成果

創薬等先端技術支援基盤プラットフォーム(BINDS)の実施者による研究支援と研究高度化の成果として輩出されたデータベース、 ツール、論文および特許を紹介します。

開発されたデータベースやツール

ケミカルシーズ・リード 探索ユニット

インシリコユニット

プラットフォーム機能最適化ユニット

BINDS支援技術に関する研究成果(論文)

Hashimoto T, Ye Y, Matsuno A,Ohnishi Y, Kitamura A, Kinjo M., Abe S, Ueno T, Yao M, Ogawa T, Matsui T, and Tanaka, Y (2019)  Encapsulation of biomacromolecules by soaking and co-crystallization into porous protein crystals of hemocyanin Biochem. Biophys. Res. Commun. 509 :2,  577-584 DOI:10.1016/j.bbrc.2018.12.096
Long Li, Motoyasu Adachi, Jian Yu, Koji Kato, Akira Shinoda, Andreas Ostermann, Tobias E Schrader, Toyoyuki Ose, Min Yao (2019)  Neutron crystallographic study of heterotrimeric glutamine amidotransferase CAB Acta Crystallographica Section F. 75 193-196 DOI:10.1107/S2053230X19000220 PMID:30839294 
Ai Niitsu, Ayako Egawa, Keisuke Ikeda, Kazuo Tachibana, and Toshimichi Fujiwara (2018)  Veratridine binding to a transmembrane helix of sodium channel Nav1.4 determined by solid-state NMR Bioorganic & Medicinal Chemistry. 26 :21,  5644-5653 DOI:10.1016/j.bmc.2018.10.012 PMID:30389410 
Takashi Matsui, Shizuka Kamata, Kentaro Ishii, Takahiro Maruno, Nouran Ghanem, Susumu Uchiyama, Koichi Kato, Atsuo Suzuki, Naoko Oda-Ueda, Tomohisa Ogawa, Yoshikazu Tanaka (2019)  SDS-induced oligomerization of Lys49-phospholipase A2 from snake venom. Scientific reports. 9 :1,  2330-2330 DOI:10.1038/s41598-019-38861-8 PMID:30787342 
Naoya Terahara, Yumi Inoue, Noriyuki Kodera, Yusuke V Morimoto, Takayuki Uchihashi, Katsumi Imada, Toshio Ando, Keiichi Namba, Tohru Minamino  (2018)  Insight into structural remodeling of the FlhA ring responsible for bacterial flagellar type III protein export. Sciences Advances. 4 :4,  eaao7054- DOI:10.1126/sciadv.aao7054 PMID:29707633 
Kazumi Saikusa, Akihisa Osakabe, Daiki Kato, Sotaro Fuchigami, Aritaka Nagadoi, Yoshifumi Nishimura, Hitoshi Kurumizaka, Satoko Akashi  (2018)  Structural Diversity of Nucleosomes Characterized by Native Mass Spectrometry. Analytical Chemistry. 90 :13,  8217-8226 DOI:10.1021/acs.analchem.8b01649 PMID:29860831 
Tomoya Kujirai, Yasuhiro Arimura, Risa Fujita, Naoki Horikoshi, Shinichi Machida, Hitoshi Kurumizaka (2018)  Methods for Preparing Nucleosomes Containing Histone Variants Methods in Molecular Biology: Histone Variants . 1832 3-20 DOI:10.1007/978-1-4939-8663-7_1 PMID:30073519 
加藤貴之, 難波啓一 (2018)  生命を解き明かすクライオ電子顕微鏡法の新時代 最新クライオ電子顕微鏡CRYO ARMの開発 顕微鏡. 53 :1,  13-17 DOI:ISSN:1349-0958
Takao Hashiguchi, Yoshinari Fukuda, Rei Matsuoka, Daisuke Kuroda, Marie Kubota, Yuta Shirogane, Shumpei Watanabe, Kouhei Tsumoto, Daisuke Kohda, Richard Karl, Plemper, Yusuke Yanagi (2018)  Structures of the prefusion form of measles virus fusion protein in complex with inhibitors Proceedings of the National Academy of Sciences. 115 :10,  2496-2501 DOI:10.1073/pnas.1718957115 PMID:29463726 
Moe Miyoshi, Masayuki Sato, Kenji Saito, Lila Otani, Katsuhiko Shirahige, Fumihito Miura, Takashi Ito, Huijuan Jia, Hisanori Kato (2018)  Maternal Protein Restriction Alters the Renal Ptger1 DNA Methylation State in SHRSP Offspring Nutrients. 10 :10,  1436- DOI:10.3390/nu10101436 PMID:30301128 
Shin-Ichiro Hiraga, Chandre Monerawela, Yuki Katou, Sophie Shaw, Kate Rm Clark, Katsuhiko Shirahige, Anne D Donaldson (2018)  Budding yeast Rif0 binds to replication origins and protects DNA at blocked replication forks EMBO Reports. 19 :9,  e46222- DOI:10.15252/embr.201846222 PMID:30104203 
Shin-Ichiro Nitta, Mari Hashimoto, Yasuhiro Kazuki, Shoko Takehara, Hiraku Suzuki, Mitsuo Oshimura, Hidetaka Akita, Kan Chiba, Kaoru Kobayashi (2018)  Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice The AAPS Journal. 20 :3,  61- DOI:10.1208/s12248-018-0186-9 PMID:29858698 
Ryoji Ito, Shuichiro Maruoka, Kaori Soda, Ikumi Katano, Kenji Kawai, Mika Yagoto, Asami Hanazawa, Takeshi Takahashi, Tomoyuki Ogura, Motohito Goto, Riichi Takahashi, Shota Toyoshima, Yoshimichi Okayama, Kenji Izuhara, Yasuhiro Gon, Shu Hashimoto, Mamoru Ito, and Satoshi Nunomura (2018)  A humanized mouse model to study asthmatic airway inflammation via the human IL-33/IL-13 axis. JCI Insight. 3 :21,  e121580- DOI:10.1172/jci.insight.121580 PMID:30385714 
Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura, Yasuhiro Kazuki (2018)  Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans Drug Metabolism and Disposition. 46 :11,  1756-1766 DOI:10.1124/dmd.118.081216 PMID:29777024 
Sonoko Kinjo, Masato Kiyomoto, Takashi Yamamoto, Kazuho Ikeo, Shunsuke Yaguchi (2018)  HpBase: A genome database of a sea urchin, Hemicentrotus pulcherrimus Development, Growth & Differentiation. 60 :3,  174-182 DOI:10.1111/dgd.12429 PMID:29532461 
Keitaro Yamashita, Kunio Hirata, and Masaki Yamamoto,  (2018)  KAMO: towards automated data processing for microcrystals Acta crystallographica, section D Structural biology. 74 441-449 DOI:10.1107/S2059798318004576 PMID:29717715 
Takehito Tanzawa, Koji Kato, Dylan Girodat, Toyoyuki Ose, Yuki Kumakura, Hans-Joachim Wieden, Toshio Uchiumi, Isao Tanaka, Min Yao (2018)  The C-terminal helix of ribosomal P stalk recognizes a hydrophobic groove of elongation factor 2 in a novel fashion Nucleic Acids Research. 46 :6,  3232-3244 DOI:10.1093/nar/gky115 PMID:29471537 
Ryuichiro Nakato, Katsuhiko Shirahige (2018)  Sensitive and robust assessment of ChIP-seq read distribution using a strand-shift profile Bioinformatics. 34 :14,  2356-2363 DOI:10.1093/bioinformatics/bty137 PMID:29528371 
Tetsuya Kuga, Yusuke Sasano, Masaki Tomizawa, Masatoshi Shibuya, Yoshiharu Iwabuchi (2018)  Expedient Entry to 1-Aminoadamantane Derivatives via Aza-Prins Cyclization of 7-Methylenebicyclo[3.3.1]nonan-3-one Oximes Synthesis. 50 :9,  1820-1826 DOI:10.1055/s-0036-1591920
Dominique Ray-Gallet, M Daniel Ricketts, Yukari Sato, Kushol Gupta, Ekaterina Boyarchuk, Toshiya Senda, Ronen Marmorstein, Genevi?ve Almouzni (2018)  Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit. Nature Communications. 9 :1,  3103- DOI:10.1038/s41467-018-05581-y PMID:30082790 
Toshihiko Sugiki, Kyoko Furuita, Toshimichi Fujiwara, Chojiro Kojima (2018)  Amino Acid Selective 13 C Labeling and 13 C Scrambling Profile Analysis of Protein α and Side-Chain Carbons in Escherichia Coli Utilized for Protein Nuclear Magnetic Resonance Biochemistry. 57 :26,  3576-3589 DOI:10.1021/acs.biochem.8b00182 PMID:29924600 
Narumi Uno, Tomohito Fujimoto, Shinya Komoto, Gene Kurosawa, Masaaki Sawa, Teruhiko Suzuki, Yasuhiro Kazuki, Mitsuo Oshimura (2018)  A luciferase complementation assay system using transferable mouse artificial chromosomes to monitor protein-protein interactions mediated by G protein-coupled receptors Cytotechnology. 70 :6,  1499-1508 DOI:10.1007/s10616-018-0231-7 PMID:30112660 
Naomi Terada, Mohammad, Rabiul Karim, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate (2018)  Expression of β-catenin in regenerating renal tubules of cisplatin-induced kidney failure in rats Clinical and Experimental Nephrology. 22 :6,  1240-1250 DOI:10.1007/s10157-018-1583-1 PMID:29802483 
Takashi Fujii, Keiichi Namba  (2019)  Complementary use of electron cryomicroscopy and X-ray crystallography: structural studies of actin and actomyosin filaments. Advances in Experimental Medicine and Biology. 1105 25-42 DOI:10.1007/978-981-13-2200-6_4 PMID:30617822 
Fumihito Miura, Takashi Ito (2018)  Post-bisulfite adaptor tagging for PCR-free whole-genome bisulfite sequencing. Methods in Molecular Biology. 1708 123-136 DOI:10.1007/978-1-4939-7481-8_7 PMID:29224142 
Ryuichiro Nakato, Katsuhiko Shirahige (2018)  Statistical Analysis and Quality Assessment of ChIP-seq Data with DROMPA Methods in molecular biology. 1672 631-643 DOI:10.1007/978-1-4939-7306-4_41 PMID:29043652 
Kazuhide Inoue & Makoto Tsuda (2018)  Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential Nature Reviews Neuroscience. 19 :3,  138-152 DOI:10.1038/nrn.2018.2 PMID:29416128 
Kazunori D. Yamada (2018)  Derivative-free neural network for optimizing the scoring functions associated with dynamic programming of pairwise-profile alignment. Algorithms for molecular biology. . 13 5- DOI:10.1186/s13015-018-0123-6 PMID:29467815 
伊藤亮治、伊藤守 (2018)  NOGマウスを用いた新しいxeno-GVHDモデル 臨床免疫・アレルギー科. 70 :1,  101-106 DOI:Z0528C ISSN
長野哲雄編 (2018)  創薬科学―メディシナルケミストへの道 東京化学同人. DOI:ISBN:9784807909483
岡部隆義、小島宏建、長野哲雄 (2018)  東大 化合物ライブラリー ケミカルバイオロジー化合物集 オーム社 日本学術振興会ケミカルバイオロジー第189委員会編. 56-62 DOI:ISBN:978-4-274-50709-0
Keiichi Namba and Takayuki Kato (2018)  Technical Development of Electron Cryomicroscopy and Contributions to Life Sciences. JEOL NEWS. 53 :1,  18-24 DOI:https://www.jeol.co.jp/en/applications/detail/1729.html
難波啓一, 加藤貴之 (2018)  クライオ電子顕微鏡法の技術開発と生命科学への貢献 日本電子news. 50 :1,  2-7 DOI:https://www.jeol.co.jp/applications/detail/1681.html
Haruhisa Kikuchi, Yoshiteru Oshima (2018)  Developments toward the Production of Diverse Natural-Product-Like Compounds: Diversity-Oriented Synthesis and Diversity-Enhanced Extracts Heterocycles. 96 1509-1527 DOI:10.3987/REV-18-885
Kenji Sugimoto, Hiroaki Fujiwara, Akihiro Takada, Dong-Gil Kim, Hirofumi Ueda, and Hidetoshi Tokuyama (2018)  Synthetic Studies Toward Isoschizogamine: Construction of Pentacyclic Core Structure Heterocycles. 97 1028-1049 DOI:10.3987/COM-18-S(T)85 PMID:  
Yoshihiko Yamamoto, Yuki Ishida, Takashi Kurohara, Masatoshi Shibuya, Takeshi Yasui (2018)  Synthesis of g-Trifluoromethyl Tetronate Derivatives from Squarates Heterocycles. 99 363-378 DOI:10.3987/COM-18-S(F)29
Hiroshi Fujisaki, Kei Moritsugu and Yasuhiro Matsunaga (2018)  Exploring configuration space and path space of biomolecules using enhanced sampling techniques: Searching for mechanism and kinetics of biomolecular functions International Journal of Molecular Sciences. 19 3177- DOI:10.3390/ijms19103177 PMID:30326661 
Erika Noro, Atsushi Yokoyama, akoto Kobayashi, Hiroki Shimada, Susumu Suzuki, Mari Hosokawa, Tomohiro Takehara, Rehana Parvin, Hiroki Shima, Kazuhiko Igarashi, Akira Sugawara (2018)  Endogenous Purification of NR4A2 (Nurr1) Identified Poly(ADP-Ribose) Polymerase 1 as a Prime Coregulator in Human Adrenocortical H295R Cells International Journal of Molecular Sciences. 19 1406- DOI:10.3390/ijms19051406 PMID:29738496 
Ashutosh Kumar and Kam Y. J. Zhang (2018)  Advances in the Development of Shape Similarity Methods and Their Application in Drug Discovery Frontiers in Chemistry. 6 315- DOI:10.3389/fchem.2018.00315 PMID:30090808 
Atsushi Hijikata (2018)  Developing a new method to predict the effect of the missense mutations on the protein function and phenotypes Impact . 2018 35-37 DOI:10.21820/23987073.2018.12.35
Akiko Higuchi, Naoki Nonaka and Kei Yura (2018)  iMusta4SLC: Database for the structural property and variations of solute carrier transporters Biophysics and Physicobiology. 15 94-103 DOI:10.2142/biophysico.15.0_94 PMID:29892515 
Masahiro Nishimura, Kayo Nozawa, and Hitoshi Kurumizaka (2018)  Crystallographic analysis of the overlapping dinucleosome as a novel chromatin unit. Biophysics and Physicobiology. 15 251-254 DOI:10.2142/biophysico.15.0_251 PMID:30713825 
赤井周司 (2018)  オキソバナジウム/加水分解酵素混合触媒による第二級アルコールの動的光学分割:メソポーラスシリカの細孔の活用 ゼオライト. 1 23-29 DOI:10.20731/zeoraito.35.1.13
Shunsuke Itai, Tomokazu Ohishi, Mika K. Kaneko, Shinji Yamada, Shinji Abe, Takuro Nakamura, Miyuki Yanaka, Yao-Wen Chang, Shun-Ichi Ohba, Yasuhiko Nishioka, Manabu Kawada, Hiroyuki Harada and Yukinari Kato (2018)  Anti-podocalyxin antibody exerts antitumor effects via antibody-dependent cellular cytotoxicity in mouse xenograft models of oral squamous cell carcinoma. Oncotarget. 9 :32,  22480-22497 DOI:10.18632/oncotarget.25132 PMID:29854293 
Akihiro Miyazaki,Hiromi Nakai, Tomoko Sonoda, Yoshihiko Hirohashi, Mika K. Kaneko, Yukinari Kato, Yoshihiko Sawa and Hiroyoshi Hiratsuka (2018)  LpMab-23-recognizing cancer-type podoplanin is a novel predictor for a poor prognosis of early stage tongue cancer. Oncotarget. 9 :30,  21156-21165 DOI:10.18632/oncotarget.24986 PMID:29765527 
姚閔,陳美容 (2018)  tRNA依存的アミノ酸システインの生合成複合体の分子機構 生化学. 90 :4,  512-518 DOI:10.14952/SEIKAGAKU.2018.900512
Shoya Inaba, Atsushi Hinohara, Masashi Tachibana, Kazutake Tsujikawa, So-Ichiro Fukada (2018)  Muscle regeneration is disrupted by cancer cachexia without loss of muscle stem cell potential PLOS One. 13 e0205467- DOI:10.1371/journal.pone.0205467 PMID:30300394 
Tomoya Takahashi, Satoru Nagatoishi, Daisuke Kuroda, Kouhei Tsumoto (2018)  Thermodynamic and computational analyses reveal the functional roles of the galloyl group of tea catechins in molecular recognition PLOS One. 13 e0204856- DOI:10.1371/journal.pone.0204856 PMID:30307946 
Tomohiro Sato,Hitomi Yuki,Keiji Ogura,Teruki Honma  (2018)  Construction of an integrated database for hERG blocking small molecules PLOS One. 13 e0199348- DOI:10.1371/journal.pone.0199348 PMID:29979714 
Yusuke Shintani, Atsuko Hayata-Takano, Keita Moriguchi, Takanobu Nakazawa, Yukio Ago, Atsushi Kasai, Kaoru Seiriki, Norihito Shintani, Hitoshi Hashimoto (2018)  β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking PLOS One. 13 e0196946- DOI:10.1371/journal.pone.0196946 PMID:29734363 
Takayoshi Matsuda, Takuhiro Ito, Chie Takemoto, Kazushige Katsura, Mariko Ikeda, Motoaki Wakiyama, Mutsuko Kukimoto-Niino, Shigeyuki Yokoyama, Yoshikazu Kurosawa, Mikako Shirouzu (2018)  Cell-free synthesis of functional antibody fragments to provide a structural basis for antibody-antigen interaction PLOS One. 13 :2,  e0193158- DOI:10.1371/journal.pone.0193158 PMID:29462206 
Vamsi K Gali, David Dickerson, Yuki Katou, Katsunori Fujiki, Katsuhiko Shirahige, Tom Owen-Hughes, Takashi Kubota, Anne D Donaldson (2018)  Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation PLOS genetics. 14 :11,  e1007783- DOI:10.1371/journal.pgen.1007783 PMID:30418970 
Satoshi Matsuyama, Mohammad Rabiul Karim, Takshi Izawa, Mitsuru Kuwamura, Jyoji Yamate  (2018)  Immunohistochemical analyses of the kinetics and distribution of macrophages in the developing rat kidney Journal of Toxicologic Pathology. 31 :3,  207-212 DOI:10.1293/tox.2018-0002 PMID:30093791 
Tomohiro Yamashita,Makoto Tsuda, Hidetoshi Tozaki-Saitoh, and Kazuhide Inouea (2018)  Green Pharma: A New Strategy for Drug Discovery in Academia by Targeting Glial Cells and ATP Receptors YAKUGAKU ZASSHI. 138 1027-1031 DOI:10.1248/yakushi.17-00211-1 PMID:30068843 
Takashi Ikawa, Shigeaki Masuda, Shuji Akai (2018)  Microflow Fluorinations of Benzynes: Efficient Synthesis of Fluoroaromatic Compounds Chemical and Pharmaceutical Bulletin. 66 1153-1164 DOI:10.1248/cpb.c18-00578 PMID:30504631 
Kei Toyama, Takuya Kobayakawa, Wataru Nomura, Hirokazu Tamamura (2018)  Inhibition of EGFR Activation by Bivalent Ligands Based on a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR Chemical and Pharmaceutical Bulletin. 66 :11,  1083-1089 DOI:10.1248/cpb.c18-00539 PMID:30381661 
Yuto Sumida, Ryu Harada, Tomoe Sumida, Daisuke Hashizume, and Takamitsu Hosoya (2018)  Hydrosilyl Group-directed Iridium-catalyzed peri-Selective C-H Borylation of Ring-fused (Hetero)Arenes Chemistry Letters. 47 :10,  1251-1254 DOI:10.1246/cl.180594
Yoshitake Nishiyama, Shuhei Kamada, Suguru Yoshida, Takamitsu Hosoya (2018)  Generation of Arynes by Selective Cleavage of a Carbon-Phosphorus Bond of o-(Diarylphosphinyl)aryl Triflates Using a Grignard Reagent Chemistry Letters. 47 :9,  1216-1219 DOI:10.1246/cl.180555
Tsubasa Matsuzawa, Keisuke Uchida, Suguru Yoshida, Takamitsu Hosoya (2018)  Synthesis of Diverse Phenothiazines by Direct Thioamination of Arynes with S-(o-Bromoaryl)-S-methylsulfilimines and Subsequent Intramolecular Buchwald-Hartwig Amination Chemistry Letters. 47 :7,  825-828 DOI:10.1246/cl.180304
Kazuya Kanemoto ,Suguru Yoshida , and Takamitsu Hosoya (2018)  Modified Conditions for Copper-Catalyzed ipso-Thiolation of Arylboronic Acid Esters with Thiosulfonates Chemistry Letters. 47 :1,  85-88 DOI:10.1246/cl.170907
Naoyuki Miyazaki, Kenji Iwasaki, Junichi Takagi (2018)  A systematic survey of conformational states in β1 and β4 integrins using negative-stain electron microscopy Journal of Cell Science. 131 :10,  jcs216754- DOI:10.1242/jcs.216754 PMID:29700202 
Yu-Taro Noguchi, Miki Nakamura, Nobumasa Hino, Jumpei Nogami, Sayaka Tsuji, Takahiko Sato, Lidan Zhang, Kazutake Tsujikawa, Toru Tanaka, Kohei Izawa, Yoshiaki Okada, Takefumi Doi, Hiroki Kokubo, Akihito Harada, Akiyoshi Uezumi, Manfred Gessler, Yasuyuki Ohkawa, So-Ichiro Fukada Affiliations expand (2019)  Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites Development. 146 dev163618- DOI:10.1242/dev.163618 PMID:30745427 
Agnes Burel, Marie-Therese Lavault, Clement Chevalier, Helmut Gnaegi, Sylvain Prigent, Antonio Mucciolo, Stephanie Dutertre, Bruno M. Humbel, Thierry Guillaudeux, Irina Kolotuev  (2018)  A targeted 3D EM and correlative microscopy method using SEM array tomography Development. 145 :12,  dev160879- DOI:10.1242/dev.160879 PMID:29802150 
Shogo Ueda, Ingrid Rosenburg Cordeiro, Yuuta Moriyama, Chika Nishimori, Kei-Ichi Kai, Reiko Yu, Ryoichiro Nakato, Katsuhiko Shirahige, Mikiko Tanaka (2019)  Cux2 refines the forelimb field by controlling expression of Raldh2 and Hox genes Biology open. 8 :2,  bio040584- DOI:10.1242/bio.040584 PMID:30651234 
Kazunori D. Yamada & Kengo Kinoshita (2018)  De novo profile generation based on sequence context specificity with the long short-term memory network BMC bioinformatcs. 19 272- DOI:10.1186/s12859-018-2284-1 PMID:30021530 
Ken Morita, Chieko Tokushige, Shintaro Maeda, Hiroki Kiyose, Mina Noura, Atsushi Iwai, Maya Yamada, Gengo Kashiwazaki, Junichi Taniguchi, Toshikazu Bando, Masahiro Hirata, Tatsuki R. Kataoka, Tatsutoshi Nakahata, Souichi Adachi, Hiroshi Sugiyama, Yasuhiko Kamikubo  (2018)  RUNX transcription factors potentially control E-selectin expression in the bone marrow vascular niche in mice Blood Advances. 2 509-515 DOI:10.1182/bloodadvances.2017009324 PMID:29500219 
Nahid Rahman, Munmun Pervin, Mizuki Kuramochi, Mohammad Rabiul Karim, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate  (2018)  M1/M2-macrophage Polarization-based Hepatotoxicity in d-galactosamine-induced Acute Liver Injury in Rats Toxicologic Pathology. 46 :7,  764-776 DOI:10.1177/0192623318801574 PMID:30253710 
Munmun Pervin, Mohammad Rabiul Karim, Mizuki Kuramochi, Takeshi Izawa, Mitsuru Kuwamura and Jyoji Yamate (2018)  Macrophage Populations and Expression of Regulatory Inflammatory Factors in Hepatic Macrophage-depleted Rat Livers under Lipopolysaccharide (LPS) Treatment Toxicologic Pathology. 46 :5,  540-552 DOI:10.1177/0192623318776898 PMID:29938593 
Bertrand Boisson, Yoshitaka Honda, Masahiko Ajiro , Jacinta Bustamante, Matthieu Bendavid, Andrew R Gennery, Yuri Kawasaki, Jose Ichishima, Mitsujiro Osawa, Hiroshi Nihira, Takeshi Shiba, Takayuki Tanaka, Maya Chrabieh , Benedetta Bigio, Hong Hur, Yuval Itan, Yupu Liang, Satoshi Okada, Kazushi Izawa, Ryuta Nishikomori, Osamu Ohara, Toshio Heike, Laurent Abel, Anne Puel, Megumu K Saito, Jean-Laurent Casanova, Masatoshi Hagiwara, Takahiro Yasumi (2018)  Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency Journal of Clinical Investigation. 129 583-597 DOI:10.1172/JCI124011 PMID:30422821 
Naoya Matsunaga, Takashi Ogino, Yukinori Hara, Takahiro Tanaka, Satoru Koyanagi and Shigehiro Ohdo (2018)  Optimized dosing schedule based on circadian dynamics of mouse breast cancer stem cells improves the anti-tumor effects of aldehyde dehydrogenase Inhibitor Cancer Research. 78 3698-3708 DOI:10.1158/0008-5472.CAN-17-4034 PMID:29735553 
Kenta Masui, Takashi Komori, Yukinari Kato, Kenkichi Masutomi, Koichi Ichimura, Satoshi Ogasawara, Mika K. Kaneko, Hiroharu Oki, Hiroyoshi Suzuki, Masayuki Nitta, Takashi Maruyama, Yoshihiro Muragaki, Takakazu Kawamata, Tatsuo Sawada, and Noriyuki Shibata  (2018)  Elevated TERT Expression in TERT-Wildtype Adult Diffuse Gliomas: Histological Evaluation with a Novel TERT-Specific Antibody. Biomed Research International. 2018 7945845- DOI:10.1155/2018/7945845 PMID:29693015 
Rehana Parvin, Erika Noro, Akiko Saito-Hakoda, Hiroki Shimada, Susumu Suzuki, Kyoko Shimizu, Hiroyuki Miyachi, Atsushi Yokoyama, and Akira Sugawara (2018)  Inhibitory Effects of a Novel PPAR-γ Agonist MEKT1 on Pomc Expression/ACTH Secretion in AtT20 Cells PPAR Research. 2018 5346272- DOI:10.1155/2018/5346272 PMID:29849538 
小島宏建、岡部隆義、宮地弘幸、長野哲雄 (2018)  基礎医学から創薬へ参入の支援 生体の科学. 69 305-309 DOI:10.11477/mf.2425200821
Dror S. Chorev, Lindsay A. Baker, Di Wu, Victoria Beilsten-Edmands, Sarah L. Rouse, Tzviya Zeev-Ben-Mordehai, Chimari Jiko, Firdaus Samsudin, Christoph Gerle, Syma Khalid, Alastair G. Stewart, Stephen J. Matthews, Kay Gr?newald, and Carol V. Robinson  (2018)  Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry Science. 362 :6416,  829-834 DOI:10.1126/science.aau0976 PMID:30442809 
Przemyslaw Nogly, Tobias Weinert, Daniel James, Sergio Carbajo, Dmitry Ozerov, Antonia Furrer, Dardan Gashi, Veniamin Borin, Petr Skopintsev, Kathrin Jaeger, Karol Nass, Petra Bath, Robert Bosman, Jason Koglin, Matthew Seaberg, Thomas Lane, Demet Kekilli, Steffen Brunle, Tomoyuki Tanaka, Wenting Wu, Christopher Milne, Thomas White, Anton Barty, Uwe Weierstall, Valerie Panneels, Eriko Nango, So Iwata, Mark Hunter, Igor Schapiro, Gebhard Schertler, Richard Neutze, Jorg Standfuss (2018)  Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser Science. 361 :6398,  eaat0094- DOI:10.1126/science.aat0094 PMID:29903883 
Takashi Murayama, Nagomi Kurebayashi, Mari Ishigami-Yuasa, Shuichi Mori, Yukina Suzuki, Ryunosuke Akima, Haruo Ogawa, Junji Suzuki, Kazunori Kanemaru, Hideto Oyamada, Yuji Kiuchi, Masamitsu Iino, Hiroyuki Kagechika, Takashi Sakurai  (2018)  Efficient high-throughput screening by ER Ca2+ measurement to identify inhibitors of ryanodine receptor Ca2+-release channels Molecular Pharmacology. 94 :1,  722-730 DOI:10.1124/mol.117.111468 PMID:29674523 
Yasuhiko Kamikubo (2018)  Genetic compensation of RUNX family transcription factors in leukemia Cancer Science. 109 2358-2363 DOI:10.1111/cas.13664 PMID:29883054 
Nicole C. Woitowich, Andrei S. Halavaty, Patricia Waltz, Christopher Kupitz, Joseph Valera, Gregory Tracy, Kevin D. Gallagher, Elin Claesson, Takanori Nakane, Suraj Pandey, Garrett Nelson, Rie Tanaka, Eriko Nango, Eiichi Mizohata, Shigeki Owada, Kensure Tono, Yasumasa Joti, Angela C. Nugent, Hardik Patel, Ayesha Mapara, James Hopkins, Phu Duong, Dorina Bizhga, Svetlana E. Kovaleva, Rachael St. Peter, Cynthia N. Hernandez, Wesley B. Ozarowski, Shatabdi Roy-Chowdhuri, Jay-How Yang, Petra Edlund, Heikki Takala, Janne Ihalainen, Jennifer Brayshaw, Tyler Norwood, Ishwor Poudyal, Petra Fromme, John C. H. Spence, Keith Moffat, Sebastian Westenhoff, Marius Schmidt, and Emina A. Stojkovic, (2018)  Structural basis for light control of cell development revealed by crystal structures of a myxobacterial phytochrome IUCrJ. 5 619-634 DOI:10.1107/S2052252518010631 PMID:30224965 
Yasuhiro Arimura, Masae Ikura, Risa Fujita, Mamiko Noda, Wataru Kobayashi, Naoki Horikoshi, Jiying Sun, Lin Shi, Masayuki Kusakabe, Masahiko Harata, Yasuyuki Ohkawa, Satoshi Tashiro, Hiroshi Kimura, Tsuyoshi Ikura, Hitoshi Kurumizaka  (2018)  Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome Nucleic Acids Research. 46 :19,  10007-10018 DOI:10.1093/nar/gky661 PMID:30053102 
Akihisa Osakabe, Zdravko J Lorkovic, Wataru Kobayashi, Hiroaki Tachiwana, Ramesh Yelagandula, Hitoshi Kurumizaka, Frederic Berger  (2018)  Histone H2A variants confer specific properties to nucleosomes and impact on chromatin accessibility Nucleic Acids Research. 46 :15,  7675-7685 DOI:10.1093/nar/gky540 PMID:29945241 
Di Luo, Daiki Kato, Jumpei Nogami, Yasuyuki Ohkawa, Hitoshi Kurumizaka, and Hidetoshi Kono  (2018)  MNase, as a probe to study the sequence-dependent site exposures in the +1 nucleosomes of yeast. Nucleic Acids Research. 46 :14,  7124-7137 DOI:10.1093/nar/gky502 PMID:29893974 
Masako Koyama, Hitoshi Kurumizaka (2018)  Structural diversity of the nucleosome. The Journal of Biochemistry. 163 :2,  85-95 DOI:10.1093/jb/mvx081 PMID:29161414 
Sonoko Kinjo, Norikazu Monma, Sadahiko Misu, Norikazu Kitamura, Junichi Imoto, Kazutoshi Yoshitake, Takashi Gojobori, and Kazuho Ikeo  (2018)  Maser: one-stop platform for NGS big data from analysis to visualization. Database (Oxford). bay027- DOI:10.1093/database/bay027 PMID:29688385 
Naohiro Kobayashi, Yoshikazu Hattori, Takashi Nagata, Shoko Shinya, Peter Guntert, Chojiro Kojima, Toshimichi Fujiwara (2018)  Noise peak filtering in multi-dimensional NMR spectra using convolutional neural networks Bioinformatics. 34 :24,  4300-4301 DOI:10.1093/bioinformatics/bty581 PMID:29985974 
Tsukasa Nakamura,Kazunori D Yamada,Kentaro Tomii,Kazutaka Katoh (2018)  Parallelization of MAFFT for large-scale multiple sequence alignments. Bioinformatics . 34 :14,  2490-2492 DOI:10.1093/bioinformatics/bty121 PMID:29506019 
Yukinari Kato, Shinji Yamada, Shunsuke Itai, Atsushi Kobayashi, Satoru Konnai, and Mika K. Kaneko (2018)  Anti-Horse Podoplanin Monoclonal Antibody PMab-219 is Useful for Detecting Lymphatic Endothelial Cells by Immunohistochemical Analysis Monoclonal Antibodies in Immunodiagnosis and ImmunotherapyVol. 37 :6,  272-274 DOI:10.1089/mab.2018.0044 PMID:30592702 
Yukinari Kato, Shinji Yamada, Shunsuke Itai, Satoru Konnai, Atsushi Kobayashi, and Mika K. Kaneko (2018)  Detection of Alpaca Podoplanin by Immunohistochemistry Using the Antibovine Podoplanin Monoclonal Antibody PMab-44 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 37 :6,  269-271 DOI:10.1089/mab.2018.0037 PMID:30570440 
Yukinari Kato, Shinji Yamada, Shunsuke Itai, Atsushi Kobayashi, Satoru Konnai, and Mika K. Kaneko (2018)  Immunohistochemical Detection of Sheep Podoplanin Using an Antibovine Podoplanin Monoclonal Antibody PMab-44 Monoclonal Antibodies in Immunodiagnosis and ImmunotherapyVol. 37 :6,  265-268 DOI:10.1089/mab.2018.0036 PMID:30570359 
Yukinari Kato, Takuya Mizuno, Shinji Yamada, Takuro Nakamura, hunsuke Itai, Miyuki Yanaka, Masato Sano, and Mika K. Kaneko (2018)  Establishment of P38Bf, a Core-Fucose-Deficient Mouse-Canine Chimeric Antibody Against Dog Podoplanin Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 37 :5,  218-223 DOI:10.1089/mab.2018.0035 PMID:30362926 
Shinji Yamada, Shunsuke Itai, Yoshikazu Furusawa, Masato Sano, Takuro Nakamura, Miyuki Yanaka, Saori Handa, Kayo Hisamatsu, Yoshimi Nakamura, Masato Fukui, Hiroyuki Harada, Takuya Mizuno, Yusuke Sakai, Satoshi Ogasawara, Takeshi Murata, Hiroaki Uchida, Hideaki Tahara, Mika K. Kaneko, and Yukinari Kato (2018)  Detection of Tiger Podoplanin Using the Anti-Cat Podoplanin Monoclonal Antibody PMab-52 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 37 :5,  224-228 DOI:10.1089/mab.2018.0033 PMID:30362928 
Shinji Yamada, Mika K. Kaneko, Yoshikazu Furusawa, Shunsuke Itai, Masato Sano, Takuro Nakamura, Miyuki Yanaka, Saori Handa, Kayo Hisamatsu, Yoshimi Nakamura, Masanori Koyanagi, Masato Fukui, Hiroyuki Harada, and Yukinari Kato (2018)  Anti-Bovine Podoplanin Monoclonal Antibody PMab-44 Detects Goat Podoplanin in Immunohistochemistry Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 38 :2,  96-99 DOI:10.1089/mab.2018.0031 PMID:30457925 
Yoshikazu Furusawa, Shinji Yamada, Shunsuke Itai, Masato Sano, Takuro Nakamura, Miyuki Yanaka, Saori Handa, Takuya Mizuno, Ken Maeda, Masato Fukui, Hiroyuki Harada, Mika K. Kaneko, and Yukinari Kato (2018)  Establishment of Monoclonal Antibody PMab-202 Against Horse Podoplanin Monoclonal Antibodies in Immunodiagnosis and ImmunotherapyVol. 37 :5,  233-237 DOI:10.1089/mab.2018.0030 PMID:30362932 
Tomoyuki Nakano, Satoshi Ogasawara, Toshiaki Tanaka, Yasukazu Hozumi, Atsumi Yamaki, Fumio Sakane, Yasuhito Shirai, Takuro Nakamura, Miyuki Yanaka, Shinji Yamada, Mika K. Kaneko, Yukinari Kato, and Kaoru Goto (2018)  DgMab-6: Antihuman DGKγ Monoclonal Antibody for Immunocytochemistry Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 37 :5,  229-232 DOI:10.1089/mab.2018.0026 PMID:30362931 
Yoshikazu Furusawa, Shinji Yamada, Shunsuke Itai, Takuro Nakamura, Masato Fukui, Hiroyuki Harada, Mika K. Kaneko, and Yukinari Kato (2018)  Elucidation of Critical Epitope of Anti-Rat Podoplanin Monoclonal Antibody PMab-2 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 37 :4,  188-193 DOI:10.1089/mab.2018.0025 PMID:30088964 
Yoshikazu Furusawa, Shunsuke Itai, Shinji Yamada, Mika K. Kaneko, and Yukinari Kato (2018)  Epitope Mapping of Anti-Telomerase Reverse Transcriptase Monoclonal Antibodies Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 37 :4,  185-187 DOI:10.1089/mab.2018.0019 PMID:30004263 
Mika K. Kaneko, Shinji Yamada, Shunsuke Itai, Yao-Wen Chang, Takuro Nakamura, Miyuki Yanaka, Hiroyuki Harada, Hiroyoshi Suzuki, and Yukinari Kato (2018)  Elucidation of the TMab-6 Monoclonal Antibody Epitope Against Telomerase Reverse Transcriptase Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 38 :3,  101-103 DOI:10.1089/mab.2018.0007 PMID:29723111 
Shinji Yamada, Mika K. Kaneko, Shunsuke Itai, Yao-Wen Chang, Takuro Nakamura, Miyuki Yanaka, Satoshi Ogasawara, Takeshi Murata, Hiroaki Uchida, Hideaki Tahara, Hiroyuki Harada, and Yukinari Kato (2018)  Epitope Mapping of Monoclonal Antibody PMab-48 Against Dog Podoplanin. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 37 :3,  162-165 DOI:10.1089/mab.2018.0006 PMID:29608407 
Shinji Yamada, Shunsuke Itai, Takuro Nakamura, Miyuki Yanaka, Yao-Wen Chang, Hiroyoshi Suzuki, Mika K. Kaneko, and Yukinari Kato. (2018)  Monoclonal Antibody L1Mab-13 Detected Human PD-L1 in Lung Cancers Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 37 :2,  110-115 DOI:10.1089/mab.2018.0004 PMID:29608408 
Mika K. Kaneko, Shunsuke Itai, Shinji Yamada, and Yukinari Kato (2018)  47-mG2a: A Mouse IgG2a-Type of PcMab-47 Useful for Detecting Podocalyxin in Esophageal Cancers by Immunohistochemistry. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 37 :3,  158-161 DOI:10.1089/mab.2018.0003 PMID:29630446 
Shinji Yamada, Shunsuke Itai, Mika K. Kaneko (2018)  Anti-Podocalyxin Monoclonal Antibody 47-mG2a Detects Lung Cancers by ImmunohistochemistryAnti-Podocalyxin Monoclonal Antibody 47-mG2a Detects Lung Cancers by Immunohistochemistry Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 37 :2,  91-94 DOI:10.1089/mab.2018.0002 PMID:29649375 
Yao-Wen Chang, Mika K. Kaneko, Shinji Yamada, and Yukinari Kato (2018)  Epitope Mapping of Monoclonal Antibody PMab-52 Against Cat Podoplanin. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 37 :2,  95-99 DOI:10.1089/mab.2017.0067 PMID:29394131 
Shinji Yamada, Shunsuke Itai, Mika K. Kaneko, Yukinari Kato (2018)  PMab-48 Recognizes Dog Podoplanin of Lymphatic Endothelial Cells. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 37 :1,  63-66 DOI:10.1089/mab.2017.0053 PMID:29256716 
Mika K. Kaneko, Shinji Yamada, Shunsuke Itai, and Yukinari Kato (2018)  Development of an Anti-HER2 Monoclonal Antibody H2Mab-139 Against Colon Cancer Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 37 :1,  59-62 DOI:10.1089/mab.2017.0052 PMID:29315012 
Tomoto Suzuki, Yuya Takakubo, Hiroharu Oki, Xing Liu, Ryusuke Honma, Yasushi Naganuma, Stuart B. Goodman, Mika K. Kaneko, Yukinari Kato, and Michiaki Takagi (2018)  Immunohistochemical Analysis of Inflammatory Rheumatoid Synovial Tissues Using Anti-Human Podoplanin Monoclonal Antibody Panel. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 37 :1,  12-19 DOI:10.1089/mab.2017.0047 PMID:29377768 
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki & Hiroshi Suemizu  (2018)  Expression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanized livers. Xenobiotica. 49 :6,  678-687 DOI:10.1080/00498254.2018.1495346 PMID:29969338 
Parijat Majumder, Till Rudack, Florian Beck, Radostin Danev, Gunter Pfeifer, Istvan Nagy, Wolfgang Baumeister (2019)  Cryo-EM structures of the archaeal PAN-proteasome reveal an around-the-ring ATPase cycle Proceedings of the National Academy of Sciences of the United States of America. 116 :2,  534-539 DOI:10.1073/pnas.1817752116 PMID:30559193 
Naoki Tsunekawa, Haruo Ogawa, Junko Tsueda, Toshihiko Akiba, and Chikashi Toyoshima (2018)  Mechanism of the E2 to E1 transition in Ca2+-pump revealed by crystal structures of gating residue mutants Proceedings of National Academy of Science USA.. 115 :50,  12722-12727 DOI:10.1073/pnas.1815472115 PMID:30482857 
Kei Moritsugu, Tohru Terada, Hironori Kokubo, Satoshi Endo, Toshimasa Tanaka and Akinori Kidera (2018)  Multiscale enhanced sampling of glucokinase: Regulation of the enzymatic reaction via a large scale domain motion The Journal of Chemical Physics. 149 72314- DOI:10.1063/1.5027444 PMID:30134720 
Shinya Watanabe, Masatsugu Ishikawa, Toshimune Nomura, Tohru Fukuyama, Satoshi Yokoshima (2018)  Total Synthesis of Lycoposerramine-R Synlett. 29 2377-2380 DOI:10.1055/s-0037-1611024
Suguru Itabashi,Masashi Shimomura,Manabu Sato,Hiroki Azuma, Kentaro Okano, Juri Sakata, Hidetoshi Tokuyama (2018)  One-Pot Reductive Allylation of Amides by Using a Combination of Titanium Hydride and an Allylzinc Reagent: Application to a Total Synthesis of (-)-Castoramin Synlett. 29 1786-1790 DOI:10.1055/s-0037-1610435
Hiromichi Egami, Yuta Ito, Takafumi Ide, Shuya Masuda, Yoshitaka Hamashima (2018)  Simple Photo-Induced Trifluoromethylation of Aromatic Rings Synthesis . 50 2948-2953 DOI:10.1055/s-0037-1609759
Kensuke Orihara, Fumiki Kawagishi, Satoshi Yokoshima, Tohru Fukuyama (2018)  Synthetic Studies of Haliclonin A: Construction of the 3-Azabicyclo[3.3.1]nonane Skeleton with a Bridge that Forms the 17-Membered Ring Synlett . 29 769-772 DOI:10.1055/s-0037-1609150
Hideki Kaneko, Takashi Ikawa, Yuta Yamamoto, Sundaram Arulmozhiraja, Hiroaki Tokiwa, Shuji Akai (2018)  3-(Triflyloxy)benzynes Enable the Regiocontrolled Cycloaddition of Cyclic Ureas to Synthesize 1,4-Benzodiazepine Derivatives Synlett. 29 :7,  943-948 DOI:10.1055/s-0036-1591924
Takashi Kurohara, Jiang Jiyue, Masatoshi Shibuya, Yoshihiko Yamamoto (2018)  Synthesis of Alkoxycarbonyldifluoromethyl-Substituted Semisquarates and Their Transformations Synthesis. 50 1687-1698 DOI:10.1055/s-0036-1591887
Takashi Ikawa, Yuta Sumii, Shigeaki Masuda, Ding Wang, Yuto Emi, Akira Takagi, Shuji Akai (2018)  Synthesis of Optically Active 2,3-Disubstituted Indoline Derivatives through Cycloaddition Reactions between Benzynes and α,β-Unsaturated γ-Aminobutyronitriles Synlett. 29 530-536 DOI:10.1055/s-0036-1591722
Yuji Kawato, Yoshitaka Hamashima (2018)  Enantioselective Bromocyclization of Allylic Amides Mediated by Phosphorus Catalysis Synlett . 29 1257-1271 DOI:10.1055/s-0036-1591579
Yuiki Kawada, Shunsuke Ohmura, Misaki Kobayashi, Wataru Nojo, Masaki Kondo, Yuka Matsuda, Junpei Matsuoka, Shinsuke Inuki, Shinya Oishi, Chao Wang, Tatsuo Saito, Masanobu Uchiyama, Takanori Suzuki, Hiroaki Ohno (2018)  Direct Synthesis of Aryl-Annulated [c]Carbazoles by Gold(I)-Catalysed Cascade Reaction of Azide-Diynes and Arenes. Chemical Science. 9 8416-8425 DOI:10.1039/C8SC03525C PMID:30542591 
Chihiro Tsukano , Motoyuki Nakajima, Sudhir M Hande, Yoshiji Takemoto (2019)  Palladium-Catalyzed Intramolecular Carboborylation of 1,3-Diene and Synthesis of ABCD Ring of Communesins. Organic Biomolecular Chemistry. 17 1731-1735 DOI:10.1039/c8ob02224k PMID:30310915 
Zhouen Zhang, Takashi Niwa, Yasuyoshi Watanabe and Takamitsu Hosoya  (2018)  Palladium(II)-mediated rapid 11C-cyanation of (hetero)arylborons Organic and Biomolecular Chemistry. 16 :41,  7711-7716 DOI:10.1039/C8OB02049C PMID:30288522 
Naohiro Horie, Shinji Kumagai, Yutaro Kotobuki, Takao Yamaguchi, Satoshi Obika  (2018)  Facile synthesis and fundamental properties of an N-methylguanidine-bridged nucleic acid (GuNA[NMe]) Organic & Biomolecular Chemistry. 16 6531-6536 DOI:10.1039/C8OB01307A PMID:30160290 
Yusuke Kitabayashi, Tohru Fukuyama, Satoshi Yokoshima (2018)  Synthesis of the [7-5-5] tricyclic core of Daphniphyllum alkaloids Organic & Biomolecular Chemistry. 16 3556-3559 DOI:10.1039/C8OB00859K PMID:29693693 
Kanako Nozawa-Kumada,Erina Abe,Shungo Ito,Masanori Shigeno and Yoshinori Kondo (2018)  Super Electron Donor-mediated Reductive Transformation of Nitrobenzenes: A Novel Strategy to Synthesize Azobenzenes and Phenazines Organic & Biomolecular Chemistry. 16 3095-3098 DOI:10.1039/C8OB00271A PMID:29634065 
Suguru Yoshida, Junko Tanaka , Yoshitake Nishiyama, Yuki Hazama, Takeshi Matsushita and Takamitsu Hosoya  (2018)  Further enhancement of the clickability of doubly sterically-hindered aryl azides by para-amino substitution Chemical Communications . 54 :96,  13499-13502 DOI:10.1039/C8CC05791E PMID:30357141 
Mahadeva M M Swamy, Yuta Murai, Yusuke Ohno, Keisuke Jojima, Akio Kihara, Susumu Mitsutake, Yasuyuki Igarashi, Jian Yu, Min Yao, Yoshiko Suga, Masaki Anetai, Kenji Monde (2018)  Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor. Chemical Communication. 54 :90,  12758-12761 DOI:10.1039/c8cc05595e PMID:30362470 
Hirokazu Tsukamoto, Kazuya Ito, Takayuki Doi (2018)  Synthesis of multi-substituted dihydrofurans via palladium-catalysed coupling between 2,3-alkadienols and pronucleophiles Chemical Communications . 54 5102-5105 DOI:10.1039/C8CC02589D PMID:29714394 
Akinobu Senoo, Satoru Nagatoishi, Anna Moberg, Linnea Nygren Babol, Tomoya Mitani, Takumi Tashima, Shota Kudo, Kouhei Tsumoto (2018)  Inhibition of homophilic dimerization and disruption of cell adhesion by P-cadherin-specific small molecules from SPR-based assays Chemical Communications . 54 5350-5353 DOI:10.1039/C8CC01964A PMID:29741543 
Suguru Yoshida, Kimiyuki Kanno, Isao Kii, Yoshihiro Misawa, Masatoshi Hagiwara and Takamitsu Hosoya (2018)  Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions Chemical Communications. 54 :30,  3705-3708 DOI:10.1039/C8CC01195H PMID:29527608 
Tomohiro Meguro, Norikazu Terashima, Harumi Ito, Yuka Koike, Isao Kii, Suguru Yoshida, Takamitsu Hosoya (2018)  Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells Chemical Communications . 54 :57,  7904-7907 DOI:10.1039/C8CC00179K PMID:29785430 
Tetsuya Kuga, Yusuke Sasano, Yoshiharu Iwabuchi (2018)  IBX as a Catalyst for Dehydration of Hydroperoxides: Green Entry to α,β-Unsaturated Ketones via Oxygenative Allylic Transposition Chemical Communications. 54 798-801 DOI:10.1039/C7CC08957K PMID:29308794 
Kazuma Matsui, Masatoshi Shibuya & Yoshihiko Yamamoto (2018)  Synthesis of pyrroles via ruthenium-catalyzed nitrogen-transfer [2+2+1] cycloaddition of α,ω-diynes using sulfoximines as nitrene surrogates Communications Chemistry. 1 21- DOI:10.1038/s42004-018-0022-2
Takashi Murayama, Haruo Ogawa, Nagomi Kurebayashi, Seiko Ohno, Minoru Horie, Takashi Sakurai  (2018)  A tryptophan residue in the caffeine-binding site of the ryanodine receptor regulates Ca2+ sensitivity Communications Biology. 1 98- DOI:10.1038/s42003-018-0103-x PMID:30271978 
Annika Bartsch, Salome Llabres, Florian Pein, Christof Kattner, Markus Schon, Manuel Diehn, Mikio Tanabe, Axel Munk, Ulrich Zachariae, Claudia Steinem (2019)  High-resolution experimental and computational electrophysiology reveals weak β-lactam binding events in the porin PorB Scientific Reports. 9 :1,  1264- DOI:10.1038/s41598-018-37066-9 PMID:30718567 
Kei Moritsugu, Hafumi Nishi, Keiichi Inariyama, Masanori Kobayashi, and Akinori Kidera (2018)  Dynamic recognition and linkage specificity in K63 di-ubiquitin and TAB2 NZF domain complex Scientific Reports. 8 16478- DOI:10.1038/s41598-018-34605-2 PMID:30405169 
Jun Tsunoda, Chihong Song, Fabiana Lica Imai, Junichi Takagi, Hiroshi Ueno, Takeshi Murata, Ryota Iino & Kazuyoshi Murata (2018)  Off-axis rotor in Enterococcus hirae V-ATPase visualized by Zernike phase plate single-particle cryo-electron microscopy Scientific Reports. 8 15632- DOI:10.1038/s41598-018-33977-9 PMID:30353110 
Vikas Dubey, Minwoo Han, Wojciech Kopec, Ilia A. Solov’yov, Kazuhiro Abe & Himanshu Khandelia  (2018)  K+ binding and proton redistribution in the E2P state of the H+, K+-ATPase. Scientific Reports. 8 :1,  12732- DOI:10.1038/s41598-018-30885-w PMID:30143663 
Yoshihide Mitsuda, Ken Morita, Gengo Kashiwazaki, Junichi Taniguchi, Toshikazu Bando, Moeka Obara, Masahiro Hirata, Tatsuki R. Kataoka, Manabu Muto, Yasufumi Kaneda, Tatsutoshi Nakahata, Pu Paul Liu, Souichi Adachi, Hiroshi Sugiyama& Yasuhiko Kamikubo (2018)  RUNX1 positively regulates ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells Scientific Reports. 8 6423- DOI:10.1038/s41598-018-24969-w PMID:29686309 
Sujin Kang, Yoshimitsu Nakanishi, Yoshiyuki Kioi, Daisuke Okuzaki, Tetsuya Kimura, Hyota Takamatsu, Shohei Koyama, Satoshi Nojima, Masayuki Nishide, Yoshitomo Hayama, Yuhei Kinehara, Yasuhiro Kato, Takeshi Nakatani, Tomomi Shimogori, Junichi Takagi, Toshihiko Toyofuku & Atsushi Kumanogoh? (2018)  Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization Nature Immunology. 19 :6,  561-570 DOI:10.1038/s41590-018-0108-0 PMID:29777213 
Kazuhiro Abe, Katsumasa Irie, Hanayo Nakanishi, Hiroshi Suzuki, Yoshinori Fujiyoshi  (2018)  Crystal Structures of the Gastric Proton Pump Nature. 556 :7700,  214-218 DOI:10.1038/s41586-018-0003-8 PMID:29618813 
Kenta Tsutsumi, Ryo Yonehara, Etsuko Ishizaka-Ikeda, Naoyuki Miyazaki, Shintaro Maeda, Kenji Iwasaki, Atsushi Nakagawa & Eiki Yamashita? (2019)  Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism, Nature communications. 10 :1,  1520- DOI:10.1038/s41467-019-09463-9 PMID:30944318 
Ruben Quintana-Cabrera, Charlotte Quirin, Christina Glytsou, Mauro Corrado, Andrea Urbani, Anna Pellattiero, Enrique Calvo, Jesas Vzquez, JosAntonio Enriquez, Christoph Gerle, Maria Eugenia Soriano, Paolo Bernardi & Luca Scorrano  (2018)  The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function. Nature Communications. 9 :1,  3399- DOI:10.1038/s41467-018-05655-x PMID:30143614 
Akihito Harada, Kazumitsu Maehara, Yusuke Ono, Hiroyuki Taguchi, Kiyoshi Yoshioka, Yasuo Kitajima, Yan Xie, Yuko Sato, Takeshi Iwasaki, Jumpei Nogami, Seiji Okada, Tetsuro Komatsu, Yuichiro Semba, Tatsuya Takemoto, Hiroshi Kimura, Hitoshi Kurumizaka & Yasuyuki Ohkawa? (2018)  Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration Nature Communications. 9 1400- DOI:10.1038/s41467-018-03845-1 PMID:29643389 
Wataru Fukasawa, Natsuki Mori, Masato Iwatsuki, Rei Hokari, Aki Ishiyama, Moe Nakajima, Takahito Ouchi, Kenichi Nonaka, Hiroki Kojima, Hirotaka Matsuo, Satoshi Omura, Kazuro Shiomi (2018)  Tolyprolinol, a new dipeptide from Tolypocladium sp. FKI-7981 Antibiotics. 71 682-684 DOI:10.1038/s41429-018-0041-3 PMID:29563600 
Takayuki Katoh, Hiroaki Suga (2018)  Ribosomal Incorporation of Consecutive β-Amino Acids Journal of the American Chemical Society. 140 12159-12167 DOI:10.1021/jacs.8b07247 PMID:30221942 
Hiromichi Egami, Tomoki Niwa, Hitomi Sato, Ryo Hotta, Daiki Rouno, Yuji Kawato, Yoshitaka Hamashima (2018)  Dianionic Phase-Transfer Catalyst for Asymmetric Fluoro-cyclization Journal of the American Chemical Society. 140 2785-2788 DOI:10.1021/jacs.7b13690 PMID:29424534 
Zutao Yu, Chuanxin Guo, Yulei Wei, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama (2018)  Pip-HoGu: An Artificial Assembly with Cooperative DNA Recognition Capable of Mimicking Transcription Factor Pairs Journal of the American Chemical Society . 140 2426-2429 DOI:10.1021/jacs.7b13275 PMID:29393635 
Yulei Wei, Ganesh N. Pandian, Zutao Yu, Tingting Zou, Yue Li, Jayant Darokar, Kaori Hashiya, Toshikazu Bando, and Hiroshi Sugiyama (2018)  A Synthetic DNA-binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation ACS Omega . 3 3608-3616 DOI:10.1021/acsomega.8b00220 PMID:30023873 
Takuya Kobayakawa, Yudai Matsuzaki, Kentaro Hozumi, Wataru Nomura, Motoyoshi Nomizu, and Hirokazu Tamamura (2018)  Synthesis of a Chloroalkene Dipeptide Isostere-Containing Peptidomimetic and Its Biological Application ACS Medicinal Chemistry Letters. 9 :1,  6-10 DOI:10.1021/acsmedchemlett.7b00234 PMID:29348803 
Shinya Tashiro, Jose M. M. Caaveiro, Makoto Nakakido, Aki Tanabe, Satoru Nagatoishi, Yasushi Tamura, Noriyuki Matsuda, Dali Liu, Quyen Q. Hoang, Kouhei Tsumoto (2018)  Discovery and Optimization of Inhibitors of the Parkinson’s Disease Associated Protein DJ-1 ACS Chemical Biology. 13 2783-2793 DOI:10.1021/acschembio.8b00701 PMID:30063823 
Masatoshi Shibuya, Masaki Okamoto, Shoji Fujita, Masanori Abe, Yoshihiko Yamamoto (2018)  Boron-Catalyzed Double Hydrofunctionalization Reactions of Unactivated Alkynes ACS Catalysis. 8 4189-4193 DOI:10.1021/acscatal.8b00955
Toshiki Akiyama, Yuki WADA, Kellie Jenkinson, Tetsuo Honma, Kazuki TSURUTA, Yusuke Tamenori, Hitoshi HANEOKA, Tsunayoshi TAKEHARA, Takeyuki Suzuki, Kenichi Murai, Hiromichi Fujioka, Yoshihiro Sato, Andrew E. H. Wheatley, Mitsuhiro Arisawa (2018)  Reusable Immobilized Iron(II) Nanoparticle Pre-Catalysts for Ligand-Free Kumada Coupling Acs Applied Nano Materials. 1 6950-6958 DOI:10.1021/acsanm.8b01742
Shinji Kawanishi , Shinya Oki , Dhiman Kundu , Shuji Akai (2019)  Lipase/Oxovanadium Co-Catalyzed Dynamic Kinetic Resolution of 2 Propargyl Alcohols: Competition between Racemization and Rearrangement Organic Letters. 21 2978-2982 DOI:10.1021/acs.orglett.9b00334 PMID:30875229 
Koki Yamamoto, Yasushi Yoshikawa, Masahito Ohue, Shinsuke Inuki, Hiroaki Ohno, Shinya Oishi  (2019)  Synthesis of Triazolo- and Oxadiazolopiperazines by Gold(I)-Catalyzed Domino Cyclization: Application to the Design of a Mitogen Activated Protein (MAP) Kinase Inhibitor. Organic Letters.. 21 373-377 DOI:10.1021/acs.orglett.8b03500 PMID:30596417 
Motohiro Yasui, Rina Ota, Chihiro Tsukano, Yoshiji Takemoto (2018)  Synthesis of cis-/All-cis-Substituted Cyclopropanes through Stereocontrolled Metalation and Pd-Catalyzed Negishi Coupling. Organic Letters.. 20 7656-7660 DOI:10.1021/acs.orglett.8b03390 PMID:30462517 
Takehiro Nishimura, Junya Kawai, Yoshiteru Oshima, Haruhisa Kikuchi (2018)  Removal of the E-Olefin Barrier of Humulene Leading to Unnatural Terpenoid-like Skeletons Organic Letters. 20 7317-7320 DOI:10.1021/acs.orglett.8b03259 PMID:30395476 
Yusuke Sasano, Naoki Kogure, Shota Nagasawa, Koki Kasabata, and Yoshiharu Iwabuchi (2018)  2-Azaadamantane N-oxyl (AZADO)/Cu Catalysis Enables Chemoselective Aerobic Oxidation of Alcohols Containing Electron-Rich Divalent Sulfur Functionalities Chemical Communications. 20 6104-6107 DOI:10.1021/acs.orglett.8b02528 PMID:30226058 
Tomohiro Meguro, Suguru Yoshida, Kazunobu Igawa, Katsuhiko Tomooka, Takamitsu Hosoya (2018)  Transient Protection of Organic Azides from Click Reactions with Alkynes by Phosphazide Formation Organic Letters. 20 :13,  4126-4130 DOI:10.1021/acs.orglett.8b01692 PMID:29901399 
Shan Lu, Shinichi Nishimura, Kei Takenaka, Masashi Ito, Taira Kato, Hideaki Kakeya (2018)  Discovery of Presaccharothriolide X, a Retro-Michael Product of Saccharothriolide B, from the Rare Actinomycete Saccharothrix sp. A1506. Organic Letters. 20 4406-4410 DOI:10.1021/acs.orglett.8b01535 PMID:30024763 
Naoka Hamada, Ayuta Yamaguchi, Shinsuke Inuki, Shinya Oishi, Hiroaki Ohno (2018)  Gold(I)-Catalyzed Oxidative Cascade Cyclization of 1,4-Diyn-3-ones for the Construction of Tropone-Fused Furan Scaffolds Organic Letters. 20 4401-4405 DOI:10.1021/acs.orglett.8b01524 PMID:30036068 
Hirokazu Tsukamoto, Yumi Nomura, Koichi Fujiwara, Shogo Hanada, Takayuki Doi (2018)  Conjugate Addition to Acylketene Acetals Derived from 1,8-Dihydroxynaphthalene and Its Application To Synthesize the Proposed Structure of Spiropreussione A Organic Letters. 20 3140-3143 DOI:10.1021/acs.orglett.8b01259 PMID:29737863 
Yusuke Sasano, Junpei Koyama, Kaori Yoshikawa, Naoki Kanoh, Eunsang Kwon, Yoshiharu Iwabuchi (2018)  Stereocontrolled Construction of ABCD Tetracyclic Ring System with Vicinal All-Carbon Quaternary Stereogenic Centers of Calyciphylline A Type Alkaloids Organic Letters. 20 3053-3056 DOI:10.1021/acs.orglett.8b01087 PMID:29733608 
Kenichi Murai, Tetsuya Kobayashi, Makoto Miyoshi, Hiromichi Fujioka (2018)  Oxidative Rearrangement of Secondary Amines Using Hypervalent Iodine(III) Reagent Organic Letters. 20 2333-2337 DOI:10.1021/acs.orglett.8b00675 PMID:29582653 
Kohei Takamoto, Shohei Yoshioka, Hiromichi Fujioka, Mitsuhiro Arisawa (2018)  Palladium-Catalyzed Seven-Membered Silacycle Construction: 1,7-Enyne Hydroxycyclization To Give a Benzosilepine Skeleton Organic Letters. 20 1773-1776 DOI:10.1021/acs.orglett.8b00271 PMID:29528660 
Saori Tanii, Mieko Arisawa, Takaya Tougo, Masahiko Yamaguchi (2018)  Catalytic Method for the Synthesis of C-N-Linked Bi(heteroaryl)s Using Heteroaryl Ethers and N‐Benzoyl Heteroarenes Organic Letters. 20 1756-1759 DOI:10.1021/acs.orglett.8b00245 PMID:29528237 
Hiromichi Egami, Shuya Masuda, Yuji Kawato, Yoshitaka Hamashima (2018)  Photofluorination of Aliphatic C-H Bonds Promoted by the Phthalimide Group Organic Letters. 20 1367-1370 DOI:10.1021/acs.orglett.8b00133 PMID:29442520 
Mieko Arisawa, Kyosuke Sawahata, Tomoki Yamada, Debayan Sarkar, Masahiko Yamaguchi (2018)  Rhodium-Catalyzed Insertion Reaction of PhP Group of Pentaphenylcyclopentaphosphine with Acyclic and Cyclic Disulfides Organic Letters. 20 938-941 DOI:10.1021/acs.orglett.7b03825 PMID:29412679 
Hideyuki Konishi, Hiromichi Tanaka, Kei Manabe (2018)  Pd-Catalyzed Selective Synthesis of Cyclic Sulfonamides and Sulfinamides Using K2S2O5 as a Sulfur Dioxide Surrogate Organic Letters. 19 1578-1581 DOI:10.1021/acs.orglett.7b00402 PMID:28277668 
Mieko Arisawa, Kyosuke Sawahata, Takuya Ichikawa, Masahiko Yamaguchi (2018)  Rhodium-Catalyzed Isomerization and Alkyne Exchange Reactions of 1,4-Dithiins via the 1,2-Ethenedithiolato Rhodium Complex Organometallics. 37 3174-3180 DOI:10.1021/acs.organomet.8b00498
Andi Klamt, Kumar Nagarathinam, Mikio Tanabe, Amit Kumar, Jochen Balbach  (2019)  Hyperbolic Pressure-Temperature Phase Diagram of the Zinc-Finger Protein apoKti11 Detected by NMR Spectroscopy. The Journal of Physical Chemistry B. 123 :4,  792-801 DOI:10.1021/acs.jpcb.8b11019 PMID:30608169 
Hiroko X. Kondo, Norio Yoshida, Matsuyuki Shirota, Kengo Kinoshita (2018)  Molecular Mechanism of Depolarization-Dependent Inactivation in W366F Mutant of Kv1.2 The Journal of Physical Chemistry B. 122 10825-10833 DOI:10.1021/acs.jpcb.8b09446 PMID:30395463 
Mitsuhiro Hirai, Satoshi Ajito, Hiroki Iwase, Shin-Ichi Takata, Noboru Ohta, Noriyuki Igarashi, Nobutaka Shimizu (2018)  Restoration of Myoglobin Native Fold from Its Initial State of Amyloid Formation by Trehalose. The journal of physical chemistry B. 122 :50,  11962-11968 DOI:10.1021/acs.jpcb.8b09379 PMID:30461273 
Mitsuhiro Hirai, Satoshi Ajito, Shouki Sato, Noboru Ohta, Noriyuki Igarashi, Nobutaka Shimizu  (2018)  Preferential Intercalation of Human Amyloid-β Peptide into Interbilayer Region of Lipid-Raft Membrane in Macromolecular Crowding Environment. The Journal of Physical Chemistry B. 122 :41,  9482-9489 DOI:10.1021/acs.jpcb.8b08006 PMID:30257562 
Zhenhai Li , Hidetoshi Kono (2018)  Investigating the Influence of Arginine Dimethylation on Nucleosome Dynamics Using All-Atom Simulations and Kinetic Analysis The Journal of Physical Chemistry B. 122 9625-9634 DOI:10.1021/acs.jpcb.8b05067 PMID:30256111 
Takeshi Ishikawa, Satoshi Mizuta, Osamu Kaneko, Kazuhide Yahata (2018)  Fragment Molecular Orbital Study of the Interaction between Sarco/Endoplasmic Reticulum Ca2+-ATPase and its Inhibitor Thapsigargin toward Anti-Malarial Development Journal of Physical Chemistry. 112 7970-7977 DOI:10.1021/acs.jpcb.8b04509 PMID:30067362 
Yoshihiko Yamamoto (2018)  Theoretical Study of the Copper-Catalyzed Hydroarylation of (Trifluoromethyl)alkyne with Phenylboronic Acid The Journal of Organic Chemistry. 83 12775-12783 DOI:10.1021/acs.joc.8b02215 PMID:30230833 
Hirokazu Tsukamoto, Shogo Hanada, Yumi Nomura, Takayuki Doi (2018)  Total Synthesis of Spiromamakone A and Structure Revision of Spiropreussione A The Journal of Organic Chemistry. 83 9430-9441 DOI:10.1021/acs.joc.8b01075 PMID:29895147 
Shohei Yoshioka, Hiroshi Aoyama, Hiromichi Fujioka, Mitsuhiro Arisawa (2018)  Cascade Multiple Diels-Alder Reactions of Styrene Derivatives with Maleimide or Maleic Anhydride The Journal of Organic Chemistry. 83 6599-6606 DOI:10.1021/acs.joc.8b00890 PMID:29775066 
Naoki Ogawa, Yousuke Yamaoka, Hiroshi Takikawa, Kazunori Tsubaki, Kiyosei Takasu (2018)  Synthesis and Properties of Tribenzocarbazoles via an Acid-Promoted Retro (2+2)-Cycloaddition of Azapropellanes, Journal of Organic Chemistry. 83 7994-8002 DOI:10.1021/acs.joc.8b00870 PMID:29863348 
Reiya Ohta, Nao Matsumoto, Yoshifumi Ueyama, Yuichi Kuboki, Hiroshi Aoyama, Kenichi Murai, Mitsuhiro Arisawa, Tomohiro Maegawa, Hiromichi Fujioka (2018)  Highly Discriminative and Chemoselective Deprotection/Transformations of Acetals with the Combination of Trialkylsilyl Triflate/2,4,6-Collidine The Journal of Organic Chemistry. 83 6432-6443 DOI:10.1021/acs.joc.8b00675 PMID:29782161 
Yoshihiro Nagao, Tatsunari Hisanaga, Takahiro Utsumi, Hiromichi Egami, Yuji Kawato, Yoshitaka Hamashima (2018)  Enantioselective Synthesis of Nelfinavir via Asymmetric Bromocyclization of Bisallylic Amide The Journal of Organic Chemistry. 83 7290-7295 DOI:10.1021/acs.joc.8b00039 PMID:29480721 
Toru Ekimoto, Tsutomu Yamane, Mitsunori Ikeguchi (2018)  Elimination of Finite-Size Effects on Binding Free Energies via the Warp-Drive Method Journal of Chemical Theory and Computation. 14 6544-6559 DOI:10.1021/acs.jctc.8b00280 PMID:30404450 
Yuka Kobayashi, Masaru Hoshino, Tomoshi Kameda, Kazuya Kobayashi, Kenichi Akaji, Shinsuke Inuki, Hiroaki Ohno, Shinya Oishi (2018)  Use of a Compact Tripodal Tris(bipyridine) Ligand to Stabilize a Single-Metal-Centered Chirality: Stereoselective Coordination of Iron(II) and Ruthenium(II) on a Semirigid Hexapeptide Macrocycle. Inorganic Chemistry.. 57 5475-5485 DOI:10.1021/acs.inorgchem.8b00416 PMID:29634246 
Kei Toyama, Wataru Nomura, Takuya Kobayakawa, Hirokazu Tamamura (2018)  Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR Bioconjugate Chemistry. 29 :6,  2050-2057 DOI:10.1021/acs.bioconjchem.8b00250 PMID:29763296 
Nasir K. Bashiruddin, Yukiko Matsunaga, Masanobu Nagano, Junichi Takagi, Hiroaki Suga (2018)  Facile synthesis of dimeric thioether-macrocyclic peptides with antibody-like affinity against Plexin-B1. Bioconjugate Chemistry. 29 :6,  1847-1851 DOI:10.1021/acs.bioconjchem.8b00219 PMID:29714478 
TsubasaMatsuzawa, SuguruYoshida, TakamitsuHosoya (2018)  Recent advances in reactions between arynes and organosulfur compounds Tetrahedron Letters. 59 :48,  4197-4208 DOI:10.1016/j.tetlet.2018.10.031
Tetsuro Murokawa, Masaru Enomoto, Takaaki Teranishi, Yusuke Ogura,Shigefumi Kuwahara (2018)  Total synthesis of JBIR-03 and asporyzin C Tetrahedron Letters. 59 4107-4109 DOI:10.1016/j.tetlet.2018.10.009
Takashi Miyagawa, Shinsuke Inuki, Maho Honda, Shinya Nakamura, Isao Nakanishi, Nobutaka Fujii, Shinya Oishi, Hiroaki Ohno (2018)  Synthesis of Jaspine B Regioisomers through Palladium-Catalyzed Stereoselective Tetrahydrofuran Formation: Insight into the Ligand Recognition of Sphingosine Kinases. Tetrahedron. 74 1802-1809 DOI:10.1016/j.tet.2018.02.042
Yusuke Nakamichi, Naoyuki Miyazaki, Kenta Tsutsumi, Akifumi Higashiura, Hirotaka Narita, Kazuyoshi Murata, Atsushi Nakagawa  (2019)  An assembly intermediate structure of Rice dwarf virus reveals a hierarchical outer capsid shell assembly mechanism, Structure. 27 :3,  439-448 DOI:10.1016/j.str.2018.10.029 PMID:30581044 
Shunsuke Kuroki, Yuji Nakai, Ryo Maeda, Naoki Okashita, Mika Akiyoshi, Yutaro Yamaguchi, Satsuki Kitano, Hitoshi Miyachi, Ryuichiro Nakato, Kenji Ichiyanagi, Katsuhiko Shirahige, Hiroshi Kimura, Yoichi Shinkai, Makoto Tachibana (2018)  Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis Stem cell Reports. 10 :4,  1340-1354 DOI:10.1016/j.stemcr.2018.02.002 PMID:29526734 
Takashi Seino, Shintaro Kawasaki, Mariko Shimokawa, Hiroki Tamagawa, Kohta Toshimitsu, Masayuki Fujii, Yuki Ohta, Mami Matano, Kosaku Nanki, Kenta KawasakiSirirat Takahashi, Shinya Sugimoto, Eisuke Iwasaki, Junichi Takagi, TakaoItoi, Minoru Kitago, Yuko Kitagawa, Takanori Kanai, Toshiro Sato  (2018)  Human pancreatic tumor organoids reveal loss of stem cell niche factor dependence during disease progression. Cell Stem Cell. 22 :3,  454-467 DOI:10.1016/j.stem.2017.12.009 PMID:29337182 
Haruki Kawase, Yukio Ago, Megumi Naito, Momoko Higuchi, Yuta Hara, Shigeru Hasebe, Shinji Tsukada, Atsushi Kasai, Takanobu Nakazawa, Tadashi Mishina, Hiroyuki Kouji, Kazuhiro Takuma, Hitoshi Hashimoto (2019)  mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model Pharmacol Biochem Behav. 176 1-5 DOI:10.1016/j.pbb.2018.11.003 PMID:30419271 
Takuma Hotani, Hiroyuki Mizuguchi, Fuminori Sakurai (2018)  Systemically Administered Reovirus-Induced Downregulation of Hypoxia Inducible Factor-1α in Subcutaneous Tumors Molecular Therapy: Oncolytics. 12 162-172 DOI:10.1016/j.omto.2018.12.012 PMID:30788427 
Fulian Lyu, Tatsuhiko Ozawa, Hiroshi Hamana, Eiji Kobayashi, Atsushi Muraguchi, Hiroyuki Kishi (2019)  A novel and simple method to produce large amounts of recombinantsoluble peptide/major histocompatibility complex monomers for analysis ofantigen-specific human T cell receptors New Biotechnology. 49 :25,  169-177 DOI:10.1016/j.nbt.2018.11.005 PMID:30465909 
Norio Suzuki, Yukari Matsuo-Tezuka, Yusuke Sasaki, Koji Sato, Kenichiro Miyauchi, Koichiro Kato, Sakae Saito, Yasushi Shimonaka, Michinori Hirata, Masayuki Yamamoto (2018)  Iron attenuates erythropoietin production by decreasing hypoxia-inducible transcription factor 2α concentrations in renal interstitial fibroblasts Kidney International. 94 900-911 DOI:10.1016/j.kint.2018.06.028 PMID:30245128 
Takeshi Kawabata (2018)  Gaussian-input Gaussian mixture model for representing density maps andatomic models Journal of Structural Biology. 203 1-16 DOI:10.1016/j.jsb.2018.03.002 PMID:29522817 
Zuben P.Brown, TakaoArimori, KenjiIwasaki, JunichiTakagi (2018)  Development of a new protein labeling system to map subunits and domains of macromolecular complexes for electron microscopy Journal of Structural Biology. 201 :3,  247-251 DOI:10.1016/j.jsb.2017.11.006 PMID:29170031 
Huping Wang, Wenyu Han, Junichi Takagi, Yao Con (2018)  Yeast Inner-Subunit PA?NZ-1 Labeling Strategy for Accurate Subunit Identification in a Macromolecular Complex through Cryo-EM Analysis Journal of molecular biology . 430 :10,  1417-1425 DOI:10.1016/j.jmb.2018.03.026 PMID:29625202 
Mika Saotome, Kengo Saito, Takeshi Yasuda, Hideaki Ohtomo, Shusei Sugiyama, Yoshifumi Nishimura, Hitoshi Kurumizaka, and Wataru Kagawa,  (2018)  Structural Basis of Homology-Directed DNA Repair Mediated by RAD52. iScience.. 3 50-62 DOI:10.1016/j.isci.2018.04.005 PMID:30428330 
Masashi Minamino, Shoin Tei, Lumi Negishi, Masato T Kanemaki, Atsunori Yoshimura, Takashi Sutani, Masashige Bando, Katsuhiko Shirahige (2018)  Temporal Regulation of ESCO2 Degradation by the MCM Complex, the CUL4-DDB1-VPRBP Complex, and the Anaphase-Promoting Complex Current biology. 28 :16,  2665-2672 DOI:10.1016/j.cub.2018.06.037 PMID:30100344 
Mitsuhiro Hirai, Satoshi Ajito, Masaaki Sugiyama, Hiroki Iwase, Shin-Ichi Takata, Nobutaka Shimizu, Noriyuki Igarashi, Anne Martel, Lionel Porcar (2018)  Direct Evidence for the Effect of Glycerol on Protein Hydration and Thermal Structural Transition. Biophysical Journal. 115 :2,  313-327 DOI:10.1016/j.bpj.2018.06.005 PMID:30021107 
Tomoyuki Ohe, Ryutaro Umezawa, Yumina Kitagawara, Daisuke Yasuda, Kyoko Takahashi, Shigeo Nakamura, Akiko Abe, Shuichi Sekine, Kousei Ito, Kentaro Okunushi, Hanae Morio, Tomomi Furihata, Naohiko Anzai, Tadahiko Mashino (2018)  Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation Bioorganic & Medicinal Chemistry. 28 3708-3711 DOI:10.1016/j.bmcl.2018.10.023 PMID:30389287 
Shohei Utsumia, Kousuke Sato, Satoshi Ichikawa (2018)  Insight into the recognition mechanism of DNA cytosine-5 methyltransferases (DNMTs) by incorporation of acyclic 5-fluorocytosine (FC) nucleosides into DNA Bioorganic & Medicinal Chemistry Letters. 28 2189-2194 DOI:10.1016/j.bmcl.2018.05.008 PMID:29752184 
Yuhei Kinoshita, Fumika Yakushiji, Hidehito Matsui, Hideaki Hanaki, Satoshi Ichikawa (2018)  Study of the structure-activity relationship of polymyxin analogues Bioorganic & Medicinal Chemistry Letters. 28 2713-2716 DOI:10.1016/j.bmcl.2018.03.028 PMID:29606572 
Takuya Kobayakawa, Nami Ohashi, Yuki Hirota, Kohei Takahashi, Yuko Yamada, Tetsuo Narumi, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada, Hirokazu Tamamura (2018)  Flexibility of Small Molecular CD4 Mimics as HIV Entry Inhibitors Bioorganic & Medicinal Chemistry. 26 :21,  5664-5671 DOI:10.1016/j.bmc.2018.10.011 PMID:30366786 
YukoKazui, ShinyaFujii, AyumiYamada, MariIshigami-Yuasa, HiroyukiKagechika, AyaTanatani (2018)  Structure-activity relationship of novel (benzoylaminophenoxy)phenol derivatives as anti-prostate cancer agents. Bioorganic & Medicinal Chemistry. 26 :18,  5118-5127 DOI:10.1016/j.bmc.2018.09.008 PMID:30228001 
Daisuke Takaya, Koji Inaka, Akifumi Omura, Kenji Takenuki, Masashi Kawanishi, Yukako Yabuki, Yukari Nakagawa, Keiko Tsuganezawa, Naoko Ogawa, Chiduru Watanabe, Teruki Honma, Kosuke Aritake, Yoshihiro Urade, Mikako Shirouzu, Akiko Tanaka (2018)  Characterization of crystal water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex by interaction energy studies Bioorganic & Medicinal Chemistry. 26 4726-4734 DOI:10.1016/j.bmc.2018.08.014 PMID:30121213 
Satoru Nagatoishi, Sou Yamaguchi, Etsuko Katoh, Keita Kajita, Takane Yokotagawa, SatoruK anai, Toshio Furuya, Kouhei Tsumoto (2018)  A combination of 19F NMR and surface plasmon resonance for site-specific hit selection and validation of fragment molecules that bind to the ATP-binding site of a kinase Bioorganic & Medicinal Chemistry. 26 1929-1938 DOI:10.1016/j.bmc.2018.02.041 PMID:29510947 
Yusuke Kawamoto, Toshikazu Bando, Hiroshi Sugiyama (2018)  Sequence-specific DNA Binding Pyrrole-Imidazole Polyamides and Their Applications Bioorganic & Medicinal Chemistry | Journal . 26 1393-1411 DOI:10.1016/j.bmc.2018.01.026 PMID:29439914 
Toby Passioura, Bhaskar Bhushan, Anthony Tumber, Akane Kawamura, Hiroaki Suga (2018)  Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A Bioorganic & Medicinal Chemistry. 26 1225-1231 DOI:10.1016/j.bmc.2018.01.013 PMID:29402611 
Koji Sugiyama, Shinji Kawanishi, Yasuhiro Oki, Marin Kamiya, Ryosuke Hanada, Masahiro Egi, Shuji Akai (2018)  Lipase-catalyzed asymmetric synthesis of naphtho[2,3-c]furan-1(3H)-one derivatives by a one-pot dynamic kinetic resolution/intramolecular Diels-Alder reaction: Total synthesis of (-)-himbacine, Bioorganic & Medicinal Chemistry. 26 1378-1386 DOI:10.1016/j.bmc.2017.08.019 PMID:28844401 
Yukinari Kato, Tomokazu Ohishi, Manabu Kawada, Naoya Maekawa, Satoru Konnai, Shunsuke Itai, Shinji Yamada, and Mika K. Kaneko (2018)  The mouse-canine chimeric anti-dog podoplanin antibody P38B exerts antitumor activity in mouse xenograft models Biochemistry and Biophysics Reports. 17 23-26 DOI:10.1016/j.bbrep.2018.11.005 PMID:30519645 
Shunsuke Itai, Shinji Yamada, Mika K. Kaneko, Masato Sano, Takuro Nakamura, Miyuki Yanaka, Saori Handa, Kayo Hisamatsu, Yoshimi Nakamura, Yoshikazu Furusawa, Masato Fukui, Tomokazu Ohishi, Manabu Kawada, Hiroyuki Harada, and Yukinari Katoa (2018)  Podocalyxin is crucial for the growth of oral squamous cell carcinoma cell line HSC-2 Biochemistry and Biophysics Reports. 15 93-96 DOI:10.1016/j.bbrep.2018.07.008 PMID:30105309 
Mika K. Kaneko, Shinji Yamada, Shunsuke Itai, Yoshikazu Furusawa, Takuro Nakamura, Miyuki Yanaka, Saori Handa, Kayo Hisamatsu, Yoshimi Nakamura, Masato Fukui, Hiroyuki Harada, and Yukinari Kato (2018)  Epitope mapping of an anti-alpha thalassemia/mental retardation syndrome X-linked monoclonal antibody AMab-6 Biochemistry and Biophysics Reports. 15 : ,  76-80 DOI:10.1016/j.bbrep.2018.07.003 PMID:30073207 
Shinji Yamada, Shunsuke Itai, Mika K Kaneko, Satoru Konnai, Yukinari Kato (2018)  Epitope mapping of anti-mouse podoplanin monoclonal antibody PMab-1 Biochemistry and Biophysics Reports. 15 52-56 DOI:10.1016/j.bbrep.2018.07.002 PMID:29998193 
Shunsuke Itai, Shinji Yamada, Mika K. Kaneko, and Yukinari Kato (2018)  Determination of critical epitope of PcMab-47 against human podocalyxin Biochemistry and Biophysics Reports. 14 78-82 DOI:10.1016/j.bbrep.2018.04.003 PMID:29872738 
Mika K. Kaneko, Shinji Yamada, Shunsuke Itai, Yao-Wen Chang, Takuro Nakamura, Miyuki Yanaka and, Yukinari Kato  (2018)  Elucidation of the critical epitope of an anti-EGFR monoclonal antibody EMab-134. Biochemistry and Biophysics Reports. 14 54-57 DOI:10.1016/j.bbrep.2018.03.010 PMID:29872734 
Shinji Yamada, Shunsuke Itai, Takuro Nakamura, Miyuki Yanaka, Mika K. Kaneko, and Yukinari Katoa (2018)  Detection of high CD44 expression in oral cancers using the novel monoclonal antibody, C44Mab-5 Biochemistry and Biophysics Reports. 14 64-68 DOI:10.1016/j.bbrep.2018.03.007 PMID:29872736 
Shinji Yamada, Shunsuke Itai, Mika K.Kaneko, Yukinari Kato (2018)  Detection of high PD-L1 expression in oral cancers by a novel monoclonal antibody L1Mab-4. Biochemistry and Biophysics Reports. 13 123-128 DOI:10.1016/j.bbrep.2018.01.009 PMID:29556567 
Taishi Yonezawa, Hirotaka Takahashi, Shiori Shikata, Tatsuya Sawasaki, Toshio Kitamura, Susumu Goyama (2018)  The ubiquitin ligase RNF38 promotes RUNX1 ubiquitination and enhances RUNX1-mediated suppression of erythroid transcription program. Biochemical and Biophysical Research Communications. 505 :3,  905-909 DOI:10.1016/j.bbrc.2018.10.006 PMID:30309654 
Hinako Kimura, Naoya Matsunagaa, Keisuke Kakimto, Miyako Watanabe, Akito Tsuruta, Naoki Kusunose, Shoya Shiromizu, Satoru Koyanagi, Shigehiro Ohdo (2018)  Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system Biochemical and Biophysical Research Communications. 503 1063-1069 DOI:10.1016/j.bbrc.2018.06.117 PMID:29958886 
ToyokazuMiura, SatoruTakeo, Edward H.Ntege, HitoshiOtsuki, TatsuyaSawasaki, TomokoIshino, EizoTakashima, TakafumiTsuboi (2018)  The malaria parasite RhopH protein complex interacts with erythrocyte calmyrin identified from a comprehensive erythrocyte protein library Biochemical and biophyisical reseach communications. 500 :2,  261-267 DOI:10.1016/j.bbrc.2018.04.056 PMID:29653104 
Takashi Matsunaga, Naoya Matsunaga, Naoki Kusunose, Eriko Ikeda, Hiroyuki Okazaki, Keisuke Kakimoto, Kengo Hamamura, Satoru Koyanagi, Shigehiro Ohdo (2018)  Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice Biochemical and Biophysical Research Communications. 498 86-91 DOI:10.1016/j.bbrc.2017.11.162 PMID:29470987 
Kentaro Shimizu, Wei Cao, Gul Saad, Michiru Shoji, and Tohru Terada (2018)  Comparative analysis of membrane protein structure databases Biochimica et Biophysica Acta-Biomembranes. 1860 :5,  1077-1091 DOI:10.1016/j.bbamem.2018.01.005 PMID:29331638 
Takuto Fujii, Takahiro Shimizu, Shota Yamamoto, Keisuke Funayama, Kyosuke Fujita, Yoshiaki Tabuchi, Akira Ikari, Hiroshi Takeshima, Hideki Sakai (2018)  Crosstalk between Na+, K+-ATPase and a Volume-Regulated Anion Channel in Membrane Microdomains of Human Cancer Cells. Biochimica et Biophysica Acta - Molecular Basis Disease.. 1864 3792-3804 DOI:10.1016/j.bbadis.2018.09.014 PMID:30251696 
IsaoKii, ShinoHirahara-Owada, MasatakaYamaguchi, TakashiNiwa, YukaKoike, RieSonamoto, HarumiIto, KayoTakahashi, ChihiroYokoyama, TakuyaHayashi, TakamitsuHosoya, YasuyoshiWatanabe (2018)  Quantification of receptor activation by oxytocin and vasopressin in endocytosis-coupled bioluminescence reduction assay using nanoKAZ Analytical Biochemistry. 549 174-183 DOI:10.1016/j.ab.2018.04.001 PMID:29627593 
Tsuyoshi Shirai (2018)  Protein structure analysis and validation The Encyclopedia of Bioinformatics and Computational Biology (eds..Shoba Ranganathan, Christian Sch?nbach, Kenta Nakai, and Michael Gribskov), Elsevier,. 512-519 DOI:10.1016/B978-0-12-809633-8.20282-3
Toru Ekimoto, Mitsunori Ikeguchi (2018)  Multiscale molecular dynamics simulations of rotary motor proteins Biophysical Review. 10 605-615 DOI:10.1007/s12551-017-0373-4 PMID:29204882 
Miki Senda and Toshiya Senda (2018)  Anaerobic crystallization of proteins Biophysical Reviews. 10 :2,  183-189 DOI:10.1007/s12551-017-0345-8 PMID:29198081 
Masatsune Kainosho, Yohei Miyanoiri, Tsutomu Terauchi and Mitsuhiro Takeda (2018)  Perspective: next generation isotope-aided methods for protein NMR spectroscopy. Journal of Biomolecular NMR. 71 :3,  119-127 DOI:10.1007/s10858-018-0198-x PMID:29934841 
Ashutosh Kumar & Kam Y. J. Zhang (2018)  A cross docking pipeline for improving pose prediction and virtual screening performance Journal of Computer-Aided Molecular Design. 32 :1,  163-173 DOI:10.1007/s10822-017-0048-z PMID:28836076 
Akane Yamamichi, Fumiharu Ohka, Kosuke Aoki, Hiromichi Suzuki, Akira Kato, Masaki Hirano, Kazuya Motomura, Kuniaki Tanahashi, Lushun Chalise, Sachi Maeda, Toshihiko Wakabayashi, Yukinari Kato, Atsushi Natsume (2018)  Immunohistochemical ATRX expression is not a surrogate for 1p19q codeletion Brain Tumor Pathology. 35 :2,  106-113 DOI:10.1007/s10014-018-0312-5 PMID:29550880 
Toru Ekimoto, Mitsunori Ikeguchi (2018)  Hybrid Methods for Modeling Protein Structures Using Molecular Dynamics Simulations and Small-Angle X-Ray Scattering Data Advances in Experimental Medicine and Biology. 1105 237-258 DOI:10.1007/978-981-13-2200-6_15 PMID:30617833 
Tohru Minamino,Takayuki Kato,Tomoko Miyata,Keiichi Namba (2018)  Electron Microscopy of Motor Structure and Possible Mechanisms. Encyclopedia of Biophysics. DOI:10.1007/978-3-642-35943-9_196-1
Hiroyuki Kishi,Tatsuhiko Ozawa, Hiroshi Hamana, Eiji Kobayashi, Atsushi Muraguchi (2018)  Isolation of Antigen-Specific, Antibody-Secreting Cells Using a Chip-Based Immunospot Array Methods in molecular biology. 1904 147-162 DOI:10.1007/978-1-4939-8958-4_6 PMID:30539469 
Wei Zhou, Hiroyuki Takeda (2018)  Production of Immunizing Antigen Proteoliposome Using Cell-Free Protein Synthesis System Methods in molecular biology. 1868 49-67 DOI:10.1007/978-1-4939-8802-0_7 PMID:30244454 
Hiroyuki Takeda (2018)  Autoantibody Profiling Using Human Autoantigen Protein Array and AlphaScreen Methods in molecular biology. 1868 93-112 DOI:10.1007/978-1-4939-8802-0_10 PMID:30244457 
Sumiyo Morita, Takuro Horii, Izuho Hatada  (2018)  Editing of DNA Methylation Using dCas9-Peptide Repeat and scFv-TET1 Catalytic Domain Fusions. Methods in Molecular Biology. 1767 419-428 DOI:10.1007/978-1-4939-7774-1_23 PMID:29524149 
Thangavel Vaijayanthi, Ganesh N. Pandian, Hiroshi Sugiyama (2018)  Chemical Control System of Epigenetics The Chemical Record. 18 1833-1853 DOI:10.1002/tcr.201800067 PMID:30378269 
Naoko Obi, Tetsuya Fukuda, Noboru Nakayama, John Ervin, Yasuhiko Bando, Toshihide Nishimura, Satoru Nagatoishi, Kouhei Tsumoto, Takeshi Kawamura (2018)  Development of drug discovery screening system by molecular interaction kinetics-mass spectrometry Rapid Communications in Mass Spectrometry. 32 665-671 DOI:10.1002/rcm.8083 PMID:29441684 
Tsukasa Nakamura, Toshiyuki Oda, Yoshinori Fukasawa, Kentaro Tomii  (2018)  Template-based quaternary structure prediction of proteins using enhanced profile-profile alignments Proteins. 86 274-282 DOI:10.1002/prot.25432 PMID:29178285 
Masatsugu Ono, Shoichiro Horita, Yumi Sato, Yayoi Nomura, So Iwata, Norimichi Nomura  (2018)  Structural basis for tumor necrosis factor blockade with the therapeutic antibody golimumab. Protein Science. 27 :6,  1038-1046 DOI:10.1002/pro.3407 PMID:29575262 
Akira R. Kinjo, Gert-Jan Bekker, Hiroshi Wako, Shigeru Endo, Yuko Tsuchiya, Hiromu Sato, Hafumi Nishi, Kengo Kinoshita, Hirofumi Suzuki, Takeshi Kawabata, Masashi Yokochi, Takeshi Iwata, Naohiro Kobayashi, Toshimichi Fujiwara, Genji Kurisu, Haruki Nakamura (2018)  New tools and functions in data-out activities at Protein Data Bank Japan (PDBj) Protein Science. 27 95-102 DOI:10.1002/pro.3273 PMID:28815765 
Yusei Takemoto, Shoya Inaba, Lidan Zhang, Kazutake Tsujikawa, Akiyoshi Uezumi, So-Ichiro Fukada (2019)  Implication of basal lamina dependency in survival of Nrf2-null muscle stem cells via an antioxidative-independent mechanism Journal of Cellular Physiology. 234 1689-1698 DOI:10.1002/jcp.27040 PMID:30070693 
Hidetomo Yokoo, Ayumi Ohsaki, Hiroyuki Kagechika, Tomoya Hirano (2018)  Unique properties of 1,5-naphthyridin-2(1H)-one derivatives as environmental-polarity-sensitive fluorescent dyes European Journal of Organic Chemistry. 2018 679-687 DOI:10.1002/ejoc.201701609
Satoshi Mizuta, Juliann Nzembi Makau, Ayako Kitagawa, Kanami Kitamura, Hiroki Otaki, Kodai Nishi, Ken Watanabe (2018)  Synthesis of Trifluoromethyl‐α,β‐unsaturated Lactones and Pyrazolinones and Discovery of Influenza Virus Polymerase Inhibitors ChemMedChem. 13 2390-2399 DOI:10.1002/cmdc.201800511 PMID:30182456 
Tomoya Hirano, Takashi Fujiwara, Hideaki Niwa, Michitake Hirano, Kasumi Ohira, Yusuke Okazaki, Shin Sato, Takashi Umehara, Yuki Maemoto, Akihiro Ito, Minoru Yoshida  (2018)  Development of novel inhibitors for histone methyltransferase SET7/9 based on cyproheptadine ChemMedChem. 13 1530-1540 DOI:10.1002/cmdc.201800233 PMID:29882380 
Zutao Yu, Wei‐Che Hsieh, Sefan Asamitsu, Kaori Hashiya, Toshikazu Bando, Danith H. Ly, Hiroshi Sugiyama (2018)  Orthogonal γPNA Dimerization Domains Empower DNA Binders with Cooperativity and Versatility Mimicking that of Transcription Factor Pairs Chemistry-A European Journal. 24 14183-14188 DOI:10.1002/chem.201801961 PMID:30003621 
Sefan Asamitsu, Shunsuke Obata, Anh Tuan Phan, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama (2018)  Simultaneous binding of hybrid molecules constructed with dual DNA-binding components to a G-quadruplex and its proximal duplex Chemistry-A European Journal. 24 4428-4435 DOI:10.1002/chem.201705945 PMID:29380465 
Gamal A. I. Moustafa, Yasuhiro Oki, Shuji Akai (2018)  Lipase-Catalyzed Dynamic Kinetic Resolution of C1- and C2- Symmetric Racemic Axially Chiral 2,2'-Dihydroxy-1,1'-biaryls Angewandte Chemie International Edition. 57 10278-10282 DOI:10.1002/anie.201804161 PMID:29704286 
Masahito Yoshida, Koya Saito, Hikaru Kato, Sachiko Tsukamoto, Takayuki Doi (2018)  Total Synthesis and Biological Evaluation of Siladenoserinol A and its Analogues Angewandte Chemie International Edition . 57 5147-5140 DOI:10.1002/anie.201801659 PMID:29508534 
Masanori Shigeno, Yusuke Kai, Tetsuya Yamada, Kazutoshi Hayashi, Kanako Nozawa-Kumada, Charline Denneval, and Yoshinori Kondo (2018)  Construction of Biaryl Scaffolds from Iodoarenes and C-H Heteroarenes Using an Amide Base Generated in-situ from Aminosilane and Fluoride Anion Asian Journal of Organic Chemistry. 7 2082-2086 DOI:10.1002/ajoc.201800438
Kenta Morita, Reiya Ohta, Kei Watanabe, Hiromichi Fujioka (2018)  Selective Transformation of β‐Disubstituted Enones and Ynones in the Presence of β‐Monosubstituted Enones Asian Journal of Organic Chemistry, 2018, 7, 829-835.. 7 829-835 DOI:10.1002/ajoc.201700711
Antonie D Kline, Ian D Krantz, Masashige Bando, Katsuhiko Shirahige, Stephenson Chea, Toyonori Sakata, Suhas Rao, Dale Dorsett, Vijay Pratap Singh, Jennifer L Gerton, Julia A Horsfield, Anne L Calof, Olivia Katz, Marco Grados, Sarah Raible, Kristin Bara ano, Gholson Lyon, Antonio Musio, Cheri S Carrico, Douglas K Clemens, Patti Caudill, Valentina Massa, Bryan E McGill, Aila Dommestrup, Julia O'Connor, Richard E Haaland (2019)  Cornelia de Lange syndrome, related disorders, and the Cohesin complex: Abstracts from the 8th biennial scientific and educational symposium 2018 American journal of medical genetics. 179 :6,  1080-1090 DOI:10.1002/ajmg.a.61108 PMID:30874362 
Mieko Arisawa, Takeru Tazawa, Wataru Ichinose, Haruki Kobayashi, Masahiko Yamaguchi (2018)  Rhodium-Catalyzed Synthesis of Dialkyl(Heteroaryl)Phosphine Sulfides by Phosphinylation of Heteroaryl Sulfides Advanced Synthesis & Catalysis. 360 3488-3491 DOI:10.1002/adsc.201800630
上田裕子,辻川和丈 (2018)  がん細胞におけるALKBHファミリーによるRNA修飾制御【総説】 実験医学. 36 3232-3238 DOI:ISSN:0288-5514

BINDSの支援を受けた研究成果(論文)

Yukie Kashima, Ayako Suzuki, Ying Liu, Masahito Hosokawa, Hiroko Matsunaga, Masataka Shirai, Kohji Arikawa, Sumio Sugano, Takashi Kohno, Haruko Takeyama, Katsuya Tsuchihara & Yutaka Suzuki?  (2018)  Combinatory use of distinct single-cell RNA-seq analytical platforms reveals the heterogeneous transcriptome response. Scientific Reports. 8 :1,  3482- DOI:10.1038/s41598-018-21161-y PMID:29472726 
Shuting Zhang, Zhenyi Hu, Hiromi Tanji, Shuangshuang Jiang, Nabanita Das, Jing Li, Kentaro Sakaniwa, Jin Jin, Yanyan Bian, Umeharu Ohto, Toshiyuki Shimizu & Hang Yin (2018)  Small-molecule inhibition of TLR8 through stabilization of its resting state Nat Chem Biol. 14 :1,  58-64 DOI:10.1038/nchembio.2518 PMID:29155428 
UmeharuOhto, Hanako Ishida, Takuma Shibata, Ryota Sato, Kensuke Miyake, Toshiyuki Shimizu (2018)  Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation Immunity. 48 :4,  649-658 DOI:10.1016/j.immuni.2018.03.013 PMID:29625894 
Hanako Ishida,Umeharu Ohto,Takuma Shibata,Kensuke Miyake,Toshiyuki Shimizu (2018)  Structural basis for species-specific activation of mouse Toll-like receptor 9 FEBS Lett. 592 :15,  2636-2646 DOI:10.1002/1873-3468.13176 PMID:29961984 
Shimizu, H., Toma-Fukai, S., Kontani, K., Katada, T., Shimizu, T (2018)  GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism Proc Natl Acad Sci U S A. 115 :38,  9563-9568 DOI:10.1073/pnas.1804740115 PMID:30190425 
Rehana Parvin, Erika Noro, Akiko Saito-Hakoda, Hiroki Shimada, Susumu Suzuki, Kyoko Shimizu, Hiroyuki Miyachi, Atsushi Yokoyama, Akira Sugawara (2018)  Inhibitory Effects of a Novel PPAR-γ Agonist MEKT1 on Pomc Expression/ACTH Secretion in AtT20 Cells. PPAR Research. 28 5346272- DOI:10.1155/2018/5346272.?eCollection 2018 PMID:29849538 
小島宏建, 岡部隆義, 宮地弘幸, 長野哲雄 (2018)  基礎医学から創薬へ参入の支援 生体の科学. 69 :4,  305-309 DOI:10.11477/mf.2425200821
Miwa Fukuda, Tomomi Sasaki, Tomoko Hashimoto, Hiroyuki Miyachi, Minoru Waki, Akira Asai, Osamu Takikawa, Osamu Ohno, Kenji Matsuno (2018)  Cyclic analogue of S-benzylisothiourea that suppresses kynurenine production without inhibiting indoleamine 2,3-dioxygenase activity. Bioorganic & Medicinal Chemistry Letters. 28 2846-2849 DOI:10.1016/j.bmcl.2018.07.034 PMID:30055888 
Takashi Matsui, Shizuka Kamata, Kentaro Ishii, Takahiro Maruno, Nouran Ghanem, Susumu Uchiyama, Koichi Kato, Atsuo Suzuki, Naoko Oda-Ueda, Tomohisa Ogawa, Yoshikazu Tanaka (2019)  SDS-induced oligomerization of Lys49-phospholipase A 2 from snake venom Science Reports. 1 :9,  2330- DOI:10.1038/s41598-019-38861-8 PMID:30787342 
Wataru Saburi, Nongluck Jaito, Koji Kato, Yuka Tanaka, Min Yao, Haruhide Mori (2018)  Biochemical and structural characterization of Marinomonas mediterranead-mannose isomerase Marme_2490 phylogenetically distant from known enzymes Biochimie. :144,  63-73 DOI:10.1016/j.biochi.2017.10.016 PMID:29107017 
Hiroki Kanazawa, Oscar M Saavedra, Juan Pablo Maianti, Simon A Young, Luis Izquierdo, Terry K Smith, Stephen Hanessian, Jiro Kondo  (2018)  Structure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside ChemMedChem. 15 :13,  1541-1548 DOI:10.1002/cmdc.201800166 PMID:29766661 
Hiroshi Yamaguchi, Toshiyuki Oda, Masahide Kikkawa, Hiroyuki Takeda  (2018)  Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly eLife. :7,  e36979- DOI:10.7554/eLife.36979 PMID:29741156 
Hiroyuki Terashima, Akihiro Kawamoto, Chinatsu Tatsumi, Keiichi Namba, Tohru Minamino, Katsumi Imada (2018)  In vitro reconstitution of functional type III protein export and insights into flagellar assembly. mBio. 3 :9,  e00988-18- DOI:10.1128/mBio.00988-18 PMID:29946050 
Emiri Hiramoto, Akihisa Tsutsumi, Risa Suzuki, Shigeru Matsuoka, Satoko Arai, Masahide Kikkawa and Toru Miyazaki (2018)  The IgM pentamer is an asymmetric pentagon with an open groove that binds the AIM protein Science Advances. 10 :4,  eaau1199- DOI:10.1126/sciadv.aau1199 PMID:30324136 
Yohta Fukuda, Takuro Matsusaki, Ka Man Tse, Eiichi Mizohata, Michael E P Murphy, Tsuyoshi Inoue (2018)  Crystallographic study of dioxygen chemistry in a copper-containing nitrite reductase from Geobacillus thermodenitrificans Acta Crystallographica Section D, Structural Biology. :74,  769-777 DOI:10.1107/S2059798318010082 PMID:30082512 
Masato Tsuyuguchi, Tetsuko Nakaniwa, Takayoshi Kinoshita (2018)  Crystal structures of human CK2a2 in new crystal forms arising from a subtle difference in salt concentration Acta Crystallographica Section F,Structural Biology Communications. :74,  288-293 DOI:10.1107/S2053230X18005204 PMID:29717996 
Ken-Ichi Miyazono, Yosuke Ohno, Hikaru Wada, Tomoko Ito, Yui Fukatsu, Akira Kurisaki, Makoto Asashima, Masaru Tanokura  (2018)  Structural basis for receptor-regulated SMAD recognition by MAN1 Nucleic Acids Research. 22 :46,  12139-12153 DOI:10.1093/nar/gky925 PMID:30321401 
Ken-Ichi Miyazono, Sonoko Ishino, Naruto Makita, Tomoko Ito, Yoshizumi Ishino, Masaru Tanokura  (2018)  Crystal structure of the novel lesion-specific endonuclease PfuEndoQ from Pyrococcus furiosus. Nucleic Acids Research. 9 :46,  4807-4818 DOI:10.1093/nar/gky261 PMID:29660024 
Masaki Kohno, Takatoshi Arakawa, Hiromi Ota, Tetsuya Mori, Tomoyuki Nishimoto, Shinya Fushinobu  (2018)  Structural features of a bacterial cyclic α-maltosyl-(1→6)-maltose (CMM) hydrolase critical for CMM recognition and hydrolysis Journal of Biological Chemistry. 43 :293,  16874-16888 DOI:10.1074/jbc.RA118.004472 PMID:30181215 
Koichi Abe, Naoki Sunagawa, Tohru Terada, Yuta Takahashi, Takatoshi Arakawa, Kiyohiko Igarashi, Masahiro Samejima, Hiroyuki Nakai, Hayao Taguchi, Masahiro Nakajima, Shinya Fushinobu (2018)  Structural and thermodynamic insights into β-1,2-glucooligosaccharide capture by a solute-binding protein in?Listeria innocua Journal of Biological Chemistry. 23 :293,  8812-8828 DOI:10.1074/jbc.RA117.001536 PMID:29678880 
Satoshi Murakami, Kumiko Kondo, Shinya Katayama, Satoshi Hara, Ei-ichiro Sunamura, Eiki Yamashita, Georg Groth, Toru Hisabori  (2018)  Structure of the γ-ε complex of cyanobacterial F?1-ATPase reveals a suppression mechanism of the γ subunit on ATP hydrolysis in phototrophs Biochemical Journal. 18 :475,  2925-2939 DOI:10.1042/BCJ20180481 PMID:30054433 
Bankala Krishnarjuna, Toshihiko Sugiki, Rodrigo A. V. Morales, Jeffrey Seow, Toshimichi Fujiwara, Karyn L. Wilde, Raymond S. Norton & Christopher A. MacRail (2018)  Transient antibody-antigen interactions mediate the strain-specific recognition of a conserved malaria epitope Communications Biology. :1,  58- DOI:10.1038/s42003-018-0063-1 PMID:30271940 
Tatsuro Nishikino, Atsushi Hijikata, Yohei Miyanoiri, Yasuhiro Onoue, Seiji Kojima, Tsuyoshi Shirai & Michio Homma (2018)  Rotational direction of flagellar motor from the conformation of FliG middle domain in marine Vibrio. Scientific Reports. 1 :8,  17793- DOI:10.1038/s41598-018-35902-6 PMID:30542147 
Kei Okatsu, Yusuke Sato, Koji Yamano, Noriyuki Matsuda, Lumi Negishi, Akiko Takahashi, Atsushi Yamagata, Sakurako Goto-Ito, Masaki Mishima, Yutaka Ito, Toshihiko Oka, Keiji Tanaka, Shuya Fukai  (2018)  Structural insights into ubiquitin phosphorylation by PINK1. Scientific Reports. 1 :8,  10382- DOI:10.1038/s41598-018-28656-8 PMID:29991771 
Atsushi Mukaiyama, Yoshihiko Furuike, Jun Abe, Shin-ichi Koda, Eiki Yamashita, Takao Kondo & Shuji Akiyama (2018)  Conformational rearrangements of the C1 ring in KaiC measure the timing of assembly with KaiB. Scientific Reports. 1 :8,  8803- DOI:10.1038/s41598-018-27131-8 PMID:29892030 
Long-Jiang Yu, Michihiro Suga, Zheng-Yu Wang-Otomo, Jian-Ren Shen (2018)  Structure of photosynthetic LH1-RC supercomplex at 1.9 A resolution. Nature. 7700 :556,  209-213 DOI:10.1038/s41586-018-0002-9 PMID:29618814 
Kenta Tsutsumi, Ryo Yonehara, Etsuko Ishizaka-Ikeda, Naoyuki Miyazaki, Shintaro Maeda, Kenji Iwasaki, Atsushi Nakagawa & Eiki Yamashita? (2019)  Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism, Nature communications. 1 :10,  1520- DOI:10.1038/s41467-019-09463-9 PMID:30944318 
Mikito Owa, Takayuki Uchihashi, Haru-Aki Yanagisawa, Takashi Yamano, Hiro Iguchi, Hideya Fukuzawa, Ken-Ichi Wakabayashi, Toshio Ando, Masahide Kikkawa  (2019)  Inner lumen proteins stabilize doublet microtubules in cilia and flagella Nature Communications. 1 :10,  1143- DOI:10.1038/s41467-019-09051-x PMID:30850601 
Tetsuya Hori, Toshiaki Okuno, Kunio Hirata, Keitaro Yamashita, Yoshiaki Kawano, Masaki Yamamoto, Masakatsu Hato, Motonao Nakamura, Takao Shimizu, Takehiko Yokomizo, Masashi Miyano & Shigeyuki Yokoyama  (2018)  Na+-mimicking ligands stabilize the inactive state of leukotriene B 4 receptor BLT1 Nature chemical biology. 3 :14,  262-269 DOI:10.1038/nchembio.2547 PMID:29309055 
Hiroto Fujii, Yoshikazu Tanaka, Hikaru Nakazawa, Aruto Sugiyama, Noriyoshi Manabe, Akira Shinoda, Nobutaka Shimizu, Takamitsu Hattori, Katsuhiro Hosokawa, Takuma Sujino, Tomoyuki Ito, Teppei Niide, Ryutaro Asano, Izumi Kumagai, Mitsuo Umetsu (2018)  Compact Seahorse-Shaped T Cell-Activating Antibody for Cancer Therapy Advances in Therapy. 3 :1,  170031- DOI:10.1002/adtp.201700031
Tomomi Kubota, Osamu Tani, Tomohiko Yamaguchi, Ichiji Namatame, Hitoshi Sakashita, Koji Furukawa, Kazuhiko Yamasaki (2018)  Crystal structures of FMN-bound and FMN-free forms of dihydroorotate dehydrogenase from Trypanosoma brucei. FEBS Open Bio. 4 :8,  680-691 DOI:10.1002/2211-5463.12403 PMID:29632820 
Hiroki Tanaka, Hideo Akutsu, Izumi Yabuta, Masashi Hara, Hayuki Sugimoto, Takahisa Ikegami, Takeshi Watanabe, and Toshimichi Fujiwara (2018)  A novel chitin binding mode of the chitin binding domain of chitinase A1 from Bacillus circulans WL-12 revealed by solid-state NMR FEBS Letters. 18 :592,  3173-3182 DOI:10.1002/1873-3468.13226 PMID:30125342 
Waraporn Auiewiriyanukul, Wataru Saburi, Koji Kato, Min Yao, Haruhide Mori (2018)  Function and structure of GH13_31 α-glucosidase with high α-(1→4)-glucosidic linkage specificity and transglucosylation activity FEBS Letters. 13 :592,  2268-2281 DOI:10.1002/1873-3468.13126 PMID:29870070 
Katsumasa Irie, Yukari Haga, Takushi Shimomura, Yoshinori Fujiyoshi  (2018)  Optimized expression and purification of NavAb provide the structural insight into the voltage dependence FEBS letters. 2 :592,  274-283 DOI:10.1002/1873-3468.12955 PMID:29274127 
Michihito Sasaki, Paulina D Anindita, Naoto Ito, Makoto Sugiyama, Michael Carr, Hideo Fukuhara, Toyoyuki Ose, Katsumi Maenaka, Ayato Takada, William W Hall, Yasuko Orba, Hirofumi Sawa  (2018)  The Role of Heparan Sulfate Proteoglycans as an Attachment Factor for Rabies Virus Entry and Infection Journal of Infectious Diseases. 217 :11,  1740-1749 DOI:10.1093/infdis/jiy081 PMID:29529215 
Yuri Sakai, Atsushi Kawaguchi, Kyosuke Nagata, Takatsugu Hirokawa (2018)  Analysis by metadynamics simulation of binding pathway of influenza virus M2 channel blockers Microbiology and Immunology. 62 :1,  34-43 DOI:10.1111/1348-0421.12561 PMID:29210473 
Yue Ma,Yamato Tsushima,Mai Sakuma,Shogo Sasaki,Keisuke Iida,Sachiko Okabe,Hiroyuki Seimiya,Takatsugu Hirokawa,Kazuo Nagasawa (2018)  Development of G-quadruplex ligands for selective induction of a parallel-type topology Organic and Biomolecular Chemistry. 16 :40,  7375-7382 DOI:10.1039/c8ob01702f PMID:30187070 
Norihiko Sugisawa , Shinobu Ohnuma , Hirofumi Ueda, Megumi Murakami, Kyoko Sugiyama, Kosuke Ohsawa, Kuniyuki Kano, Hidetoshi Tokuyama, Takayuki Doi , Junken Aoki, Masaharu Ishida, Katsuyoshi Kudoh, Takeshi Naitoh, Suresh V. Ambudkar, and Michiaki Unno  (2018)  Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell Molecular Pharmaceutics. 15 :9,  4021-4030 DOI:10.1021/acs.molpharmaceut.8b00457 PMID:30052463 
根本圭一郎、澤崎達也 (2018)  チロシンリン酸化によるジベレリン応答の新しい制御機構 バイオインダストリー. 76 232-225 DOI:ISSN:0914-8981
Go Kasuya, Takanori Nakane, Takeshi Yokoyama, Yanyan Jia, Masato Inoue, Kengo Watanabe, Ryoki Nakamura, Tomohiro Nishizawa, Tsukasa Kusakizako, Akihisa Tsutsumi, Haruaki Yanagisawa, Naoshi Dohmae, Motoyuki Hattori, Hidenori Ichijo, Zhiqiang Yan, Masahide Kikkawa, Mikako Shirouzu, Ryuichiro Ishitani & Osamu Nureki  (2018)  Cryo-EM structures of the human volume-regulated anion channel LRRC8 Nature Structural & Molecular Biology. 25 :9,  797-804 DOI:1038/s41594-018-0109-6 PMID:30127360 
Xiao-Man Liu, Akinori Yamasaki, Xiao-Min Du, Valerie C Coffman, Yoshinori Ohsumi, Hitoshi Nakatogawa, Jian-Qiu Wu, Nobuo N Noda, and Li-Lin Du  (2018)  Lipidation-independent vacuolar functions of Atg8 rely on its noncanonical interaction with a vacuole membrane protein eLife. 7 e41237- DOI:10.7554/eLife.41237 PMID:30451685 
千田美紀, 安達成彦, Maharani Pertiwi Koentjoro, 小川直人, 千田俊哉 (2018)  LysRタイプ転写調節因子CbnRのDNA結合ドメインとDNAとの複合体構造 日本結晶学会誌. 60 :2月3日,  135-141 DOI:10.5940/jcrsj.60.135
平林 淳, 胡 丹, 舘野 浩章, 桑原 直之, 加藤 龍一, 八木 史郎 (2018)  キノコ由来ガレクチンACGの糖認識メカニズム Trends in Glycoscience and Glycotechnology. 30 :172,  SJ33-SJ46 DOI:10.4052/tigg.1736.1SJ
Hisakata Yamada, Tatsuhiko Ozawa, Hiroyuki Kishi, Seiji Okada, Yasuharu Nakashima, Atsushi Muraguchi and Yasunobu Yoshikai (2018)  Cutting Edge: B Cells Expressing Cyclic Citrullinated Peptide-Specific Antigen Receptor Are Tolerized in Normal Conditions Journal of Immunology. 201 :12,  3492-3496 DOI:10.4049/jimmunol.1800826 PMID:30420436 
Asuka Morikawa, Tomoatsu Hayashi, Mana Kobayashi, Yuki Kato, Katsuhiko Shirahige, Takehiko Itoh, Mitsuyoshi Urashima, Aikou Okamoto, Tetsu Akiyama (2018)  Somatic copy number alterations have prognostic impact in patients with ovarian clear cell carcinoma OncologyReports. 40 :1,  309-318 DOI:10.3892/or.2018.6419 PMID:29749539 
Tomohiro Tanaka, Tatsuhiko Ozawa, Eiji Oga, Atsushi Muraguchi, and Hiroaki Sakurai (2018)  Cisplatin-induced non-canonical endocytosis of EGFR via p38 phosphorylation of the C-terminal region containing Ser-1015 in non-small cell lung cancer cells Oncology Letters. 15 :6,  9251-9256 DOI:10.3892/ol.2018.8485 PMID:29805654 
Yue Ma,Keisuke Iida,Shogo Sasaki,Takatsugu Hirokawa,Brahim Heddi,Anh Tuan Phan,Kazuo Nagasawa (2019)  Synthesis and Telomeric G-Quadruplex-Stabilizing Ability of Macrocyclic Hexaoxazoles Bearing Three Side Chains Molecules. 24 263- DOI:10.3390/molecules24020263 PMID:30642002 
Shin-ichi Kawaguchi, Yuhei Gonda, Takuya Yamamoto, Yuki Sato, Hiroyuki Shinohara, Yohsuke Kobiki, Atsuhiko Ichimura, Takashi Dan, Motohiro Sonoda, Toshio Miyata, Akiya Ogawa and Tadayuki Tsujita (2018)  Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-1. Molecules. 23 885- DOI:10.3390/molecules23040885 PMID:29641495 
Hiroshi Kanno, Yuqun Xu, Taykua Miyakawa, Atsuhiko Kubo, Tetsuhiro Higashida, Nahoko Baily Kobayashi, Tetsuhiko Yoshida and Masaru Tanokura (2018)  BC-Box Motif-Mediated Neuronal Differentiation of Somatic Stem Cells International journal of molecular sciences. 19 :2,  466- DOI:10.3390/ijms19020466 PMID:29401731 
Noritoshi Shamoto, Keishi Narita, Tomohiro Kubo, Toshiyuki Oda, and Sen Takeda (2018)  CFAP70 Is a Novel Axoneme-Binding Protein That Localizes at the Base of the Outer Dynein Arm and Regulates Ciliary Motility Cells. 7 :9,  124- DOI:10.3390/cells7090124 PMID:30158508 
Caroline Sunggip, Kakeru Shimoda, Sayaka Oda, Tomohiro Tanaka, Kazuhiro Nishiyama, Supachoke Mangmool, Akiyuki Nishimura, Takuro Numaga-Tomita, Motohiro Nishida (2018)  TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy Frontiers in Pharmacology. 9 523- DOI:10.3389/fphar.2018.00523 PMID:29872396 
Yasuyuki Suzuki, Tomio Ogasawara, Yuki Tanaka, Hiroyuki Takeda, Tatsuya Sawasaki, Masaki Mogi, Shuang Liu, and Kazutaka Maeyama (2018)  Functional G-Protein-Coupled Receptor (GPCR) Synthesis: The Pharmacological Analysis of Human Histamine H1 Receptor (HRH1) Synthesized by a Wheat Germ Cell-Free Protein Synthesis System Combined with Asolectin Glycerosomes. Frontiers in Pharmacology. 9 :38,  DOI:10.3389/fphar.2018.00038 PMID:29467651 
Sayaka Tsuda, Xiaoxin Zhang, Hiroshi Hamana, Tomoko Shima, Akemi Ushijima, Kei Tsuda, Atsushi Muraguchi, Hiroyuki Kishi, and Shigeru Saito (2018)  Clonally Expanded Decidual Effector Regulatory T Cells Increase in Late Gestation of Normal Pregnancy, but Not in Preeclampsia, in Humans. Frontiers in Immunology. 9 1934- DOI:10.3389/fimmu.2018.01934 PMID:30197648 
Sakurako Goto-Ito, Nobukatsu Morooka, Atsushi Yamagata, Yusuke Sato, Ken Sato, and Shuya Fukai (2019)  Structural basis of guanine nucleotide exchange for Rab11 by SH3BP5 Life Science Alliance. 2 :2,  e201900297- DOI:10.26508/lsa.201900297 PMID:30872413 
Nobuaki Yasuo, Keisuke Watanabe, Hideto Hara, Kentaro Rikimaru, Masakazu Sekijima (2018)  Predicting Strategies for Lead Optimization via Learning to Rank IPSJ Transactions on Bioinformatics. 11 41-47 DOI:10.2197/ipsjtbio.11.41
Yusuke Nakatsu, Yasuka Matsunaga, Koji Ueda, Takeshi Yamamotoya, Yuki Inoue, Masa-ki Inoue, Yu Mizuno, Akifumi Kushiyama, Hiraku Ono, Midori Fujishiro, Hisanaka Ito, Takayoshi Okabe, Tomoichiro Asano (2018)  Development of Pin1 inhibitors and their potential as therapeutic agents. Current Medicinal Chemistry. 27 3314-3329 DOI:10.2174/0929867325666181105120911 PMID:30394205 
Tianqi Dai, Yunlong Hu, Fulian Lv, Tatsuhiko Ozawa, Xin Sun, Jingjing Huang, Xiaojian Han, Hiroyuki Kishi, Atsushi Muraguchi, Aishun Jin (2018)  Analysis of the clinical significance of DCLK1+ colorectal cancer using novel monoclonal antibodies against DCLK1 OncoTargets and Therapy. 11 5047-5057 DOI:10.2147/OTT.S169928 PMID:30174443 
Hiroaki Taniguchi, Akihiro Fujimoto, Hidetoshi Kono, Mayuko Furuta, Masashi Fujita and Hidewaki Nakagawa (2018)  Loss-of-function mutations in Zn-finger DNA-binding domain of HNF4A cause aberrant transcriptional regulation in liver cancer Oncotarget. 9 26144-26156 DOI:10.18632/oncotarget.25456 PMID:29899848 
Ryoichi Tashima, Keisuke Koga, Misuzu Sekine, Kensho Kanehisa, Yuta Kohro, Keiko Tominaga, Katsuyuki Matsushita, Hidetoshi Tozaki-Saitoh, Yugo Fukazawa, Kazuhide Inoue, Hiromu Yawo, Hidemasa Furue, Makoto Tsuda (2018)  Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-like Sensory and Emotional Behaviors after Nerve Injury in Rats eNeuro. 5 e0450-17- DOI:10.1523/ENEURO.0450-17.2018 PMID:29468190 
Kumiko Nakada-Tsukui, Tsuyoshi Sekizuka, Emi Sato-Ebine, Aleyla Escueta-de Cadiz, Dar-der Ji, Kentaro Tomii, Makoto Kuroda, Tomoyoshi Nozaki  (2018)  AIG1 affects in vitro and in vivo virulence in clinical isolates of Entamoeba histolytica PLOS Pathogens. 14 e1006882- DOI:10.1371/journal.ppat.1006882 PMID:29554130 
Shin Hayase, Hongdi Wang, Eri Ohgushi, Masahiko Kobayashi, Chihiro Mori, Haruhito Horita, Katsuhiko Mineta, Wan-Chun Liu, Kazuhiro Wada (2018)  Vocal practice regulates singing activity-dependent genes underlyingage-independent vocal learning in songbirds. PLOS Biology. 16 :9,  e2006537- DOI:10.1371/journal.pbio.2006537 PMID:30208028 
Ryuzo Azuma, Sae Kishi, Greg Gutmann, Akihiko Konagaya (2018)  All-atom molecular dynamics of film supported flat-shaped DNA origami in water Chem-Bio Informatics Journal. 18 96-118 DOI:10.1273/cbij.18.96
Ryoji Ito (2018)  Development of the next generation humanized mouse for drug discovery Folia Pharmacologica Japonica (Japanese). 151 :4,  160-165 DOI:10.1254/fpj.151.160 PMID:29628464 
安田 大輔, 小畠 りか, 髙橋 恭子, 大江 知之, 増野 匡彦 (2018)  アカデミアにおけるHit-to-Leadの実践 ~Keap1-Nrf2タンパク間相互作用阻害剤の創製~ 薬学雑誌. 138 1059-1065 DOI:10.1248/yakushi.17-00211-5 PMID:30068847 
Naosuke Morikawa, Masashi Tachibana, Yukio Ago, Hiroshi Goda, Fuminori Sakurai, Hiroyuki Mizuguchi (2018)  LY341495, an mGluR2/3 Antagonist, Regulates the Immunosuppressive Function of Myeloid-Derived Suppressor Cells and Inhibits Melanoma Tumor Growth Biological and Pharmaceutical Bulletin. 41 1866-1869 DOI:10.1248/bpb.b18-00055 PMID:30504687 
Keisuke Shirakura, Ryosuke Ishiba, Taito Kashio, Risa Funatsu, Toru Tanaka, So-Ichiro Fukada, Kenji Ishimoto, Nobumasa Hino, Masuo Kondoh, Yukio Ago, Yasushi Fujio, Kiichiro Yano, Takefumi Doi, William C Aird, Yoshiaki Okada (2019)  The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation Journal of Cell Science. 132 jcs220228- DOI:10.1242/jcs.220228 PMID:30510113 
Ayaka Nakanishi, Naoe Kaneko, Hiroyuki Takeda, Tatsuya Sawasaki, Shinnosuke Morikawa, Wei Zhou, Mie Kurata, Toshihiro Yamamoto, Sheikh Mohammad Fazle Akbar, Tamotsu Zako & Junya Masumoto (2018)  Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system. Inflammation and Regeneration. 38 27- DOI:10.1186/s41232-018-0085-6 PMID:30459926 
Tomohiro Okagawa, Satoru Konnai, Asami Nishimori, Naoya Maekawa, Shinya Goto,Ryoyo Ikebuchi, Junko Kohara,Yasuhiko Suzuki, Shinji Yamada, Yukinari Kato, Shiro Murata, and Kazuhiko Ohashi (2018)  Cooperation of PD-1 and LAG-3 in the exhaustion of CD4+ and CD8+ T cells during bovine leukemia virus infection Veterinary Research. 49 :1,  50- DOI:10.1186/s13567-018-0543-9 PMID:29914540 
J. Luis Espinoza, Mahmoud I. Elbadry, Kazuhisa Chonabayashi, Yoshinori Yoshida, Takamasa Katagiri, Kenichi Harada, Noriharu Nakagawa, Yoshitaka Zaimoku, Tatsuya Imi, Hiroyuki Takamatsu, Tatsuhiko Ozawa, Hiroyuki Maruyama, Hassan A. Hassanein, Amal Khalifa A. Noreldin, Katsuto Takenaka, Koichi Akashi, Hiroshi Hamana, Hiroyuki Kishi, Yoshiki Akatsuka, Shinji Nakao  (2018)  Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack Blood Advances. 2 :4,  390-400 DOI:10.1182/bloodadvances.2017013342 PMID:29472446 
Zhuting Hu, Annabelle J. Anandappa, Jing Sun, Jintaek Kim, Donna E. Leet, David J. Bozym, Christina Chen, Louise Williams, Sachet A. Shukla, Wandi Zhang, Diana Tabbaa, Scott Steelman, Oriol Olive, Kenneth J. Livak, Hiroyuki Kishi, Atsushi Muraguchi, Indira Guleria, Jonathan Stevens, William J. Lane, Ute E. Burkhardt, Edward F. Fritsch, Donna Neuberg, Patrick A. Ott, Derin B. Keskin, Nir Hacohen, Catherine J. Wu  (2018)  A cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens. Blood . 132 :18,  1911-1921 DOI:10.1182/blood-2018-04-843763 PMID:30150207 
Kiyomi Shitaoka, Hiroshi Hamana, Hiroyuki Kishi, Yoshihiro Hayakawa, Eiji Kobayashi, Kenta Sukegawa, Xiuhong Piao, Fulian Lyu, Takuya Nagata, Daisuke Sugiyama, Hiroyoshi Nishikawa, Atsushi Tanemura, Ichiro Katayama, Mutsunori Murahashi, Yasushi Takamatsu, Kenzaburo Tani, Tatsuhiko Ozawa and Atsushi Muraguchi (2018)  Identification of Tumoricidal TCRs from Tumor-Infiltrating Lymphocytes by Single-Cell Analysis Cancer Immunology Research. 6 :4,  378-388 DOI:10.1158/2326-6066.CIR-17-0489 PMID:29475880 
Masahiko Ajiro,Hiroyuki Sakai,Hiroshi Onogi,Makoto Yamamoto,Eriko Sumi,Teruo Sawada,Takashi Nomura,Kenji Kabashima,Takamitsu Hosoya,Masatoshi Hagiwara (2018)  CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia. Clin Cancer Res. 24 4518-4528 DOI:10.1158/1078-0432.ccr-17-3119 PMID:29712686 
Yamato Sajiki, Satoru Konnai, Tomohiro Okagawa, Asami Nishimori, Naoya Maekawa, Shinya Goto, Ryoyo Ikebuchi, Reiko Nagata, Satoko Kawaji, Yumiko Kagawa, Shinji Yamada, Yukinari Kato, Chie Nakajima, Yasuhiko Suzuki, Shiro Murata, Yasuyuki Mori, Kazuhiko Ohashi (2018)  Prostaglandin E2 Induction Suppresses the Th1 Immune Responses in Cattle with Johne's Disease Infection and immunity. 86 :5,  e00910-17- DOI:10.1128/IAI.00910-17 PMID:29483289 
Misugi Uraji, Haruka Tamura, Eiichi Mizohata, Jiro Arima, Kun Wan, Ken'ichi Ogawa, Tsuyoshi Inoue, Tadashi Hatanaka (2018)  Loop of Streptomyces Feruloyl Esterase Plays an Important Role in the Enzyme's Catalyzing the Release of Ferulic Acid from Biomass Applied and Environmental Microbiology. 84 :3,  e02300-17- DOI:10.1128/AEM.02300-17 PMID:29150515 
Akiyuki Nishimura, Tsukasa Shimauchi, Tomohiro Tanaka, Kakeru Shimoda, Takashi Toyama, Naoyuki Kitajima, Tatsuya Ishikawa, Naoya Shindo, Takuro Numaga-Tomita, Satoshi Yasuda, Yoji Sato, Koichiro Kuwahara, Yoshito Kumagai, Takaaki Akaike, Tomomi Ide, Akio Ojida, Yasuo Mori, Motohiro Nishida (2018)  Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence Science Signaling. 11 eaat5185- DOI:10.1126/scisignal.aat5185 PMID:30425165 
Ken-Ichi Miyazono, Saho Moriwaki, Tomoko Ito, Akira Kurisaki, Makoto Asashima, Masaru Tanokura (2018)  Hydrophobic patches on SMAD2 and SMAD3 determine selective binding to cofactors. Science Signaling. 11 :523,  eaao7227- DOI:10.1126/scisignal.aao7227 PMID:29588413 
Haruhiko Ehara , Tomoya Kujirai , Yuka Fujino , Mikako Shirouzu, Hitoshi Kurumizaka , Shun-Ichi Sekine  (2019)  Structural insight into nucleosome transcription by RNA polymerase II with elongation factors Science. 363 :6428,  744-747 DOI:10.1126/science.aav8912 PMID:30733384 
Tomoya Kujirai, Haruhiko Ehara, Yuka Fujino, Mikako Shirouzu, Shun-ichi Sekine, Hitoshi Kurumizaka (2018)  Structural basis of the nucleosome transition during RNA polymerase II passage Science. 362 :6414,  595-598 DOI:10.1126/science.aau9904 PMID:30287617 
Chiaki Ohtaka-Maruyama, Mayumi Okamoto, Kentaro Endo, Minori Oshima, Noe Kaneko, Kei Yura, Haruo Okado, Takaki Miyata, Nobuaki Maeda (2018)  Synaptic transmission from subplate neurons controls radial migration of neocortical neurons Science . 360 313-316 DOI:10.1126/science.aar2866 PMID:29674592 
Takahide Hibi, Hokuto Ohtsuka, Takafumi Shimasaki, Shougo Inui, Masatoshi Shibuya, Hideki Tatsukawa, Kei Kanie, Yoshihiko Yamamoto, Hirofumi Aiba (2018)  Tschimganine and its derivatives extend the chronological life span of yeast via activation of the Sty1 pathway Genes to Cells . 23 620-637 DOI:10.1111/gtc.12604 PMID:29900664 
Yohei Katsuyama, Yukari Sato, Yoshinori Sugai, Yousuke Higashiyama, Miki Senda, Toshiya Senda, Yasuo Ohnishi (2018)  Crystal structure of the nitrosuccinate lyase CreD in complex with fumarate provides insights into the catalytic mechanism for nitrous acid elimination. The FEBS Journal. 285 :8,  1540-1555 DOI:10.1111/febs.14429 PMID:29505698 
Jumpei Kondo, Tomoya Ekawa, Hiroko Endo, Kanami Yamazaki, Norio Tanaka, Yoji Kukita, Hiroaki Okuyama, Jiro Okami, Fumio Imamura, Masayuki Ohue, Kikuya Kato, Taisei Nomura, Arihiro Kohara, Seiichi Mori, Shingo Dan, Masahiro Inoue (2019)  High-throughput screening in colorectal cancer tissue-originated spheroids Cancer Science. 110 345-355 DOI:10.1111/cas.13843 PMID:30343529 
Anna Mizutani,Yoko Yashiroda,Yukiko Muramatsu,Haruka Yoshida,Tsubasa Chikada,Takeshi Tsumura,Masayuki Okue,Fumiyuki Shirai,Takehiro Fukami,Minoru Yoshida,Hiroyuki Seimiya (2018)  RK‐287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model Cancer Science. 109 4003-4014 DOI:10.1111/cas.13805 PMID:30238564 
Nobuaki Yasuo, Yusuke Nakashima, Masakazu Sekijima (2018)  CoDe-DTI: Collaborative Deep Learning-based Drug-Target Interaction Prediction 2018 IEEE International Conference on Bioinformatics and Biomedicine. 792-797 DOI:10.1109/BIBM.2018.8621368
Tomonari Horikawa, Li Wei Hung, Heung Bok Kim, David Shaya, Chang Yub Kim, Thomas C Terwilliger, Eiki Yamashita, Maho Aoki, Ui Okada, Satoshi Murakami (2018)  BpeB, a major resistance-nodulation-cell division transporter from Burkholderia cenocepacia: construct design, crystallization and preliminary structural analysis. Acta Crystallographica Section F, Structural bilogy of commuinications. 74 710-716 DOI:10.1107/S2053230X18013547 PMID:30387776 
Jun Takeuchi, Kai Jiang, Kei Hirabayashi, Yusaku Imamura, Yashan Wu, Yuqun Xu, Takuya Miyakawa, Hidemitsu Nakamura, Masaru Tanokura, Tadao Asami  (2018)  Rationally designed strigolactone analogs as antagonists of the D14 receptor Plant & cell physiology. 59 :8,  1545-1554 DOI:10.1093/pcp/pcy087 PMID:29727000 
Sari Ogasawara, Yoshiro Chuman, Takahiro Michiba, Rui Kamada, Toshiaki Imagawa, Kazuyasu Sakaguchi  (2018)  Inhibition of protein phosphatase PPM1D enhances retinoic acid-induced differentiation in human embryonic carcinoma cell line The Journal of Biochemistry. 165 471-477 DOI:10.1093/jb/mvy119 PMID:30576481 
Jung-Wei Chang, Yusuke Sato, Tetsuhiro Ogawa, Takatoshi Arakawa, Shuya Fukai, Shinya Fushinobu, Haruhiko Masaki (2018)  Crystal structure of the central and the C-terminal RNase domains of colicin D implicated its translocation pathway through inner membrane of target cell. The Journal of Biochemistry. 164 :5,  329-339 DOI:10.1093/jb/mvy056 PMID:29905832 
Kazuhiro Miyanabe, Hiroki Akiba, Daisuke Kuroda, Makoto Nakakido, Osamu Kusano-Arai, Hiroko Iwanari, Takao Hamakubo, Jose M M Caaveiro, Kouhei Tsumoto (2018)  Intramolecular H-bonds govern the recognition of a flexible peptide by an antibody The Journal of Biochemistry. 164 :1,  65-76 DOI:10.1093/jb/mvy032 PMID:29924367 
Tomohiro Kubo, Yuqing Hou, Deborah A Cochran, George B Witman, Toshiyuki Oda (2018)  A microtubule-dynein tethering complex regulates the axonemal inner dynein f (I1) Molecular biology of the cell. 29 :9,  1060-1074 DOI:10.1091/mbc.E17-11-0689 PMID:29540525 
Masayuki Sugiura, Moe Nakahara, Chihaya Yamada, Takatoshi Arakawa, Motomitsu Kitaoka, Shinya Fushinobu (2018)  Identification, functional characterization, and crystal structure determination of bacterial levoglucosan dehydrogenase. The Journal of Biological Chemistry. 293 :45,  17375-17386 DOI:10.1074/jbc.RA118.004963 PMID:30224354 
Toshihiko Sugiki, Daichi Egawa, Keigo Kumagai, Chojiro Kojima, Toshimichi Fujiwara, Koh Takeuchi, Ichio Shimada, Kentaro Hanada, Hideo Takahashi (2018)  Phosphoinositide binding by the PH domain in ceramide transfer protein (CERT) is inhibited by hyperphosphorylation of an adjacent serine-repeat motif The Journal of Biological Chemistry. 293 :28,  11206-11217 DOI:10.1074/jbc.RA118.002465 PMID:29848549 
Keisuke Tachibana, Tomohiro Yuzuriha, Ryotaro Tabata, Syohei Fukuda, Takashi Maegawa, Rika Takahashi, Keiichi Tanimoto, Hirofumi Tsujino, Kazuto Nunomura, Bangzhong Lin, Yoshiharu Matsuura, Toshiya Tanaka, Takao Hamakubo, Juro Sakai, Tatsuhiko Kodama, Tadayuki Kobayashi, Kenji Ishimoto, Hiroyuki Miyachi, Takefumi Doi (2018)  Discovery of peroxisome proliferator-activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line Journal of Biological Chemistry. 293 :26,  10333-10343 DOI:10.1074/jbc.RA118.002077 PMID:29764933 
Mitsunori Shiroishi, Yuji Ito, Kenta Shimokawa, Jae Man Lee, Takahiro Kusakabe, Tadashi Ueda (2018)  Structure-function analyses of a stereotypic rheumatoid factor unravel the structural basis for germline-encoded antibody autoreactivity The Journal of Biological Chemistry. 293 :18,  7008-7016 DOI:10.1074/jbc.M117.814475 PMID:29523691 
Tomohiro Tanaka, Yue Zhou, Tatsuhiko Ozawa, Ryuya Okizono, Ayako Banba, Tomohiro Yamamura, Eiji Oga, Atsushi Muraguchi and Hiroaki Sakurai (2018)  Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation Journal of Biological Chemistry. 293 :7,  2288-2301 DOI:10.1074/jbc.M117.811299 PMID:29255092 
Atsuhiko Sakai, Taito Matsuda, Hiroyoshi Doi, Yukiko Nagaishi, Kiyoko Kato, and Kinichi Nakashima  (2018)  Ectopic neurogenesis induced by prenatal antiepileptic drug exposure augments seizure susceptibility in adult mice. Proceedings of the National Academy of Sciences of the United States of America. 115 :16,  4270-4275 DOI:10.1073/pnas.1716479115 PMID:29610328 
Suguru Yoshida, Tomoko Kuribara, Takamoto Morita, Tsubasa Matsuzawa, Kazushi Morimoto, Takuya Kobayashi and Takamitsu Hosoya (2018)  Expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors RSC Advances. 8 :39,  21754-21758 DOI:10.1039/c8ra04035d
Hui-Min Qin,Takuya Miyakawa,Akira Inoue,Ryuji Nishiyama,Akira Nakamura, Atsuko Asano,Takao Ojima and Masaru Tanokura (2018)  Structural basis for controlling the enzymatic properties of polymannuronate preferred alginate lyase FlAlyA from the PL-7 family Chemical communications. 54 :5,  555-558 DOI:10.1039/c7cc06523j PMID:29292806 
Yasuhiro Isogai, Hiroshi Imamura, Setsu Nakae, Tomonari Sumi, Ken-ichi Takahashi, Taro Nakagawa, Antonio Tsuneshige, Tsuyoshi Shirai (2018)  Tracing whale myoglobin evolution by resurrecting ancient proteins Scientific Reports. 8 16883- DOI:10.1038/s41598-018-34984-6 PMID:30442991 
Wenyu Miao, Katsuya Sakai, Naoya Ozawa, Takumi Nishiuchi, Yoshinori Suzuki, Kenichiro Ito, Tomomi Morioka, Masataka Umitsu, Junichi Takagi, Hiroaki Suga & Kunio Matsumoto  (2018)  Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist Scientific Reports. 8 16492- DOI:10.1038/s41598-018-34835-4 PMID:30405161 
Kouta Mayanagi,Sonoko Ishino,Tsuyoshi Shirai,Takuji Oyama,Shinichi Kiyonari,Daisuke Kohda,Kosuke Morikawa,Yoshizumi Ishino (2018)  Direct visualization of DNA baton pass between replication factors bound to PCNA Scientific Reports. 8 16209- DOI:10.1038/s41598-018-34176-2 PMID:30385773 
Yujiro Higuchi, Hitomi Matsufuji, Masanari Tanuma, Takatoshi Arakawa, Kazuki Mori, Chihaya Yamada, Risa Shofia, Emiko Matsunaga, Kosuke Tashiro, Shinya Fushinobu, Kaoru Takegawa (2018)  Identification and characterization of a novel β-D-galactosidase that releases pyruvylated galactose. Scientific Reports. 8 :1,  12013- DOI:10.1038/s41598-018-30508-4 PMID:30104607 
Karessa White, Mi-Jung Kim, Chul Han, Hyo-Jin Park, Dalian Ding, Kevin Boyd, Logan Walker, Paul Linser, Zaimary Meneses, Cole Slade, Jonathan Hirst, Katherine Santostefano, Naohiro Terada, Takuya Miyakawa, Masaru Tanokura, Richard Salvi & Shinichi Someya (2018)  Loss of IDH2 accelerates age-related hearing loss in male mice Scientific reports. 8 :1,  5039- DOI:10.1038/s41598-018-23436-w PMID:29567975 
Keiichirou Nemoto, Makiko Kagawa, Akira Nozawa, Yoshinori Hasegawa, Minoru Hayashi, Kenichiro Imai, Kentaro Tomii & Tatsuya Sawasaki (2018)  Identification of new abscisic acid receptor agonists using a wheat cell-free based drug screening system Scientific Reports. 8 4268- DOI:10.1038/s41598-018-22538-9 PMID:29523814 
Yukie Kashima, Ayako Suzuki, Ying Liu, Masahito Hosokawa, Hiroko Matsunaga, Masataka Shirai, Kohji Arikawa, Sumio Sugano, Takashi Kohno, Haruko Takeyama, Katsuya Tsuchihara & Yutaka Suzuki  (2018)  Combinatory use of distinct single-cell RNA-seq analytical platforms reveals the heterogeneous transcriptome response. Scientific Reports. 8 :1,  3482- DOI:10.1038/s41598-018-21161-y PMID:29472726 
Kana Tanabe, Jiaan Liu, Daiki Kato, Hitoshi Kurumizaka, Kenzo Yamatsugu, Motomu Kanai& Shigehiro A. Kawashima (2018)  LC-MS/MS-based quantitative study of the acyl group- and site-selectivity of human sirtuins to acylated nucleosomes Scientific Reports. 8 :1,  2656- DOI:10.1038/s41598-018-21060-2 PMID:29422688 
Saori Roppongi, Yoshiyuki Suzuki, Chika Tateoka, Mayu Fujimoto, Saori Morisawa, Ippei Iizuka, Akihiro Nakamura, Nobuyuki Honma, Yosuke Shida, Wataru Ogasawara, Nobutada Tanaka, Yasumitsu Sakamoto, Takamasa Nonaka (2018)  Crystal structures of a bacterial dipeptidyl peptidase IV reveal a novel substrate recognition mechanism distinct from that of mammalian orthologues. Scientific Reports. 8 :1,  2714- DOI:10.1038/s41598-018-21056-y PMID:29426867 
Tomoki Shojima, Feng Hou, Yusuke Takahashi, Yoshitaka Matsumura, Masahiko Okai, Akira Nakamura, Katsutoshi Mizuno, Kazuo Inaba, Masaki Kojima, Takuya Miyakawa, Masaru Tanokura (2018)  Crystal structure of a Ca 2+-dependent regulator of flagellar motility reveals the open-closed structural transition Scientific Reports. 8 :1,  2014- DOI:10.1038/s41598-018-19898-7 PMID:29386625 
Atmika Paudel, Suresh Panthee, Makoto Urai, Hiroshi Hamamoto, Tomohiko Ohwada& Kazuhisa Sekimizu (2018)  Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model Scientific Reports. 8 1578- DOI:10.1038/s41598-018-19867-0 PMID:29371643 
Yoshiaki Yasutake, Shin-Ichiro Hattori, Hironori Hayashi, Kouki Matsuda, Noriko Tamura, Satoru Kohgo, Kenji Maeda, Hiroaki Mitsuya (2018)  HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir. Scientific Reports. 8 :1,  1624- DOI:10.1038/s41598-018-19602-9 PMID:29374261 
Hidetsugu Asada, Shoichiro Horita, Kunio Hirata, Mitsunori Shiroishi, Yuki Shiimura, Hiroko Iwanari, Takao Hamakubo, Tatsuro Shimamura, Norimichi Nomura, Osamu Kusano-Arai, Tomoko Uemura, Chiyo Suno, Takuya Kobayashi & So Iwata  (2018)  Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog Nature Structural & Molecular Biology. 25 :7,  570-576 DOI:10.1038/s41594-018-0079-8 PMID:29967536 
Daria Merkurjev , Wan-Ting Hong , Kei Iida , Ikumi Oomoto , Belinda J Goldie , Hitoshi Yamaguti , Takayuki Ohara , Shin-Ya Kawaguchi , Tomoo Hirano , Kelsey C Martin , Matteo Pellegrini , Dan Ohtan Wang  (2018)  Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts. Nature Neuroscience. 21 1004-1014 DOI:10.1038/s41593-018-0173-6 PMID:29950670 
Jennifer R Molina, Yuting Sun, Marina Protopopova, Sonal Gera, Madhavi Bandi, Christopher Bristow, Timothy McAfoos, Pietro Morlacchi, Jeffrey Ackroyd, Ahmed-Noor A Agip, Gheath Al-Atrash, John Asara, Jennifer Bardenhagen, Caroline C Carrillo, Christopher Carroll, Edward Chang, Stefan Ciurea, Jason B Cross, Barbara Czako, Angela Deem, Naval Daver, John Frederick de Groot, Jian-Wen Dong, Ningping Feng, Guang Gao, Jason Gay, Mary Geck Do, Jennifer Greer, Virginia Giuliani, Jing Han, Lina Han, Verlene K Henry, Judy Hirst, Sha Huang, Yongying Jiang, Zhijun Kang, Tin Khor, Sergej Konoplev, Yu-Hsi Lin, Gang Liu, Alessia Lodi, Timothy Lofton, Helen Ma, Mikhila Mahendra, Polina Matre, Robert Mullinax, Michael Peoples, Alessia Petrocchi, Jaime Rodriguez-Canale, Riccardo Serreli, Thomas Shi, Melinda Smith, Yoko Tabe, Jay Theroff, Stefano Tiziani, Quanyun Xu, Qi Zhang, Florian Muller, Ronald A DePinho, Carlo Toniatti, Giulio F Draetta, Timothy P Heffernan, Marina Konopleva, Philip Jones, M Emilia Di Francesco, Joseph R Marszalek (2018)  An inhibitor of oxidative phosphorylation exploits cancer vulnerability. Nature Medicine. 24 :7,  1036-1046 DOI:10.1038/s41591-018-0052-4 PMID:29892070 
Ryoji Suno, Sangbae Lee, Shoji Maeda, Satoshi Yasuda, Keitaro Yamashita, Kunio Hirata, Shoichiro Horita, Maki S. Tawaramoto, Hirokazu Tsujimoto, Takeshi Murata, Masahiro Kinoshita, Masaki Yamamoto, Brian K. Kobilka, Nagarajan Vaidehi, So Iwata & Takuya Kobayashi  (2018)  Structural insights into the subtype-selective antagonist binding to the M 2 muscarinic receptor Nature chemical biology. 14 :12,  1150-1158 DOI:10.1038/s41589-018-0152-y PMID:30420692 
Toru Sengoku, Takehiro Suzuki, Naoshi Dohmae, Chiduru Watanabe, Teruki Honma, Yasushi Hikida, Yoshiki Yamaguchi, Hideyuki Takahashi, Shigeyuki Yokoyama, Tatsuo Yanagisawa (2018)  Structural basis of protein arginine rhamnosylation by glycosyltransferase EarP. Natature Chemical Biology. 14 :4,  368-374 DOI:10.1038/s41589-018-0002-y PMID:29440735 
Shohei Nosaki, Takuya Miyakawa, Yuqun Xu, Akira Nakamura, Kei Hirabayashi, Tadao Asami, Takeshi Nakano, Masaru Tanokura (2018)  Structural basis for brassinosteroid response Structural basis for brassinosteroid response by BIL1/BZR1 Nature Plants. 4 :10,  771-776 DOI:10.1038/s41477-018-0255-1 PMID:30287951 
Wataru Shihoya, Tamaki Izume, Asuka Inoue, Keitaro Yamashita, Francois Marie Ngako Kadji, Kunio Hirata, Junken Aoki, Tomohiro Nishizawa, Osamu Nureki (2018)  Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation. Nature Communications. 9 :1,  4711- DOI:10.1038/s41467-018-07094-0 PMID:30413709 
Mizuho Kajikawa, Toyoyuki Ose, Yuko Fukunaga, Yuki Okabe, Naoki Matsumoto, Kento Yonezawa, Nobutaka Shimizu, Simon Kollnberger, Masanori Kasahara & Katsumi Maenaka (2018)  Structure of MHC class I-like MILL2 reveals heparan-sulfate binding and interdomain flexibility. Nature Communications. 9 :1,  4330- DOI:10.1038/s41467-018-06797-8 PMID:30337538 
Yuqun Xu, Takuya Miyakawa, Shohei Nosaki, Akira Nakamura, Ying Lyu, Hidemitsu Nakamura, Umeharu Ohto, Hanako Ishida, Toshiyuki Shimizu, Tadao Asami & Masaru Tanokura (2018)  Structural analysis of HTL and D14 proteins reveals the basis for ligand selectivity in Striga Nature communications. 9 :1,  3947- DOI:10.1038/s41467-018-06452-2 PMID:30258184 
Atsushi Yamagata, Sakurako Goto-Ito, Yusuke Sato, Tomoko Shiroshima, Asami Maeda, Masahiko Watanabe, Takashi Saitoh, Katsumi Maenaka, Tohru Terada, Tomoyuki Yoshida, Takeshi Uemura, Shuya Fukai (2018)  Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction. Nature Communications. 9 :1,  3964- DOI:10.1038/s41467-018-06333-8 PMID:30262834 
Kumar Nagarathinam, Yoshiko Nakada-Nakura, Christoph Parthier, Tohru Terada, Narinobu Juge,Frank Jaenecke, Kehong Liu, Yunhon Hotta, Takaaki Miyaji, Hiroshi Omote, So Iwata,Norimichi Nomura, Milton T. Stubbs & Mikio Tanabe (2018)  Outward open conformation of a Major Facilitator Superfamily multidrug/H+ antiporter provides insights into switching mechanism Nature communications. 9 :1,  4005- DOI:10.1038/s41467-018-06306-x PMID:30275448 
Keisuke Yoshida, Masafumi Muratani, Hiromitsu Araki, Fumihito Miura, Takehiro Suzuki, Naoshi Dohmae, Yuki Katou, Katsuhiko Shirahige, Takashi Ito, Shunsuke Ishii  (2018)  Mapping of histone-binding sites in histone replacement-completed spermatozoa. Nature Communications. 9 :1,  3885- DOI:10.1038/s41467-018-06243-9 PMID:30250204 
Masamichi Nagae, Yasuhiko Kizuka, Emiko Mihara, Yu Kitago, Shinya Hanashima, Yukishige Ito,Junichi Takagi, Naoyuki Taniguchi & Yoshiki Yamaguchi (2018)  Structure and mechanism of cancer-associatedN-acetylglucosaminyltransferase-V Nature Communications. 9 3380- DOI:10.1038/s41467-018-05931-w PMID:30140003 
Naomi Tsuburaya, Kengo Homma, Tsunehiko Higuchi, Andrii Balia, Hiroyuki Yamakoshi, Norio Shibata, Seiichi Nakamura, Hidehiko Nakagawa, Shin-ichi Ikeda, Naoki Umezawa, Nobuki Kato, Satoshi Yokoshima, Masatoshi Shibuya, Manabu Shimonishi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Isao Naguro, Keiko Imamura, Haruhisa Inoue, Takao Fujisawa & Hidenori Ichijo (2018)  A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model Nature communications. 9 2668- DOI:10.1038/s41467-018-05127-2 PMID:29991716 
Natsuko Hama, Yasushi Totoki, Fumihito Miura, Kenji Tatsuno, Mihoko Saito-Adachi, Hiromi Nakamura, Yasuhito Arai, Fumie Hosoda, Tomoko Urushidate, Shoko Ohashi, Wakako Mukai, Nobuyoshi Hiraoka, Hiroyuki Aburatani, Takashi Ito, Tatsuhiro Shibata (2018)  Epigenetic landscape influences the liver cancer genome architecture Nature Communications. 9 :1,  1643- DOI:10.1038/s41467-018-03999-y PMID:29691395 
Atsushi Yamagata, Yuri Miyazaki, Norihiko Yokoi, Hideki Shigematsu, Yusuke Sato, Sakurako Goto-Ito, Asami Maeda, Teppei Goto, Makoto Sanbo, Masumi Hirabayashi, Mikako Shirouzu, Yuko Fukata, Masaki Fukata& Shuya Fukai (2018)  Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22 Nature Communications. 9 1546- DOI:10.1038/s41467-018-03947-w PMID:29670100 
Sakurako Goto-Ito, Atsushi Yamagata, Yusuke Sato, Takeshi Uemura, Tomoko Shiroshima, Asami Maeda, Ayako Imai, Hisashi Mori, Tomoyuki Yoshida, Shuya Fukai (2018)  Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation Nature Communications. 9 :1,  269- DOI:10.1038/s41467-017-02417-z PMID:29348429 
Tomio S Takahashi, Yoshihiro Hirade, Aya Toma, Yusuke Sato, Atsushi Yamagata, Sakurako Goto-Ito, Akiko Tomita, Shinichiro Nakada, Shuya Fukai (2018)  Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168 Nature Communications. 9 :1,  170- DOI:10.1038/s41467-017-02345-y PMID:29330428 
Yu Nakashima, Takahiro Mori, Hitomi Nakamura, Takayoshi Awakawa, Shotaro Hoshino, Miki Senda, Toshiya Senda& Ikuro Abe (2018)  Structural and Computational Bases for Dramatic Skeletal Rearrangement in Anditomin Biosynthesis Journal of the American chemical society. 140 :30,  9743-9750 DOI:10.1021/jacs.8b06084 PMID:29972643 
Junichi Taniguchi, Yihong Feng, Ganesh N. Pandian, Fumitaka Hashiya, Takuya Hidaka, Kaori Hashiya, Soyoung Park, Toshikazu Bando, Shinji Ito, Hiroshi Sugiyama (2018)  Biomimetic Artificial Epigenetic Code for Targeted Acetylation of Histones Journal of the American Chemical Society . 140 7108-7115 DOI:10.1021/jacs.8b01518 PMID:29792694 
Nobutaka Numoto, Narutoshi Kamiya, Gert-Jan Bekker, Yuri Yamagami, Satomi Inaba, Kentaro Ishii, Susumu Uchiyama, Fusako Kawai, Nobutoshi Ito, and Masayuki Oda (2018)  Structural Dynamics of the PET-Degrading Cutinase-like Enzyme from Saccharomonospora viridis AHK190 in Substrate-Bound States Elucidates the Ca2+-Driven Catalytic Cycle Biochemistry. 57 5289-5300 DOI:10.1021/acs.biochem.8b00624 PMID:30110540 
HitoshiOuchi, TomohiroAsakawa, KazutadaIkeuchi, MakotoInai, Jae-HoonChoi, HirokazuKawagishi, ToshiyukiKan (2018)  Synthesis of double-13C-labeled imidazole derivatives Tetrahedron Letters. 59 3516-3518 DOI:10.1016/j.tetlet.2018.07.048
Hiroto Sagara, Masaki Kanakogi, Yuki Tara, Hitoshi Ouchi, Junko Kimura, Yukiko Kaneko, Makoto Inai, Tomohiro Asakawa, Tomohisa Ishikawa, Toshiyuki Kan (2018)  Concise synthesis of polymethoxyflavone sudachitin and its derivatives, and biological evaluations Tetrahedron Letters. 59 1816-1818 DOI:10.1016/j.tetlet.2018.03.064
Yohei Korogi, Shimpei Gotoh, Satoshi Ikeo, Yuki Yamamoto, Naoyuki Sone, Koji Tamai, Satoshi Konishi, Tadao Nagasaki, Hisako Matsumoto, Isao Ito, Toyofumi F Chen-Yoshikawa, Hiroshi Date, Masatoshi Hagiwara, Isao Asaka, Akitsu Hotta, Michiaki Mishima, Toyohiro Hirai  (2019)  In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids. Stem Cell Reports.. 12 431-440 DOI:10.1016/j.stemcr.2019.01.014 PMID:30773483 
Chihoko Kobayashi, Masahiko Kato, Hidekazu Nagaya, Nobutaka Shimizu, Kazuhiro Ishibashi, Masayu kiIshikawa, Etsuko Katoh (2019)  Purification and functional characterization of tomato mosaic virus130K protein expressed in silkworm pupae using a baculovirus vector. Protein Expression and Purification. 154 85-90 DOI:10.1016/j.pep.2018.10.001 PMID:30291968 
Sanae Tabata, YuKitago, Yuki Fujii, Emiko Mihara, Keiko Tamura-Kawakami, Naoko Norioka, Katsu Takahashi, Mika K. Kaneko, Yukinari Kato,Junichi Takagi  (2018)  An anti-peptide monoclonal antibody recognizing the tobacco etch virus protease-cleavage sequence and its application to a tandem tagging system Protein expression and purification. 147 94-99 DOI:10.1016/j.pep.2018.03.004 PMID:29550370 
Haruka Sakaue,Takuya Shiota,Naoya Ishizaka,Shin Kawano,Yasushi Tamura,Kher Shing Tan,Kenichiro Imai,Chie Motono,Takatsugu Hirokawa,Kentaro Taki,Non Miyata,Osamu Kuge,Trevor Lithgow,Toshiya Endo (2019)  Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly Molecular Cell. 73 1044-1055 DOI:10.1016/j.molcel.2019.01.003 PMID:30738703 
Zhiqi Xie, Yukio Ago, Naoki Okada, Masashi Tachibana  (2018)  Valproic acid attenuates immunosuppressive function of myeloid-derived suppressor cells Journal of Pharmacological Sciences. 137 359-365 DOI:10.1016/j.jphs.2018.06.014 PMID:30177294 
Motoyasu Hosokawa, Akihide Takeuchi, Jun Tanihata, Kei Iida, Shinichi Takeda, Masatoshi Hagiwara (2019)  Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy iScience. 13 229-242 DOI:10.1016/j.isci.2019.02.023 PMID:30870781 
Hiroyuki Okano, Misato Baba, Ryota Hidese, Kei Iida, Tongyang Li, Kenji Kojima, Teisuke Takita, Itaru Yanagihara, Shinsuke Fujiwara, Kiyoshi Yasukawa (2018)  Accurate fidelity analysis of the reverse transcriptase by a modified next-generation sequencing Enzyme and Microbial Technology. 115 81-85 DOI:10.1016/j.enzmictec.2018.05.001 PMID:29859606 
Makoto Tanaka, Yunhao Zhu, Masafumi Shionyu, Nozomi Ota, Natsumi Shibata, Chihiro Watanabe, Akihito Mizusawa, Ryuzo Sasaki, Tamio Mizukami, Isamu Shiina, Makoto Hasegawa (2018)  Ridaifen-F conjugated with cell-penetrating peptides inhibits intracellular proteasome activities and induces drug-resistant cell death European Journal of Medicinal Chemistry. 146 636-650 DOI:10.1016/j.ejmech.2018.01.045 PMID:29407987 
Yinglei Sheng, Hirofumi Watanabe, Keiya Maruyama, Chiduru Watanabe, Yoshio Okiyama, Teruki Honma, Kaori Fukuzawa, Shigenori Tanaka (2018)  Towards Good Correlation Between Fragment Molecular Orbital Interaction Energies and Experimental IC 50 for Ligand Binding: A Case Study of p38 MAP Kinase Computational and Structural Biotechnology Journal. 16 421-434 DOI:10.1016/j.csbj.2018.10.003 PMID:30450166 
Yoichiro Fujioka, Shinya Nishide, Toyoyuki Ose, Tadaki Suzuki, Izumi Kato, Hideo Fukuhara, Mari Fujioka, Kosui Horiuchi, Aya O. Satoh, Prabha Nepal, Sayaka Kashiwagi, Jing Wang,Mika Horiguchi, Yuko Sato, Sarad Paudel, Asuka Nanbo, Tadaaki Miyazaki, Hideki Hasegawa, Katsumi Maenaka, Yusuke Ohba  (2018)  A Sialylated Voltage-Dependent Ca2+ Channel Binds Hemagglutinin and Mediates Influenza A Virus Entry into Mammalian Cells Cell Host & Microbe. 23 809-818 DOI:10.1016/j.chom.2018.04.015 PMID:29779930 
Zhikuan Zhang, Umeharu Ohto, Takuma Shibata, Masato Taoka, Yoshio Yamauchi, Ryota Sato, Nikunj M. Shukla, Sunil A. David, Toshiaki Isobe, Kensuke Miyake, Toshiyuki Shimizu  (2018)  Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands Cell Reports. 25 :12,  3371-3381 DOI:10.1016/j.celrep.2018.11.081 PMID:30566863 
Akihide Takeuchi, Kei Iida, Toshiaki Tsubota, Motoyasu Hosokawa, Masatsugu Denawa, J B Brown, Kensuke Ninomiya, Mikako Ito, Hiroshi Kimura, Takaya Abe, Hiroshi Kiyonari, Kinji Ohno, Masatoshi Hagiwara (2018)  Loss of Sfpq causes long-gene transcriptopathy in the brain. Cell Reports. 23 1326-1341 DOI:10.1016/j.celrep.2018.03.141 PMID:29719248 
Gengo Kashiwazaki, Rina Maeda, Takashi Kawase, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama (2018)  Evaluation of alkylating pyrrole-imidazole polyamide conjugates by a novel method for high-throughput sequencer Bioorganic & Medicinal Chemistry. 26 1-7 DOI:10.1016/j.bmc.2017.08.057 PMID:29224995 
Akito Kawai, Keishi Yamasaki, Taisuke Enokida, Shuichi Miyamoto, Masaki Otagiri (2018)  Crystal structure analysis of human serum albumin complexed with sodium 4-p henylbutyrate Biochemistry and Biophysics Reports. 13 78-82 DOI:10.1016/j.bbrep.2018.01.006 PMID:29387812 
Atsushi Uematsu, Kohki Kido, Erika Manabe, Hiroyuki Takeda, Hirotaka Takahashi, Minoru Hayashi, Yuuki Imai, Tatsuya Sawasaki (2018)  DANFIN functions as an inhibitor of transcription factor NF-kB and potentiates the antitumor effect of bortezomib in multiple myeloma. Biochemical and Biophysical Research Communications. 495 :3,  2289-2295 DOI:10.1016/j.bbrc.2017.12.142 PMID:29284118 
Tatsuhiko Ozawa, Hideyuki Masaki, Tomohiko Takasaki, Ikuko Aoyama, Takahiro Yumisashi, Atsushi Yamanaka, Eiji Konishi, Yoh Ohnuki, Atsushi Muraguchi, Hiroyuki Kishi (2018)  Human monoclonal antibodies against West Nile virus from Japanese encephalitis-vaccinated volunteers Antiviral Research. 154 58-65 DOI:10.1016/j.antiviral.2018.04.011 PMID:29665373 
Paulina D.Anindita, MichihitoSasaki, KazumaOkada, NaotoIto, MakotoSugiyama, NorikoSaito-Tarashima, oriakiMinakawa, SatoshiShuto, SatokoOtsuguro, SatoshiIchikawa, AkiraMatsuda, KatsumiMaenaka,YasukoOrba,HirofumiSawa (2018)  Ribavirin-related compounds exert in vitro inhibitory effects toward rabies virus Antiviral Research. 154 1-9 DOI:10.1016/j.antiviral.2018.03.011 PMID:29601893 
Nanao Suzuki, Yuuki Takamuku, Tomohiro Asakawa, Makoto Inai, Tomoya Hino, So Iwata, Toshiyuki Kan, Takeshi Murata (2018)  An efficient screening method for purifying and crystallizing membrane proteins using modified clear-native PAGE Analytical Biochemistry. 584 7-14 DOI:10.1016/j.ab.2018.02.007 PMID:29432751 
Yusuke Kato, Takuya Miyakawa & Masaru Tanokura (2018)  Overview of the mechanism of cytoskeletal motors based on structure Biophysical reviews. 10 :2,  571-581 DOI:10.1007/s12551-017-0368-1 PMID:29235081 
Satomi Inaba, Narutoshi Kamiya, Gert-Jan Bekker, Fusako Kawai & Masayuki Oda (2018)  Folding thermodynamics of PET-hydrolyzing enzyme Cut190 depending on Ca2+ concentration Journal of Thermal Analysis and Colorimetry. 135 2655-2663 DOI:10.1007/s10973-018-7447-9
Masashi Morita, Shun Matsumoto, Airi Sato, Kengo Inoue, Dzmitry G. Kostsin, Kozue Yamazaki, Kosuke Kawaguchi, Nobuyuki Shimozawa, Stephan Kemp, Ronald J. Wanders, Hirotatsu Kojima, Takayoshi Okabe, Tsuneo Imanaka (2018)  Stability of the ABCD1 Protein with a Missense Mutation: A Novel Approach to Finding Therapeutic Compounds for X-Linked Adrenoleukodystrophy JIMD Reports. 44 23-31 DOI:10.1007/8904_2018_118 PMID:29926352 
Setsu Nakae,Masafumi Shionyu,Tomohisa Ogawa,Tsuyoshi Shirai (2018)  Structures of jacalin-related lectin PPL3 regulating pearl shell biomineralization Proteins, Structure, Function, and Bioinformatics. 86 644-653 DOI:10.1002/prot.25491 PMID:29524263 
Naomi Ohbayashi, Kazutaka Murayama, Miyuki Kato‐Murayama, Mutsuko Kukimoto‐Niino, Tamami Uejima, Takayoshi Matsuda, Noboru Ohsawa, Shigeyuki Yokoyoma, 4ProfHiroshi Nojima, Mikako Shirouzu  (2018)  Structural Basis for the Inhibition of Cyclin G‐Associated Kinase by Gefitinib ChemistryOpen. 7 :9,  721-727 DOI:10.1002/open.201800177 PMID:30214852 
Maiko Okumura,Tatsuhiko Ozawa,Hiroshi Hamana,Yu Norimatsu,Reina Tsuda,Eiji Kobayashi, Koichiro Shinoda, Hirofumi Taki, Kazuyuki Tobe,Johji Imura,Eiji Sugiyama, Hiroyuki Kishi, Atsushi Muraguchi (2018)  Autoantibodies reactive to PEP08 are clinically related with morbidity and severity of interstitial lung disease in connective tissue diseases European Journal of Immunology. 48 :10,  1717-1727 DOI:10.1002/eji.201747381 PMID:29989658 
Hamza Hanieh , Kazuya Masuda , Hozaifa Metwally , Jaya P Chalise , Maged Mohamed , Kishan K Nyati , Daron M Standley , Songling Li , Mitsuru Higa , Mohammad M Zaman , Tadamitsu Kishimoto  (2018)  Arid5a stabilizes OX40 mRNA in murine CD4(+) T cells by recognizing a stem-loop structure in its 3'UTR. European Journal of Immunology. 48 :4,  593-604 DOI:10.1002/eji.201747109 PMID:29244194 
Wataru Kakuguchi, Takao Nomura, Tetsuya Kitamura, Satoko Otsuguro, Kazuhiro Matsushita, Masahiro Sakaitani, Katsumi Maenaka, Kanchu Tei (2018)  Suramin, screened from an approved drug library, inhibits HuR functions and attenuates malignant phenotype of oral cancer cells Cancer Medecine. 7 6269-6280 DOI:10.1002/cam4.1877 PMID:30449075 
Naoki Kamo, Gosuke Hayashi, Akimitsu Okamoto (2018)  Triple Function of 4‐Mercaptophenylacetic Acid Promotes One‐Pot Multiple Peptide Ligation Angewandte Chemie. 57 :50,  16533-16537 DOI:10.1002/ange.201809765 PMID:30346110