成果

創薬等先端技術支援基盤プラットフォーム(BINDS)の実施者による研究支援と研究高度化の成果として輩出されたデータベース、 ツール、論文および特許を紹介します。

開発されたデータベースやツール

ケミカルシーズ・リード 探索ユニット

インシリコユニット

プラットフォーム機能最適化ユニット

BINDS支援技術に関する研究成果(論文)

Hiroko Matsunaga, Koji Arikawa, Miki Yamazaki, Ryota Wagatsuma, Keigo Ide, Samuel Ashok Zachariah, Kazuya Takamochi, Kenji Suzuki, Takuo Hayashi, Masahito Hosokawa, Hideki Kambara, Haruko Takeyama (2022)  Reproducible and sensitive micro-tissue RNA-sequencing from formalin-fixed paraffin-embedded tissue for spatial gene expression analysis bioRxiv. 486169- DOI:10.1101/2022.03.29.486169
Masahide Kikkawa and Haruaki Yanagisawa (2021)  Identifying proteins in the cell by tagging techniques for cryo-electron microscopy Microscopy. 71 :S1,  i60-i65 DOI:10.1093/jmicro/dfab059 PMID:35275186 
Yoshikazu Furuta, Fumihito Miura, Takahiro Ichise, Shouta M.M. Nakayama, Yoshinori Ikenaka, Tuvshinzaya Zorigt, Mai Tsujinouchi, Mayumi Ishizuka, Takashi Ito, Hideaki Higashi (2022)  A GCDGC-specific DNA (cytosine-5) methyltransferase that methylates the GCWGC sequence on both strands and the GCSGC sequence on one strand. PLoS One. 17 :3,  e265225- DOI:10.1371/journal.pone.0265225 PMID:35312710 
Rika Idogawa, Akihiro Kobayashi, Youngchan Kim, Ken Shimomori, Takamitsu Hosoya, Suguru Yoshida (2021)  Hydride reduction of o-(fluorosilyl)benzodifluorides for subsequent C?F transformations Chemical Communications. 58 :21,  3521-3524 DOI:10.1039/d1cc06761c PMID:35195117 
Takayoshi Nakaoka, Ken-ichi Kaneko, Satsuki Irie, Aya Mawatari, Ami Igesaka, Yuta Uetake, Hidenori Ochiai, Takashi Niwa, Emi Yamano, Yasuhiro Wada, Masaaki Tanaka, Kohei Kotani, Hideki Kawahata, Joji Kawabe, Yukio Miki, Hisashi Doi, Takamitsu Hosoya, Maeda Kazuya, Hiroyuki Kusuhara, Yuichi Sugiyama, Yasuyoshi Watanabe  (2021)  Clinical evaluation of [18F]pitavastatin for quantitative analysis of hepatobiliary transporter activity Drug Metabolism and Pharmacokinetics. DOI:10.1016/j.dmpk.2022.100449

BINDSの支援を受けた研究成果(論文)

Kamimura, N., Watanabe, S., Sugimoto, K, Senda, M, Araki, T, Yu H. Y, Hishiyama, S, Kajita, S, Senda, T, and Masai, E. (2022)  Exploration and structure-based engineering of alkenal double bond reductases catalyzing the Cα-Cβ double bond reduction of coniferaldehyde. New Biotechnology. 68 57-67 DOI:10.1016/j.nbt.2022.01.007 PMID:35101610 
Effi Haque, Aamir Salam Teeli, Dawid Winiarczyk, Masahiko Taguchi, Shun Sakuraba, Hidetoshi Kono, Pawel Leszczynski, Mariusz Pierzchala and Hiroaki Taniguchi (2022)  HNF1A POU Domain Mutations Found in Japanese Liver Cancer Patients Cause Downregulation of HNF4A Promoter Activity with Possible Disruption in Transcription Networks Genes. 13 :3,  413- DOI:10.3390/genes13030413 PMID:35327967 
Yasuhiro Yunoki, Atsushi Matsumoto, Ken Morishima, Anne Martel, Lionel Porcar, Nobuhiro Sato, Rina Yogo, Taiki Tominaga, Rintaro Inoue, Maho Yagi-Utsumi, Aya Okuda, Masahiro Shimizu, Reiko Urade, Kazuki Terauchi, Hidetoshi Kono, Hirokazu Yagi, Koichi Kato, Masaaki Sugiyama (2022)  Overall structure of a fully assembled complex in the cyanobacterial circadian clock system analyzed by an integrated biophysical and computational approach Commucations Biology. 5 :1,  184- DOI:10.1038/s42003-022-03143-z PMID:35273347