 DOI:10.1021/acs.joc.0c02640 PMID:33350304 
Takuya Kobayakawa, Kohei Tsuji, Kiju Konno, Ai Himeno, Ami Masuda, Tingting Yang, Kohei Takahashi, Yusuke Ishida, Nami Ohashi, Takeo Kuwata, Kaho Matsumoto, Kazuhisa Yoshimura, Hiromi Sakawaki, Tomoyuki Miura, Shigeyoshi Harada, Shuzo Matsushita, Hirokazu Tamamura (2021)  Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors Journal of Medicinal Chemistry. 64 :3,  1481-1496 DOI:10.1021/acs.jmedchem.0c01153 PMID:33497209 
Hirokazu Tsukamoto, Saki Nakamura, Akito Tomida, Takayuki Doi (2020)  Scalable Total Syntheses and Structure-Activity Relationships of HaouaminesA, B, and Their Derivatives as Stable Formate Salts Chemistry A European Journal. 26 :55,  12528-12532 DOI:10.1002/chem.202001756 PMID:32291830 
Hiroyuki Terashima, Chinatsu Tatsumi, Akihiro Kawamoto, Keiichi Namba, Tohru Minamino, and Katsumi Imada (2020)  In Vitro Autonomous Construction of the Flagellar Axial Structure in Inverted Membrane Vesicles Biomolecules. 10 :1,  126- DOI:10.3390/biom10010126 PMID:31940802 
Mao Oide, Takayuki Kato, Tomotaka Oroguchi, Masayoshi Nakasako (2020)  Energy landscape of domain motion in glutamate dehydrogenase deduced from cryo-electron microscopy. The FEBS Journal. 287 :16,  3472-3493 DOI:10.1111/febs.15224 PMID:31976609 
David Vizarraga, Akihiro Kawamoto, U Matsumoto, Ramiro Illane, Rosa Perez-Luqu, Jesus Mart?n, Rocco Mazzolini, Paula Bierge, Oscar Q Pich, Mateu Espasa, Isabel Sanfeliu, Juliana Esperalba, Miguel Fernandez-Huerta, Margot P Scheffer, Jaume Pinyol, Achilleas S Frangakis, Maria Lluch-Senar, Shigetarou Mori, Keigo Shibayama, Tsuyoshi Kenri, Takayuki Kato, Keiichi Namba, Ignacio Fita, Makoto Miyata, David Aparicio (2020)  Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae. Nature Communications. 11 :1,  5188- DOI:10.1038/s41467-020-18777-y PMID:33057023 
Yosuke Inoue, Yuya Hanazono, Kentaro Noi, Akihiro Kawamoto, Masato Kimatsuka, Ryuhei Harada, Kazuki Takeda, Ryoichi Kita, Natsuki Iwamasa, Kyoka Shibata, Keiichi Noguchi, Yasuteru Shigeta, Keiichi Namba, Teru Ogura, Kunio Miki, Kyosuke Shinohara, Masafumi Yohda (2020)  Split conformation of Chaetomium thermophilum Hsp104 disaggregase Structure. 29 :7,  721-730 DOI:10.1016/j.str.2021.02.002 PMID:33651974 
Naoya Terahara, Keiichi Namba, Tohru Minamino (2020)  Dynamic exchange of two types of stator units in Bacillus subtilis flagellar motor in response to environmental changes. Computational and Structural Biotechnology Journal. 18 2897-2907 DOI:10.1016/j.csbj.2020.10.009 PMID:33163150 
Keisuke Tachibana, Yumi Iwashita, Erika Wakayama, Itsuki Nishino, Taiki Nishikaji, Masuo Kondoh (2020)  Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A Review Pharmaceutics. 12 :12,  1236- DOI:10.3390/pharmaceutics12121236 PMID:33352631 
Takuro Horii, Ryosuke Kobayashi, Mika Kimura, Sumiyo Morita, Izuho Hatada  (2020)  Calcium-Free and Cytochalasin B Treatment Inhibits Blastomere Fusion in 2-Cell Stage Embryos for the Generation of Floxed Mice via Sequential Electroporation cells. 9 :5,  1088- DOI:10.3390/cells9051088 PMID:32354036 
Minto Nakagawa, Mohammad Rabiul Karim, Takeshi Izawa, Mitsuru Kuwamura and Jyoji Yamate (2020)  Immunophenotypical Characterization of M1/M2 Macrophages and Lymphocytes in Cisplatin-Induced Rat Progressive Renal Fibrosis Cells. 10 :2,  257- DOI:10.3390/cells10020257 PMID:33525592 
Yusuke V Morimoto, Keiichi Namba, Tohru Minamino (2020)  GFP fusion to the N-terminus of MotB affects the proton channel activity of the bacterial flagellar motor in Salmonella. Biomolecules. 10 :9,  1255- DOI:10.3390/biom10091255 PMID:32872412 
米澤健人, 清水伸隆 (2020)  ゲル濾過クロマトグラフィーと組み合わせたタンパク質X線溶液散乱解析技術 生物物理. 60 180- DOI:10.2142/biophys.60.180
Yoko Hayashi-Takanaka, Yuto Kina, Fumiaki Nakamura, Leontine E Becking, Yoichi Nakao, Takahiro Nagase, Naohito Nozaki, Hiroshi Kimura (2020)  Histone modification dynamics as revealed by multicolor immunofluorescence-based single-cell analysis Journal of cell science. 133 :14,  jcs243444.- DOI:10.1242/jcs.243444 PMID:32576661 
Takuro Horii, Sumiyo Morita, Shinjiro Hino, Mika Kimura, Yuko Hino, Hiroshi Kogo, Mitsuyoshi Nakao, Izuho Hatada (2020)  Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome Genome Biology. 21 :1,  77- DOI:10.1186/s13059-020-01991-8 PMID:32234052 
守屋俊夫 (2020)  200 kV単粒子クライオ電子顕微鏡による小さいタンパク質の三次元構造再構築におけるボックスサイズと粒子マスク直径の決定方法 顕微鏡. 55 :1,  37-42 DOI:10.11410/kenbikyo.55.1_37
Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki, and Hiroshi Suemizu (2020)  Human Aldehyde Oxidase 1-mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes Drug Metabolism and Disposition. 48 :7,  580-586 DOI:10.1124/dmd.120.091090 PMID:32357972 
Xiaomei Sun,Yuxin Ye,Naofumi Sakurai,Koji Kato,Keizo Yuasa, Akihiko Tsuji, Min Yao (2020)  Crystallographic analysis of Eisenia hydrolysis‐enhancing protein using a long wavelength for native‐SAD phasing Acta Crystallographica Section F, Structural bilogy of commuinications. 76 20-24 DOI:10.1107/S2053230X19016716 PMID:31929182 
Naoyuki Miyazaki, Kosuke Murakami, Tomoichiro Oka, Motohiro Miki, Kenji Iwasaki, Kazuhiko Katayama, Kazuyoshi Murata (2021)  Atomic structure of human sapovirus capsid by single particle cryo-electron microscopy bioRxiv. - DOI:10.1101/2021.02.09.429995
Ryoji Ito, Ikumi Katano, Iyo Otsuka, Takeshi Takahashi, Hiroshi Suemizu, Mamoru Ito and Peter J. Simons (2020)  Bovine β-lactoglobulin-induced passive systemic anaphylaxis model using humanized NOG hIL-2/hGM-CSF transgenic mice international immunology. 33 :3,  183-189 DOI:10.1093/intimm/dxaa067 PMID:33027513 
Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki, and Hiroshi Suemizu (2020)  Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes Xenobiotica. 50 :6,  733-740 DOI:10.1080/00498254.2019.1688892 PMID:31690163 
Rie Koga, Mami Yamamoto, Takahiro Kosugi, Naohiro Kobayashi, Toshihiko Sugiki, Toshimichi Fujiwara, Nobuyasu Koga (2020)  Robust folding of a de novo designed ideal protein even with most of the core mutated to valine Proceedings of the National Academy of Sciences of the United States of America. 117 :49,  31149-31156 DOI:10.1073/pnas.2002120117 PMID:33229587 
Masatoshi Maeki, Sho Ito, Reo Takeda, Go Ueno, Akihiko Ishida, Hirofumi Tani, Masaki Yamamoto and Manabu Tokeshi (2020)  Room-temperature crystallography using a microfluidic protein crystal array device and its application to protein?ligand complex structure analysis Chemical Science. 11 :34,  9072-9087 DOI:10.1039/D0SC02117b PMID:34094189 
Koji Kato, Naoyuki Miyazaki, Tasuku Hamaguchi, Yoshiki Nakajima, Fusamichi Akita, Koji Yonekura, Jian-Ren Shen (2021)  High-resolution cryo-EM structure of photosystem II reveals damage from high-dose electron beams Communications biology. 4 :1,  382- DOI:10.1038/s42003-021-01919-3 PMID:33753866 
Minghao Chen, Masato Ishizaka, Shun Narai, Masaki Horitani, Naoki Shigi, Min Yao & Yoshikazu Tanaka (2020)  The [4Fe-4S] cluster of sulfurtransferase TtuA desulfurizes TtuB during tRNA modification in Thermus thermophilus Communications Biology. 3 :1,  168- DOI:10.1038/s42003-020-0895-3 PMID:32265486 
Tomohito Yamada, Toru Yoshida, Akihiro Kawamoto, Kaoru Mitsuoka, Kenji Iwasaki, Hideaki Tsuge (2020)  Cryo-EM structures reveal translocational unfolding in the clostridial binary iota toxin complex Nature Structural & Molecular Biology. 27 :3,  288-296 DOI:10.1038/s41594-020-0388-6 PMID:32123390 
Maoqing Dong, Giuseppe Deganutti, Sarah J Piper, Yi-Lynn Liang, Maryam Khoshouei, Matthew J Belousoff, Kaleeckal G Harikumar, Christopher A Reynolds, Alisa Glukhova, Sebastian G B Furness, Arthur Christopoulos, Radostin Danev, Denise Wootten, Patrick M Sexton, Laurence J Miller (2020)  Structure and dynamics of the active Gs-coupled human secretin receptor Nature Communications. 11 :1,  4137- DOI:10.1038/s41467-020-17791-4 PMID:32811827 
Yurika Yamada, Keiichi Namba & Takashi Fujii  (2020)  Cardiac muscle thin filament structures reveal calcium regulatory mechanism Nature Communications. 11 :1,  153- DOI:10.1038/s41467-019-14008-1 PMID:31919429 
Koji Kato, Toshiyuki Shinoda, Ryo Nagao, Seiji Akimoto, Takehiro Suzuki, Naoshi Dohmae, Min Chen, Suleyman I. Allakhverdiev, Jian-Ren Shen, Fusamichi Akita, Naoyuki Miyazaki, Tatsuya Tomo (2020)  Structural basis for the adaptation and function of chlorophyll f in photosystem I Nature Communications. 11 :1,  238- DOI:10.1038/s41467-019-13898-5 PMID:31932639 
Du?an Kolarski, Simon Miller, Tsuyoshi Oshima, Yoshiko Nagai, Yugo Aoki, Piermichele Kobauri, Ashutosh Srivastava, Akiko Sugiyama, Kazuma Amaike, Ayato Sato, Florence Tama, Wiktor Szymanski, Ben L Feringa, Kenichiro Itami, Tsuyoshi Hirota (2020)  Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock. Journal of the American Chemical Society,. 143 :4,  2078-2087 DOI:10.1021/jacs.0c12280 PMID:33464888 
Yoh Matsuki, Tomoaki Sugishita, Toshimichi Fujiwara (2020)  Surface-Only Spectroscopy for Diffusion-Limited Systems Using Ultra-Low Temperature DNP MAS NMR at 16.4 T Journal of Physical Chemistry C. 124 :34,  18609-18614 DOI:10.1021/acs.jpcc.0c04873
Tatsuki Asai, Naruhiko Adachi, Toshio Moriya, Hideyuki Oki, Takamitsu Maru, Masato Kawasaki, Kano Suzuki, Sisi Chen, Ryohei Ishii, Kazuko Yonemori, Shigeru Igaki, Satoshi Yasuda, Satoshi Ogasawara, Toshiya Senda, Takeshi Murata (2021)  Cryo-EM structure of K+-bound hERG channel complexed with the blocker astemizole Structure. 29 :3,  203-212 DOI:10.1016/j.str.2020.12.007 PMID:33450182 
Kenta Okamoto, Ricardo J Ferreira, Daniel S D Larsson, Filipe R N C Maia, Haruhiko Isawa, Kyoko Sawabe, Kazuyoshi Murata, Janos Hajdu, Kenji Iwasaki, Peter M Kasson, Naoyuki Miyazaki (2020)  Acquired Functional Capsid Structures in Metazoan Totivirus-like dsRNA Virus Structure. 28 :8,  888-896 DOI:10.1016/j.str.2020.04.016 PMID:32413288 
Yuichi Yoshimura, Masatomo So, Yohei Miyanoiri (2020)  Carbonyl 13C-detect solution-state protein NMR experiments to circumvent amide-solvent exchange broadening: Application to β2-microglobulin Biochimica et Biophysica Acta, Proteins and Proteomics. 1869 :3,  140593- DOI:10.1016/j.bbapap.2020.140593 PMID:33359410 
Hiroko Izumi-Nakaseko, Masachika Fujiyoshi, Mihoko Hagiwara-Nagasawa, Ai Goto, Koki Chiba, Ryuichi Kambayashi, Atsuhiko T. Naito, Kentaro Ando, Yasunari Kanda, Itsuko Ishii, Atsushi Sugiyama (2020)  Dasatinib can Impair Left Ventricular Mechanical Function But May Lack Proarrhythmic Effect: A Proposal of Non-clinical Guidance for Predicting Clinical Cardiovascular Adverse Events of Tyrosine Kinase Inhibitors Cardiovascular Toxicology. 20 :1,  58-70 DOI:10.1007/s12012-019-09538-5 PMID:31280457 
Tohru Minamino, Akihiro Kawamoto, Miki Kinoshita, Keiichi Namba (2020)  Molecular organization and assembly of the export apparatus of flagellar type III secretion systems. Current Topics in Microbiology and Immunology. 427 91-107 DOI:10.1007/82_2019_170 PMID:31172377 
Yuji Sumii , Naoyuki Kotoku , Chisu Han , Kentaro Kamiya , Andi Setiawan , Catherine Vilcheze , William R Jacobs Jr , Masayoshi Arai  (2020)  3-(Phenethylamino)demethyl(oxy)aaptamine as an anti-dormant mycobacterial substance: Isolation, evaluation and total synthesis Tetrahedron Letters. 61 :22,  151924- DOI:10.1016/j.tetlet.2020.151924 PMID:32577043 
Rui Tang, Atsushi Kimishima, Andi Setiawan, Masayoshi Arai (2020)  Secalonic acid D as a selective cytotoxic substance on the cancer cells adapted to nutrient starvation Journal of Natural Medicines . 74 :2,  495-500 DOI:10.1007/s11418-020-01390-0 PMID:32002808 
Yuko Tsuchiya, Kentaro Tomii (2020)  Structural Modeling and Ligand-Binding Prediction for Analysis of Structure-Unknown and Function-Unknown Proteins Using FORTE Alignment and PoSSuM Pocket Search Methods in molecular biology. 2165 1-11 DOI:10.1007/978-1-0716-0708-4_1 PMID:32621216 
田島健次, 今井友也, 姚閔,  (2020)  酢酸菌におけるセルロースの合成セルロースナノファイバーを紡ぎ出す超精密ナノマシンの秘密に迫る 化学と生物. 58 453- DOI:ISSN:0453-073X
Yuji Mochizuki, Tatsuya Nakano, Kota Sakakura, Yoshio Okiyama, Hiromasa Watanabe, Koichiro Kato, Yoshinobu Akinaga, Shinya Sato, Jun-inchi Yamamoto, Katsumi Yamashita, Tadashi Murase, Takeshi Ishikawa, Yuto Komeiji, Yuji Kato, Naoki Watanabe, Takashi Tsukamoto, Hirotoshi Mori, Koji Okuwaki, Shigenori Tanaka, Akifumi Kato, Chiduru Watanabe, and Kaori Fukuzawa (2020)  The ABINIT-MP Program Recent Advances of the Fragment Molecular Orbital Method: Enhanced Performance and Applicability. 53-67 DOI:ISBN:978-981-15-9235-5 (eBook)
Kaori Fukuzawa, Shigenori Tanaka, Yoichiro Yagi, Noriyuki Kurita, Norihito Kawashita, Kenichiro Takaba, and Teruki Honma (2020)  FMO Drug Design Consortium Recent Advances of the Fragment Molecular Orbital Method: Enhanced Performance and Applicability. 127-182 DOI:ISBN:978-981-15-9235-5 (eBook)
安達成彦, 千田俊哉 (2020)  クライオ電子顕微鏡を使いたいと思ったら イメージング時代の構造生命科学 実験医学増刊. 38 206- DOI:ISBN:978-4-7581-0385-5
山田悠介, 千田俊哉 (2020)  X線結晶構造解析─技術革新 イメージング時代の構造生命科学 実験医学増刊. 38 48- DOI:ISBN:978-4-7581-0385-5
Kazumasa Oda, Takashi Nomura, Takanori Nakane, Keitaro Yamashita, Keiichi Inoue, Shota Ito, Johannes Vierock, Kunio Hirata , Andres D Maturana, Kota Katayama, Tatsuya Ikuta, Itsuki Ishigami, Tamaki Izume, Rie Umeda, Ryuun Eguma, Satomi Oishi, Go Kasuya, Takafumi Kato, Tsukasa Kusakizako, Wataru Shihoya, Hiroto Shimada, Tomoyuki Takatsuji, Mizuki Takemoto, Reiya Taniguchi, Atsuhiro Tomita, Ryoki Nakamura, Masahiro Fukuda, Hirotake Miyauchi, Yongchan Lee, Eriko Nango, Rie Tanaka, Tomoyuki Tanaka, Michihiro Sugahara, Tetsunari Kimura, Tatsuro Shimamura, Takaaki Fujiwara, Yasuaki Yamanaka, Shigeki Owada, Yasumasa Joti, Kensuke Tono, Ryuichiro Ishitani, Shigehiko Hayashi, Hideki Kandori, Peter Hegemann, So Iwata, Minoru Kubo, Tomohiro Nishizawa, Osamu Nureki (2021)  Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin eLife. 10 e62389- DOI:10.7554/eLife.62389 PMID:33752801 
Kohki Kido, Satoshi Yamanaka, Shogo Nakano, Kou Motani, Souta Shinohara, Akira Nozawa, Hidetaka Kosako, Sohei Ito, Tatsuya Sawasaki (2020)  AirID, a novel proximity biotinylation enzyme, for analysis of protein-protein interactions eLife. 9 e54983- DOI:10.7554/eLife.54983 PMID:32391793 
Elin Claesson, Weixiao Yuan Wahlgren, Heikki Takala, Suraj Pandey, Leticia Castillon, Valentyna Kuznetsova, Leocadie Henry, Matthijs Panman, Melissa Carrillo, Joachim Kubel, Rahul Nanekar, Linnea Isaksson, Amke Nimmrich, Andrea Cellini, Dmitry Morozov, Michal Maj, Moona Kurttila, Robert Bosman, Eriko Nango, Rie Tanaka, Tomoyuki Tanaka, Luo Fangjia, So Iwata, Shigeki Owada, Keith Moffat, Gerrit Groenhof, Emina A Stojkovic, Janne A Ihalainen, Marius Schmidt, Sebastian Westenhoff  (2020)  The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser eLife. 9 e53514- DOI:10.7554/eLife.53514 PMID:32228856 
松垣直宏, 山田悠介, 引田理英, 平木雅彦, 千田美紀, 千田俊哉 (2020)  長波長X線を利用したタンパク質結晶構造解析 日本結晶学会誌. 62 :1,  56-61 DOI:10.5940/jcrsj.62.56
Kazumi Saikusa, Haruna Hidaka, Shunsuke Izumi, Satoko Akashi (2020)  Mass spectrometric characterization of histone H3 isolated from in-vitro reconstituted and acetylated nucleosome core particle massspectrometry . 9 :1,  A0090- DOI:10.5702/massspectrometry.A0090 PMID:33224699 
Kenji Ishimoto, Shinsaku Nakagawa (2020)  Application of Amorphous Solid Dispersion Technology for Functional Food Development Oleoscience. 20 :2,  53-60 DOI:10.5650/oleoscience.20.53
Kazuyuki Saito, Wang Zhou, Shohei Sato, Keita Takubo, Kazunori Furutsu, Ahmed A. B. Mohamed, Euis Maras Purwati, Takashi Ikawa, Shuji Akai (2021)  Regio-Complementary Preparation of 6- and 7-Fluoro-1,2,3,4-tetrahydroquinolines via the Cyclization of Catecholamines Followed by Deoxyfluorination Heterocycles. 103 902-917 DOI:10.3987/COM-20-S(K)56
Yuichi Onda, Kazuki Fukushi, Kosuke Ohsawa, Masahito Yoshida, Yuichi Masuda, Takayuki Doi (2020)  Synthesis of a Biphenylalanine Analogue of Apratoxin A Displaying Substantially Enhanced Cytotoxicity Heterocycles. 101 679-691 DOI:10.3987/COM-19-S(F)35
Mieko Arisawa, Katsuya Nakai, Tomoki Yamada, Ren Suzuki, Masahiko Yamaguchia (2020)  Synthesis of cycloalkyl/steroidal heteroaryl sulfides using rhodium-catalyzed heteroaryl exchange reaction Heterocycles. 100 104-118 DOI:10.3987/COM-19-14147
Kyosuke Ueda and Satoshi Yokoshima (2020)  Synthetic Studies on Densanins: Stereoselective Construction of a Pyrrolidine Ring Containing a Quaternary Carbon Heterocycles. 103 DOI:10.3987/COM - 20 - S(K)4
Hiroaki Hase, Masaya Aoki, Kentaro Matsumoto, Shuichi Nakai, Toshiyuki Nagata, Aya Takeda, Kazuhiro Ueda, Kentaro Minami, Kaori Kitae, Kentaro Jingushi Yuko Ueda, Masatatsu Yamamoto, Tatsuhiko Furukawa, Masami Sato, Kazutake Tsujikawa (2021)  Cancer type-SLCO1B3 promotes epithelial-mesenchymal transition resulting in the tumour progression of non-small cell lung cancer Oncology Reports. 45 309-316 DOI:10.3892/or.2020.7839 PMID:33155667 
Mika K Kaneko, Tomokazu Ohishi, Junko Takei, Masato Sano, Takuro Nakamura, Hideki Hosono, Miyuki Yanaka, Teizo Asano, Yusuke Sayama, Hiroyuki Harada, Manabu Kawada, Yukinari Kato (2020)  Anti-EpCAM monoclonal antibody exerts antitumor activity against oral squamous cell carcinomas OncologyReports. 44 :6,  2517-2526 DOI:10.3892/or.2020.7808 PMID:33125138 
Junko Takei, Mika K. Kaneko, Tomokazu Ohishi, Hideki Hosono, Takuro Nakamura, Miyuki Yanaka, Masato Sano, Teizo Asano, Yusuke Sayama, Manabu Kawada, Hiroyuki Harada, Yukinari Kato (2020)  A defucosylated anti-CD44 monoclonal antibody 5-mG2a-f exerts antitumor effects in mouse xenograft models of oral squamous cell carcinoma OncologyReports. 44 :5,  1949-1960 DOI:10.3892/or.2020.7735 PMID:33000243 
Hideki Hosono, Tomokazu Ohishi, Junko Takei, Teizo Asano, Yusuke Sayama, Manabu Kawada, Mika K. Kaneko, Yukinari Kato (2020)  The anti-epithelial cell adhesion molecule (EpCAM) monoclonal antibody EpMab-16 exerts antitumor activity in a mouse model of colorectal adenocarcinoma Oncology Letters. 20 :6,  383- DOI:10.3892/ol.2020.12246 PMID:33154781 
Yoshikazu Furusawa, Mika Kato Kaneko, Yukinari Kato (2020)  Establishment of C20 Mab-11, a novel anti-CD20 monoclonal antibody, for the detection of B cells Oncology Letters. 20 :2,  1961-1967 DOI:10.3892/ol.2020.11753 PMID:32724441 
Yusuke Sayama, Mika K Kaneko, Yukinari Kato (2020)  Development and characterization of TrMab-6, a novel anti-TROP2 monoclonal antibody for antigen detection in breast cancer Molecular medicine reports. 23 :2,  92- DOI:10.3892/mmr.2020.11731 PMID:33300065 
Hideki Hosono, Junko Takei, Tomokazu Ohishi, Masato Sano, Teizo Asano, Yusuke Sayama, Takuro Nakamura, Miyuki Yanaka, Manabu Kawada, Hiroyuki Harada, Mika Kato Kaneko, Yukinari Kato (2020)  Anti-EGFR monoclonal antibody 134-mG2a exerts antitumor effects in mouse xenograft models of oral squamous cell carcinoma International Journal of Molecular Medicine . 46 :4,  1443-1452 DOI:10.3892/ijmm.2020.4700 PMID:32945346 
Ryo Hatada, Koji Okuwaki, Kazuki Akisawa, Yuji Mochizuki, Yuma Handa, Kaori Fukuzawa, Yuto Komeiji, Yoshio Okiyama, and Shigenori Tanaka (2020)  Statistical interaction analyses between SARS-CoV-2 main protease and inhibitor N3 by combining molecular dynamics simulation and fragment molecular orbital calculation Applied Physics Express. 14 27003- DOI:10.35848/1882-0786/abdac6
Naoyoshi Maeda, Akira Matsuda, Satoko Otsuguro, Masahiko Takahashi, Masahiro Fujii, Katsumi Maenaka (2020)  Antitumor Effect of Sugar-Modified Cytosine Nucleosides on Growth of Adult T-Cell Leukemia Cells in Mice Vaccines. 8 658- DOI:10.3390/vaccines8040658 PMID:33167425 
Takashi Tadokoro, Cassandra M. Modahl, Katsumi Maenaka, and Narumi Aoki-Shioi (2020)  Cysteine-Rich Secretory Proteins (CRISPs) From Venomous Snakes: An Overview of the Functional Diversity in A Large and Underappreciated Superfamily Toxins. 12 175- DOI:10.3390/toxins12030175 PMID:32178374 
Mutsuki Mori, Takeshi Izawa , Yohei Inai, Sho Fujiwara, Ryo Aikawa, Mitsuru Kuwamura and Jyoji Yamate (2020)  Dietary Iron Overload Differentially Modulates Chemically-Induced Liver Injury in Rats Nutrients. 12 :9,  2784- DOI:10.3390/nu12092784 PMID:32932999 
Mieko Arisawa, Masahiko Yamaguchi (2020)  Rhodium-Catalyzed Synthesis of Organosulfur Compounds Involving S-S Bond Cleavage of Disulfides and Sulfur Molecules. 25 3595- DOI:10.3390/molecules25163595 PMID:32784672 
Waleed A Abdel-Naime, Atsushi Kimishima, Andi Setiawan, John Refaat Fahim, Mostafa A Fouad, Mohamed Salah Kamel, Masayoshi Arai (2020)  Mitochondrial Targeting in an Anti-austerity Approach involving Bioactive Metabolites Isolated from the Marine-Derived Fungus Aspergillus sp Marine Drugs. 18 555- DOI:10.3390/md18110555 PMID:33171814 
Takenori Shimo, Yusuke Nakatsuji, Keisuke Tachibana, Satoshi Obika  (2020)  Design and In Vitro Evaluation of Splice-Switching Oligonucleotides Bearing Locked Nucleic Acids, Amido-Bridged Nucleic Acids, and Guanidine-Bridged Nucleic Acids International Journal of Molecular Sciences. 22 3526- DOI:10.3390/ijms22073526 PMID:33805378 
Yuka Tsuji, Mizuki Kuramochi, Hossain M. Golbar, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate (2020)  Acetaminophen-Induced Rat Hepatotoxicity Based on M1/M2-Macrophage Polarization, in Possible Relation to Damage-Associated Molecular Patterns and Autophagy International Journal of Molecular Sciences. 21 :23,  8998- DOI:10.3390/ijms21238998 PMID:33256230 
Meirong Chen, Zuoqi Gai, Chiaki Okada, Yuxin Ye, Jian Yu, Min Yao  (2020)  Flexible NAD+ Binding in Deoxyhypusine Synthase Reflects the Dynamic Hypusine Modification of Translation Factor IF5A International Journal Molecular. Science. 21 :15,  5509- DOI:10.3390/ijms21155509 PMID:32752130 
Nat Sakol, Ayako Egawa and Toshimichi Fujiwara, (2020)  Gadolinium complexes as contrast agent for cellular NMR spectroscopy International Journal of Molecular Sciences. 21 :11,  4042- DOI:10.3390/ijms21114042 PMID:32516957 
Chisa Katou-Ichikawa, Hironobu Nishina, Miyuu Tanaka, Shigeo Takenaka, Takeshi Izawa, Mitsuru Kuwamura Jyoji Yamate (2020)  Participation of Somatic Stem Cells, Labeled by a Unique Antibody (A3) Recognizing Both N-glycan and Peptide, to Hair Follicle Cycle and Cutaneous Wound Healing in Rats International Journal of Molecular Sciences. 21 :11,  3806- DOI:10.3390/ijms21113806 PMID:32471256 
Sumiyo Morita, Takuro Horii, Mika Kimura, Izuho Hatada (2020)  Synergistic Upregulation of Target Genes by TET1 and VP64 in the dCas9-SunTag Platform International Journal of Molecular Sciences. 21 :5,  1574- DOI:10.3390/ijms21051574 PMID:32106616 
Tomohiro Yamashita, Sawako Kamikaseda, Aya Tanaka, Hidetoshi Tozaki-Saitoh, Jose M M Caaveiro, Kazuhide Inoue , Makoto Tsuda  (2021)  New Inhibitory Effects of Cilnidipine on Microglial P2X7 Receptors and IL-1β Release: An Involvement in its Alleviating Effect on Neuropathic Pain Cells. 10 434- DOI:10.3390/cells10020434 PMID:33670748 
Hirotaka Takahashi, Satoshi Yamanaka, Shohei Kuwada, Kana Higaki, Kohki Kido, Yusuke Sato, Shuya Fukai, Fuminori Tokunaga, Tatsuya Sawasaki (2020)  A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors Biomedicines. 8 :6,  152- DOI:10.3390/biomedicines8060152 PMID:32512835 
Shuto Takeuchi, Takuya Kawanai, Ryosuke Yamauchi, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Satoshi Asano, Atsuko Hayata-Takano, Takanobu Nakazawa, Koji Yano, Naotaka Horiguchi, Shinsaku Nakagawa, Kazuhiro Takuma, James A Waschek, Hitoshi Hashimoto, Yukio Ago (2020)  Activation of the VPAC2 Receptor Impairs Axon Outgrowth and Decreases Dendritic Arborization in Mouse Cortical Neurons by a PKA-Dependent Mechanism Frontiers in Neuroscience. 14 521- DOI:10.3389/fnins.2020.00521 PMID:32581681 
Dianita S Saputri , Songling Li , Floris J van Eerden , John Rozewicki , Zichang Xu , Hendra S Ismanto , Ana Davila , Shunsuke Teraguchi , Kazutaka Katoh , Daron M Standley (2020)  Flexible, Functional, and Familiar: Characteristics of SARS-CoV-2 Spike Protein Evolution Frontiers in Microbiology. 11 2112- DOI:10.3389/fmicb.2020.02112 PMID:33042039 
Chiduru Watanabe, Yoshio Okiyama, Shigenori Tanaka, Kaori Fukuzawa, Teruki Honma (2020)  Molecular Recognition of SARS-CoV-2 Spike Glycoprotein: Quantum Chemical Hot Spot and Epitope Analyses Biological and Medicinal Chemistry. DOI:10.26434/chemrxiv.13200176
Waleed Abdel-Naime, John Refaat, Mostafa Ahmed, Masayoshi Arai (2021)  Anti-dormant mycobacterial activity of Melissa officinalis L. (Lemon balm) The Journal of Advanced Biomedical and Pharmaceutical Sciences. DOI:10.21608/jabps.2021.50882.1112
Woong-Hee Shin ,Keiko Kumazawa ,Kenichiro Imai, Takatsugu Hirokawa, Daisuke Kihara (2020)  Current Challenges and Opportunities in Designing Protein-Protein Interaction Targeted Drugs Advances and Applications in Bioinformatics and Chemistry. 13 11-25 DOI:10.2147/AABC.S235542 PMID:33209039 
Atsushi Hijikata, Clara Shionyu, Setsu Nakae, Masafumi Shionyu, Motonori Ota, Shigehiko Kanaya, Tsuyoshi Shirai (2020)  Current Status of Structure-based Drug Repurposing against COVID-19 by Targeting SARS-CoV-2 Proteins Biophysics and Physicobiology. 18 226-240 DOI:10.2142/biophysico.bppb-v18.025 PMID:34745807 
Satoshi Yamanaka, Hidetaka Murai, Daisuke Saito, Gembu Abe, Etsuko Tokunaga, Takahiro Iwasaki, Hirotaka Takahashi, Hiroyuki Takeda, Takayuki Suzuki, Norio Shibata, Koji Tamura, Tatsuya Sawasaki (2020)  Thalidomide and its metabolite 5-hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF The EMBO journal. 40 :4,  e105375- DOI:10.15252/embj.2020105375 PMID:33470442 
Keiichiro Sato, Yumi Hamasaki, Kiyoshiro Fukui, Kazuki Ito, Kazunari Miyamichi, Masabumi Minami and Taiju Amano (2020)  Amygdalohippocampal Area Neurons That Project to the Preoptic Area Mediate Infant-Directed Attack in Male Mice The Journal of Neuroscience. 40 3981-3994 DOI:10.1523/JNEUROSCI.0438-19.2020 PMID:32284340 
Masataka Michigami, Kentaro Takahashi, Haruna Yamashita, Zhengmao Ye, Ikuhiko Nakase, Ikuo Fujii (2020)  A “ligand-targeting” peptide-drug conjugate: Targeted intracellular drug delivery by VEGFbinding helix-loop-helix peptides via receptormediated endocytosis PLOS One. 16 e0247045- DOI:10.1371/journal.pone.0247045 PMID:33630870 
Kaname Kojima, Shu Tadaka, Fumiki Katsuoka, Gen Tamiya, Masayuki Yamamoto, Kengo Kinoshita (2020)  A genotype imputation method for de-identified haplotype reference information by using recurrent neural network PLOS Computational Biology. 16 e1008207- DOI:10.1371/journal.pcbi.1008207 PMID:33001993 
Noa Hada, Mizuki Kuramochi, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate  (2020)  Effects of dexamethasone on hepatic macrophages in normal livers and thioacetamide-induced acute liver lesions in rats Journal of Toxicologic Pathology. 33 :4,  237-246 DOI:10.1293/tox.2020-0016 PMID:33239842 
Yohei Inai, Takeshi Izawa, Mutsuki Mori, Machi Atarashi, Seiichirou Tsuchiya, Mitsuru Kuwamura, Jyoji Yamate (2020)  Analyses of Hemorrhagic Diathesis in High-Iron Diet-Fed Rats Journal of Toxicologic Pathology. 34 :1,  33-41 DOI:10.1293/tox.2020-0004 PMID:33627943 
Mizuki Kuramochi, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate (2020)  Involvement of neutrophils in rat livers by low-dose thioacetamide administration The Journal of Veterinary Medical Science . 83 :3,  390-396 DOI:10.1292/jvms.20-0581 PMID:33473068 
Chizuru Miura, Naoya Shindo, Kei Okamoto, Keiko Kuwata, Akio Ojida (2020)  Fragment-Based Discovery of Irreversible Covalent Inhibitors of Cysteine Proteases Using Chlorofluoroacetamide Library Chemical & pharmaceutical bulletin. 68 1074-1081 DOI:10.1248/cpb.c20-00547 PMID:33132374 
Kenta Morita, Kenichi Murai, Mitsuhiro Arisawa, Hiromichi Fujioka (2020)  Selective Reduction of α,β-Unsaturated Weinreb Amides in the Presence of α,β-Unsaturated Esters Chemical & pharmaceutical bulletin. 68 1100-1103 DOI:10.1248/cpb.c20-00545 PMID:33132377 
Juri Sakata, Kazunari Akita, Manabu Sato, Masashi Shimomura, and Hidetoshi Tokuyama (2020)  Cyclic Sulfamidite as Simultaneous Protecting Group for Amino Alcohols: Development of a Mild Deprotection Protocol Using Thiophenol Chemical and Pharmaceutical Bulletin. 68 996-1000 DOI:10.1248/cpb.c20-00531 PMID:32999152 
Kenzo Yahata, Shin Yoshioka, Shuhei Hori, Shu Sakurai, Yuki Kaneko, Kai Hasegawa, Shuji Akai (2020)  One-Pot Dehydrogenative Ketone Synthesis from Aldehydes and Non-Activated Hydrocarbons Chemical and Pharmaceutical Bulletin - J-Stage. 68 336-338 DOI:10.1248/cpb.c20-00075 PMID:32074521 
Misaki Niu, Atsushi Kasai, Kaoru Seiriki, Misuzu Hayashida, Masato Tanuma, Rei Yokoyama Yumi Hirato, Hitoshi Hashimoto (2021)  Altered Functional Connectivity of the Orbital Cortex and Striatum Associated with Catalepsy Induced by Dopamine D1 and D2 Antagonists Biological & Pharmaceutical Bulletin. 44 442-447 DOI:10.1248/bpb.b20-01006 PMID:33642553 
Shinsuke Inuki. Hiroaki Ohno (2020)  Total Syntheses of Myriocin, Mycestericins and Sphingofungin E: Sphingosine Analogues Containing aβ, β'-Dihydroxy a-Amino Acid Framework Chemical Society of Japan. 50 1313-1324 DOI:10.1246/cl.210133
Yoshitake Nishiyama, Kei Akiyama, Yuki Sakata, Takamitsu Hosoya, and Suguru Yoshida (2021)  Facile Synthesis of Tetraarylpyrazines by Sequential Cross-coupling Approach Chemistry Letters. 50 :1,  180-183 DOI:10.1246/cl.200715
Akihiro Kobayashi, Tsubasa Matsuzawa, Takamitsu Hosoya, and Suguru Yoshida (2020)  One-pot Synthesis of Allyl Sulfides from Sulfinate Esters and Allylsilan through Reduction of Alkoxysulfonium Intermediates Chemistry Letters. 49 :7,  813-816 DOI:10.1246/cl.200285
Tsuneyuki Kobayashi, Takamitsu Hosoya, and Suguru Yoshida (2020)  Aryne Reaction and Cross-Coupling Approach for the Synthesis of Diverse N-Arylphenylalanine Derivatives Chemistry Letters. 49 :7,  809-812 DOI:10.1246/cl.200276
Kotaro Mutsuura,Yuki Sakata,Keisuke Uchida,Takamitsu Hosoya and Suguru Yoshida  (2020)  Synthesis of Thioxanthones through Formal C-H Thiolation of Benzoic Acid Esters and Acid-mediated Direct Cyclization Chemistry Letters. 49 :7,  753-756 DOI:10.1246/cl.200190
Kazuya Kanemoto, Yuki Sakata, Takamitsu Hosoya, Suguru Yoshida (2020)  Synthesis of Phenoxathiins and Phenothiazines by Aryne Reactions with Thiosulfonates Chemistry Letters. 49 :5,  593-596 DOI:10.1246/cl.200132
Yoshihiko Yamamoto,Naohiro Hirako and Takeshi Yasui (2020)  A Combined Experimental and Computational Study on the Palladium-Catalyzed Sequential [2+2+1] Spirocyclization/Arene C-H Activation of 4-Iodo-2-quinolones with Diphenylacetylene Bulletin of the Chemical Society of Japan . 94 623-631 DOI:10.1246/bcsj.20200328
Yoshio Okiyama, Tatsuya Nakano, Chiduru Watanabe, Kaori Fukuzawa, Yuto Komeiji, Katsunori Segawa, and Yuji Mochizuki (2020)  Acceleration of environmental electrostatic potential using Cholesky decomposition with adaptive metric (CDAM) for fragment molecular orbital (FMO) method Bulletin of the Chemical Society of Japan. 94 91-96 DOI:10.1246/bcsj.20200227
Tsukasa Sawato ,Mieko Arisawa , and Masahiko Yamaguchi (2020)  Reversible Formation of Self-assembly Gels Containing Giant Vesicles in Trifluoromethylbenzene Using Oxymethylenehelicene Oligomers with Terminal C16 Alkyl Groups Bulletin of the Chemical Society of Japan. 93 1497-1503 DOI:10.1246/bcsj.20200164
Takashi Niwa, Takamitsu Hosoya (2020)  Molecular Renovation Strategy for Expeditious Synthesis of Molecular Probes Bulletin of the Chemical Society of Japan. 93 :2,  230-248 DOI:10.1246/bcsj.20190310
Yoko Yagishita, Akira Uruno, Thomas W Kensler, and Masayuki Yamamoto, (2020)  SUN-LB101 NRF2 Represses Obesity-Associated Adipose Tissue Inflammation in Mice Jouenal of the Endocrine Society. -- DOI:10.1210/jendso/bvaa046.2014
Kohei Kitagawa, Kensuke Matsumura, Masayuki Baba, Momoka Kondo, Tomoya Takemoto, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa (2021)  Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZWT/Q1038R mouse model of autism spectrum disorder Molecular Brain. 14 56- DOI:10.1186/s13041-021-00769-8 PMID:33726803 
Keisuke Koga, Yuto Shiraishi, Ryo Yamagata, Hidetoshi Tozaki-Saitoh, Miho Shiratori-Hayashi, Makoto Tsuda (2020)  Intrinsic braking role of descending locus coeruleus noradrenergic neurons in acute and chronic itch in mice Molecular brain. 13 144- DOI:10.1186/s13041-020-00688-0 PMID:33109226 
Ahmed M. Zaher, Jianyu Lin, Masayoshi Arai (2020)  Cytotoxic activity of abietane-type diterpenes isolated from Taxodium distichum against cancer cells adapted to nutrient-starved conditions Natural Product Communications. 15 DOI:10.1177/1934578X20915298
Nahid Rahman, Mizuki Kuramochi, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate (2020)  Characterization of Immature Myofibroblasts of Stellate Cell or Mesenchymal Cell Origin in D-Galactosamine-Induced Liver Injury in Rats Veterinary Pathology. 58 :1,  80-90 DOI:10.1177/0300985820963097 PMID:33054583 
Masaaki Koga, Mohammad Rabiul Karim, Mizuki Kuramochi, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate  (2020)  Appearance of Heterogeneous Macrophages During Development of Isoproterenol- Induced Rat Myocardial Fibrosis Toxicologic Pathology. 49 :5,  1048-1061 DOI:10.1177/0192623320982526 PMID:33397220 
Hironobu Nishina, Chisa Katou-Ichikawa, Mizuki Kuramochi, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate (2020)  Participation of Somatic Stem Cells, Recognized by a Unique A3 Antibody, in Mucosal Epithelial Regeneration in Dextran Sulfate Sodium (DSS)-Induced Rat Colonic Lesions Toxicologic Pathology. 48 :4,  560-569 DOI:10.1177/0192623320906817 PMID:32122285 
Ai Hashimoto, Mohammad Rabiul Karim, Mizuki Kuramochi, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate (2020)  Characterization of Macrophages and Myofibroblasts Appearing in Dibutyltin Dichloride-Induced Rat Pancreatic Fibrosis Toxicologic Pathology. 48 :3,  509-523 DOI:10.1177/0192623319893310 PMID:31896309 
Masato Tanuma, Atsushi Kasai, Kazuki Bando, Naoyuki Kotoku, Kazuo Harada, Masafumi Minoshima, Kosuke Higashino, Atsushi Kimishima, Masayoshi Arai, Yukio Ago, Kaoru Seiriki, Kazuya Kikuchi, Satoshi Kawata, Katsumasa Fujita, Hitoshi Hashimoto (2020)  Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain. JCI Insight. 5 e133348- DOI:10.1172/jci.insight.133348 PMID:32125287 
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Sandra Huber, Anina Bar, Selina Epp, Jacqueline Schmuckli-Maurer, Naja Eberhard, Bruno M. Humbel, Andrew Hemphill, Kerry Woods (2020)  Recruitment of Host Nuclear Pore Components to the Vicinity of Theileria Schizonts mSphere. 5 :1,  e00709-19- DOI:10.1128/mSphere.00709-19 PMID:32024710 
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Daniel Hilger, Kaavya Krishna Kumar, Hongli Hu, Mie Fabricius Pedersen, Evan S O'Brien, Lise Giehm, Christine Jennings, Gozde Eskici, Asuka Inoue, Michael Lerch, Jesper Mosolff Mathiesen, Georgios Skiniotis, Brian K Kobilka  (2020)  Structural insights into differences in G protein activation by family A and family B GPCRs Science. 369 eaba3373- DOI:10.1126/science.aba3373 PMID:32732395 
Jeffrey S Smith , Thomas F Pack , Asuka Inoue , Claudia Lee , Kevin Zheng , Issac Choi , Dylan S Eiger , Anmol Warman , Xinyu Xiong , Zhiyuan Ma , Gayathri Viswanathan , Ian M Levitan , Lauren K Rochelle , Dean P Staus , Joshua C Snyder , Alem W Kahsai , Marc G Caron, Sudarshan Rajagopal Affiliations expand (2021)  Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors Science. 371 eaay1833- DOI:10.1126/science.aay1833 PMID:33479120 
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Kavita A. Iyer, Yifan Hu, Ashok R. Nayak, Nagomi Kurebayashi, Takashi Murayama, Montserrat Samso (2020)  Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM Science Advances. 6 :31,  eabb2964- DOI:10.1126/sciadv.abb2964 PMID:32832689 
Shoko Sato, Naoki Tanaka, Yasuhiro Arimura, Tomoya Kujirai, Hitoshi Kurumizaka (2020)  The N-terminal and C-terminal Halves of Histone H2A.Z Independently Function in Nucleosome Positioning and Stability Genes Cells. 25 :8,  538-546 DOI:10.1111/gtc.12791 PMID:32500630 
Takashi Tadokoro,Mst Lubna Jahan,Yuri Ito,Maino Tahara,Surui Chen,Atsutoshi Imai,Natsumi Sugimura,Koki Yoshida,Mizuki Saito,Toyoyuki Ose,Takao Hashiguchi,Makoto Takeda,Hideo Fukuhara,Katsumi Maenaka (2020)  Biophysical characterization and single-chain Fv construction of a neutralizing antibody to measles virus The FEBS Journal. 287 145-159 DOI:10.1111/febs.14991 PMID:31287622 
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Rui Tang, Dongyi Zhou, Atsushi Kimishima, Andi Setiawan & Masayoshi Arai (2020)  Selective cytotoxicity of marine-derived fungal metabolite (3S,6S)-3,6-dibenzylpiperazine-2,5-dione against cancer cells adapted to nutrient starvation The journal of Antibiotics. 73 873-875 DOI:10.1038/s41429-020-0340-3 PMID:32587348 
Takahito Ouchi, Yoshihiro Watanabe, Kenichi Nonaka, Reiko Muramatsu, Chikako Noguchi, Miho Tozawa, Rei Hokari, Aki Ishiyama, Rima Koike, Hidehito Matsui, Yukihiro Asami, Yuki Inahashi, Takahiro Ishii, Toshiaki Teruya, Masato Iwatsuki, Hideaki Hanaki, Satoshi Omura  (2020)  Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021 Journal of Antibiotics. 73 365-371 DOI:10.1038/s41429-020-0292-7 PMID:32139881 
Kazumi Saikusa, Daiki Kato, Aritaka Nagadoi, Hitoshi Kurumizaka, Satoko Akashi (2020)  Native Mass Spectrometry of Protein and DNA Complexes Prepared in Nonvolatile Buffers. Journal of the American Society for Mass Spectrometry. 31 :3,  711-718 DOI:10.1021/jasms.9b00145 PMID:31999114 
Go Hirai, Marie Kato, Hiroyuki Koshino, Eri Nishizawa, Kana Oonuma, Eisuke Ota, Toru Watanabe, Daisuke Hashizume, Yuki Tamura, Mitsuaki Okada, Taeko Miyagi, and Mikiko Sodeoka (2020)  Ganglioside GM3 Analogues Containing Monofluoromethylene-Linked Sialoside:Synthesis,Stereochemical Effects, Conformational Behavior, and Biological Activities JACS Au. 1 137-146 DOI:10.1021/jacsau.0c00058 PMID:34467279 
Sayaka Imanishi,Takayuki Katoh,Yizhen Yin,Mituhiro Yamada,Marina Kawai,Hiroaki Suga (2020)  In Vitro Selection of Macrocyclic d/l-Hybrid Peptides against Human EGFR Journal of the American Chemical Society. 143 5680-5684 DOI:10.1021/jacs.1c02593 PMID:33822597 
Yutaro Tsubono, Yusuke Kawamoto, Takuya Hidaka, Ganesh N Pandian, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama (2020)  A Near-Infrared Fluorogenic Pyrrole-Imidazole Polyamide Probe for Live-Cell Imaging of Telomeres Journal of the American chemical society. 142 17356-17363 DOI:10.1021/jacs.0c04955 PMID:32955878 
Yohei Matsumoto, Jun Sawamura, Yumi Murata, Takashi Nishikata, Ryo Yazaki, Takashi Ohshima (2020)  Amino Acid Schiff Base Bearing Benzophenone Imine As a Platform for Highly Congested Unnatural α-Amino Acid Synthesis Journal of the American Chemical Society. 142 8498-8505 DOI:10.1021/jacs.0c02707 PMID:32316721 
Wei-Guang Wang, Hang Wang, Lian-Qiong Du, Min Li, Lin Chen, Jian Yu, Gui-Guang Cheng, Meng-Tao Zhan, Qiu-Fen Hu, Lihan Zhang, Min Yao, Yudai Matsuda (2020)  Molecular Basis for the Biosynthesis of an Unusual Chain-Fused Polyketide, Gregatin A, Journal of the American Chemical Society. 142 :18,  8464-8472 DOI:10.1021/jacs.0c02337 PMID:32275405 
Tsukushi Tanaka, Ryo Yazaki, Takashi Ohshima (2020)  Chemoselective Catalytic α-Oxidation of Carboxylic Acids: Iron/Alkali Metal Cooperative Redox Active Catalysis Journal of the American Chemical Society . 142 4517-4524 DOI:10.1021/jacs.0c00727 PMID:32052625 
Juliann Nzembi Makau, Ayako Kitagawa, Kanami Kitamura, Tomoko Yamaguchi, Satoshi Mizuta (2020)  Design and Development of an HBT-Based Ratiometric Fluorescent Probe to Monitor Stress-Induced Premature Senescence ACS Omega. 5 11299-11307 DOI:10.1021/acsomega.9b04208 PMID:32478217 
Ramon Francisco Avena, Lin Qiao, Yuki Fujii, Kohei Otomo, Hirokazu Ishii, Takeyuki Suzuki, Hirofumi Tsujino, Tadayuki Uno, Yasuo Tsutsumi, Yusuke Kawashima, Tatsuya Takagi, Kenichi Murai, Tomoni Nemoto, Mitsuhiro Arisawa (2020)  Absorption, Fluorescence, and Two-photon Excitation Ability of 5-Phenylisolidolo[2,1-a]quinolines ACS Omega. 5 2473-2479 DOI:10.1021/acsomega.9b04070 PMID:32064407 
Yasuhiro Tateishi, Tomoyuki Ohe, Mai Ogawa, Kyoko Takahashi, Shigeo Nakamura, and Tadahiko Mashino (2020)  Development of Novel Diclofenac Analogs Designed to Avoid Metabolic Activation and Hepatocyte Toxicity ACS omega. 5 32608-32616 DOI:10.1021/acsomega.0c04942 PMID:33376898 
Yuto Murakami, Hayato Fukuda,Ryuta Muromoto, Koki Hirashima, KoheiIshimura, Koichi Fujiwara,Jun Ishihara, Tadashi Matsuda, MizukiWatanabe, and Satoshi Shuto  (2020)  Design and Synthesis of Benzene Congeners of ResolvinE2, aProresolving Lipid Mediator, as Its Stable Equivalents ACS medicinal chemistry letters. 11 479-484 DOI:10.1021/acsmedchemlett.9b00596 PMID:32292553 
Kohei Ishimura, Hayato Fukuda, Koichi Fujiwara, Ryuta Muromoto, Koki Hirashima, Yuto Murakami, Mizuki Watanabe, Jun Ishihara, Tadashi Matsuda, and Satoshi Shuto (2020)  Synthesis of Resolvin E1 and Its Conformationally Restricted Cyclopropane Congeners with Potent Anti-Inflammatory Effect ACS medicinal chemistry letters. 12 256-261 DOI:10.1021/acsmedchemlett.0c00639 PMID:33603972 
Takefumi Kuranaga, Mayuri Minote, Ryota Morimoto, Chengqian Pan, Haruka Ogawa, Hideaki Kakeya (2020)  Highly Sensitive Labeling Reagents for Scarce Natural Products ACS Chemical Biology. 15 2499-2506 DOI:10.1021/acschembio.0c00517 PMID:32865386 
Ziyang Zhang, Rong Gao, Qi Hu,Hayden Peacock, D Matthew Peacock, Shizhong Dai, Kevan M Shokat, Hiroaki Suga (2020)  GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf ACS Central Science. 6 1753-1761 DOI:10.1021/acscentsci.0c00514 PMID:33145412 
Mieko Arisawa, Kohei Fukumoto, and Masahiko Yamaguchi (2020)  Rhodium-Catalyzed Oxidation of Unprotected Peptide Thiols to Disulfides with Oxygen in Water ACS Catalysis. 10 15060-15064 DOI:10.1021/acscatal.0c04799
Fumihisa Kobayashi, Masashi Fujita, Takafumi Ide, Yuta Ito, Kenji Yamashita, Hiromichi Egami, and Yoshitaka Hamashima (2020)  Dual-Role Catalysis by Thiobenzoic Acid in C α - H Arylation under Photoirradiation ACS catalysis. 11 82-87 DOI:10.1021/acscatal.0c04722
Yuta Kondo, Tetsuya Kadota, Yoshinobu Hirazawa, Kazuhiro Morisaki, Hiroyuki Morimoto, Takashi Ohshima (2020)  Scandium(III) Triflate Catalyzed Direct Synthesis of N-Unprotected Ketimines Organic Letters. 22 120-125 DOI:10.1021/acs.orglett.9b04038 PMID:31854997 
Hiroaki Shimizu, Kohei Yoshinaga, Satoshi Yokoshima (2020)  Nitrone Formation by Reaction of an Enolate with a Nitro Group Organic Letters. 23 2704-2709 DOI:10.1021/acs.orglett.1c00603 PMID:33724047 
Tsubasa Matsuzawa, Takamitsu Hosoya, Suguru Yoshida (2020)  Transition-Metal-Free Synthesis of N-Arylphenothiazines through an N- and S-Arylation Sequence Organic Letters. 23 :6,  2347-2352 DOI:10.1021/acs.orglett.1c00515 PMID:33667111 
Daiki Takeda, Makoto Yoritate, Hiroki Yasutomi, Suzuka Chiba, Takahiro Moriyama, Atsushi Yokoo, Kazuteru Usui , Go Hirai (2020)  β-Glycosyl Trifluoroborates as Precursors for Direct α-CGlycosylation: Synthesis of 2-Deoxy-α-C-glycosides Organic Letters. 23 1940-1944 DOI:10.1021/acs.orglett.1c00402 PMID:33625241 
Mai Minoshima, Keisuke Uchida, Yu Nakamura, Takamitsu Hosoya, Suguru Yoshida (2020)  Acylalkylation of Arynes Generated from o-Iodoaryl Triflates with Hydrosilanes and Cesium Fluoride Organic Letters. 23 :5,  1868-1873 DOI:10.1021/acs.orglett.1c00279 PMID:33606548 
Akihiro Sugawara, Hirokazu Takada, Tomoyasu Hirose, Aoi Kimishima, Takeshi Yamada, Masaki Toda, Toru Kojima, Takanori Matsumaru, Toshiaki Sunazuka (2020)  Pd-catalyzed Regio- and Stereoselective Hydrostannylation of an Alkyl Ethynyl Ether/One-Pot Stille Coupling Enables the Synthesis of 14-Membered Macrolactone of Luminamicin Alkyl Ethynyl Ether/One-Pot Stille Coupling Enables the Synthesis of 14-Membered M Organic Letters. 23 1758-1763 DOI:10.1021/acs.orglett.1c00183 PMID:33591766 
Mizushi Yanagihara, Kenichi Murai, Naoki Kishimoto, Towa Abe, Shogo Misumi, Mitsuhiro Arisawa (2021)  Total Synthesis and Biological Evaluation of the Potent HIV Latency- Reversing Agent Ansellone A and its Analogues Organic Letters. 23 1720-1725 DOI:10.1021/acs.orglett.1c00151 PMID:33570413 
Tomohiro Kurose, Chihiro Tsukano, Takeshi Nanjo , Yoshiji Takemoto (2020)  Total Synthesis of Lyconesidine B, a Lycopodium Alkaloid with an Oxygenated, Amine-Type Fawcettimine Core Organic Letters. 23 676-681 DOI:10.1021/acs.orglett.0c03816 PMID:33325708 
Kanako Nozawa-Kumada, Takuto Ojima, Moeto Inagi, Masanori Shigeno, Yoshinori Kondo  (2020)  Di- tert-butyl Peroxide (DTBP)-Mediated Oxysilylation of Unsaturated Carboxylic Acids for the Synthesis of Silyl Lactones Organic Letters. 22 9591-9596 DOI:10.1021/acs.orglett.0c03640 PMID:33269934 
Rika Idogawa, Youngchan Kim, Ken Shimomori, Takamitsu Hosoya, Suguru Yoshida (2020)  Single C-F Transformations of o-Hydrosilyl Benzotrifluorides with Trityl Compounds as All-in-One Reagents Organic Letters. 22 :23,  9292-9297 DOI:10.1021/acs.orglett.0c03529 PMID:33180503 
Masanori Shigeno, Kazutoshi Hayashi, Kanako Nozawa-Kumada, Yoshinori Kondo (2020)  Catalytic C(sp2)-C(sp3) Bond Formation of Methoxyarenes by the Organic Superbase t-Bu-P4 Organic Letters. 22 9107-9113 DOI:10.1021/acs.orglett.0c03507 PMID:33175552 
Makoto Yoritate, Yuki Morita, Manuel Gemander, Masaki Morita, Tomohiro Yamashita, Mikiko Sodeoka, and Go Hirai (2020)  Synthesis of DFGH-Ring Derivatives of Physalins via One-Pot Construction of GH-Ring and Evaluation of Their NF-κB-Inhibitory Activity Organic Letters. 22 8877-8881 DOI:10.1021/acs.orglett.0c03255 PMID:33124828 
Yu Nakamura, Yuki Sakata, Takamitsu Hosoya, Suguru Yoshida  (2020)  Synthesis of Functionalized Benzopyran/Coumarin-Derived Aryne Precursors and Their Applications Organic Letters. 22 :21,  8505-8510 DOI:10.1021/acs.orglett.0c03106 PMID:33048552 
Yousuke Yamaoka, Takamori Nakayama, Shota Kawai, Kiyosei Takasu (2020)  Total Synthesis of (-)-Sigillin A: A Polychlorinated and Polyoxygenated Natural Product Organic Letters. 22 7721-7724 DOI:10.1021/acs.orglett.0c02930 PMID:32935991 
Yuto Sumida, Ryu Harada, Tomoe Sumida, Kohei Johmoto, Hidehiro Uekusa, Takamitsu Hosoya  (2020)  Synthesis of Dibenzofurans by Cu-Catalyzed Deborylative Ring Contraction of Dibenzoxaborin Organic Letters. 22 :16,  6687-6691 DOI:10.1021/acs.orglett.0c02584 PMID:32806152 
Toshiki Akiyama, Yuki Wada, Makito Yamada, Yasunori Shio, Tetsuo Honma, Shuhei Shimoda, Kazuki Tsuruta, Yusuke Tamenori, Hitoshi Haneoka, Takeyuki Suzuki, Kazuo Harada, Hayato Tsurugi, Kazushi Mashima, Jun-ya Hasegawa, Yoshihiro Sato, and Mitsuhiro Arisawa (2020)  Self-Assembled Multilayer Iron(0) Nanoparticle Catalyst for Ligand- Free Carbon-Carbon/Carbon-Nitrogen Bond-Forming Reactions Organic Letters. 22 7244-7249 DOI:10.1021/acs.orglett.0c02574 PMID:32903001 
Hiromichi Egami, Ryo Hotta, Minami Otsubo, Taiki Rouno, Tomoki Niwa, Kenji Yamashita, and Yoshitaka Hamashima (2020)  Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst Organic Letters. 22 5656-5660 DOI:10.1021/acs.orglett.0c02026 PMID:32608984 
Yohei Morishita, Yu Aoki, Mei Ito, Daisuke Hagiwara, Kensho Torimaru, Daichi Morita, Teruo Kuroda, Hanako Fukano, Yoshihiko Hoshino, Masato Suzuki, Tohru Taniguchi, Keiji Mori, Teigo Asai  (2020)  Genome Mining-Based Discovery of Fungal Macrolides Modified by Glycosylphosphatidylinositol (GPI)-Ethanolamine Phosphate Transferase Homologues Organic Letters. 22 5876-5879 DOI:10.1021/acs.orglett.0c01975 PMID:32663020 
Jun Hirabayashi, Fumika Yakushiji, Akira Katsuyama, and Satoshi Ichikawa (2020)  Total Synthesis of Acaulide and Acaulone A Organic Letters. 22 5545-5549 DOI:10.1021/acs.orglett.0c01907 PMID:32619097 
Yumi Yamashita, Louna Poignant, Juri Sakata, and Hidetoshi Tokuyama  (2020)  Divergent Total Syntheses of Isobatzellines A/B and Batzelline A Organic Letters. 22 6239-6243 DOI:10.1021/acs.orglett.0c01894 PMID:32623895 
Kenji Watanabe, Nodoka Terao, Isao Kii, Reiko Nakagawa, Takashi Niwa , Takamitsu Hosoya (2020)  Indolizines Enabling Rapid Uncaging of Alcohols and Carboxylic Acids by Red Light-Induced Photooxidation Organic Letters. 22 :14,  5434-5438 DOI:10.1021/acs.orglett.0c01799 PMID:32615768 
Keita Kojima, Fumika Yakushiji, Akira Katsuyama , Satoshi Ichikawa (2020)  Total Synthesis of Echinomycin and Its Analogues Organic Letters. 22 4217-4221 DOI:10.1021/acs.orglett.0c01268 PMID:32379459 
Taro Tsuji, Takafumi Tanaka, Tsukushi Tanaka, Ryo Yazaki, Takashi Ohshima (2020)  Catalytic Aerobic Cross-Dehydrogenative Coupling of Azlactones en Route to α,α-Disubstituted α-Amino Acids Organic Letters. 22 4164-4170 DOI:10.1021/acs.orglett.0c01248 PMID:32396012 
Haruka Murakami, Tomohiro Asakawa, Yoshihiro Muramatsu, Ryo Ishikawa, Aiki Hiza, Yuta Tsukaguchi, Yohei Tokumaru, Masahiro Egi, Makoto Inai, Hitoshi Ouchi, Fumihiko Yoshimura, Tohru Taniguchi, Yoshinobu Ishikawa, Mitsuru Kondo, and Toshiyuki Kan (2020)  Total Synthesis of Sophoraflavanone H and Con firmation of Its Absolute Configuration Organic Letters. 22 3820-3824 DOI:10.1021/acs.orglett.0c01063 PMID:32324417 
Yusuke Miura , Hitoshi Ouchi , Makoto Inai , Taisei Osawa , Fumihiko Yoshimura , Junichiro Kanazawa , Masanobu Uchiyama, Mitsuru Kondo , Toshiyuki Kan (2020)  Synthetic Studies on Pactamycin: A Synthesis of Johnson's Intermediate Organic Letters. 22 3515-3518 DOI:10.1021/acs.orglett.0c00959 PMID:32319784 
Masashi Shimomura, Manabu Sato, Hiroki Azuma, Juri Sakata, Hidetoshi Tokuyama (2020)  Total Synthesis of (-)-Lepadiformine A via Radical Translocation-Cyclization Reaction Organic Letters. 22 3313-3317 DOI:10.1021/acs.orglett.0c00474 PMID:32182082 
Shoutaro Iwase, Yusuke Suzuki, Shinji Tanaka, Masato Kitamura (2020)  CpRu/Br-nsted Acid-Catalyzed Enantioselective Dehydrative Cyclization of Pyrroles N-Tethered with Allylic Alcohols Organic Letters. 22 1929-1933 DOI:10.1021/acs.orglett.0c00290 PMID:32069061 
Takayoshi Nakaoka, Yuta Uetake, Ken-ichi Kaneko, Takashi Niwa, Hidenori Ochiai, Satsuki Irie, Yoshie Suezaki, Natsumi Otsuka, Emi Hayashinaka, Yasuhiro Wada, Yilong Cui, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama, Takamitsu Hosoya, and Yasuyoshi Watanabe (2020)  Practical Synthesis of [18F]Pitavastatin and Evaluation of Hepatobiliary Transport Activity in Rats by Positron Emission Tomography Molecular Pharmaceutics. 17 :6,  1884-1898 DOI:10.1021/acs.molpharmaceut.9b01284 PMID:32271581 
Nobuaki Takahashi, Kensuke Kaneko, Hideaki Kakeya (2020)  Total Synthesis and Antimicrobial Activity of Tumescenamide C and Its Derivatives The Journal of Organic Chemistry. 85 4530-4535 DOI:10.1021/acs.joc.9b03516 PMID:32067449 
Takashi Ikawa, JingKai Sun, Akira Takagi, Shuji Akai (2020)  One-Pot Generation of Functionalized Benzynes from Readily Available 2-Hydroxyphenylboronic Acids The Journal of Organic Chemistry. 85 3383-3392 DOI:10.1021/acs.joc.9b03169 PMID:32013426 
Takuya Kobayakawa, Chika Azuma, Yuki Watanabe, Shunsuke Sawamura, Atsuhiko Taniguchi, Yoshio Hayashi, Kohei Tsuji, Hirokazu Tamamura (2020)  Development of Methods for Convergent Synthesis of Chloroalkene Dipeptide Isosteres and Its Application The journal of organic chemisty. 86 :7,  5091-5101 DOI:10.1021/acs.joc.0c03019 PMID:33734682 
Chengqian Pan, Takefumi Kuranaga, Xun Cao, Takehiro Suzuki, Naoshi Dohmae, Naoya Shinzato, Hiroyasu Onaka, Hideaki Kakeya (2021)  Amycolapeptins A and B, cyclic nonadepsipeptides produced by combined-culture of Amicolatopsis sp. and Tsukamurella pulmonis. The Journal of Organic Chemistry.. 86 1843-1849 DOI:10.1021/acs.joc.0c02660 PMID:33410699 
Yoshihiko Yamamoto, Motoji Sakai, Yuki Ishida, Takeshi Yasui (2020)  Synthesis of 1_(Difluoromethyl)alk-1-enes via Palladium-Catalyzed SN2'-Type Substitution Reaction of Difluoromethylated Allylic Phosphates with 1,3-Dicarbonyl Compounds and Imides The Journal of Organic chemistry. 86 1053-1064 DOI:10.1021/acs.joc.0c02538 PMID:33253567 
Motoyuki Isoda, Yuta Uetake, Tadashi Takimoto, Junpei Tsuda, Takamitsu Hosoya, and Takashi Niwa (2021)  Convergent Synthesis of Fluoroalkenes Using a Dual-Reactive Unit The journal of organic chemisty. 86 :2,  1622-1632 DOI:10.1021/acs.joc.0c02474 PMID:33400531 
Hayato Fukuda, Hiroyuki Ikeda, Ryuta Muromoto, Koki Hirashima, Kohei Ishimura, Koichi Fujiwara, Haruka Aoki-Saito, Takeshi Hisada, Mizuki Watanabe, Jun Ishihara, Tadashi Matsuda, Satoshi Shuto (2020)  Synthesis of Resolvin E3, a Proresolving Lipid Mediator,and Its Deoxy Derivatives: Identification of 18-DeoxyresolvinE3 as a Potent Anti-inflammatory Agent The Journal of Organic chemistry. 85 14190-14200 DOI:10.1021/acs.joc.0c01701 PMID:32942849 
Miyuki Yamaguchi, Ryoya Hagiwara, Kanami Gayama, Kohei Suzuki, Yusuke Sato, Hideyuki Konishi, and Kei Manabe (2020)  Direct C3-Selective Arylation of N-Unsubstituted Indoles with Aryl Chlorides, Triflates, and Nonaflates Using a Palladium-Dihydroxyterphenylphosphine Catalyst The Journal of Organic chemistry. 85 10902-10912 DOI:10.1021/acs.joc.0c01494 PMID:32806091 
Jiawei Qiu, Shohei Ohno, Tsuyoshi Matsuzaki, Takeyuki Suzuki, Kenichi Murai, Mitsuhiro Arisawa (2020)  Iridium-Catalyzed Intramolecular Cycloisomerization between Functionalized Alkyne with Aryl Vinyl Ether: Synthesis of 2-Vinyl-3-Functionalized Methyl-Benzofurans The Journal of Organic Chemistry. 85 10198-10205 DOI:10.1021/acs.joc.0c00954 PMID:32578432 
Shohei Ohno, and Mitsuhiro Arisawa (2020)  Cyclizations of benzo-fused substrates involving two multiple bonds, including heteroatom-substituted unsaturated bond The Journal of Organic Chemistry. 85 6831-6843 DOI:10.1021/acs.joc.0c00452 PMID:32294383 
Tsuneyuki Kobayashi, Takamitsu Hosoya, Suguru Yoshida (2020)  Consecutive Aryne Generation Strategy for the Synthesis of 1,3-Diarylpyrazoles The Journal of Organic Chemistry. 85 :6,  4448-4462 DOI:10.1021/acs.joc.0c00172 PMID:32027500 
Hitoshi Ouchi, Takuya Namiki, Kenji Iwamoto, Nobuo Matsuzaki, Makoto Inai, Mihaya Kotajima, Jing Wu, Jae-Hoon Choi, Yoko Kimura, Hirofumi Hirai, Xiaonan Xie, Hirokazu Kawagishi, Toshiyuki Kan (2020)  S-Adenosylhomocysteine Analogue of a Fairy Chemical, Imidazole4-carboxamide, as its Metabolite in Rice and Yeast and SyntheticInvestigations of Related Compounds Journal of Natural products. 84 453-458 DOI:10.1021/acs.jnatprod.0c01269 PMID:33480692 
Xi Jiang, Ashutosh Kumar, Yasutaka Motomura, Tian Liu, Yong Zhou, Kazuyo Moro, Kam Y. J. Zhang, Qing Yang (2020)  A series of compounds bearing a dipyrido-pyrimidine scaffold acting as novel human and insect pest chitinases inhibitors Journal of Medicinal Chemistry. 63 :3,  987-1001 DOI:10.1021/acs.jmedchem.9b01154 PMID:31928006 
Harue Sasaki, Hiroyuki Masuno, Haru Kawasaki, Ayana Yoshihara, Nobutaka Numoto, Nobutoshi Ito, Hiroaki Ishida, Keiko Yamamoto, Naoya Hirata, Yasunari Kanda, Emiko Kawachi, Hiroyuki Kagechika, and Aya Tanatani (2020)  Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists Journal of Medicinal Chemistry. 64 :1,  516-526 DOI:10.1021/acs.jmedchem.0c01420 PMID:33369416 
Takuya Uto, Yuki Ikeda, Naoki Sunagawa, Kenji Tajima, Min Yao, Toshifumi Yui (2021)  Molecular dynamics simulation of cellulose synthase subunit D octamer with cellulose chains from acetic acid bacteria: Insight into dynamic behaviors and thermodynamics on substrate recognition Journal of Chemical Theory and Computation. 17 :1,  488-496 DOI:10.1021/acs.jctc.0c01027 PMID:33382615 
Junichi Higo , Takeshi Kawabata , Ayumi Kusaka , Kota Kasahara , Narutoshi Kamiya , Ikuo Fukuda , Kentaro Mori , Yutaka Hata , Yoshifumi Fukunishi , Haruki Nakamura  (2020)  Molecular Interaction Mechanism of a 14-3-3 Protein with a Phosphorylated Peptide Elucidated by Enhanced Conformational Sampling Journal of Chemical Information and Modeling. 60 4867-4880 DOI:10.1021/acs.jcim.0c00551 PMID:32910853 
Kazuki Akisawa, Ryo Hatada, Koji Okuwaki, Yuji Mochizuki, Kaori Fukuzawa, Yuto Komeiji, Shigenori Tanaka (2020)  Fragment Molecular Orbital Based Interaction Analyses on COVID-19 Main Protease -Inhibitor N3 Complex (PDB ID: 6LU7) Journal of chemical information and modeling. 60 3593-3602 DOI:10.1021/acs.jcim.0c00283 PMID:32539372 
Koichiro Kato, Tomohide Masuda, Chiduru Watanabe, Naoki Miyagawa, Hideo Mizouchi, Shumpei Nagase, Kikuko Kamisaka, Kanji Oshima, Satoshi Ono, Hiroshi Ueda, Atsushi Tokuhisa, Ryo Kanada, Masateru Ohta, Mitsunori Ikeguchi, Yasushi Okuno, Kaori Fukuzawa, Teruki Honma (2020)  High-precision Atomic Charge Prediction for Protein Systems Using Fragment Molecular Orbital Calculation and Machine Learning Journal of Chemical Information and Modeling . 60 3361-3368 DOI:10.1021/acs.jcim.0c00273 PMID:32496771 
Assen Marintchev, Takuhiro Ito (2020)  eIF2B and the Integrated Stress Response: A Structural and Mechanistic View Biochemistry. 59 :13,  1299-1308 DOI:10.1021/acs.biochem.0c00132 PMID:32200625 
Takashi Moriwaki, Satoshi Abe, Mitsuo Oshimura, Yasuhiro Kazuki (2020)  Transchromosomic technology for genomically humanized animals Experimental Cell Research. 390 :2,  111914- DOI:10.1016/j.yexcr.2020.111914 PMID:32142854 
Bart Buijsse, Piet Trompenaars, Veli Altin, Radostin Danev, Robert M Glaeser  (2020)  Spectral DQE of the Volta phase plate Ultramicroscopy. 218 113079- DOI:10.1016/j.ultramic.2020.113079 PMID:32739753 
Motoyoshi Ohara, Akari Ikeda, Asuka Nakajima, Takanori Ono, Yoshihiko Noguchi, Akito Watanabe, Tomoyasu Hirose, Toshiaki Sunazuka Noguchi, Akito Watanabe, Tomoyasu Hirose, Sunazuka (2020)  Towards the total synthesis of aurodox: preparation of the key hemiacetal-lactone Tetrahedron Letters. 66 152799- DOI:10.1016/j.tetlet.2020.152799
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Afifa Ayu Koesoema, Daron M. Standley, Kotchakorn T.sriwong, Mayumi Tamura, Tomoko Matsuda (2020)  Access to both enantiomers of substituted 2-tetralol analogs by a highly enantioselective reductase. Tetrahedron Letters. 61 :13,  15168210- DOI:10.1016/j.tetlet.2020.151682
Atsushi Kimishim, Hayato Saito, Ayuta Yamaguchi, Masayoshi Arai (2020)  A stereoselective construction of a cis-1,2-oxazadecaline skeleton using a substrate-controlled intramolecular oxy-Michael addition of tyrosine-derived hydroxylamines. Tetrahedron Letters . 61 151412- DOI:10.1016/j.tetlet.2019.151412
Atsushi Umehara, Hirofumi Ueda, Hidetoshi Tokuyama (2020)  Synthesis of leuconoxine, leuconodine B, and rhazinilam by transformation of melodinine E via 6-hydro-21-dehydroxyleuconolam Tetrahedron. 79 131809-131813 DOI:10.1016/j.tet.2020.131809
Hideyuki Konishi, Minoru Kumon, Miyuki Yamaguchi, Kei Manabe (2020)  Palladium-catalyzed external-CO-free reductive carbonylation of aryl sulfonates Tetrahedron. 76 DOI:10.1016/j.tet.2020.131639
Kanato Umeki, Yusuke Ueda, Juri Sakata, Hidetoshi Tokuyama (2020)  Total syntheses of (-)-emestrin H and (-)-asteroxepin Tetrahedron. 76 131630-131640 DOI:10.1016/j.tet.2020.131630
Melissa Carrillo, Suraj Pandey, Juan Sanchez, Moraima Noda, Ishwor Poudyal, Luis Aldama, Tek Narsingh Malla, Elin Claesson, Weixiao Yuan Wahlgren, Denisse Feliz, Vukica Srajer, Michal Maj, Leticia Castillon, So Iwata, Eriko Nango, Rie Tanaka, Tomoyuki Tanaka, Luo Fangjia, Kensuke Tono, Shigeki Owada, Sebastian Westenhoff, Emina A Stojkovic, Marius Schmidt  (2021)  High-resolution crystal structures of transient intermediates in the phytochrome photocycle Structure. 29 :7,  743-754 DOI:10.1016/j.str.2021.03.004 PMID:33756101 
Hidetoshi Kono, Hisashi Ishida (2020)  Nucleosome unwrapping and unstacking Current Opinion in Structural Biology. 64 119-125 DOI:10.1016/j.sbi.2020.06.020 PMID:32738677 
Atsunori Oshima (2020)  Structural insights into gap junction channels boosted by cryo-EM Current Opinion in Structural Biology. 63 42-48 DOI:10.1016/j.sbi.2020.03.008 PMID:32339861 
Tomoya Kujirai, Hitoshi Kurumizaka (2020)  Transcription through the nucleosome Current Opinion in Structural Biology . 61 42-49 DOI:10.1016/j.sbi.2019.10.007 PMID:31790919 
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Hiroki Kusaka, Shunsuke Kita, Takashi Tadokoro, Kouki Yoshida, Yoshiyuki Kasai, Harumi Niiyama, Yukari Fujimoto, Shinya Hanashima, Michio Murata, Shigeru Sugiyama, Toyoyuki Ose, Kimiko Kuroki, Katsumi Maenaka (2020)  Efficient preparation of human and mouse CD1d proteins using silkworm baculovirus expression system Protein Expression and Purification. 172 DOI:10.1016/j.pep.2020.105631 PMID:32213313 
Kohei Nakajima, Mikako Ogawa (2020)  Phototoxicity in near-infrared photoimmunotherapy is influenced by the subcellular localization of antibody-IR700 Photodiagnosis and Photodynamic Therapy. 31 DOI:10.1016/j.pdpdt.2020.101926 PMID:32717450 
Moe Ichikawa, Ryosuke Negoro, Kanae Kawai, Tomoki Yamashita, Kazuo Takayama, Hiroyuki Mizuguchi (2021)  Vinblastine treatment decreases the undifferentiated cell contamination of human iPS cell-derived intestinal epithelial-like cells Molecular Therapy: Methods & Clinical Development. 20 463-472 DOI:10.1016/j.omtm.2021.01.005 PMID:33614822 
Yuri Inose, Yasuhiko Izumi, Yuki Takada-Takatori, Akinori Akaike, Yutaka Koyama, Shuji Kaneko, Toshiaki Kume (2020)  Protective effects of Nrf2-ARE activator on dopaminergic neuronal loss in Parkinson disease model mice: Possible involvement of heme oxygenase-1 Neuroscience Letters. 736 DOI:10.1016/j.neulet.2020.135268 PMID:32712353 
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Naozumi Kondo, Hiromu Iwasaki, Toshiyuki Tokiwa, Satoshi Omura, Kenichi Nonaka (2020)  Simplicillium spumae (Cordycipitaceae, Hypocreales), a new hyphomycetes from aquarium foam in Japan Micoscience. 61 116-121 DOI:10.1016/j.myc.2020.02.002
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Alisa F Zyryanova, Kazuhiro Kashiwagi, Claudia Rato, Heather P Harding, Ana Crespillo-Casado, Luke A Perera, Ayako Sakamoto, Madoka Nishimoto, Mayumi Yonemochi, Mikako Shirouzu, Takuhiro Ito, David Ron (2021)  ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B Molecular Cell. 81 :1,  88-103 DOI:10.1016/j.molcel.2020.10.031 PMID:33220178 
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Kengo Hirao, Sophie Andrews, Kimiko Kuroki, Hiroki Kusaka, Takashi Tadokoro, Shunsuke Kita, Toyoyuki Ose, Sarah L. Rowland-Jones, and Katsumi Maenaka (2020)  Structure of HIV-2 Nef Reveals Features Distinct from HIV-1 Involved in Immune Regulation iScience.. 23 100758- DOI:10.1016/j.isci.2019.100758 PMID:31927483 
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Haruka Takeuchi, Shinsuke Inuki, Kohei Nakagawa, Takaaki Kawabe, Atsuhiko Ichimura, Shinya Oishi, Hiroaki Ohno  (2020)  Total Synthesis of Zephycarinatines via Photocatalytic Reductive Radical ipso-Cyclization. Angewandte Chemie International Edition. 59 21210-21215 DOI:10.1002/anie.202009399 PMID:32770565 
Keigo Murakami, Tatsuya Toma, Tohru Fukuyama, Satoshi Yokoshima (2020)  Total Synthesis of Tetrodotoxin Angewandte Chemie. 59 6253-6257 DOI:10.1002/ange.201916611 PMID:31985136 
Yoshiji Takemoto, Hiroki Murakami, Ayano Yamada, and Kenichi Michigami (2020)  Novel Aza-Michael Addition-Asymmetric Protonation to α,β- Unsaturated Carboxylic Acids with Chiral Thiourea-Boronic Acid Hybrid Catalysts Asian journal of organic chemistry. 10 1097-1101 DOI:10.1002/ajoc.202100145
Mieko Arisawa, Ren Suzuki, Keiichiro Ohashi, and Masahiko Yamaguchi (2020)  Rhodium‐Catalyzed Synthesis of Heteroarylselenyl Esters from Diheteroaryl Diselenides and Acid Fluorides Asian Journal of Organic Chemistry. 9 553-556 DOI:10.1002/ajoc.202000077
Tatsuki Utsumi,Kenta Noda,Daichi Kawauchi,Hirofumi Ueda,Hidetoshi Tokuyama (2020)  Nitrile Synthesis by Aerobic Oxidation of Primary Amines and in situ Generated Imines from Aldehydes and Ammonium Salt with Grubbs Catalyst Advanced Synthesis & Catalysis. 362 3583-3588 DOI:10.1002/adsc.202000663
Chandrika N Deshpande, Corbin R Azucenas, Bo Qiao, Norimichi Nomura, Vicky Xin, Josep Font, So Iwata, Tomas Ganz, Elizabeta Nemeth, Bryan Mackenzie, Mika Jormakka (2020)  Isolation and thermal stabilization of mouse ferroportin FEBS Open Bio.. 11 :1,  26-34 DOI:10.1002/2211-5463.13039 PMID:33190422 

BINDSの支援を受けた研究成果(論文)

Ayaka Sugeno, Wenhui Piao, Miki Yamazaki, Kiyofumi Takahashi, Koji Arikawa, Hiroko Matsunaga, Masahito Hosokawa, Daisuke Tominaga, Yoshio Goshima, Haruko Takeyama, Toshio Ohshima (2020)  Cortical transcriptome analysis after spinal cord injury reveals the regenerative mechanism of central nervous system in CRMP2 knock-in mice neural regeneration reserch. 16 :7,  1258-1265 DOI:10.4103/1673-5374.301035 PMID:33318403 
Shuangshuang Jiang, Hiromi Tanji, Kejun Yin, Shuting Zhang, Kentaro Sakaniwa, Jian Huang, Yi Yang, Jing Li, Umeharu Ohto, Toshiyuki Shimizu, Hang Yin (2020)  Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface J. Med. Chem. 63 :8,  4117-4132 DOI:10.1021/acs.jmedchem.9b02128 PMID:32233366 
Mamiko Masutani,Shunya Sakurai,Toshiyuki Shimizu,Umeharu Ohto (2020)  Crystal structure of TEX101, a glycoprotein essential for male fertility, reveals the presence of tandemly arranged Ly6/uPAR domains FEBS Lett. 594 :18,  3020-3031 DOI:10.1002/1873-3468.13875 PMID:32608065 
Shunya Sakurai Toshiyuki Shimizu, Umeharu Ohtoa (2020)  Crystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases Acta Crystallogr F Struct Biol Commun. 76 :8,  326-333 DOI:10.1107/S2053230X20009012 PMID:32744243 
Teratani, T, Tomita, K, Toma-Fukai, S, Nakamura, Y, Itoh, T, Shimizu, H, Shiraishi, Y, Sugihara, N, Higashiyama M, Shimizu, T, Inoue, I, Takenaka, Y, Hokari, R, Adachi, T, Shimizu, Miura, S, Kanai, T (2020)  Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling Free Radic Biol Med. 156 45-56 DOI:10.1016/j.freeradbiomed.2020.06.005 PMID:32553752 
Kubota M, Hashiguchi T (2020)  Large-Scale Expression and Purification of Mumps Virus Hemagglutinin-Neuraminidase for Structural Analyses and Glycan-Binding Assays Method Mol Biol.. 2132 641-652 DOI:10.1007/978-1-0716-0430-4_55 PMID:32306363 
Yuko Takagi, Naoyuki Kuwabara, Truong Tat Dang, Koji Furukawa, C Kiong Ho (2020)  Crystal structures of the RNA triphosphatase from Trypanosoma cruzi provide insights into how it recognizes the 59-end of the RNA substrate J Biol Chem. 295 :27,  9076-9086 DOI:10.1074/jbc.RA119.011811 PMID:32381506 
宮地弘幸 (2020)  低分子医薬品今昔 化学と教育. 68 :7,  282-285 DOI:10.20665/kakyoshi.68.7_282
宮地 弘幸, 安田 公助, 金光 佳世子, 榑林 陽一 (2021)  アカデミア創薬Hit to Lead支援の最前線:東京大学創薬機構構造展開ユニットのあゆみ MEDCHEM NEWS. 31 :1,  13-16 DOI:10.14894/medchem.31.1_13
Takuya Yoshida, Hiroya Oki, Michihiro Doi, Syohei Fukuda, Tomohiro Yuzuriha, Ryotaro Tabata, Kenji Ishimoto, Kazuki Kawahara, Tadayasu Ohkubo, Hiroyuki Miyachi, Takefumi Doi, Keisuke Tachibana (2020)  Structural Basis for PPARα Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives Scientific Reports. 10 :1,  7623- DOI:10.1038/s41598-020-64527-x PMID:32376995 
Hidaka Haga, Ryo Yamada, Hisanao Izumi, Yasuharu Shinoda, Ichiro Kawahata, Hiroyuki Miyachi, Kohji Fukunaga (2020)  Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice Pharmacol. Biochem. Behav.. 191 172891- DOI:10.1016/j.pbb.2020.172891 PMID:32126223 
Yasuharu Shinoda, Yifei Wang, Tetsunori Yamamoto, Hiroyuki Miyachi, Kohji Fukunaga (2020)  Analysis of binding affinity and docking of novel fatty acid-?binding protein (FABP) ligands Journal of Pharmacological Sciences. 143 :4,  264-271 DOI:10.1016/j.jphs.2020.05.005 PMID:32499096 
Yamato Sajiki, Satoru Konnai, Tomohiro Okagawa, Naoya Maekawa, Hayato Nakamura, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, and Kazuhiko Ohashi (2021)  A TLR7 agonist activates bovine Th1 response and exerts antiviral activity against bovine leukemia virus Developmental & Comparative Immunology. 114 103847- DOI:10.1016/j.dci.2020.103847 PMID:32888966 
Masahiko Okuda, Toru Ekimoto, Jun-Ichi Kurita, Mitsunori Ikeguchi, Yoshifumi Nishimura (2021)  Structural and dynamical insights into the PH domain of p62 in human TFIIH Nucleic Acids Research. 49 :5,  2916-2930 DOI:10.1093/nar/gkaa1045 PMID:33211877 
Kenta Echigoya, Masako Koyama, Lumi Negishi, Yoshimasa Takizawa, Yuka Mizukami, Hideki Shimabayashi, Akari Kuroda, Hitoshi Kurumizaka (2020)  Nucleosome binding by the pioneer transcription factor OCT4 Scientific Reports. 10 :1,  11832- DOI:10.1038/s41598-020-68850-1 PMID:32678275 
Tomoya Kujirai, Christian Zierhut, Yoshimasa Takizawa, Ryan Kim, Lumi Negishi, Nobuki Uruma, Seiya Hirai, Hironori Funabiki, Hitoshi Kurumizaka  (2020)  Structural basis for the inhibition of cGAS by nucleosomes Science. 370 :6515,  455-458 DOI:10.1126/science.abd0237 PMID:32912999 
Hisashi Yoshida, Sam-Yong Park, Gyosuke Sakashita, Yuko Nariai, Kanako Kuwasako, Yutaka Muto, Takeshi Urano, Eiji Obayashi  (2020)  Elucidation of the aberrant 3′splice site selection by cancer-associated mutations on the U2AF1 Nature Communications. 11 :1,  4744- DOI:10.1038/s41467-020-18559-6 PMID:32958768 
Hiroki Tanaka, Yoshimasa Takizawa, Motoki Takaku, Daiki Kato, Yusuke Kumagawa, Sara A Grimm, Paul A Wade, Hitoshi Kurumizaka (2020)  Interaction of the pioneer transcription factor GATA3 with nucleosomes Nature Communications. 11 :1,  4136- DOI:10.1038/s41467-020-17959-y PMID:32811816 
Tomoko Yamaguchi, Shoko Toma, Naoya Terahara, Tomoko Miyata, Masamichi Ashihara, Tohru Minamino, Keiichi Namba, Takayuki Kato (2020)  Structural and Functional Comparison of Salmonella Flagellar Filaments Composed of FljB and FliC Biomolecules. 10 :2,  246- DOI:10.3390/biom10020246 PMID:32041169 
Masahiko Okuda and Yoshifumi Nishimura  (2020)  The Eaf3 chromodomain acts as a pH sensor for gene expression by altering its binding affinity for histone methylated-lysine residues. Bioscience Reports . 40 :2,  DOI:10.1042/BSR20191958 PMID:32031206 
Keiichi Namba (2020)  A proposed gear mechanism for torque generation in the flagellar motor. Nature structural & molecular biology . 27 :11,  1004-1006 DOI:10.1038/s41594-020-00514-0 PMID:32958949 
Yasuo Tsunaka, Hideaki Ohtomo, Kosuke Morikawa, Yoshifumi Nishimura (2020)  Partial replacement of nucleosomal DNA with human FACT induces dynamic exposure and acetylation of histone H3 N-terminal tails iScience. 23 :10,  101641- DOI:10.1016/j.isci.2020.101641 PMID:33103079 
Satoshi Murakami, Ui Okada, Hendrik W. van Veen (2020)  Tripartite transporters as mechano‐transmitters in periplasmic alternating‐access mechanisms FEBS Letters. 594 :23,  3908-3919 DOI:10.1002/1873-3468.13929 PMID:32936941  
Shuichi Otani, Shohei Miki, Yuta Nakamura, Kenji Ishimoto, Yukio Ago, Shinsaku Nakagawa. (2020)  Improved Bioavailability of b-Carotene by Amorphous Solid Dispersion Te66chnology in Rats. Jouranal of nutritional science and vitaminology. 2 :66,  207-210 DOI:10.3177/jnsv.66.207 PMID:32350183 
Cheng-Han Ho, Yoshimasa Takizawa, Wataru Kobayashi, Yasuhiro Arimura, Hiroshi Kimura, Hitoshi Kurumizaka (2020)  Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase Life Science alliance. 4 :4,  e202000919- DOI:10.26508/lsa.202000919 PMID:33574035 
Hiroshi Iijima, Katsuki Takebe, Mamoru Suzuki, Hiroko Kobayashi, TomokoTakamiya, Hiroaki Saito, Norio Niwa, and Takao Kuwada-Kusunose (2020)  Crystal Structure of Catechol O-Methyltransferase Complexed with Nitecapone Chemical and Pharmaceutical Bulletin. 5 :68,  447-451 DOI:10.1248/cpb.c20-00011 PMID:32378542 
Yuto Shiraishi, Keisuke Koga, Ryo Yamagata, Izuho Hatada, Miho Shiratori-Hayashi, Makoto Tsuda (2020)  α1A-adrenaline receptors in dorsal horn inhibitory neurons have an inhibitory role in the regulation of chloroquine-induced itch in mice Molecular Brain. 1 :14,  55- DOI:10.1186/s13041-021-00768-9 PMID:33726812 
Hisako Sugimoto, Takuro Horii, Jun-Na Hirota, Yoshitake Sano, Yo Shinoda, Ayumu Konno, Hirokazu Hirai, Yasuki Ishizaki, Hajime Hirase, Izuho Hatada, Teiichi Furuichi, Tetsushi Sadakata (2020)  The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL afects the cerebellum in mice Molecular brain. 1 :14,  52- DOI:10.1186/s13041-021-00766-x PMID:33712038 
Masayuki Miyake, Tohru Terada, Michiko Shimokawa, Naohisa Sugimoto, Takatoshi Arakawa, Kentaro Shimizu, Kiyohiko Igarashi, Kiyotaka Fujita, Shinya Fushinobu (2020)  Structural analysis of β-L-arabinobiose-binding protein in the metabolic pathway of hydroxyproline-rich glycoproteins in Bifidobacterium longum The FEBS Journal. 23 :287,  5114-5129 DOI:10.1111/febs.15315 PMID:32246585 
Sho Ito and Tatsuya Nishino (2020)  Structural analysis of the chicken FANCM-MHF complex and its stability Acta Crystallographica Section F, Structural bilogy of commuinications. :77,  1-7 DOI:10.1107/S2053230X20016003 PMID:33439149 
Takuya Yoshizawa, Junso Fujita, Haruna Terakado, Mayuki Ozawa, Natsuko Kuroda, Shun Ichi Tanaka, Ryo Uehara, Hiroyoshi Matsumura (2020)  Crystal structures of the cell-division protein FtsZ from Klebsiella pneumoniae and Escherichia coli Acta Crystallographica Section F, Structural Biology Communications. :76,  86-93 DOI:10.1107/S2053230X2000076X PMID:32039890 
Hongjie Li, Yoshiki Nakajima, Takashi Nomura, Michihiro Sugahara, Shinichiro Yonekura, Siu Kit Chan, Takanori Nakane, Takahiro Yamane, Yasufumi Umena, Mamoru Suzuki, Tetsuya Masuda, Taiki Motomura, Hisashi Naitow,c Yoshinori Matsuura,c Tetsunari Kimura,g Kensuke Tono,c,h Shigeki Owada,c,h Yasumasa Joti,c,h Rie Tanaka,c,i Eriko Nango,c,j Fusamichi Akita,a,k Minoru Kubo,b,c So Iwata,c,i Jian-Ren Shena and Michihiro Suga (2020)  Capturing structural changes of the S1 to S2 transition of photosystem II using time-resolved serial femtosecond crystallography IUCrJ. :8,  431-443 DOI:10.1107/S2052252521002177 PMID:33953929 
Yuya Sasajima, Takayuki Kato, Tomoko Miyata, Keiichi Namba, Makoto Miyata (2020)  Elucidation of fibril structure responsible for swimming in 3 Spiroplasma using electron microscopy bioRxiv. DOI:10.1101/2021.02.24.432793
Shogo Matsumoto, Shotaro Uehara, Hidetaka Kamimura, Hiroshi Ikeda, Satoshi Maeda, Machiko Hattori, Megumi Nishiwaki, Kazuhiko Kato, Hiroshi Yamazaki (2020)  Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped for P450 2C19 Xenobiotica. 4 :51,  479-493 DOI:10.1080/00498254.2020.1871113 PMID:33455494 
Misaki Ishii, Makoto Nakakido, Jose M M Caaveiro, Daisuke Kuroda, C J Okumura, Toshiaki Maruyama, Kevin Entzminger, Kouhei Tsumoto (2020)  Structural Basis for Antigen Recognition by Methylated Lysine Specific Antibodies The Journal of biological chemistry. :296,  100176- DOI:10.1074/jbc.RA120.015996 PMID:33303630 
Yasunori Watanabe, Yasushi Tamura, Chika Kakuta, Seiya Watanabe and Toshiya Endo  (2020)  Structural basis for interorganelle phospholipid transport mediated by VAT-1 The Journal of Biological Chemistry. 10 :295,  3257-3268 DOI:10.1074/jbc.RA119.011019 PMID:32005660 
Simon Miller, Ashutosh Srivastava, Yoshiko Nagai, Yoshiki Aikawa, Florence Tama, Tsuyoshi Hirota  (2021)  Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation Proceedings of the National Academy of Sciences of the United States of America. 26 :118,  e2026191118- DOI:10.1073/pnas.2026191118 PMID:34172584 
Yohta Fukuda, Yu Hirano, Katsuhiro Kusaka, Tsuyoshi Inoue, Taro Tamada (2020)  High-resolution neutron crystallography visualizes an OH-bound resting state of a copper-containing nitrite reductase. Proceedings of the National Academy of Sciences of the United States of America. 8 :117,  4071-4077 DOI:10.1073/pnas.1918125117 PMID:32041886 
Orkun Coruh, Anna Frank, Hideaki Tanaka, Akihiro Kawamoto, Eithar El-Mohsnawy, Takayuki Kato, Keiichi Namba, Christoph Gerle, Marc M Nowaczyk, Genji Kurisu (2021)  Cryo-EM structure of a functional monomeric Photosystem I from Thermosynechococcus elongatus reveals red chlorophyll cluster. Communications biology. 1 :4,  304- DOI:10.1038/s42003-021-01808-9 PMID:33686186 
Ryoki Nakamura, Tomohiro Numata, Go Kasuya, Takeshi Yokoyama, Tomohiro Nishizawa, Tsukasa Kusakizako, Takafumi Kato, Tatsuya Hagino, Naoshi Dohmae, Masato Inoue, Kengo Watanabe, Hidenori Ichijo, Masahide Kikkawa, Mikako Shirouzu, Thomas J Jentsch, Ryuichiro Ishitani, Yasunobu Okada, Osamu Nureki (2020)  Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation Communications Biology. 1 :3,  240- DOI:10.1038/s42003-020-0951-z PMID:32415200 
Hiroto Shimada, Tsukasa Kusakizako, T. H. Dung Nguyen, Tomohiro Nishizawa, Tomoya Hino, Makoto Tominaga & Osamu Nureki (2020)  The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism Nature structural & molecular biology. 7 :27,  645-652 DOI:10.1038/s41594-020-0439-z PMID:32572254 
Yuta Kohro, Tsuyoshi Matsuda, Kohei Yoshihara, Keita Kohno, Keisuke Koga, Ryuichi Katsuragi, Takaaki Oka, Ryoichi Tashima, Sho Muneta, Takuya Yamane, Shota Okada, Kazuya Momokino, Aogu Furusho, Kenji Hamase, Takumi Oti, Hirotaka Sakamoto, Kenichiro Hayashida,Rosuke Kobayashi, Takuro Horii, Izuho Hatada, Hidetoshi Tozaki-Saitoh, Katsuhiko Mikoshiba, Verdon Taylor, Kazuhide Inoue, Makoto Tsuda (2020)  Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity Nature Neuroscience. 11 :23,  1376-1387 DOI:10.1038/s41593-020-00713-4 PMID:33020652 
Shinya Tanaka, Wataru Ise, Takeshi Inoue, Ayako Ito, Chisato Ono, Yoshihito Shima, Shuhei Sakakibara, Manabu Nakayama, Kentaro Fujii, Ikuo Miura, Jafar Sharif, Haruhiko Koseki, Pandelakis A Koni, Indu Raman, Quan-Zhen Li, Masato Kubo, Katsunori Fujiki, Ryuichiro Nakato, Katsuhiko Shirahige, Hiromitsu Araki, Fumihito Miura, Takashi Ito, Eiryo Kawakami, Yoshihiro Baba, Tomohiro Kurosaki (2020)  Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity Nature immunology. 8 :21,  950-961 DOI:10.1038/s41590-020-0700-y PMID:32572241 
Rina C Sakata, Soh Ishiguro, Hideto Mori, Mamoru Tanaka, Kenji Tatsuno, Hiroki Ueda, Shogo Yamamoto, Motoaki Seki, Nanami Masuyama, Keiji Nishida, Hiroshi Nishimasu, Kazuharu Arakawa, Akihiko Kondo, Osamu Nureki, Masaru Tomita, Hiroyuki Aburatani, Nozomu Yachie  (2020)  Base Editors for Simultaneous Introduction of C-to-T and A-to-G Mutations Nature Biotechnology. 7 :38,  865-869 DOI:10.1038/s41587-020-0509-0 PMID:32483365 
Hirotake Furihata, Satoshi Yamanaka, Toshiaki Honda, Yumiko Miyauchi, Atsuko Asano, Norio Shibata, Masaru Tanokura, Tatsuya Sawasaki, Takuya Miyakawa (2020)  Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide Nature communications. 1 :11,  4578- DOI:10.1038/s41467-020-18488-4 PMID:32929090 
Norimasa Iwanami, Divine-Fondzenyuy Lawir, Katarzyna Sikora, Connor O Meara, Kohei Takeshita, Michael Schorpp, Thomas Boehm (2020)  Transgenerational inheritance of impaired larval Tcell development in zebrafish Nature communications. 1 :11,  4505- DOI:10.1038/s41467-020-18289-9 PMID:32908148 
Yuki Shiimura, Shoichiro Horita, Akie Hamamoto, Hidetsugu Asada, Kunio Hirata, Misuzu Tanaka, Kenji Mori, Tomoko Uemura, Takuya Kobayashi, So Iwata, Masayasu Kojima (2020)  Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode Nature communications. 1 :11,  4160- DOI:10.1038/s41467-020-17554-1 PMID:32814772 
Ryo Nagao, Koji Kato, Kentaro Ifuku, Takehiro Suzuki, Minoru Kumazawa, Ikuo Uchiyama, Yasuhiro Kashino, Naoshi Dohmae, Seiji Akimoto, Jian-Ren Shen, Naoyuki Miyazaki, Fusamichi Akita (2020)  Structural Basis for Assembly and Function of a Diatom Photosystem I-light-harvesting Supercomplex Nature Communications. 1 :11,  2481- DOI:10.1038/s41467-020-16324-3 PMID:32424145 
Hayato Tsuyuzaki, Masahito Hosokawa, Koji Arikawa, Takuya Yoda, Naoyuki Okada, Haruko Takeyama, Masamitsu Sato (2020)  Time-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking in fission yeast Nature communications. 1 :11,  1265- DOI:10.1038/s41467-020-15060-y PMID:32152323 
Michihisa Ueda, Tsubasa Aoki, Takayoshi Akiyama, Takayuki Nakamuro, Keitaro Yamashita, Haruaki Yanagisawa, Osamu Nureki, Masahide Kikkawa, Eiichi Nakamura, Takuzo Aida, Yoshimitsu Itoh (2020)  Alternating Heterochiral Supramolecular Copolymerization Journal of the American chemical society. 13 :143,  5121-5126 DOI:10.1021/jacs.1c00823 PMID:33755459 
Hua Lu, Takayuki Nakamuro, Keitaro Yamashita, Haruaki Yanagisawa, Osamu Nureki, Masahide Kikkawa, Han Gao, Jiangwei Tian, Rui Shang, Eiichi Nakamura (2020)  B/N-Doped p-Arylenevinylene Chromophores: Synthesis, Properties, and Microcrystal Electron Crystallographic Study Journal of the American Chemical Society. 44 :142,  18990-18996 DOI:10.1021/jacs.0c10337 PMID:33089998 
Keisuke Yoshida, Toshio Maekawa, Nhung Hong Ly, Shin-Ichiro Fujita, Masafumi Muratani, Minami Ando, Yuki Katou, Hiromitsu Araki, Fumihito Miura, Katsuhiko Shirahige, Mariko Okada, Takashi Ito, Bruno Chatton, Shunsuke Ishii (2020)  ATF7-Dependent Epigenetic Changes Are Required for the Intergenerational Effect of a Paternal Low-Protein Diet Molecular Cell. 3 :78,  445-458 DOI:10.1016/j.molcel.2020.02.028 PMID:32197065 
Toshiyuki Oda, Haruaki Yanagisawa, Takeyuki Wakabayashi (2020)  Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin Journal of Structural Biology. 3 :209,  107450- DOI:10.1016/j.jsb.2020.107450 PMID:31954841 
Shotaro Kamata, Takuji Oyama, Kenta Saito, Akihiro Honda, Yume Yamamoto, Keisuke Suda, Ryo Ishikawa, Toshimasa Itoh, Yasuo Watanabe, Takahiro Shibata, Koji Uchida, Makoto Suematsu, Isao Ishii  (2020)  PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates iScience. 11 :23,  10172- DOI:10.1016/j.isci.2020.101727 PMID:33205029 
Norimasa Iwanami, Kohei Takeshita, Divine-Fondzenyuy Lawir, Isao Suetake, Shoji Tajima, Katarzyna Sikora, Ines Trancoso, Connor OMeara, Iliana Siamishi, Yousuke Takahama, Makoto Furutani-Seiki, Hisato Kondoh, Yasushige Yonezawa, Michael Schorpp, Thomas Boehm (2020)  Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1 iScience. 7 :23,  101260- DOI:10.1016/j.isci.2020.101260 PMID:32585597 
Hanayo Nakanishi, Tomohiro Nishizawa, Katsumori Segawa, Osamu Nureki, Yoshinori Fujiyoshi, Shigekazu Nagata, Kazuhiro Abe (2020)  Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM Cell reports. 13 :32,  108208- DOI:10.1016/j.celrep.2020.108208 PMID:32997992 
Ryuichi Yamada, Akira Oguri, Katsunori Fujiki, Katsuhiko Shirahige, Hirotaka Takezoe, Naoki Takahashi, Yoshiakira Kanai (2020)  Single-cell transcriptional analysis reveals developmental stage-dependent changes in retinal progenitors in the murine early optic vesicle Biochemical and Biophysical Research Communications. :543,  80-86 DOI:10.1016/j.bbrc.2021.01.043 PMID:33548738 
Satoshi Fukuhara, Kazuhiro Kobayashi, Tsukasa Kusakizako, Wataru Iida, Kato Masahiko, Wataru Shihoya, Osamu Nureki (2020)  Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein Biochemical and Biophysical Research Communications. 4 :533,  861-866 DOI:10.1016/j.bbrc.2020.08.042 PMID:33008599 
Masafumi Tanaka, Hisayasu Miyake, Satoko Oka, Shintaro Maeda. Kenji Iwasaki. Takahiro Mukai (2020)  Effects of charged lipids on the physicochemical and biological properties of lipid-styrene maleic acid copolymer discoidal particles Biochimica et Biophysica Acta-Biomembranes. 5 :1862,  183209- DOI:10.1016/j.bbamem.2020.183209 PMID:32004520 
Yohei Miyanoiri, Mitsuhiro Takeda, Tsutomu Terauchi, Masatsune Kainoshobe (2020)  Recent developments in isotope-aided NMR methods for supramolecular protein complexes-SAIL aromatic TROSY Biochimica et Biophysica Acta, General Subjects. 2 :1864,  129439- DOI:10.1016/j.bbagen.2019.129439 PMID:31593752 
Taro Masuda, Seiki Baba, Koichi Matsuo, Shinji Ito, Bunzo Mikami  (2020)  The High-Resolution Crystal Structure of Lobster Hemocyanin Shows Its Enzymatic Capability as a Phenoloxidase Archives of Biochemistry and Biophysics . :688,  108370- DOI:10.1016/j.abb.2020.108370 PMID:32380017 
Akiyuki Taruno & Kengo Nomura & Tsukasa Kusakizako& Zhongming Ma & Osamu Nureki & J. Kevin Foskett (2021)  Taste transduction and channel synapses in taste buds Pflugers Archiv: European Journal of Physiology. 1 :473,  3-13 DOI:10.1007/s00424-020-02464-4 PMID:32936320 
Kazumasa Oda, Yongchan Lee, Pattama Wiriyasermkul, Yoko Tanaka, Mizuki Takemoto, Keitaro Yamashita, Shushi Nagamori, Tomohiro Nishizawa, Osamu Nureki (2020)  Consensus mutagenesis approach improves the thermal stability of system xc- transporter, xCT, and enables cryo-EM analyses Protein science. 12 :29,  2398-2407 DOI:10.1002/pro.3966 PMID:33016372 
Kenji Ishimoto, Yuta Nakamura, Shuichi Otani, Shohei Miki, Soya Maeda, Taiki Iwamoto, Yuma Konishi, Yukio Ago & Shinsaku Nakagawa  (2021)  Examination of dissolution ratio of b-carotene in water for practical application of b-carotene amorphous solid dispersion Journal of Food Science and Technology . 4 :59,  114-122 DOI:10.1007/s13197-021-04991-z PMID:35068557 
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Keisuke Tokunaga, Mami Sato, Keiko Kuwata, Chizuru Miura, Hirokazu Fuchida, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo, Naoya Shindo, and Akio Ojida (2020)  Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins Journal of the American Chemical Society. 142 18522-18531 DOI:10.1021/jacs.0c07490 PMID:33047956 
Fusako Kawai, Takeshi Kawabata, Masayuki Oda (2020)  Current State and Perspectives Related to the Polyethylene Terephthalate Hydrolases Available for Biorecycling ACS Sustainable Chemistry & Engineering. 8 8894-8908 DOI:10.1021/acssuschemeng.0c01638
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Tomohiro Sato, Katsuhiko Sekimata, Naoki Sakai, Hisami Watanabe, Chiemi Mishima-Tsumagari, Tomonori Taguri, Takehisa Matsumoto, Yoshifumi Fujii, Noriko Handa, Akiko Tanaka, Mikako Shirouzu, Shigeyuki Yokoyama, Yoshinobu Hashizume, Kohei Miyazono, Hiroo Koyama, and Teruki Honma (2020)  Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Appr ACS Omega. 5 11411-11423 DOI:10.1021/acsomega.9b04245 PMID:32478230 
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Mami Sato, Hirokazu Fuchida, Naoya Shindo, Keiko Kuwata, Keisuke Tokunaga, Guo Xiao-Lin, Ryo Inamori, Keitaro Hosokawa, Kosuke Watari, Tomohiro Shibata, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo, Mayumi Ono, and Akio Ojida (2020)  Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines ACS Medicinal Chemistry Letters. 11 1137-1144 DOI:10.1021/acsmedchemlett.9b00574 PMID:32550993 
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