成果

創薬等先端技術支援基盤プラットフォーム(BINDS)の実施者による研究支援と研究高度化の成果として輩出されたデータベース、 ツール、論文および特許を紹介します。

開発されたデータベースやツール

ケミカルシーズ・リード 探索ユニット

インシリコユニット

プラットフォーム機能最適化ユニット

BINDS支援技術に関する研究成果(論文)

Shibamoto M, Higo T, Naito AT, Nakagawa A, Sumida T, Okada K, Sakai T, Kuramoto Y, Yamaguchi T, Ito M, Masumura Y, Higo S, Lee JK, Hikoso S, Komuro I, Sakata Y.  (2019)  Activation of DNA Damage Response and Cellular Senescence in Cardiac Fibroblasts Limit Cardiac Fibrosis After Myocardial Infarction. Int Heart J.. 60 :4,  944-957 DOI:10.1536/ihj.18-701 PMID:31257341 
Sugiyama A, Hagiwara-Nagasawa M, Kambayashi R, Goto A, Chiba K, Naito AT, Kanda Y, Matsumoto A, Izumi-Nakaseko H. (2019)  Analysis of electro-mechanical relationship in human iPS cell-derived cardiomyocytes sheets under proarrhythmic condition assessed by simultaneous field potential and motion vector recordings. relationship in human iPS cell-derived cardiomyocytes sheets u J Pharmacol Sci.. 140 :4,  317-320 DOI:10.1016/j.jphs.2019.07.006 PMID:31377016 
Michihiro Suga, Shin-Ichiro Ozawa, Kaori Yoshida-Motomura, Fusamichi Akita, Naoyuki Miyazaki, Yuichiro Takahashi? (2019)  Structure of the green algal photosystem I supercomplex with a decameric light-harvesting complex I Nature Plants. 5 :6,  626-636 DOI:10.1038/s41477-019-0438-4 PMID:31182847 
Masahito Yoshida, Masazumi Saito, Shinya Ito, Koji Ogawa, Naoki Goshima, Kazuhiro Nagata, Takayuki Doi (2020)  Structure?Activity Relationship Study on Col-003, a Protein?Protein Interaction Inhibitor between Collagen and Hsp47 Chemical and Pharmaceutical Bulletin. 68 :3,  220-226 DOI:10.1248/cpb.c19-00634 PMID:31582590 
Shuichi Nakamura, Yuta Hanaizumi, Yusuke V Morimoto, Yumi Inoue, Marc Erhardt, Tohru Minamino, Keiichi Namba  (2020)  Direct observation of speed fluctuations of flagellar motor rotation at extremely low load close to zero. Molecular Microbiology. 113 :4,  755-765 DOI:10.1111/mmi.14440 PMID:31828860 
Miki Kinoshita, Seina Tanaka, Yumi Inoue, Keiichi Namba, Shin-Ichi Aizawa, Tohru Minamino  (2020)  The flexible linker of the secreted FliK ruler is required for export switching of the flagellar protein export apparatus. Scientific Reports. 10 :1,  838- DOI:10.1038/s41598-020-57782-5 PMID:31964971 
Akihito Harada, Kazumitsu Maehara, Tetsuya Handa, Yasuhiro Arimura, Jumpei Nogami, Yoko Hayashi-Takanaka, Katsuhiko Shirahige, Hitoshi Kurumizaka, Hiroshi Kimura& Yasuyuki Ohkawa? (2019)  A chromatin integration labelling method enables epigenomic profiling with lower input Nature Cell Biology. 21 :2,  287-296 DOI:10.1038/s41556-018-0248-3 PMID:30532068 
Yumi Inoue, Yuya Ogawa, Miki Kinoshita, Naoya Terahara, Masafumi Shimada, Noriyuki Kodera, Toshio Ando, Keiichi Namba, Akio Kitao, Katsumi Imada, Tohru Minamino  (2019)  Structural insights into the substrate specificity switching mechanism of the type III protein export apparatus. Structure. 27 :6,  965-976 DOI:10.1016/j.str.2019.03.017 PMID:31031200 
Yonezawa K, Takahashi M, Yatabe K, Nagatani Y, Shimizu N. (2019)  Software for serial data analysis measured by SEC-SAXS/UV-Vis spectroscopy AIP Conference Proceedings. 2054 60082- DOI:10.1063/1.5084713
Daniel James, Tobias Weinert, Petr Skopintsev, Antonia Furrer, Dardan Gashi, Tomoyuki Tanaka, Eriko Nango, Przemyslaw Nogly, Joerg Standfuss  (2019)  Improving high viscosity extrusion of microcrystals for time-resolved serial femtosecond crystallography at X-ray lasers Journal of Visualized Experiments :JoVE. :144,  e59087- DOI:10.3791/59087 PMID:30882786 
Peter Horvath, Takayuki Kato, Tomoko Miyata and Keiichi Namba (2019)  Structure of Salmonella Flagellar Hook Reveals Intermolecular Domain Interactions for the Universal Joint Function Biomolecules. 9 :9,  462- DOI:10.3390/biom9090462 PMID:31505847 
Giorgia Benzi, Alain Camasses, Yoshimura Atsunori, Yuki Katou, Katsuhiko Shirahige, Simonetta Piatti (2020)  A common molecular mechanism underlies the role of Mps1 in chromosome biorientation and the spindle assembly checkpoint EMBO Reports. 21 :6,  e50257- DOI:10.15252/embr.202050257 PMID:32307893 
Ryuichiro Nakato, Youichiro Wada, Ryo Nakaki, Genta Nagae, Yuki Katou, Shuichi Tsutsumi, Natsu Nakajima, Hiroshi Fukuhara, Atsushi Iguchi, Takahide Kohro, Yasuharu Kanki, Yutaka Saito, Mika Kobayashi, Akashi Izumi-Taguchi, Naoki Osato, Kenji Tatsuno, Asuka Kamio, Yoko Hayashi-Takanaka, Hiromi Wada, Shinzo Ohta, Masanori Aikawa, Hiroyuki Nakajima, Masaki Nakamura, Rebecca C McGee, Kyle W Heppner, Tatsuo Kawakatsu, Michiru Genno, Hiroshi Yanase, Haruki Kume, Takaaki Senbonmatsu, Yukio Homma, Shigeyuki Nishimura, Toutai Mitsuyama, Hiroyuki Aburatani, Hiroshi Kimura, Katsuhiko Shirahige (2019)  Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells epigenetics Chromatin. 12 :1,  77- DOI:10.1186/s13072-019-0319-0 PMID:31856914 
Yotaro Ochi, Ayana Kon, Toyonori Sakata, Masahiro M Nakagawa, Naotaka Nakazawa, Masanori Kakuta, Keisuke Kataoka, Haruhiko Koseki, Manabu Nakayama, Daisuke Morishita, Tatsuaki Tsuruyama, Ryunosuke Saiki, Akinori Yoda, Rurika Okuda, Tetsuichi Yoshizato, Kenichi Yoshida, Yusuke Shiozawa, Yasuhito Nannya, Shinichi Kotani, Yasunori Kogure, Nobuyuki Kakiuchi, Tomomi Nishimura, Hideki Makishima, Luca Malcovati, Akihiko Yokoyama, Kengo Takeuchi, Eiji Sugihara, Taka-Aki Sato, Masashi Sanada, Akifumi Takaori-Kondo, Mario Cazzola, Mineko Kengaku, Satoru Miyano, Katsuhiko Shirahige, Hiroshi I Suzuki, Seishi Ogawa (2020)  Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes cancer discovery. 10 :6,  836-853 DOI:10.1158/2159-8290.CD-19-0982 PMID:32249213 
Terunaga Nakagawa  (2019)  Structures of the AMPA receptor in complex with its auxiliary subunit cornichon Science. 366 :6470,  1259-1263 DOI:10.1126/science.aay2783 PMID:31806817 
Batuujin Burendei, Ruriko Shinozaki, Masakatsu Watanabe, Tohru Terada, Kazutoshi Tani, Yoshinori Fujiyoshi, and Atsunori Oshima  (2020)  Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids Science Advances. 6 :7,  eaax3157- DOI:10.1126/sciadv.aax3157 PMID:32095518 
Kaoru Kobayashi,Jiro Kuze,Satoshi Abe,Shoko Takehara,Genki Minegishi,Katsuhide Igarashi,Satoshi Kitajima,Jun Kanno,Takushi Yamamoto,Mitsuo OshimuraandYasuhiro Kazuki (2019)  CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis Molecular Pharmacology. 96 :5,  600-608 DOI:10.1124/mol.119.117333 PMID:31455676 
Shibom Basu, Vincent Olieric, Filip Leonarski, Naohiro Matsugaki, Yoshiaki Kawano, Tomizaki Takashi, Chia-Ying Huang, Yusuke Yamada, Laura Vera, Natacha Olieric, Jerome Basquin, Justyna A. Wojdyla, Oliver Bunk, Kay Diederichs, Masaki Yamamoto and Meitian Wang (2019)  Long-wavelength native-SAD phasing: opportunities and challenges IUCr . 6 373-386 DOI:10.1107/S2052252519002756 PMID:31098019 
Hidetaka Watanabe , Ken Higashimoto, Noriko Miyake, Sumiyo Morita, Takuro Horii, Mika Kimura, Takayuki Suzuki, Toshiyuki Maeda, Hidenori Hidaka, Saori Aoki, Hitomi Yatsuki, Nobuhiko Okamoto, Tetsuji Uemura, Izuho Hatada, Naomichi Matsumoto, Hidenobu Soejima  (2020)  DNA methylation analysis of multiple imprinted DMRs in Sotos syndrome reveals IGF2-DMR0 as a DNA methylation-dependent, P0 promoter-specific enhancer FASEB Journal. 34 :1,  960-973 DOI:10.1096/fj.201901757R PMID:31914674 
Alexander Amberg, Lennart T Anger, Joel Bercu, David Bower, Kevin P Cross, Laura Custer, James S Harvey, Catrin Hasselgren, Masamitsu Honma, Candice Johnson, Robert Jolly, Michelle O Kenyon, Naomi L Kruhlak, Penny Leavitt, Donald P Quigley, Scott Miller, David Snodin, Lidiya Stavitskaya, Andrew Teasdale, Alejandra Trejo-Martin, Angela T White, Joerg Wichard, Glenn J Myatt  (2019)  Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: is aromatic N-oxide a structural alert for predicting DNA-reactive mutagenicity? Mutagenesis. 34 :1,  67-82 DOI:10.1093/mutage/gey020 PMID:30189015 
Takeshi Morita, Yoshiyuki Shigeta, Tomoko Kawamura, Yurika Fujita, Hiroshi Honda, Masamitsu Honma  (2019)  In silico prediction of chromosome damage: comparison of three (Q)SAR models Mutagenesis. 34 :1,  91-100 DOI:10.1093/mutage/gey017 PMID:30085209 
Noriyuki Igarashi, Hideaki Takagi, Hiromasa Ohta, Takeharu Mori, Shogo Tomita, Yasuko Nagatani, Takashi Kosuge, Hiroshi Okuda, and Nobutaka Shimizu (2019)  Further developments of the tender x-ray diffractometer at BL-15A2 of the photon factory. AIP Conference Proceedings. 2054 :1,  60043- DOI:10.1063/1.5084674
Nozomi Hanzawa, Koshi Hashimoto , Xunmei Yuan, Kenichi Kawahori, Kazutaka Tsujimoto, Miho Hamaguchi, Toshiya Tanaka, Yuya Nagaoka, Hiroshi Nishina, Sumiyo Morita, Izuho Hatada, Tetsuya Yamada, Yoshihiro Ogawa (2020)  Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing Scientific reports. 10 :1,  5181- DOI:10.1038/s41598-020-62035-6 PMID:32198422 
Radostin Danev (2019)  Electrons see the light Nature Methods. 16 :10,  966-967 DOI:10.1038/s41592-019-0577-6 PMID:31562470 
Noritaka Nishida, Yuta Komori, Osamu Takarada,Atsushi Watanabe, Satoko Tamura, Satoshi Kubo, Ichio Shimada, and Masahide Kikkawa (2020)  Structural basis for two-way communication between dynein and microtubules Nat Commun. 11 :1,  1038- DOI:10.1038/s41467-020-14842-8 PMID:32098965 
Masamichi Ito, Hironori Hara, Norifumi Takeda, Atsuhiko T. Naito, Seitaro Nomura, Masaki Kondo, YutakaHata, MasanobuUchiyama, Hiroyuki Morita, Issei Komuro (2019)  Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes Journal of Molecular and Cellular Cardiology. 128 90-95 DOI:10.1016/j.yjmcc.2019.01.020 PMID:30684499 
Radostin Danev, Haruaki Yanagisawa, Masahide Kikkawa  (2019)  Cryo-Electron Microscopy Methodology: Current Aspects and Future Directions Trends in Biochemical Sciences . 44 :10,  837-848 DOI:10.1016/j.tibs.2019.04.008 PMID:31078399 
Masakazu Sugishima, Kei Wada, MasakiUnno, Keiichi Fukuyama (2019)  Bilin-metabolizing enzymes: site-specific reductions catalyzed by two different type of enzymes Current Opinion in Structural Biology. 59 73-80 DOI:10.1016/j.sbi.2019.03.005 PMID:30954759 
Yi-Lynn Liang, Matthew J Belousoff, Peishen Zhao, Cassandra Koole, Madeleine M Fletcher, Tin T Truong, Villy Julita, George Christopoulos, H Eric Xu, Yan Zhang, Maryam Khoshouei, Arthur Christopoulos, Radostin Danev, Patrick M Sexton, Denise Wootten  (2020)  Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation Molecular Cell. 77 :3,  656-668.e.5 DOI:10.1016/j.molcel.2020.01.012 PMID:32004469 
Yuxin Ye, Meirong Chen, Koji Kato, Min Yao (2019)  The pH-dependent conformational change of eukaryotic translation initiation factor 5: Insights into partner-binding manner biochemical and biophysical research communications. 519 :1,  186-191 DOI:10.1016/j.bbrc.2019.08.128 PMID:31492496 
Eiki Yamashita, Atsushi Nakagawa (2019)  SPring-8 BL44XU, a synchrotron radiation beamline for biological macromolecular assemblies, operated by the Institute for Protein Research, Osaka University Biophysical Reviews. 11 :4,  521-523 DOI:10.1007/s12551-019-00557-8 PMID:31338695 
Tianyu Wang,Shumpei Nakagawa,Takahito Miyake,Genzui Setsu,Sumihiro Kunisue,Kaoru Goto,Akira Hirasawa,Hitoshi Okamura,Yoshiaki Yamaguchi,Masao Doi  (2020)  Identification and Functional Characterisation of N-Linked Glycosylation of the Orphan G Protein-Coupled Receptor Gpr176. Scientific Reports. 10 :1,  4429- DOI:10.1038/s41598-020-61370-y PMID:32157140 
Keisuke Tachibana, Kenji Ishimoto, Rika Takahashi, Hirokazu Kadono, Takuya Awaji, Tomohiro Yuzuriha, Toshiya Tanaka, Takao Hamakubo, Juro Sakai, Tatsuhiko Kodama, Shunji Aoki, Takefumi Doi (2019)  Development of a Ligand ScreeningTool Using Full-Length Human Peroxisome Proliferator-Activated Receptor-Expressing Cell Lines to Ameliorate Metabolic Syndrome Chemical and Pharmaceutical Bulletin. 67 :3,  199-202 DOI:10.1248/cpb.c18-00627 PMID:30827999 
KensukeMatsumura, MasayukiBaba, KazukiNagayasu, KanaYamamoto, MomokaKondo,KoheiKitagawa, TomoyaTakemoto, KaoruSeiriki, AtsushiKasai, YukioAgo AtsukoHayata-Takano, NorihitoShintani, ToshihikoKuriuTokuichiIguchi, MakotoSato, KazuhiroTakuma, RyotaHashimoto, HitoshiHashimoto, TakanobuNakazawa (2019)  Autism-associated protein kinase D2 regulates embryonic cortical neuron development. Biochem Biophys Res Commun. 519 :3,  626-632 DOI:10.1016/j.bbrc.2019.09.048 PMID:31540692 
Chun Fang, Yoshitaka Moriwaki, Aikui Tian, Caihong Li, Kentaro Shimizu (2019)  Identifying short disorder-to-order binding regions in disordered proteins with a deep convolutional neural network method Journal of Bioinformatics and Computational Biology. 17 :1,  1950004- DOI:10.1142/S0219720019500045 PMID:30866736 
Yoshitaka Moriwaki, Mirai Yato, Tohru Terada, Seiji Saito, Noriyuki Nukui, Takumi Iwasaki, Tatsunari Nishi, Yuko Kawaguchi, Ken Okamoto, Takatoshi Arakawa, Chihaya Yamada, Shinya Fushinobu, Kentaro Shimizu (2019)  Understanding the Molecular Mechanism Underlying the High Catalytic Activity of p-Hydroxybenzoate Hydroxylase Mutants for Producing Gallic Acid Biochemistry. 58 :45,  4543-4558 DOI:10.1021/acs.biochem.9b00443 PMID:31639299 
辻川和丈 (2019)  Perspective/Retrospective 創薬における連携を成功させるには ~ワンストップアカデミア創薬基盤~ 日本薬学会構造活性相関ニュースレター(SAR News). 36 1-7 DOI:JST資料番号:U1076A
加藤貴之, 牧野文信, 難波啓一. (2019)  クライオ電子顕微鏡による単粒子解析法:可溶性タンパク質. Electron cryomicroscopy and single particle image analysis of soluble proteins. 細胞 2019年10月臨時増刊号 構造生物学の最前線. 51 :12,  12-15 DOI:ISSN:1347-1767
土方敦司, 辻 敏之, 塩生真史, 白井 剛 (2019)  超分子グラフシステムによるGWAS解析の研究 細胞. 51 34-38 DOI:ISSN:1346-7557
辻川和丈 (2019)  ALKBH3を分子標的とする革新的がん治療創薬展開 実験医学. 37 1791-1793 DOI:ISSN:0288-5514
石坂優人, 陳明皓, 奈良井峻, 堀谷正樹, 田中良和, 姚閔 (2019)  鉄硫黄クラスターが関与するtRNAチオ化修飾酵素の詳細な反応機構解明を目指した研究 Photon Factory News. 37 :3,  20-24 DOI:http://pfwww.kek.jp/publications/pfnews/37_3/saikin3.pdf
Kenta Yamamoto, Vikas Dubey, Katsumasa Irie, Hanayo Nakanishi, Himanshu Khandelia, Yoshinori Fujiyoshi, and Kazuhiro Abe  (2019)  A single K+-binding site in the crystal structure of the gastric proton pump. eLife. 8 e47701- DOI:10.7554/eLife.47701 PMID:31436534 
Gert-Jan BEKKER,工藤高裕,池川恭代,山下鈴子,栗栖源嗣 (2019)  Protein Data Bankで利用するPDBx/mmCIF形式について 日本結晶学会誌. 61 159-160 DOI:10.5940/jcrsj.61.159
内田圭祐, 吉田 優, 細谷孝充 (2019)  多成分集積を指向した合成のためのアライン化学 有機合成化学協会誌. 77 :2,  145-162 DOI:10.5059/yukigoseikyokaishi.77.145
Kimiko Kuroki, Haruki Matsubara, Ryo Kanda, Naoyuki Miyashita, Mitsunori Shiroishi, Yuko Fukunaga, Jun Kamishikiryo, Atsushi Fukunaga, Hideo Fukuhara, Kaoru Hirose, Joan S. Hunt, Yuji Sugita, Shunsuke Kita, Toyoyuki Ose and Katsumi Maenaka (2019)  Structural and Functional Basis for LILRB Immune Checkpoint Receptor Recognition of HLA-G Isoforms Journal of Immunology. 203 3386-3394 DOI:10.4049/jimmunol.1900562 PMID:31694909 
Yu Nakamura, Suguru Yoshida, and Takamitsu Hosoya (2019)  Recent Advances in Synthetic Hetaryne Chemistry Heterocycles . 98 :12,  1623-1677 DOI:10.3987/REV-19-917
Yoshihiko Yamamoto (2019)  Recent Advances in Transition-Metal-Catalyzed Synthesis of 3- and/or 4-Aryl-2(1H)-quinolones Heterocycles. 98 1309-1344 DOI:10.3987/REV-19-914
Kenji Watanabe, Junpei Tsuda, Hidenori Ochiai, Takashi Niwa, and Takamitsu Hosoya (2019)  Divergent Synthesis of Photoaffinity Probe Candidates by Click Reactions of Azido-Substituted Aryltrifluoromethyldiazirines Heterocycles. 99 :2,  1366-1387 DOI:10.3987/COM-18-S(F)76
Yoshitake Nishiyama, Yoshihiro Misawa, Yuki Hazama, Kazuhiro Oya, Suguru Yoshida, Takamitsu Hosoya (2019)  Synthesis of Diverse 3-Azido-5-(azidomethyl)benzene Derivatives via Formal C-H Azidation and Functional Group-Selective Transformations Heterocycles. 99 :2,  1053-1072 DOI:10.3987/COM-18-S(F)72
Hirokazu Tsukamoto, Yumi Nomura, Takayuki Doi (2019)  First Total Synthesis of Palmarumycin C6 Based on Double Oxa-Michael Addition of 1,8-Dihydroxynaphthalene to 3-Bromo-1-indenone Heterocycles. 99 549-565 DOI:10.3987/COM-18-S(F)52
Takahito Satoh, Touma Adachi, Kentaro Okano, Juri Sakata, Hidetoshi Tokuyama (2019)  Synthetic Studies on Plakinidines Heterocycles. 99 310-323 DOI:10.3987/COM-18-S(F)26
Junko Takei, Mika Kato Kaneko, Tomokazu Ohishi, Manabu Kawada, Hiroyuki Harada, and Yukinari Kato (2019)  A novel anti-EGFR monoclonal antibody (EMab-17) exerts antitumor activity against oral squamous cell carcinomas via antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. Oncology Letters. 19 :4,  2809-2816 DOI:10.3892/ol.2020.11384 PMID:32218834 
Hideo Fukuhara, Yuri Ito, Miyuki Sako, Mizuho Kajikawa, Koki Yoshida, Fumio Seki, Mwila Hilton Mwaba, Takao Hashiguchi, Masa-aki Higashibata, Toyoyuki Ose, Kimiko Kuroki, Makoto Takeda and Katsumi Maenaka (2019)  Specificity of Morbillivirus Hemagglutinins to Recognize SLAM of Different Species Viruses. 11 761- DOI:10.3390/v11080761 PMID:31430904 
Sefan Asamitsu, Shunsuke Obata, Zutao Yu, Toshikazu Bando and Hiroshi Sugiyama (2019)  Recent Progress of Targeted G-quadruplex-Preferred Ligands Toward Cancer Therapy Molecules. 24 429- DOI:10.3390/molecules24030429 PMID:30682877 
Takashi Kawachi, Shun Tanaka, Akinori Fukuda, Yuji Sumii, Andi Setiawan , Naoyuki Kotoku, Motomasa Kobayashi, Masayoshi Arai (2019)  Target identification of the marine natural products dictyoceratin-A and -C as selective growth inhibitors in cancer cells adapted to hypoxic environments. Marine Drugs. 17 163- DOI:10.3390/md17030163 PMID:30857246 
Atsushi Furukawa, Manami Meguro, Rika Yamazaki, Hiroshi Watanabe, Ami Takahashi, Kimiko Kuroki and Katsumi Maenaka (2019)  Evaluation of the Reactivity and Receptor Competition of HLA-G Isoforms toward Available Antibodies: Implications of Structural Characteristics of HLA-G Isoforms International Journal of Molecular Sciences. 20 5947- DOI:10.3390/ijms20235947 PMID:31779209 
Yuzuru Kubohara, Haruhisa Kikuchi (2019)  Dictyostelium: An Important Source of Structural and Functional Diversity in Drug Discovery Cells. 8 6- DOI:10.3390/cells8010006 PMID:30583484 
Rand Naffouje, Punita Grover, Hongyang Yu, Arun Sendilnathan, Kara Wolfe, Nazanin Majd, Eric P. Smith, Koh Takeuchi, Toshiya Senda, Satoshi Kofuji and Atsuo T. Sasaki  (2019)  Anti-Tumor Potential of IMP-Dehydrogenase Inhibitors: A Century-Long Story. Cancers . 11 :9,  1346- DOI:10.3390/cancers11091346 PMID:31514446 
Abhishek Singharoy, Chris Chipot, Toru Ekimoto, Kano Suzuki, Mitsunori Ikeguchi, Ihiro Yamato, Takeshi Murata (2019)  Rotational Mechanism Model of the Bacterial V1 Motor Based on Structural and Computational Analyses Frontiers in Physiology. 10 46- DOI:10.3389/fphys.2019.00046 PMID:30804798 
Koji Sato, Naonori Kumagai, Norio Suzuki (2019)  Alteration of the DNA Methylation Signature of Renal Erythropoietin-Producing Cells Governs the Sensitivity to Drugs Targeting the Hypoxia-Response Pathway in Kidney Disease Progression Frontiers in Genetics. 10 1134- DOI:10.3389/fgene.2019.01134 PMID:31798631 
Nobutaka Wakamatsu,Ming Huang,Naoaki Ono,Md.Altaf-Ul-Amin,Shigehiko Kanaya (2019)  Prediction of Metabolite Activities by Repetitive Clustering of the Structural Similarity Based Networks Journal of Computer Aided Chemistry. 20 76-83 DOI:10.2751/jcac.20.76
Zihan Tian, Cao Wei, Yutaka Moriwaki, Tohru Terada, Shugo Nakamura, Kazuya Sumikoshi, Fang Chun, Kentaro Shimizu (2019)  Prediction of protein-metal ion-binding sites using sequence homology and machine-learning methods Advanced Bioinformatics & Chemistry. 1 :1,  25-36 DOI:10.25163/abc.11208022130119
Takumi Yasuno, Tomoyuki Ohe, Hitomi Ikeda, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino (2019)  Synthesis and antitumor activity of novel pyridinium fullerene derivatives Int J Nanomedicine. 14 6325-6337 DOI:10.2147/IJN.S212045 PMID:31496689 
Mika Sakamoto, Hirofumi Suzuki, and Kei Yura (2019)  Relationship between conformation shift and disease related variation sites in ATP-binding cassette transporter proteins. Biophysics and Physicobiology. 16 68-79 DOI:10.2142/biophysico.16.0_68 PMID:30923664 
Takeshi Kawabata (2019)  Detection of cave pockets in large molecules: Spaces into which internal probes can enter, but external probes from outside cannot Biophysics and Physicobiology. 16 391-406 DOI:10.2142/biophysico.16.0_391 PMID:31984193 
Toru Ekimoto, Yuichi Kokabu, Tomotaka Oroguchi, Mitsunori Ikeguchi (2019)  Combination of coarse-grained molecular dynamics simulations and small-angle X-ray scattering experiments Biophysics and Physicobiology . 16 377-390 DOI:10.2142/biophysico.16.0_377 PMID:31984192 
Hidetoshi Kono, Shun Sakuraba, Hisashi Ishida (2019)  Free energy profile for unwrapping outer superhelical turn of CENP-A nucleosome Biophysics and Physicobiology. 16 337-343 DOI:10.2142/biophysico.16.0_337 PMID:31984189 
Kei Moritsugu, Tsubasa Ito and Akinori Kidera (2019)  Allosteric response to ligand binding: Molecular dynamics study of the N-terminal domains in IP3 receptor Biophysics and Physicobiology . 16 232-239 DOI:10.2142/biophysico.16.0_232 PMID:31984176 
Atsushi Matsumoto (2019)  Dynamic analysis of ribosome by a movie made from many three-dimensional electron-microscopy density maps Biophysics and Physicobiology. 16 108-113 DOI:10.2142/biophysico.16.0_108 PMID:31131181 
Atsuko Hayata-Takano, Toshihiko Kamo, Harui Kijima, Kaoru Seiriki, Katsuya Ogata, Yukio Ago, Takanobu Nakazawa, Yusuke Shintani, Kosuke Higashino, Kazuki Nagayasu, Norihito Shintani, Atsushi Kasai, James A Waschek, Hitoshi Hashimoto (2019)  Pituitary adenylate cyclase-activating polypeptide modulates dendritic spine maturation and morphogenesis via microRNA-132 upregulation The Journal of Neuroscience. 39 4208-4220 DOI:10.1523/JNEUROSCI.2468-18.2019 PMID:30886013 
Sunitha Narasimha, Konstantin O. Nagornov, Laure Menin, Antonio Mucciolo, Astrid Rohwedder, Bruno M. Humbel, Martin Stevens, Andreas S. Thum, Yury O. Tsybin, Roshan K.Vijendravarma  (2019)  Drosophila melanogaster cloak their eggs with pheromones, which prevents cannibalism PLOS Biology. 17 :1,  e2006012- DOI:10.1371/journal.pbio.2006012 PMID:30629594 
Masaaoki Koga, Mizuki Kuramochi, Mohammad Rabiul Karim, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate (2019)  Immunohistochemical characterization of myofibroblasts appearing in isoproterenol-induced rat myocardial fibrosis Journal of Veterinary Medical Science . 81 :1,  127-133 DOI:10.1292/jvms.18-0599 PMID:30464077 
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Shuichi Mori, Nozomi Tsuemoto, Tomoya Kasagawa, Eiichi Nakano, Shinya Fujii, Hiroyuki Kagechika (2019)  Development of Boron-Cluster-Based Progesterone Receptor Antagonists Bearing a Pentafluorosulfanyl (SF5) Group Chemical and Pharmaceutical Bulletin. 67 :12,  1278-1283 DOI:10.1248/cpb.c19-00522 PMID:31787654 
Kanako Nozawa-Kumada, Kosuke Nakamura, Satoshi Kurosu, Yuki Iwakawa, Charline Denneval, Masanori Shigeno, Yoshinori Kondo (2019)  Tetramethylammonium Fluoride Tetrahydrate-Mediated Transition Metal-Free Coupling of Aryl Iodides with Unactivated Arenes in Air Chemical and Pharmaceutical Bulletin. 67 1042-1045 DOI:10.1248/cpb.c19-00452 PMID:31582624 
Yuta Ito, Akihiro Touyama, Minako Uku, Hiromichi Egami, Yoshitaka Hamashima (2019)  Thiocyanation of Aromatic and Heteroaromatic Compounds with 1-Chloro-1,2-benziodoxol-3-(1H)-one and (Trimethylsilyl)isothiocyanate. Chemical and Pharmaceutical Bulletin. 67 1015-1018 DOI:10.1248/cpb.c19-00352 PMID:31474724 
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Nianchao Qian, Atsuhiko Ichimura, Daisuke Takei, Reiko Sakaguchi, Akihiro Kitani, Ryohei Nagaoka, Masato Tomizawa, Yuu Miyazaki, Hitoshi Miyachi, Tomohiro Numata, Sho Kakizawa, Miyuki Nishi, Yasuo Mori, Hiroshi Takeshima  (2019)  TRPM7 Channels Mediate Spontaneous Ca2+ Fluctuations in Growth Plate Chondrocytes That Promote Bone Development. Science Signaling. 12 eaaw4847- DOI:10.1126/scisignal.aaw4847 PMID:30967513 
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Yusuke Sayama, Masato Sano, Mika K. Kaneko, and Yukinari Kato (2019)  Epitope Analysis of an Anti-Whale Podoplanin Monoclonal Antibody, PMab-237, Using Flow Cytometry. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 39 :1,  17-22 DOI:10.1089/mab.2019.0045 PMID:31934820 
Junko Takei, Shinji Yamada, Satoru Konnai, Tsuyoshi Ishinazaka, Michito Shimozuru, Mika K. Kaneko, and Yukinari Kato (2019)  PMab-241 Specifically Detects Bear Podoplanin of Lymphatic Endothelial Cells in the Lung of Brown Bear. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 38 :6,  282-284 DOI:10.1089/mab.2019.0038 PMID:31721640 
Mika K. Kaneko, Yusuke Sayama, Masato Sano, and Yukinari Kato (2019)  The Epitope of PMab-210 Is Located in Platelet Aggregation-Stimulating Domain-3 of Pig Podoplanin. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 38 :6,  271-276 DOI:10.1089/mab.2019.0037 PMID:31663836 
Yukinari Kato, Yusuke Sayama, Masato Sano, and Mika K. Kaneko (2019)  Epitope Analysis of an Antihorse Podoplanin Monoclonal Antibody PMab-219. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 38 :6,  266-270 DOI:10.1089/mab.2019.0034 PMID:31638470 
Yusuke Sayama, Masato Sano, Yoshikazu Furusawa, Mika K. Kaneko, and Yukinari Kato (2019)  Epitope Mapping of PMab-225 an Anti-Alpaca Podoplanin Monoclonal Antibody Using Flow Cytometry. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 38 :6,  255-260 DOI:10.1089/mab.2019.0033 PMID:31613697 
Masato Sano, Mika K. Kaneko, and Yukinari Kato (2019)  Epitope Mapping of Monoclonal Antibody PMab-233 Against Tasmanian Devil Podoplanin. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 38 :6,  261-265 DOI:10.1089/mab.2019.0032 PMID:31621497 
Yukinari Kato, Junko Takei, Yoshikazu Furusawa, Yusuke Sayama, Masato Sano, Satoru Konnai, Atsushi Kobayashi, Hiroyuki Harada, Maki Takahashi, Hiroyoshi Suzuki, Shinji Yamada, and Mika K. Kaneko (2019)  Epitope Mapping of Anti-Bear Podoplanin Monoclonal Antibody PMab-247. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 38 :5,  230-233 DOI:10.1089/mab.2019.0025 PMID:31535919 
Tomoyuki Nakano, Satoshi Ogasawara, Toshiaki Tanaka, Yasukazu Hozumi, Masato Sano, Yusuke Sayama, Shinji Yamada, Mika K. Kaneko, Yukinari Kato, and Kaoru Goto (2019)  DzMab-1: Anti-Human Diacylglycerol Kinaseζ Monoclonal Antibody for Immunocytochemistry. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 38 :4,  179-182 DOI:10.1089/mab.2019.0024 PMID:31403910 
Shinji Yamada, Shunsuke Itai, Yoshikazu Furusawa, Mika K. Kaneko, and Yukinari Kato (2019)  Epitope Mapping of Antipig Podoplanin Monoclonal Antibody PMab-213. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 38 :5,  224-229 DOI:10.1089/mab.2019.0023 PMID:31464569 
Junko Takei, Shunsuke Itai, Hiroyuki Harada, Yoshikazu Furusawa, Takashi Miwa, Masato Fukui, Takuro Nakamura, Masato Sano, Yusuke Sayama, Miyuki Yanaka, Saori Handa, Kayo Hisamatsu, Yoshimi Nakamura, Shinji Yamada, Mika K. Kaneko, and Yukinari Kato (2019)  Characterization of Anti-Goat Podoplanin Monoclonal Antibody PMab-235 Using Immunohistochemistry Against Goat Tissues. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 38 :5,  213-219 DOI:10.1089/mab.2019.0022 PMID:31403389 
Masato Sano, Mika K. Kaneko, and Yukinari Kato (2019)  Epitope Mapping of Anti-Diacylglycerol Kinase Zeta Monoclonal Antibody DzMab-1 for Immunohistochemical Analyses Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 38 :4,  175-178 DOI:10.1089/mab.2019.0020 PMID:31355694 
Junko Takei, Yoshikazu Furusawa, Shinji Yamada, Takuro Nakamura, Yusuke Sayama, Masato Sano, Satoru Konnai, Atsushi Kobayashi, Hiroyuki Harada, Mika K. Kaneko, and Yukinari Kato (2019)  PMab-247 Detects Bear Podoplanin in Immunohistochemical Analysis Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 38 :4,  171-174 DOI:10.1089/mab.2019.0019 PMID:31313968 
Yukinari Kato, Tomokazu Ohishi, Shinji Yamada, Shunsuke Itai, Junko Takei, Masato Sano, Takuro Nakamura, Hiroyuki Harada, Manabu Kawada, and Mika K. Kaneko (2019)  Anti-Human Epidermal Growth Factor Receptor 2 Monoclonal Antibody H2Mab-41 Exerts Antitumor Activity in a Mouse Xenograft Model of Colon Cancer Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 38 :4,  157-161 DOI:10.1089/mab.2019.0017 PMID:31199696 
Shinji Yamada, Shunsuke Itai, Takuro Nakamura, Junko Takei, Masato Sano, Satoru Konnai, Atsushi Kobayashi, Shotaro Nakagun, Yoshiyasu Kobayashi, Mika K. Kaneko, and Yukinari Kato (2019)  Immunohistochemical Analysis of the Harbor Porpoise Using Antipodoplanin Antibody PMab-237. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 38 :3,  104-107 DOI:10.1089/mab.2019.0014 PMID:31161964 
Yukinari Kato, Yoshikazu Furusawa, Shunsuke Itai, Junko Takei, Takuro Nakamura, Masato Sano, Hiroyuki Harada, Shinji Yamada, and Mika K. Kaneko (2019)  Establishment of an Anticetacean Podoplanin Monoclonal Antibody PMab-237 for Immunohistochemical Analysis Establishment of an Anticetacean Podoplanin Monoclonal Antibody PMab-237 for Immunohistochemical Analysis. 38 :3,  108-113 DOI:10.1089/mab.2019.0013 PMID:31161965 
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Hugh Nakamura, Chihiro Tsukano, Takuma Yoshida, Motohiro Yasui, Shinsuke Yokouchi, Yusuke Kobayashi, Masayuki Igarashi, Yoshiji Takemoto (2019)  Total Synthesis of Caprazamycin A: Practical and Scalable Synthesis of syn-β-Hydroxyamino Acids and Introduction of a Fatty Acid Side Chain to 1,4-Diazepanone. Journal of the American Chemical Society. 141 8527-8540 DOI:10.1021/jacs.9b02220 PMID:31067040 
Yi-Lynn Liang,Matthew J Belousoff,Madeleine M Fletcher,Xin Zhang,Maryam Khoshouei,Giuseppe Deganutti,Cassandra Koole,Sebastian G B Furness,Laurence J Miller,Debbie L Hay,Arthur Christopoulos,Christopher A Reynolds,Radostin Danev,Denise Wootten,Patrick M Sexton (2020)  Structure and Dynamics of Adrenomedullin Receptors AM 1 and AM 2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins ACS Pharmacology & Translational Science. 3 :2,  263-284 DOI:10.1021/acsptsci.9b00080 PMID:32296767 
Mizushi Yanagihara, Reiya Ohta, Kenichi Murai, Mitsuhiro Arisawa, Hiromichi Fujioka (2019)  Chemoselective Transformations of Aromatic Methoxymethyl Ethers Using Trialkylsilyl Triflate and 2,2’-Bipyridyl ACS Omega. 4 8465-8471 DOI:10.1021/acsomega.9b00643 PMID:31459935 
Yuki Fujii, Yukinori Suwa, Yuki Wada, Tsunayoshi Takehara, Takeyuki Suzuki, Yusuke Kawashima, Norihito Kawashita, Tatsuya Takagi, Hiromichi Fujioka, Mitsuhiro Arisawa (2019)  Metal-Free Nitrogen-Containing Polyheterocyclic Near-Infrared (NIR) Absorption Dyes: Synthesis, Absorption Properties, and Theoretical Calculation of Substituted 5-Methylisoindolo[2,1-a]quinolines ACS Omega. 4 5064-5075 DOI:10.1021/acsomega.9b00315 PMID:31459684 
Kotaro Koiwai, Jun Tsukimoto, Tetsuya Higashi, Fumitaka Mafun, Ken Miyajima, Takanori Nakane, Naohiro Matsugaki, Ryuichi Kato, Serena Sirigu, Arjen Jakobi, Matthias Wilmanns, Michihiro Sugahara, Tomoyuki Tanaka, Kensuke Tono, Yasumasa Joti, Makina Yabashi, Osamu Nureki, Eiichi Mizohata, Toru Nakatsu, Eriko Nango, So Iwata, Leonard M. G. Chavas, Toshiya Senda, Kohji Itoh, Fumiaki Yumoto (2019)  Improvement of Production and Isolation of Human Neuraminidase-1 in Cellulo Crystals. ACS Applied Bio Materials. 2 :11,  4941-4952 DOI:10.1021/acsabm.9b00686 PMID:35021494 
Kenzo Yahata , Yuki Kaneko , Shuji Akai (2020)  Cobalt-Catalyzed Intermolecular Markovnikov Hydroamination of Nonactivated Olefins: N2-Selective Alkylation of Benzotriazole Organic Letters. 22 598-603 DOI:10.1021/acs.orglett.9b04375 PMID:31898910 
Misaki Kawamoto, Shuntaro Sato, Masaru Enomoto, Yusuke Ogura, Shigefumi Kuwahara (2019)  Total Synthesis of Diocollettines A via an Acid-Promoted Oxa-Michael-Aldol-Acetalization Cascade Organic Letters. 21 10099-10101 DOI:10.1021/acs.orglett.9b04074 PMID:31794233 
Keisuke Uchida, Yasunori Minami, Suguru Yoshida, Takamitsu Hosoya (2019)  Synthesis of Diverse g-Aryl-b-ketoesters via Aryne Intermediates Generated by C-C Bond Cleavage Organic Letters. 21 :22,  9019-9023 DOI:10.1021/acs.orglett.9b03418 PMID:31647244 
Shohei Ohno, Jiawei Qiu, Ray Miyazaki, Hiroshi Aoyama, Kenichi Murai, Jun-ya Hasegawa, Mitsuhiro Arisawa (2019)  Ni-Catalyzed Cycloisomerization between 3‐Phenoxy Acrylic Acid Derivatives and Alkynes via Intramolecular Cleavage and Formation of the C-O Bond To Give 2,3-Disubstituted Benzofurans Organic Letters. 21 8400-8403 DOI:10.1021/acs.orglett.9b03170 PMID:31573210 
Yumi Hayashi, Tomoyasu Hirose, Masato Iwatsuki,Satoshi Omura,Toshiaki Sunazuka (2019)  Synthesis of the Antimalarial Peptide Aldehyde, a Precursor of Kozupeptin A, Utilizing a Designed Hydrophobic Anchor Molecule Organic Letters. 21 8229-8233 DOI:10.1021/acs.orglett.9b02966 PMID:31524407 
Naoki Ogawa, Yousuke Yamaoka, Hiroshi Takikawa, Kiyosei Takasu  (2019)  Synthesis of Polycyclic Spirocarbocyles via Acid-Promoted Ring-Contraction/Dearomative Ring-Closure Cascade of Oxapropellanes Organic Letters. 21 7563-7567 DOI:10.1021/acs.orglett.9b02835 PMID:31497972 
Aya Yoshimura, Shinichi Nishimura, Takehiro Suzuki, Akira Hattori, Naoshi Dohmae, Taira Kato, Hideaki Kakeya (2019)  Isolation, Structure Elucidation and Conformational Regulation of Myropeptins, Lipopeptides from a Fungus Myrothecium Rodium Organic Letters. 21 7524-7528 DOI:10.1021/acs.orglett.9b02801 PMID:31497968 
Hirokazu Tsukamoto, Tatsuya Konno, Kazuya Ito, Takayuki Doi (2019)  Palladium(0)-Lithium Iodide Cocatalyzed Asymmetric Hydroalkylation of Conjugated Enynes with Pronucleophiles Leading to 1,3-Disubstituted Allenes Organic Letters. 21 6811-6814 DOI:10.1021/acs.orglett.9b02439 PMID:31442059 
Masanori Shigeno, Ryutaro Nakamura, Kazutoshi Hayashi, Kanako Nozawa-Kumada, and Yoshinori Kondo (2019)  Catalytic Amination of β-(Hetero)arylethyl Ethers by Phosphazene Base t-Bu-P4 Organic Letters. 21 6695-6699 DOI:10.1021/acs.orglett.9b02309 PMID:31403305 
Yu Nakamura, Yoshihiro Miyata, Keisuke Uchida, Suguru Yoshida, Takamitsu Hosoya (2019)  3-Thioaryne Intermediates for the Synthesis of Diverse Thioarenes Organic Letters. 21 :13,  5252-5258 DOI:10.1021/acs.orglett.9b01862 PMID:31247741 
Masanori Shigeno, Kazutoshi Hayashi , Kanako Nozawa-Kumada, Yoshinori Kondo (2019)  Organic Superbase t-Bu-P4 Catalyzes Amination of Methoxy(hetero)arenes Organic Letters. 21 5505-5508 DOI:10.1021/acs.orglett.9b01805 PMID:31264886 
Taku Imaizumi, Yumi Yamashita, Yuki Nakazawa, Kentaro Okano, Juri Sakata, Hidetoshi Tokuyama (2019)  Total Synthesis of (+)-CC-1065 Utilizing Ring Expansion Reaction of Benzocyclobutenone Oxime Sulfonate Organic Letters. 21 6185-6189 DOI:10.1021/acs.orglett.9b01690 PMID:31188001 
Hiroyuki Hakamata, Hirofumi Ueda, Hidetoshi Tokuyama (2019)  Construction of Indole Structure on Pyrroloindolines via AgNTf2-Mediated Amination/Cyclization Cascade: Application to Total Synthesis of (+)-Pestalazine B Organic Letters. 21 4205-4209 DOI:10.1021/acs.orglett.9b01399 PMID:31117711 
Masanori Shigeno, Keita Sasaki, Kanako Nozawa-Kumada, and Yoshinori Kondo (2019)  Double-Carboxylation of Two C-H Bonds in 2-Alkylheteroarenes Using LiO-t-Bu/CsF Organic Letters. 21 4515-4519 DOI:10.1021/acs.orglett.9b01386 PMID:31150257 
Yuta Uetake, Motoyuki Isoda, Takashi Niwa, Takamitsu Hosoya (2019)  Synthesis of (2,2-Diborylvinyl)arenes by Rhodium-Catalyzed Desulfanylative gem-Diborylation of 2-Arylvinyl Sulfides Organic Letters. 21 :13,  4933-4938 DOI:10.1021/acs.orglett.9b01253 PMID:31247744 
Kazuya Kanemoto, Suguru Yoshida, Takamitsu Hosoya (2019)  Synthesis of Alkynyl Sulfides by Copper-Catalyzed Thiolation of Terminal Alkynes Using Thiosulfonates Organic Letters. 21 :9,  3172-3177 DOI:10.1021/acs.orglett.9b00875 PMID:31002255 
Yasuhiro Ii, Satoru Hirabayashi, Shohei Yoshioka, Hiroshi Aoyama, Kenichi Murai, Hiromichi Fujioka, Mitsuhiro Arisawa (2019)  Pd-catalyzed Migratory Cycloisomerization of N-Allyl-o-allenylaniline Derivatives Organic Letters. 21 3501-3504 DOI:10.1021/acs.orglett.9b00676 PMID:31070372 
Wataru Yamakoshi, Mitsuhiro Arisawa, Kenichi Murai (2019)  Oxidative Rearrangement of Primary Amines Using PhI(OAc)2 and Cs2CO3 Organic Letters. 21 3023-3027 DOI:10.1021/acs.orglett.9b00559 PMID:30998017 
Masanori Shigeno, Kunihito Nakaji, Kanako Nozawa-Kumada, and Yoshinori Kondo (2019)  Catalytic Amide-Base System of TMAF and N(TMS)3 for Deprotonative Coupling of Benzylic C(sp3)-H Bonds with Carbonyls Organic Letters. 21 2588-2592 DOI:10.1021/acs.orglett.9b00550 PMID:30950279 
Yumi Hayashi, Wataru Fukasawa, Tomoyasu Hirose, Masato Iwatsuki, Rei Hokari, Aki Ishiyama, Masahiro Kanaida, Kenichi Nonaka, Akira Take, Kazuhiko Otoguro, Satoshi Omura,Kazuro Shiomi, Toshiaki Sunazuka (2019)  Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species: Isolation, Structural Elucidation, Total Synthesis, and Bioactivity Organic Letters. 21 2180-2184 DOI:10.1021/acs.orglett.9b00483 PMID:30859827 
Noriaki Kiya, Yu Hidaka, Kazuteru Usui, Go Hirai (2019)  Synthesis of CH2-Linked α(1,6)-Disaccharide Analogues by α-Selective Radical Coupling C-Glycosylation Organic Letters. 21 1588-1593 DOI:10.1021/acs.orglett.9b00133 PMID:30794422 
Haruki Inada, Masatoshi Shibuya, Yoshihiko Yamamoto  (2019)  Direct Synthesis of Free a-Amino Acids by Telescoping Three-Step Process from 1,2-Diols Organic Letters. 21 709-713 DOI:10.1021/acs.orglett.8b03910 PMID:30645138 
Kenzo Yahata , Shu Sakurai , Shuhei Hori , Shin Yoshioka , Yuki Kaneko , Kai Hasegawa , Shuji Akai (2020)  Coupling Reaction between Aldehydes and Non-Activated Hydrocarbons via the Reductive Radical-Polar Crossover Pathway Organic Letters. 22 1199-1203 DOI:10.1021/acs.orglett.0c00096 PMID:31939300 
Yusuke Sasano, Hikaru Sato, Shinsuke Tadokoro, Masami Kozawa, and Yoshiharu Iwabuchi (2019)  Safe and Scalable Aerobic Oxidation by 2-Azaadamantan-2-ol (AZADOL)/NOx Catalysis: Large-Scale Preparation of Shi’s Catalyst Organic Process Research & Development. 23 571-577 DOI:10.1021/acs.oprd.8b00456
Masanori Shigeno, Yuki Fujii, Akihisa Kajima, Kanako Nozawa-Kumada, and Yoshinori Kondo (2019)  Catalytic Deprotonative α-Formylation of Heteroarenes by an Amide Base Generated In Situ from TMAF and N(TMS)3 Organic Process Research & Development. 23 443-451 DOI:10.1021/acs.oprd.8b00247
Kota Katayama, Kohei Suzuki, Ryoji Suno, Hirokazu Tsujimoto, So Iwata, Takuya Kobayashi, Hideki Kandori  (2019)  Ligand Binding-Induced Structural Changes in the M2 Muscarinic Acetylcholine Receptor Revealed by Vibrational Spectroscopy The Journal of Physical Chemistry Letters. 10 :22,  7270-7276 DOI:10.1021/acs.jpclett.9b02942 PMID:31692352 
Ayuta Yamaguchi, Shinsuke Inuki, Yusuke Tokimizu, Shinya Oishi, Hiroaki Ohno  (2020)  Gold(I)-Catalyzed Cascade Cyclization of Anilines with Diynes: Controllable Formation of Eight-Membered Ring-Fused Indoles and Propellane-Type Indolines. Journal of Organic Chemistry. 85 2543-2559 DOI:10.1021/acs.joc.9b03256 PMID:31913037 
Tomoyoshi Kawamura, Hirokazu Moriya, Masatoshi Shibuya, Yoshihiko Yamamoto  (2019)  Diastereoselective Methylation at the Congested b-Position of a Butenolide Ring: Studies toward the Synthesis of seco-Prezizaane-type Sesquiterpenes The Journal of Organic Chemistry. 84 12508-12519 DOI:10.1021/acs.joc.9b02017 PMID:31539248 
Kazuma Shimoda, Yousuke Yamaoka, Dongeun Yoo, Ken-Ichi Yamada, Hiroshi Takikawa, Kiyosei Takasu  (2019)  Total Syntheses of Allelopathic 4-Oxyprotoilludanes, Melleolides and Echinocidins The Journal of Organic Chemistry. 84 11014-11024 DOI:10.1021/acs.joc.9b01589 PMID:31403293 
Junpei Matsuoka, Hiroshi Kumagai, Shinsuke Inuki, Shinya Oishi, Hiroaki Ohno  (2019)  Construction of the Pyrrolo[2,3-d]carbazole Core of Spiroindoline Alkaloids by Gold-Catalyzed Cascade Cyclization of Ynamide. The Journal of Organic Chemistry. 84 9358-9363 DOI:10.1021/acs.joc.9b01149 PMID:31244165 
Kosuke Ohsawa, Masato Sugai, Linnan Zhang, Yuichi Masuda, Masahito Yoshida, and Takayuki Doi (2019)  Total Synthesis and Structural Revision of Cyclotetrapeptide Asperterrestide A The Journal of Organic Chemistry. 84 6765-6779 DOI:10.1021/acs.joc.9b00526 PMID:31070032 
Tatsuya Yamada, Tomohiko Hayashi, Simon Hikiri, Naohiro Kobayashi, Hiroshi Yanagawa, Mitsunori Ikeguchi, Masato Katahira, Takashi Nagata, Masahiro Kinoshita (2019)  How Does the Recently Discovered Peptide MIP Exhibit Much Higher Binding Affinity than an Anticancer Protein p53 for an Oncoprotein MDM2 Journal of Chemical Information and Modeling. 59 3533-3544 DOI:10.1021/acs.jcim.9b00226 PMID:31282659 
Maxwell M. Sakyiamah,Wataru Nomura, Takuya Kobayakawa, Hirokazu Tamamura (2019)  Development of a NanoBRET-based Sensitive Screening Method for CXCR4 Ligands Bioconjugate Chemistry. 30 :5,  1442-1450 DOI:10.1021/acs.bioconjchem.9b00182 PMID:30973227 
Keitou Shu, Naoya Iwamoto, Kaori Honda, Yasumitsu Kondoh, Hiroyuki Hirano, Hiroyuki Osada, Hiroaki Ohno, Nobutaka Fujii, Shinya Oishi  (2019)  Development of Mirror-Image Screening Systems for XIAP BIR3 Domain Inhibitors Bioconjugate Chemistry. 30 1395-1404 DOI:10.1021/acs.bioconjchem.9b00154 PMID:30888797 
Kouhei Yoshida, Satoru Nagatoishi, Daisuke Kuroda, Nanao Suzuki, Takeshi Murata, Kouhei Tsumoto (2019)  Phospholipid Membrane Fluidity Alters Ligand Binding Activity of a G Protein-Coupled Receptor by Shifting the Conformational Equilibrium Biochemistry. 58 504-508 DOI:10.1021/acs.biochem.8b01194 PMID:30618239 
Daisuke Saigusa, Ritsumi Saito, Komei Kawamoto, Akira Uruno, Kuniyuki Kano, Junken Aoki, Masayuki Yamamoto, Tadafumi Kawamoto (2019)  Conductive Adhesive Film Expands the Utility of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Analytical Chemistry. 91 8979-8986 DOI:10.1021/acs.analchem.9b01159 PMID:31251568 
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MakitoYamada, MitsuhiroArisawa (2020)  Recent topics on reusable immobilized iron nanoparticle pre-catalysts Tetrahedron Letters. 61 151422- DOI:10.1016/j.tetlet.2019.151422
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Takuto Fujii, Siriporn Phutthatiraphap, Takahiro Shimizu, Hiroshi Takeshima, Hideki Saka (2019)  Non-morphogenic Effect of Sonic Hedgehog on Gastric H+,K+-ATPase Activity. Biochemical and Biophysical Research Communications. 518 605-609 DOI:10.1016/j.bbrc.2019.08.099 PMID:31445709 
Takeru Chigira, Satoru Nagatoishi, Hiroyuki Takeda, Tetsuro Yoshimaru, Toyomasa Katagiri, Kouhei Tsumoto (2019)  Biophysical characterization of the breast cancer-related BIG3-PHB2 interaction: Effect of non-conserved loop region of BIG3 on the structure and the interaction Biochemical and Biophysical Research Communications. 518 183-189 DOI:10.1016/j.bbrc.2019.08.028 PMID:31421830 
Naohiro Katagiri, Satoru Nagatoishi, Kouhei Tsumoto, Hideya Endo (2019)  Structural features of methionine aminopeptidase2-active corepeptide essential for binding with S100A4 Biochemical and Biophysical Research Communications. 516 1123-1129 DOI:10.1016/j.bbrc.2019.07.006 PMID:31284952 
Naoki Horikoshi, Tomoya Kujirai, Koichi Sato, Hiroshi Kimura, Hitoshi Kurumizaka (2019)  Structure-based design of an H2A.Z.1 mutant stabilizing a nucleosome in vitro and in vivo. Biochemical and Biophysical Research Communications. 515 :4,  719-724 DOI:10.1016/j.bbrc.2019.06.012 PMID:31186139 
Naoya Matsunaga, Yuya Yoshida, Naoki Kitajou, Akira Shiraishi, Naoki Kusunose, Satoru Koyanagi, Shigehiro Ohdo (2019)  Microcurrent stimulation activates the circadian machinery in mice Biochemical and Biophysical Research Communications. 513 293-299 DOI:10.1016/j.bbrc.2019.02.022 PMID:30944082 
Norimichi Nomura, Yayoi Nomura, Yumi Sato, So Iwata (2019)  Crystallographic approaches to study the interaction modes of PD-1- and CTLA-4-blocking antibodies Methods in Enzymology. 629 383-399 DOI:10.1016/bs.mie.2019.10.008 PMID:31727250 
Mohammad Bozlul Karim, Shigehiko Kanaya and Md. Altaf-Ul-Amin (2019)  Implementation of BiClusO and its comparison with other biclustering algorithms Applied Network Science. 4 79- DOI:10.1007/s41109-019-0180-x
Hiroshi Ushijima, Rena Maekawa, Eri Igarashi, Satoko Akashi (2019)  Rapid and definitive analysis of in vitro DNA methylation by nanoelectrospray ionization mass spectrometry. Journal of Amrican society for Mass Spectrometry. 30 :11,  2335-2346 DOI:10.1007/s13361-019-02304-5 PMID:31529403 
Gert-Jan Bekker, Takeshi Kawabata & Genji Kurisu  (2020)  The Biological Structure Model Archive (BSM-Arc): an archive for in silico models and simulations Biophysical Reviews. 12 371-375 DOI:10.1007/s12551-020-00632-5 PMID:32026396 
Takahiro Jomori, Yasumasa Hara, Miho Sasaoka, Kazuo Harada, Andi Setiawan, Kazumasa Hirata, Atsushi Kimishima, Masayoshi Arai (2020)  Mycobacterium smegmatis alters the production of secondary metabolites by marine-derived Aspergillus niger Journal of Natural Medicines. 74 76-82 DOI:10.1007/s11418-019-01345-0 PMID:31321600 
Tatsuhiro Igawa, Shuhei Kishikawa, Yoshito Abe, Tomohiro Yamashita, Saki Nagai, Mitsunori Shiroishi, Chinatsu Shinozaki, Hiroyuki Tanaka, Hidetoshi Tozaki-Saitoh, Makoto Tsuda, Kazuhide Inoue, and Tadashi Ueda (2019)  Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure Purinergic Signal. 15 27-35 DOI:10.1007/s11302-019-09646-5 PMID:30684150 
Ashutosh Kumar, Kam Y. J. Zhang (2019)  Improving ligand 3D shape similarity-based pose prediction with a continuum solvent model Journal of Computer-Aided Molecular Design. 33 :12,  1045-1055 DOI:10.1007/s10822-019-00220-0 PMID:31463704 
Satoshi Yamasaki,Takayuki Amemiya,Yukimitsu Yabuki,Katsuhisa Horimoto,Kazuhiko Fukui (2019)  ToGo-WF: prediction of RNA tertiary structures and RNA-RNA/protein interactions using the KNIME workflow Journal of Computer-Aided Molecular Design. 33 497-507 DOI:10.1007/s10822-019-00195-y PMID:30840170 
Ashutosh Kumar & Kam Y. J. Zhang  (2019)  Shape similarity guided pose prediction: lessons from D3R Grand Challenge 3 Journal of Computer-Aided Molecular Design. 33 :1,  47-59 DOI:10.1007/s10822-018-0142-x PMID:30084081 
Christoph Gerle  (2019)  Essay on Biomembrane Structure. The Journal of Membrane Biology . 252 :2月3日,  115-130 DOI:10.1007/s00232-019-00061-w PMID:30877332 
Suguru Yoshida, Takamitsu Hosoya  (2019)  Target Identification of Bioactive Compounds by Photoaffinity Labeling Using Diazido Probes Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules. 335-355 DOI:10.1007/978-981-13-6244-6_14
Songling Li, Jan Wilamowski, Shunsuke Teraguchi, Floris J van Eerden, John Rozewicki, Ana Davila, Zichang Xu, Kazutaka Katoh, Daron M Standley  (2019)  Structural Modeling of Lymphocyte Receptors and Their Antigens Methods in Molecular Biology. 2048 207-229 DOI:10.1007/978-1-4939-9728-2_17 PMID:31396940 
Tomoko Sunami,Hidetoshi Kono  (2019)  Balance between DNA-binding affinity and specificity enables selective recognition of longer target sequences in vivo Protein Science . 28 1630-1639 DOI:10.1002/pro.3677 PMID:31299133 
Kengo Kasama, Hiroshi Aoyama, Shuji Akai  (2020)  Enantiodivergent synthesis of axially chiral biphenyls from σ-symmetric 1,1'-biphenyl-2,6-diol derivatives by single lipase-catalyzed acylative and hydrolytic desymmetrization European Journal of Organic Chemistry. 2020 654-661 DOI:10.1002/ejoc.201901583
Shogo Tsukaguchi, Ryo Towada, Masaru Enomoto, Yusuke Ogura, Shigefumi Kuwahara (2019)  Unified total synthesis of hetiamachins A-D European Journal of Organic Chemistry. 2019 6110-6116 DOI:10.1002/ejoc.201901114
Daichi Kawauchi, Hirofumi Ueda, Hidetoshi Tokuyama (2019)  Double Functionalization of Styrenes by Cu-mediated Assisted Tandem Catalysis European Journal of Organic Chemistry. 2019 2056-2060 DOI:10.1002/ejoc.201900088
Masahito Yoshida, Kenta Adachi, Hayato Murase, Hiroshi Nakagawa, Takayuki Doi (2019)  Parallel Synthesis and Biological Evaluation of Destruxin E Analogs Modified with a Side Chain in the α-Hydroxycarboxylic Acid Moiety European Journal of Organic Chemistry. 2019 1669-1676 DOI:10.1002/ejoc.201801826
Takashi Murayama, Nagomi Kurebayashi (2019)  Assays for modulators of ryanodine receptor (RyR)/Ca2+ release channel activity for drug discovery for skeletal muscle and heart diseases. Current Protocols in Pharmacology. 87 :1,  e71- DOI:10.1002/cpph.71 PMID:31834676 
Hidetomo Yokoo, Hiroyuki Kagechika, Ayumi Ohsaki, Tomoya Hirano (2019)  A Polarity‐Sensitive Fluorescent Amino Acid and its Incorporation into Peptides for the Ratiometric Detection of Biomolecular Interactions ChemPlusChem. 84 1716-1719 DOI:10.1002/cplu.201900489 PMID:31943883 
Nora Taricska, Daniel Horvath, Dora K Menyhard, Hanna Akontz-Kiss, Masahiro Noji, Masatomo So, Yuji Goto, Toshimichi Fujiwara, Andras Perczel  (2020)  The route from the folded to the amyloid state: exploring the potential energy surface of a drug-like miniprotein Chemistry. 26 :9,  1893- DOI:10.1002/chem.201905181 PMID:31961031 
Takashi Ikawa , Shigeaki Masuda , Shuji Akai  (2020)  One-Pot Generation of Benzynes from Phenols: Formation of Primary Anilines by the Deoxyamination of Phenols Chemistry A European Journal. 26 4320-4332 DOI:10.1002/chem.201904987 PMID:31894622 
Toshitaka Okamura, Syusuke Egoshi, Kosuke Dodo, Mikiko Sodeoka, Yoshiharu Iwabuchi, Naoki Kanoh (2019)  Highly Chemoselective gem‐Difluoropropargylation of Aliphatic Alcohols Chemistry A European Journal. 25 16002-16006 DOI:10.1002/chem.201904366 PMID:31625215 
Masanori Shigeno, Takuya Okawa, Masaya Imamatsu, Kanako Nozawa-Kumada, and Yoshinori Kondo (2019)  Catalytic alkynylation of polyfluoroarenes by amide base generated in situ Chemistry A European Journal. 25 10294-10297 DOI:10.1002/chem.201901501 PMID:31206844 
Masanori Shigeno, Kazutoshi Hayashi, Kanako Nozawa-Kumada, and Yoshinori Kondo (2019)  Phosphazene Base-tBu‐P4 Catalyzed Methoxy-Alkoxy Exchange Reaction on (Hetero)Arenes Chemistry A European Journal . 25 6077-6081 DOI:10.1002/chem.201900498 PMID:30807672 
Masanori Shigeno, Kazuya Hanasaka, Keita Sasaki, Kanako Nozawa-Kumada, and Yoshinori Kondo (2019)  Direct Carboxylation of Electron‐Rich Heteroarenes Promoted by LiO‐tBu with CsF and [18]Crown‐6 Chemistry A European Journal . 25 3235-3239 DOI:10.1002/chem.201805926 PMID:30637844 
Haruhisa Kikuchi, Kosuke Kawai, Yota Nakashiro, Takayuki Yonezawa, Kumi Kawaji , Eiichi. N. Kodama, Yoshiteru Oshima (2019)  Construction of a Meroterpenoid‐Like Compounds Library Based on Diversity‐Enhanced Extracts Chemistry A European Journal. 25 1106-1112 DOI:10.1002/chem.201805417 PMID:30379362 
Takuya Kobayakawa, Kento Ebihara, Yuzuna Honda, Masayuki Fujino, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura (2019)  Dimeric C34 Derivatives Linked through Disulfide Bridges as New HIV‐1 Fusion Inhibitors ChemBioChem. 20 2101-2108 DOI:10.1002/cbic.201900187 PMID:31012222 
Tomohiro Ito, Masaki Tsutsumi, Ken-Ichi Yamada, Hiroshi Takikawa, Yousuke Yamaoka, Kiyosei Takasu (2019)  Synthesis of Functionalized Medium-Sized trans-Cycloalkenes by 4π Electrocyclic Ring Opening-Alkylation Sequence Angewandte Chemie International Edition. 58 11836-11840 DOI:10.1002/anie.201906665 PMID:31259460 
Takaya Ikeuchi, Shinsuke Inuki, Shinya Oishi, Hiroaki Ohn (2019)  Gold(I)-Catalyzed Cascade Cyclization Reactions of Allenynes for the Synthesis of Fused Cyclopropanes and Acenaphthenes Angewandte Chemie International Edition. 58 7792-7796 DOI:10.1002/anie.201903384 PMID:30985049 
Kanako Nozawa-Kumada, Satoshi Kurosu, Masanori Shigeno, Yoshinori Kondo (2019)  Peroxydisulfate‐Mediated Transition‐Metal‐Free Oxidative C(sp3)-H Bond Lactonization Asian Journal of Organic Chemistry. 8 1080-1083 DOI:10.1002/ajoc.201900167
Masatoshi Shibuya, Shoji Fujita, Masanori Abe, Yoshihiko Yamamoto  (2019)  Boron-Catalyzed Hydroamination/Hydroallylation and Hydroamination/Hydrocyanation of Unactivated Alkynes Asian Journal of Organic Chemistry. 8 1075-1079 DOI:10.1002/ajoc.201900165
Yoshihiko Yamamoto, Yuki Ishida, Yosuke Takamizu, Takeshi Yasui (2019)  Synthesis of (Diifluoromethyl)cycloalkenes from 2-Cycloalkenones by Utilizing Phospha-Brook Rearrangement Advanced Synthesis & Catalysis. 361 3739-3743 DOI:10.1002/adsc.201900469
Hirokazu Tsukamoto, Ayumu Kawase, Takayuki Doi (2019)  Palladium-Catalyzed Umpolung Type-II Cyclization of Allylic Carbonate-Aldehydes Leading to 3-Methylenecycloalkanol Derivatives Advanced Synthesis & Catalysis. 361 3733-3738 DOI:10.1002/adsc.201900450

BINDSの支援を受けた研究成果(論文)

Takayuki Matsumura, Tadayoshi Ikebe, Koji Arikawa, Masahito Hosokawa, Michio Aiko, Aoi Iguchi, Ikuko Togashi, Sayaka Kai, Sakiko Ohara, Naoya Ohara, Makoto Ohnishi, Haruo Watanabe, Kazuo Kobayashi, Haruko Takeyama, Sho Yamasaki, Yoshimasa Takahashi, Manabu Ato (2019)  Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice cell reports. 27 :2,  561-571 DOI:10.1016/j.celrep.2019.03.056 PMID:30970258 
Sakamoto Y, Roppongi S, Suzuki Y, Ishihara T, Hidaka K, Nakamura N, Honma N, Ogasawara W, Tanaka N. (2019)  The Crystal Structure of Peptidase Toward Drug Discovery Int. J. Microgravity Sci. Appl. 36 :1,  360106- DOI:10.15011//jasma.36.360106
Toma-Fukai S. and Shimizu, T (2019)  Structural Insights into the Regulation Mechanism of Small GTPases by GEFs Molecules. 24 :18,  3308- DOI:10.3390/molecules24183308 PMID:31514408 
Kubota M, Matsuoka R, Suzuki T, Yonekura K, Yanagi Y, Hashiguchi T. (2019)  Molecular Mechanism of the Flexible Glycan Receptor Recognition by Mumps Virus J Virol.. 93 :15,  1-13 DOI:10.1128/JVI.00344-19 PMID:31118251 
Matsuo K, Cheng A, Yabuki Y, Takahata I, Miyachi H, Fukunaga K. (2019)  MPTP-induced α-synuclein oligomerization by fatty acid-binding protein 3 ligand in MPTP-treated mice. Neuropharmacology. 150 164-174 DOI:10.1016/j.neuropharm.2019.03.029
An Cheng, Yasuharu Shinoda, Tetsunori Yamamoto, Hiroyuki Miyachi, Kohji Fukunaga (2019)  Development of FABP3 ligands that inhibit arachidonic acid-induced α-synuclein oligomerization. Brain Res. 1707 190-197 DOI:10.1016/j.brainres.2018.11.036 PMID:30496735 
Yoshimasa Takizawa,Cheng-Han Ho,Hiroaki Tachiwana,Hideyuki Matsunami,Wataru Kobayashi,Midori Suzuki,Yasuhiro Arimura,Tetsuya Hori,Tatsuo Fukagawa,Melanie D Ohi,Matthias Wolf,Hitoshi Kurumizaka (2020)  Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome Structure. 28 :1,  44-53 DOI:10.1016/j.str.2019.10.016 PMID:31711756 
Wataru Kobayashi,Yoshimasa Takizawa,Maya Aihara,Lumi Negishi,Hajime Ishii,Hitoshi Kurumizaka (2019)  Structural and biochemical analyses of the nuclear pore complex component ELYS identify residues responsible for nucleosome binding Commun Biol. 2 163- DOI:10.1038/s42003-019-0385-7 PMID:31069272 
Afifa Ayu Koesoema, Yosuke Sugiyama, Kotchakorn T. Sriwong, Zichang Xu, Samantha Verina, Daron M. Standley, Miki Senda, Toshiya Senda & Tomoko Matsuda (2019)  Reversible control of enantioselectivity by the length of ketone substituent in biochatlytic reduction. Applied Microbiology and Biotechnology. 103 :23-24,  9529-9541 DOI:10.1007/s00253-019-10206-5 PMID:31720775 
加藤貴之,難波啓一 (2019)  クライオ電子顕微鏡法の最近の進歩. 日本分析化学会 ぶんせき. :9,  392-397 DOI:http://www.jsac.or.jp/bunseki/201909.html
Takayuki Kato, Fumiaki Makino, Tomoko Miyata, P?ter Horv?th & Keiichi Namba  (2019)  Structure of the native supercoiled flagellar hook as a universal joint Nature Communications. 10 :1,  5295- DOI:10.1038/s41467-019-13252-9 PMID:31757961 
Yasuhiro Arimura, Hiroaki Tachiwana, Hiroki Takagi, Tetsuya Hori, Hiroshi Kimura, Tatsuo Fukagawa & Hitoshi Kurumizaka? (2019)  The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism. Nature Communications. 10 :1,  576- DOI:10.1038/s41467-019-08314-x PMID:30718488 
Takayuki Kato, Fumiaki Makino, Takanori Nakane, Naoya Terahara, Takeshi Kaneko, Yuko Shimizu, Sohei Motoki, Isamu Ishikawa, Koji Yonekura, Keiichi Namba  (2019)  CryoTEM with a Cold Field Emission Gun That Moves Structural Biology into a New Stage Microscopy and Microanalysis. 25 998-999 DOI:10.1017/S1431927619005725
Satoshi Yasuda, Tomohiko Hayashi, Yuta Kajiwara, Takeshi Murata, and Masahiro Kinoshita (2019)  Analyses based on statistical thermodynamics for large difference between thermophilic rhodopsin and xanthorhodopsin in terms of thermostability The Journal of Chemical Physics. 150 :5,  55101- DOI:10.1063/1.5082217 PMID:30736678 
Edgar Ferrer-Gonzalez, Junso Fujita, Takuya Yoshizawa, Julia M. Nelson, Alyssa J. Pilch, Elani Hillman, Mayuki Ozawa, Natsuko Kuroda, Hassan M. Al-Tameemi, Jeffrey M. Boyd, Edmond J. LaVoie, Hiroyoshi Matsumura, Daniel S. Pilch (2019)  Structure-Guided Design of a Fluorescent Probe for the Visualization of FtsZ in Clinically Important Gram-Positive and Gram-Negative Bacterial Pathogens Scientific Reports. :9,  20092- DOI:10.1038/s41598-019-56557-x PMID:31882782 
Halil I Ciftci, Raymond G Sierra, Chun Hong Yoon, Zhen Su, Hiroshi Tateishi, Ryoko Koga, Koiwai Kotaro, Fumiaki Yumoto, Toshiya Senda, Mengling Liang, Soichi Wakatsuki, Masami Otsuka, Mikako Fujita, Hasan DeMirci (2019)  Serial Femtosecond X-Ray Diffraction of HIV-1 Gag MA-IP6 Microcrystals at Ambient Temperature International Journal of Molecular Sciences. 7 :20,  1675- DOI:10.3390/ijms20071675 PMID:30987231 
Jin Jin, Shinsaku Togo, Kotaro Kadoya, Miniwan Tulafu, Yukiko Namba, Moe Iwai, Junko Watanabe, Kumi Nagahama, Takahiro Okabe, Moulid Hidayat, Yuzo Kodama, Hideya Kitamura, Takashi Ogura, Norikazu Kitamura, Kazuho Ikeo, Shinichi Sasaki, Shigeru Tominaga, and Kazuhisa Takahashi  (2019)  Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1 Respiratory Research. 1 :20,  119- DOI:10.1186/s12931-019-1093-z PMID:31185973 
Yujiro Toyoshima, Hidemitsu Kitamura, Huihui Xiang, Yosuke Ohno, Shigenori Homma, Hideki Kawamura, Norihiko Takahashi, Toshiya Kamiyama, Mishie Tanino, Akinobu Taketomi (2019)  IL6 modulates the immune status of the tumor microenvironment to facilitate metastatic colonization of colorectal cancer cells. Cancer Immunology Research. 12 :7,  1944-1957 DOI:10.1158/2326-6066.CIR-18-0766 PMID:31554639 
Tohru Minamino, Yumi Inoue, Miki Kinoshita, Keiichi Namba (2020)  FliK-driven conformational rearrangements of FlhA and FlhB are required for export switching of the flagellar protein export apparatus. Journal of Bacteriology. 3 :202,  e00637-19- DOI:10.1128/JB.00637-19 PMID:31712281 
Masahiro Hiraizumi, Keitaro Yamashita, Tomohiro Nishizawa, Osamu Nureki (2019)  Cryo-EM structures capture the transport cycle of the P4-ATPase flippase Science. 6458 :365,  1149-1155 DOI:10.1126/science.aay3353 PMID:31416931 
Yumi Inoue, Miki Kinoshita, Keiichi Namba, Tohru Minamino (2019)  Mutational analysis of the C-terminal cytoplasmic domain of FlhB, a transmembrane component of the flagellar type III protein export apparatus in Salmonella. Genes to Cells. 6 :24,  408-421 DOI:10.1111/gtc.12684 PMID:30963674 
Mihoko Takenoya, Tatsuro Shimamura, Ryuji Yamanaka, Yuya Adachi, Shinsaku Ito, Yasuyuki Sasaki, Akira Nakamura, Shunsuke Yajima (2019)  Structural basis for the substrate recognition of aminoglycoside 7"-phosphotransferase-Ia from Streptomyces hygroscopicus Acta Crystallographica Section F, Structural bilogy of commuinications. :75,  599-607 DOI:10.1107/S2053230X19011105 PMID:31475927 
Akira Hirata, Keisuke Okada, Kazuaki Yoshii, Hiroyuki Shiraishi, Shinya Saijo, Kento Yonezawa, Nobutaka Shimizu, Hiroyuki Hori (2019)  Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition. Nucleic Acids Research. 20 :47,  10942-10955 DOI:10.1093/nar/gkz856 PMID:31586407 
Chisae Nagiri, Wataru Shihoya, Asuka Inoue, Francois Marie Ngako Kadji, Junken Aoki, and Osamu Nureki  (2019)  Crystal structure of human endothelin ET B receptor in complex with peptide inverse agonist IRL2500 Communications biology. :2,  236- DOI:10.1038/s42003-019-0482-7 PMID:31263780 
Yasumitsu Sakamoto, Yoshiyuki Suzuki, Akihiro Nakamura, Yurie Watanabe, Mizuki Sekiya, Saori Roppongi, Chisato Kushibiki, Ippei Iizuka, Osamu Tani, Hitoshi Sakashita, Koji Inaka, Hiroaki Tanaka, Mitsugu Yamada, Kazunori Ohta, Nobuyuki Honma, Yosuke Shida, Wataru Ogasawara, Mayumi Nakanishi-Matsui, Takamasa Nonaka, Hiroaki Gouda & Nobutada Tanaka  (2019)  Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase Scientific reports. 1 :9,  13587- DOI:10.1038/s41598-019-49984-3 PMID:31537874 
Kanako Terakado Kimura, Hidetsugu Asada, Asuka Inoue, Francois Marie Ngako Kadji, Dohyun Im, Chihiro Mori, Takatoshi Arakawa, Kunio Hirata, Yayoi Nomura, Norimichi Nomura, Junken Aoki, So Iwata, Tatsuro Shimamura  (2019)  Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine Nature Structural Molecular Biology. 2 :26,  121-128 DOI:10.1038/s41594-018-0180-z PMID:30723326 
Yuhei Araiso, Akihisa Tsutsumi, Jian Qiu, Kenichiro Imai, Takuya Shiota, Jiyao Song, Caroline Lindau, Lena-Sophie Wenz, Haruka Sakaue, Kaori Yunoki, Shin Kawano, Junko Suzuki, Marilena Wischnewski, Conny Sch?tze, Hirotaka Ariyama, Toshio Ando, Thomas Becker, Trevor Lithgow, Nils Wiedemann, Nikolaus Pfanner, Masahide Kikkawa & Toshiya Endo  (2019)  Structure of the mitochondrial import gate reveals distinct preprotein paths Nature. 7782 :575,  395-401 DOI:10.1038/s41586-019-1680-7 PMID:31600774 
Ali D. Malay, Naoyuki Miyazaki, Artur Biela, Soumyananda Chakraborti, Karolina Majsterkiewicz, Izabela Stupka, Craig S. Kaplan, Agnieszka Kowalczyk, Bernard M. A. G. Piette, Georg K. A. Hochberg, Di Wu, Tomasz P. Wrobel, Adam Fineberg, Manish S. Kushwah, Mitja Kelemen, Primoz Vavpetic, Primoz Pelicon, Philipp Kukura, Justin L. P. Benesch, Kenji Iwasaki, Jonathan G. Heddle. (2019)  An ultra-stable gold-coordinated protein cage displaying reversible assembly Nature. 7756 :569,  438-442 DOI:10.1038/s41586-019-1185-4 PMID:31068697 
Ryo Nagao, Koji Kato, Takehiro Suzuki, Kentaro Ifuku, Ikuo Uchiyama, Yasuhiro Kashino, Naoshi Dohmae, Seiji Akimoto, Jian-Ren Shen, Naoyuki Miyazaki, Fusamichi Akita (2019)  Structural basis for energy harvesting and dissipation in a diatom PSII-FCPII supercomplex. Nature Plants. 8 :5,  890-901 DOI:10.1038/s41477-019-0477-x PMID:31358960 
Joanne L Parker, Simon Newstead (2019)  Structural basis of nucleotide sugar transport across the Golgi membrane. Nature. 7681 :551,  521-524 DOI:10.1038/nature24464 PMID:29143814 
Diego F. Gauto, Pavel Macek, Alessandro Barducci, Hugo Fraga, Audrey Hessel, Tsutomu Terauchi, David Gajan, Yohei Miyanoiri, Jerome Boisbouvier, Roman Lichtenecke, Masatsune Kainosho, Paul Schanda (2019)  Aromatic Ring Dynamics, Thermal Activation, and Transient Conformations of a 468 kDa Enzyme by Specific 1H-13C Labeling and Fast Magic-Angle Spinning NMR Journal of the American Chemical Society. 28 :141,  11183-11195 DOI:10.1021/jacs.9b04219 PMID:31199882 
YutaTabuchi, YoshihikoHirohashi, ShinichiHashimoto, TasukuMariya, TakuyaAsano,KazuhoIkeoTakafumiKuroda, MasahitoMizuuchi, AikoMurai, SeiUno, NorikoKawai, TerufumiKubo, MunehideNakatsugawa, TakayukiKanaseki, TomohideTsukahara, TsuyoshiSaito, ToshihikoTorigoe  (2019)  Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma. Experimental and Molecular Pathology. :106,  78-88 DOI:10.1016/j.yexmp.2018.11.013 PMID:30503404 
Naoki Takizawa, Yoshitoshi Ogura, Yoko Fujita, Takeshi Noda, Hideki Shigematsu, Tetsuya Hayashi, Ken Kurokawa  (2019)  Local structural changes of the influenza A virus ribonucleoprotein complex by single mutations in the specific residues involved in efficient genome packaging. Virology. :531,  126-140 DOI:10.1016/j.virol.2019.03.004 PMID:30875489 
Mutsuko Kukimoto-Niino, Kengo Tsuda, Kentaro Ihara, Chiemi Mishima-Tsumagari,Keiko Honda, Noboru Ohsawa, Mikako Shirouzu  (2019)  Structural basis for the dual substrate specificity of DOCK7 guanine nucleotide exchange factor Structure. 5 :27,  741-748 DOI:10.1016/j.str.2019.02.001 PMID:30853411 
Hiroki Yamaguchi, Akiko Kamegawa, Kunio Nakata, Tatsuki Kashiwagi, Toshimi Mizukoshi, Yoshinori Fujiyoshi, Kazutoshi Tani  (2019)  Structural insights into thermostabilization of leucine dehydrogenase from its atomic structure by cryo-electron microscopy Jounral of Structural Biology. 1 :205,  11-21 DOI:10.1016/j.jsb.2018.12.001 PMID:30543982 
Takahiro Yoshinaka, Hidetaka Kosako, Takuma Yoshizumi, Ryo Furukawa, Yu Hirano, Osamu Kuge, Taro Tamada, Takumi Koshiba (2019)  Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region. iScience. :19,  1065-1078 DOI:10.1016/j.isci.2019.08.056 PMID:31522117 
Tatsuo Yanagisawa, Mitsuo Kuratani, Eiko Seki, Nobumasa Hino, Kensaku Sakamoto, Shigeyuki Yokoyama  (2019)  Structural basis for genetic-code expansion with bulky lysine derivatives by an engineered pyrrolysyl-tRNA synthetase Cell chemical biology. 7 :26,  936-949 DOI:10.1016/j.chembiol.2019.03.008 PMID:31031143 
Sanae Hayashi, Anis Khan, Brenna C. Simons, Chriss Homan, Takeshi Matsui, Kenji Ogawa, Keigo Kawashima, Shuko Murakami, Satoru Takahashi, Masanori Isogawa, Kazuho Ikeo,Masashi Mizokami, Brian J. McMahon, Yasuhito Tanaka  (2019)  An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People. Hepatology. 1 :69,  19-33 DOI:10.1002/hep.30111 PMID:29893492 
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