BINDS支援技術に関する研究成果(論文)
Takuya Yoda, Maiko Tanabe, Toshiyuki Tsuji, Takao Yoda, Sonoko Ishino, Tsuyoshi Shirai, Yoshizumi Ishino, Haruko Takeyama & Hirokazu Nishida?
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Exonuclease processivity of archaeal replicative DNA polymerase in association with PCNA is expedited by mismatches in DNA. Scientific Reports.
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Takuya Yoda, Masahito Hosokawa, Kiyofumi Takahashi, Chikako Sakanashi, Haruko Takeyama & Hideki Kambara (2017)
Site-specific gene expression analysis using an automated tissue micro-dissection punching system. Sientific Reports.
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4325-
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Hisashi Tatebe, Shinichi Murayama, Toshiya Yonekura, Tomoyuki Hatano, David Richter, Tomomi Furuya, Saori Kataoka, Kyoko Furuita, Chojiro Kojima, Kazuhiro Shiozaki (2017)
Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit eLife.
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Masao Ohashi, Hiroyuki Miyachi (2017)
Design and Synthesis of Peroxisome Proliferator-activated Receptor (PPAR) Gamma Antagonists Based on the Principle of Operation of Nuclear Receptor I. Yakugaku Zasshi. .
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Shinichi Machida, Yoshimasa Takizawa, Masakazu Ishimaru, Yukihiko Sugita, Satoshi Sekine, Jun-ichi Nakayama, Matthias Wolf, Hitoshi Kurumizaka
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Structural Basis of Heterochromatin Formation by Human HP1 Molecular Cell.
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Satomi Shimura, Koichi Watashi, Kento Fukano, Michael Peel, Ann Sluder, Fumihiro Kawai, Masashi Iwamoto, Senko Tsukuda, Junko S. Takeuchi, Takeshi Miyake, Masaya Sugiyama, Yuki Ogasawara, Sam-Yong Park, Yasuhito Tanaka, Hiroyuki Kusuhara, Masashi Mizokami, Camille Sureau, Takaji Wakita (2017)
Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity Journal of Hepatology.
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加藤貴之, 難波啓一 (2017)
2017年ノーベル化学賞 クライオ電子顕微鏡法の開発 現代化学.
12
40-44
Christopher D. M. Hutchison, Violeta Cordon-Preciado, Rhodri M. L. Morgan, Takanori Nakane, Josie Ferreira, Gabriel Dorlhiac, Alvaro Sanchez-Gonzalez, Allan S. Johnson, Ann Fitzpatrick, Clyde Fare,1 Jon P. Marangos, Chun Hong Yoon, Mark S. Hunter, Daniel P. DePonte, S?bastien Boutet, Shigeki Owada, Rie Tanaka, Kensuke Tono, So Iwata, and Jasper J. van Thor (2017)
X-ray Free Electron Laser Determination of Crystal Structures of Dark and Light States of a Reversibly Photoswitching Fluorescent Protein at Room Temperature International Journal of Molecular Sciences.
18
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Takashi Fujii, Hideyuki Matsunami, Yumi Inoue, Keiichi Namba (2018)
Evidence for the hook supercoiling mechanism of the bacterial flagellum. Biophysics and Physicobiology.
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28-32
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Keisuke Komoda, Masanori Narita, Keitaro Yamashita, Isao Tanaka, Min Yao (2017)
Asymmetric Trimeric Ring Structure of the Nucleocapsid Protein of Tospovirus. Journal of Virology.
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Masamichi Nagae, Sushil K. Mishra,Makiko Neyazaki,Rika Oi,Akemi Ikeda,Naohiro Matsugaki,Satoko Akashi,Hiroshi Manya,Mamoru Mizuno,Hirokazu Yagi, Koichi Kato,Toshiya Senda,Tamao Endo,Terukazu Nogi,Yoshiki Yamaguchi (2017)
3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy. Genes Cells.
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Ayaka Harada,Naofumi Kamimura,Koh Takeuchi,Hong Yang Yu,Eiji Masai,Toshiya Senda (2017)
The crystal structure of a new O-demethylase from Sphingobium sp. strain SYK-6. The FEBS Journal.
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Masayuki Okuyama, Kana Matsunaga, Ken-Ichi Watanabe, Keitaro Yamashita, Takayoshi Tagami, Asako Kikuchi, Min Ma, Patcharapa Klahan, Haruhide Mori, Min Yao, Atsuo Kimura (2017)
Efficient synthesis of α-galactosyl oligosaccharides using a mutant Bacteroides thetaiotaomicron retaining α-galactosidase (BtGH97b) The FEBS Journal.
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Hisashi Naitow, Yoshinori Matsuura, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Rie Tanaka, Tomoyuki Tanaka, Michihiro Sugahara, Jun Kobayashi, Eriko Nango, So Iwata, and Naoki Kunishima,
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Protein?ligand complex structure from serial femtosecond crystallography using soaked thermolysin microcrystals and comparison with structures from synchrotron radiation Acta Crystallographica, secion D, structural biology.
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702-709
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Carol C L Chen, Preeti Goyal, Mohammad M Karimi, Marie H Abildgaard, Hiroshi Kimura, Matthew C Lorincz (2018)
H3S10ph broadly marks early-replicating domains in interphase ESCs and shows reciprocal antagonism with H3K9me2 Genome research.
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Yoshitoshi Ogura, Yasuhiro Gotoh, Takehiko Itoh, Mitsuhiko P Sato, Kazuko Seto, Shyuji Yoshino, Junko Isobe, Yoshiki Etoh, Mariko Kurogi, Keiko Kimata, Eriko Maeda, Denis Pi?rard, Masahiro Kusumoto, Masato Akiba, Kiyoshi Tominaga, Yumi Kirino, Yuki Kato, Katsuhiko Shirahige, Tadasuke Ooka, Nozomi Ishijima, Ken-Ichi Lee, Sunao Iyoda, Jacques Georges Mainil, Tetsuya Hayashi (2017)
Population structure of Escherichia coli O26 : H11 with recent and repeated stx2 acquisition in multiple lineages mcrobial Genomics.
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Hikaru Shimizu, Sachiko Toma-Fukai, Shinya Saijo, Nobutaka Shimizu, Kenji Kontani, Toshiaki Katada, Toshiyuki Shimizu (2017)
Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding. The Journal of Biological Chemistry.
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Mayo Sato, Dorothee Liebschner, Yusuke Yamada, Naohiro Matsugaki, Takatoshi Arakawa, Siobhan S. Wills, Mitchell Hattie, Keith A. Stubbs, Tasuku Ito, Toshiya Senda, Hisashi Ashida and Shinya Fushinobu (2017)
The first crystal structure of a family 129 glycoside hydrolase from a probiotic bacterium reveals critical residues and metal cofactors Journal of Biological Chemistry.
292
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Jessica L Thomaston, Rahel A Woldeyes, Takanori Nakane, Ayumi Yamashita, Tomoyuki Tanaka, Kotaro Koiwai, Aaron S Brewster, Benjamin A Barad, Yujie Chen, Thomas Lemmin, Monarin Uervirojnangkoorn, Toshi Arima, Jun Kobayashi, Tetsuya Masuda, Mamoru Suzuki, Michihiro Sugahara, Nicholas K Sauter, Rie Tanaka, Osamu Nureki, Kensuke Tono, Yasumasa Joti, Eriko Nango, So Iwata, Fumiaki Yumoto, James S Fraser, William F DeGrado (2017)
XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction Proceedings of the National Academy of Sciences of the United States of America.
14
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Yuko Ueda, Ikumi Ooshio, Yasuyuki Fusamae, Kaori Kitae, Megumi Kawaguchi, Kentaro Jingushi, Hiroaki Hase, Kazuo Harada, Kazumasa Hirata, Kazutake Tsujikawa (2017)
AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells Scientific Reports.
7
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Alexander Gorel, Koji Motomura, Hironobu Fukuzawa, R. Bruce Doak, Marie Luise Grunbein, Mario Hilpert, Ichiro Inoue, Marco Kloos, Gabriela Nass Kov?cs, Eriko Nango, Karol Nass, Christopher M Roome, Robert L Shoeman, Rie Tanaka, Kensuke Tono, Lutz Foucar, Yasumasa Joti, Makina Yabashi, So Iwata, Kiyoshi Ueda, Thomas R. M Barends & Ilme Schlichting? (2017)
Two-colour serial femtosecond crystallography dataset from gadoteridol-derivatized lysozyme for MAD phasing Scientific Data.
4
170188-
DOI:10.1038/sdata.2017.188 PMID:29231920
Michihiro Sugahara, Takanori Nakane, Tetsuya Masuda, Mamoru Suzuki, Shigeyuki Inoue, Changyong Song, Rie Tanaka, Toru Nakatsu, Eiichi Mizohata, Fumiaki Yumoto, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Osamu Nureki, Keiji Numata, Eriko Nango & So Iwata (2017)
Hydroxyethyl cellulose matrix applied to serial crystallography. Scientific Reports.
7
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703-
DOI:10.1038/s41598-017-00761-0 PMID:28386083
Yi-Lynn Liang, Maryam Khoshouei, Alisa Glukhova, Sebastian G B Furness, Peishen Zhao, Lachlan Clydesdale, Cassandra Koole, Tin T Truong, David M Thal, Saifei Lei, Mazdak Radjainia, Radostin Danev, Wolfgang Baumeister, Ming-Wei Wang, Laurence J Miller, Arthur Christopoulos, Patrick M Sexton, Denise Wootten (2018)
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex Nature.
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Toshihiko Sugiki, Naohiro Kobayashi, Toshimichi Fujiwara (2017)
Modern Technologies of Solution Nuclear Magnetic Resonance Spectroscopy for Three-dimensional Structure Determination of Proteins Open Avenues for Life Scientists Computational and structural biotechnology journal.
15
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Eiryo Kawakami,Naruhiko Adachi, Toshiya Senda, Masami Horikoshi
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Leading role of TBP in the establishment of complexity in eukaryotic transcription initiation systems. Cell Reports .
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Atsuko Shirai, Takayuki Kawaguchi, Hideaki Shimojo, Daisuke Muramatsu, Mayumi Ishida-Yonetani, Yoshifumi Nishimura, Hiroshi Kimura, Jun-ichi Nakayama, Yoichi Shinkai
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Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly. eLife.
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Shuji Akai (2017)
加水分解酵素と金属の触媒集積型動的光学分割:ラセミ体アルコールを光学的に純粋な化合物に収率100% で変換する新手法 有機合成化学協会誌.
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Jun Hirabayashi, Dan Hu, Hiroaki Tateno, Naoyuki Kuwabara, Ryuichi Kato, Fumio Yagi (2018)
Carbohydrate Recognition Mechanism of the Mushroom Galectin ACG. Trends in Glycoscience and Glycotechnology.
30
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SE75-SE88
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Shuang Liu, Hitoshi Hasegawa, Erika Takemasa, Yasuyuki Suzuki, Keizou Oka, Takeshi Kiyoi, Hiroyuki Takeda, Tomio Ogasawara, Tatsuya Sawasaki, Masaki Yasukawa and Kazutaka Maeyama (2017)
Efficiency and Safety of CRAC Inhibitors in Human Rheumatoid Arthritis Xenograft Models. Journal of Immunology.
199
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Kimiko Kuroki, Kazuhiro Mio, Ami Takahashi, Haruki Matsubara, Yoshiyuki Kasai, Sachie Manaka, Masahide Kikkawa, Daizo Hamada, Chikara Sato and Katsumi Maenaka (2017)
Cutting Edge: Class II-like Structural Features and Strong Receptor Binding of the Nonclassical HLA-G2 Isoform Homodimer Journal of Immunology.
198
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Mieko Arisawa, Saori Tanii, Takeru Tazawa, and Masahiko Yamaguchi (2017)
Synthesis of Unsymmetric HetArXHetAr’ Compounds by Rhodium-Catalyzed Heteroaryl Exchange Reaction Heterocycles.
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2179-2207
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Soichiro Sato, Azusa Hirayama, Tohma Adachi, Daichi Kawauchi, Hirofumi Ueda, Hidetoshi Tokuyama (2017)
AgNTf2-Mediated Arylation of Bromopyrroloindolines Heterocycles.
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1940-1957
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Takafumi Ide, Kazunori Shimizu, Yuji Kawato, Hiromichi Egami, and Yoshitaka Hamashima (2017)
α-Functionalization of TetrahHeterocyclesydroisoquinolines with Activated Alkyl Bromides under Photoredox Catalysis Heterocycles.
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738-747
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Yoshihiko Yamamoto, Yusuke Takamizu, Takashi Kurohara, Masatoshi Shibuya (2017)
Synthesis of g-Trifluoromethyl Tetronate Derivatives from Squarates Heterocycles.
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525-539
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Naoyoshi Maeda and Katsumi Maenaka (2017)
The Roles of Matricellular Proteins in Oncogenic Virus-Induced Cancers and Their Potential Utilities as Therapeutic Targets International Journal of Molecular Sciences.
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Hideyuki Konishi,Masataka Fukuda,Tsuyoshi Ueda,Kei Manabe (2017)
Palladium-Catalyzed External-CO-Free Reductive Carbonylation of Bromoarenes Organic Syntheses.
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大木規央,伊関峰生,朴三用 (2017)
光活性化アデニル酸シクラーゼ合成酵素OaPACの活性化機構解明 Journal of Japanese Biochemical Society..
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アカデミア創薬を牽引する東京大学創薬機構のさらなる基盤構築:東京大学創薬機構構造展開ユニット設立 MEDCHEM NEWS .
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Yuri Shibata, Fuminori Tokunaga, Eiji Goto, Ginga Komatsu, Jin Gohda, Yasushi Saeki, Keiji Tanaka, Hirotaka Takahashi, Tatsuya Sawasaki, Satoshi Inoue, Hiroyuki Oshiumi, Tsukasa Seya, Hiroyasu Nakano, Yuetsu Tanaka, Kazuhiro Iwai, Jun-ichiro Inoue
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HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains. PLOS Pathogens.
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Kazuhisa Honma, Satoshi Abe, Takeshi Endo, Narumi Uno, Mitsuo Oshimura, Tetsuya Ohbayashi, Yasuhiro Kazuki (2018)
Development of a multiple-gene-loading method by combining multi-integration system-equipped mouse artificial chromosome vector and CRISPR-Cas9 PLOS One.
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Daisuke Satoh, Satoru Iwado, Satoshi Abe, Kanako Kazuki, Shinobu Wakuri, Mitsuo Oshimura, Yasuhiro Kazuki (2017)
Establishment of a novel hepatocyte model that expresses four cytochrome P450 genes stably via mammalian-derived artificial chromosome for pharmacokinetics and toxicity studies PLOS One.
12
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e0187072-
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Yeondae Kwon, Yukikazu Natori, Masaru Tanokura (2017)
New approach to generating insights for aging research based on literature mining and knowledge integration PLOS One.
12
e0183534-
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Hiroyuki Takeda, Wei Zhou, Kohki Kido, Ryoji Suno, Takahiro Iwasaki, Takuya Kobayashi, Tatsuya Sawasaki (2017)
CP5 system, for simple and highly efficient protein purification with a C-terminal designed mini tag PLOS One.
12
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e0178246-
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Satoru Nagatoishi, Jose M M Caaveiro, Kouhei Tsumoto (2017)
Biophysical Analysis of the Protein-Small Molecule Interactions to Develop Small Molecule Drug Discovery Yakugaku Zasshi.
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大江 知之, 高橋 恭子, 中村 成夫, 増野 匡彦 (2017)
肝毒性を示す医薬品の代謝活性化機構の解析とそれに基づいた創薬戦略 薬学雑誌.
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Hideyuki Konishi (2017)
Creation of Novel Toxic Gas Surrogates and the Development of Safe and Facile Catalytic Reactions. Advanced Synthesis & Catalysis.
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Shuichi Mori, Ryohei Takagaki, Shinya Fujii, Ko Urushibara, Aya Tanatani, Hiroyuki Kagechika (2017)
Novel non-steroidal progesterone receptor ligands based on m-carborane containing a secondary alcohol: Effect of chirality on ligand activity. Chemical and Pharmaceutical Bulletin.
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Shun-ichiro Uesugi, Yusuke Sasano, Shogo Matsui, Naoki Kanoh, Yoshiharu Iwabuchi (2017)
Concise, Protecting-Group-Free Synthesis of (+)-Nemonapride via Eu(OTf)3-Catalyzed Aminolysis of 3,4-Epoxy Alcohol Chemical and Pharmaceutical Bulletin.
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Katsunori Takahashi, Haruhisa Kikuchi, Van Hai Nguyen, Yoshiteru Oshima, Hirotaka Ishigaki, Junko Nakajima-Shimada, Yuzuru Kubohara (2017)
Biological activities of novel derivatives of differentiation-inducing factor 3 from Dictyostelium discoideum Biological and Pharmaceutical Bulletin.
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Takashi Niwa, Hidenori Ochiai, Motoyuki Isoda, Takamitsu Hosoya (2017)
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Tomohiro Meguro ,Suguru Yoshida , and Takamitsu Hosoya (2017)
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Shota Mori, Masatoshi Shibuya, Yoshihiko Yamamoto (2017)
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Masahito Yoshida, Koji Umeda, Takayuki Doi (2017)
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Hisashi Mizutani, Hideaki Sugawara, Ashley M. Buckle, Takeshi Sangawa, Ken-ichi Miyazono, Jun Ohtsuka, Koji Nagata, Tomoki Shojima, Shohei Nosaki, Yuqun Xu, Delong Wang, Xiao Hu, Masaru Tanokura & Kei Yura (2017)
REFOLDdb: a new and sustainable gateway to experimental protocols for protein refolding BMC Structural Biology.
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Kazunori D. Yamada, Satoshi Omori, Hafumi Nishi & Masaru Miyagi (2017)
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Simple adjustment of the sequence weight algorithm remarkably enhances PSI-BLAST performance BMC Bioinformatics.
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Kentaro Kamiya, Masayoshi Arai, Andi Setiawan, Motomasa Kobayashi (2017)
Anti-dormant Mycobacterial Activity of Viomellein and Xanthomegnin, Naphthoquinone Dimers Produced by Marine-derived Aspergillus sp Natural Product Communications.
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Akihiro Ito, Mitsuhiko Ohta, Yukinari Kato, Shunko Inada, Toshio Kato, Susumu Nakata,Yasushi Yatabe, Mitsuo Goto, Norio Kaneda, Kenichi Kurita, Hayao Nakanishi,and Kenji Yoshida (2018)
A Real-Time Near-Infrared Fluorescence Imaging Method for the Detection of Oral Cancers in Mice Using an Indocyanine Green-Labeled Podoplanin Antibody. Technology in Cancer Research & Treatment.
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Ikuo Hirano, Norio Suzuki, Shun Yamazaki, Hiroki Sekine, Naoko Minegishi,Ritsuko Shimizu, Masayuki Yamamoto (2017)
Renal Anemia Model Mouse Establishedby Transgenic Rescue with anErythropoietin Gene Lacking KidneySpecific Regulatory Elements Molecular and Cellular Biology.
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Lei Yu, Takashi Moriguchi, Hiroshi Kaneko, Makiko Hayashi, Atsushi Hasegawa, Masahiro Nezu, Hideyuki Saya, Masayuki Yamamoto, Ritsuko Shimizu (2017)
Reducing Inflammatory Cytokine Production from Renal Collecting Duct Cells by Inhibiting GATA2 Ameliorates Acute Kidney Injury Molecular and Cellular Biology.
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Haruhiko Ehara, Takeshi Yokoyama, Hideki Shigematsu, Shigeyuki Yokoyama, Mikako Shirouzu, Shun-ichi Sekine (2017)
Structure of the complete elongation complex of RNA polymerase II with basal factors Science.
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Hiroshi Kaneko,Takehide Katoh, Ikuo Hirano, Atsushi Hasegawa, Tadayuki Tsujita, Masayuki Yamamoto, Ritsuko Shimizu (2017)
Induction of erythropoietin gene expression in epithelial cells by chemicals identified in GATA inhibitor screenings Genes to Cells.
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Keitaro Yamashita, Naoyuki Kuwabara, Takanori Nakane, Tomohiro Murai, Eiichi Mizohata, Michihiro Sugahara, Dongqing Pan, Tetsuya Masuda, Mamoru Suzuki, Tomomi Sato, Atsushi Kodan, Tomohiro Yamaguchi, Eriko Nango, Tomoyuki Tanaka, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Hiroshi Manya, Tamao Endo, Ryuichi Kato, Toshiya Senda, Hiroaki Kato, So Iwata, Hideo Ago, Masaki Yamamoto, Fumiaki Yumoto, and Toru Nakatsua, (2017)
Experimental phase determination with seleno- methionine or mercury-derivatization in serial femtosecond crystallography IUCrJ.
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Protein microcrystallography using synchrotron radiation IUCr Journals.
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Minoru Kubo, Eriko Nango, Kensuke Tono, Tetsunari Kimura, Shigeki Owada, Changyong Song, Fumitaka Mafun, Ken Miyajima, Yoshihiro Takeda, Jun-ya Kohnoi Naoya Miyauchi, Takanori Nakane, Tomoyuki Tanaka, Takashi Nomura, Jan Davidsson, Rie Tanaka, Michio Murata, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Richard Neutze, Makina Yabashi, and So Iwata, (2017)
Nanosecond pump-probe device for time-resolved serial femtosecond crystallography developed at SACLA Journal of Synchrotron Radiation.
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