成果

創薬等先端技術支援基盤プラットフォーム(BINDS)の実施者による研究支援と研究高度化の成果として輩出されたデータベース、 ツール、論文および特許を紹介します。

開発されたデータベースやツール

ケミカルシーズ・リード 探索ユニット

インシリコユニット

プラットフォーム機能最適化ユニット

BINDS支援技術に関する研究成果(論文)

Takuya Yoda, Maiko Tanabe, Toshiyuki Tsuji, Takao Yoda, Sonoko Ishino, Tsuyoshi Shirai, Yoshizumi Ishino, Haruko Takeyama & Hirokazu Nishida?  (2017)  Exonuclease processivity of archaeal replicative DNA polymerase in association with PCNA is expedited by mismatches in DNA. Scientific Reports. 7 44582- DOI:10.1038/srep44582 PMID:28300173 
Takuya Yoda, Masahito Hosokawa, Kiyofumi Takahashi, Chikako Sakanashi, Haruko Takeyama & Hideki Kambara (2017)  Site-specific gene expression analysis using an automated tissue micro-dissection punching system. Sientific Reports. 7 :1,  4325- DOI:10.1038/s41598-017-04616-6 PMID:28659603 
Hisashi Tatebe, Shinichi Murayama, Toshiya Yonekura, Tomoyuki Hatano, David Richter, Tomomi Furuya, Saori Kataoka, Kyoko Furuita, Chojiro Kojima, Kazuhiro Shiozaki (2017)  Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit eLife. 6 e19594- DOI:10.7554/eLife.19594 PMID:28264193 
Masao Ohashi, Hiroyuki Miyachi (2017)  Design and Synthesis of Peroxisome Proliferator-activated Receptor (PPAR) Gamma Antagonists Based on the Principle of Operation of Nuclear Receptor I. Yakugaku Zasshi. . 137 :8,  957-967 DOI:10.1248/yakushi.17-00047 PMID:28768949 
Shinichi Machida, Yoshimasa Takizawa, Masakazu Ishimaru, Yukihiko Sugita, Satoshi Sekine, Jun-ichi Nakayama, Matthias Wolf, Hitoshi Kurumizaka  (2018)  Structural Basis of Heterochromatin Formation by Human HP1 Molecular Cell. 69 :3,  385-397 DOI:10.1016/j.molcel.2017.12.011 PMID:29336876 
Satomi Shimura, Koichi Watashi, Kento Fukano, Michael Peel, Ann Sluder, Fumihiro Kawai, Masashi Iwamoto, Senko Tsukuda, Junko S. Takeuchi, Takeshi Miyake, Masaya Sugiyama, Yuki Ogasawara, Sam-Yong Park, Yasuhito Tanaka, Hiroyuki Kusuhara, Masashi Mizokami, Camille Sureau, Takaji Wakita (2017)  Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity Journal of Hepatology. 66 :4,  685-692 DOI:10.1016/j.jhep.2016.11.009 PMID:27890789 
加藤貴之, 難波啓一 (2017)  2017年ノーベル化学賞 クライオ電子顕微鏡法の開発 現代化学. 12 40-44
Christopher D. M. Hutchison, Violeta Cordon-Preciado, Rhodri M. L. Morgan, Takanori Nakane, Josie Ferreira, Gabriel Dorlhiac, Alvaro Sanchez-Gonzalez, Allan S. Johnson, Ann Fitzpatrick, Clyde Fare,1 Jon P. Marangos, Chun Hong Yoon, Mark S. Hunter, Daniel P. DePonte, S?bastien Boutet, Shigeki Owada, Rie Tanaka, Kensuke Tono, So Iwata, and Jasper J. van Thor (2017)  X-ray Free Electron Laser Determination of Crystal Structures of Dark and Light States of a Reversibly Photoswitching Fluorescent Protein at Room Temperature International Journal of Molecular Sciences. 18 :9,  1918- DOI:10.3390/ijms18091918 PMID:28880248 
Takashi Fujii, Hideyuki Matsunami, Yumi Inoue, Keiichi Namba (2018)  Evidence for the hook supercoiling mechanism of the bacterial flagellum. Biophysics and Physicobiology. 15 28-32 DOI:10.2142/biophysico.15.0_28 PMID:29607277 
Keisuke Komoda, Masanori Narita, Keitaro Yamashita, Isao Tanaka, Min Yao (2017)  Asymmetric Trimeric Ring Structure of the Nucleocapsid Protein of Tospovirus. Journal of Virology. 91 :20,  e01002-17- DOI:10.1128/JVI.01002-17 PMID:28768868 
Masamichi Nagae, Sushil K. Mishra,Makiko Neyazaki,Rika Oi,Akemi Ikeda,Naohiro Matsugaki,Satoko Akashi,Hiroshi Manya,Mamoru Mizuno,Hirokazu Yagi, Koichi Kato,Toshiya Senda,Tamao Endo,Terukazu Nogi,Yoshiki Yamaguchi (2017)  3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy. Genes Cells. 22 :4,  348-359 DOI:10.1111/gtc.12480 PMID:28251761 
Ayaka Harada,Naofumi Kamimura,Koh Takeuchi,Hong Yang Yu,Eiji Masai,Toshiya Senda (2017)  The crystal structure of a new O-demethylase from Sphingobium sp. strain SYK-6. The FEBS Journal. 284 :12,  1855-1867 DOI:10.1111/febs.14085 PMID:28429420 
Masayuki Okuyama, Kana Matsunaga, Ken-Ichi Watanabe, Keitaro Yamashita, Takayoshi Tagami, Asako Kikuchi, Min Ma, Patcharapa Klahan, Haruhide Mori, Min Yao, Atsuo Kimura (2017)  Efficient synthesis of α-galactosyl oligosaccharides using a mutant Bacteroides thetaiotaomicron retaining α-galactosidase (BtGH97b) The FEBS Journal. 284 :5,  766-783 DOI:10.1111/febs.14018 PMID:28103425 
Hisashi Naitow, Yoshinori Matsuura, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Rie Tanaka, Tomoyuki Tanaka, Michihiro Sugahara, Jun Kobayashi, Eriko Nango, So Iwata, and Naoki Kunishima,  (2017)  Protein?ligand complex structure from serial femtosecond crystallography using soaked thermolysin microcrystals and comparison with structures from synchrotron radiation Acta Crystallographica, secion D, structural biology. 73 702-709 DOI:10.1107/S2059798317008919 PMID:28777085 
Carol C L Chen, Preeti Goyal, Mohammad M Karimi, Marie H Abildgaard, Hiroshi Kimura, Matthew C Lorincz (2018)  H3S10ph broadly marks early-replicating domains in interphase ESCs and shows reciprocal antagonism with H3K9me2 Genome research. 28 :1,  37-51 DOI:10.1101/gr.224717.117 PMID:29229671 
Yoshitoshi Ogura, Yasuhiro Gotoh, Takehiko Itoh, Mitsuhiko P Sato, Kazuko Seto, Shyuji Yoshino, Junko Isobe, Yoshiki Etoh, Mariko Kurogi, Keiko Kimata, Eriko Maeda, Denis Pi?rard, Masahiro Kusumoto, Masato Akiba, Kiyoshi Tominaga, Yumi Kirino, Yuki Kato, Katsuhiko Shirahige, Tadasuke Ooka, Nozomi Ishijima, Ken-Ichi Lee, Sunao Iyoda, Jacques Georges Mainil, Tetsuya Hayashi (2017)  Population structure of Escherichia coli O26 : H11 with recent and repeated stx2 acquisition in multiple lineages mcrobial Genomics. 3 :11,  e000141- DOI:10.1099/mgen.0.000141 PMID:29208163 
Hikaru Shimizu, Sachiko Toma-Fukai, Shinya Saijo, Nobutaka Shimizu, Kenji Kontani, Toshiaki Katada, Toshiyuki Shimizu (2017)  Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding. The Journal of Biological Chemistry. 292 :32,  13441-13448 DOI:10.1074/jbc.M117.792556 PMID:28630045 
Mayo Sato, Dorothee Liebschner, Yusuke Yamada, Naohiro Matsugaki, Takatoshi Arakawa, Siobhan S. Wills, Mitchell Hattie, Keith A. Stubbs, Tasuku Ito, Toshiya Senda, Hisashi Ashida and Shinya Fushinobu (2017)  The first crystal structure of a family 129 glycoside hydrolase from a probiotic bacterium reveals critical residues and metal cofactors Journal of Biological Chemistry. 292 :29,  12126-12138 DOI:10.1074/jbc.M117.777391 PMID:28546425 
Jessica L Thomaston, Rahel A Woldeyes, Takanori Nakane, Ayumi Yamashita, Tomoyuki Tanaka, Kotaro Koiwai, Aaron S Brewster, Benjamin A Barad, Yujie Chen, Thomas Lemmin, Monarin Uervirojnangkoorn, Toshi Arima, Jun Kobayashi, Tetsuya Masuda, Mamoru Suzuki, Michihiro Sugahara, Nicholas K Sauter, Rie Tanaka, Osamu Nureki, Kensuke Tono, Yasumasa Joti, Eriko Nango, So Iwata, Fumiaki Yumoto, James S Fraser, William F DeGrado (2017)  XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction Proceedings of the National Academy of Sciences of the United States of America. 14 :51,  13357-13362 DOI:10.1073/pnas.1705624114 PMID:28835537 
Yuko Ueda, Ikumi Ooshio, Yasuyuki Fusamae, Kaori Kitae, Megumi Kawaguchi, Kentaro Jingushi, Hiroaki Hase, Kazuo Harada, Kazumasa Hirata, Kazutake Tsujikawa (2017)  AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells Scientific Reports. 7 42271- DOI:10.1038/srep42271 PMID:28205560 
Alexander Gorel, Koji Motomura, Hironobu Fukuzawa, R. Bruce Doak, Marie Luise Grunbein, Mario Hilpert, Ichiro Inoue, Marco Kloos, Gabriela Nass Kov?cs, Eriko Nango, Karol Nass, Christopher M Roome, Robert L Shoeman, Rie Tanaka, Kensuke Tono, Lutz Foucar, Yasumasa Joti, Makina Yabashi, So Iwata, Kiyoshi Ueda, Thomas R. M Barends & Ilme Schlichting? (2017)  Two-colour serial femtosecond crystallography dataset from gadoteridol-derivatized lysozyme for MAD phasing Scientific Data. 4 170188- DOI:10.1038/sdata.2017.188 PMID:29231920 
Michihiro Sugahara, Takanori Nakane, Tetsuya Masuda, Mamoru Suzuki, Shigeyuki Inoue, Changyong Song, Rie Tanaka, Toru Nakatsu, Eiichi Mizohata, Fumiaki Yumoto, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Osamu Nureki, Keiji Numata, Eriko Nango & So Iwata  (2017)  Hydroxyethyl cellulose matrix applied to serial crystallography. Scientific Reports. 7 :1,  703- DOI:10.1038/s41598-017-00761-0 PMID:28386083 
Yi-Lynn Liang, Maryam Khoshouei, Alisa Glukhova, Sebastian G B Furness, Peishen Zhao, Lachlan Clydesdale, Cassandra Koole, Tin T Truong, David M Thal, Saifei Lei, Mazdak Radjainia, Radostin Danev, Wolfgang Baumeister, Ming-Wei Wang, Laurence J Miller, Arthur Christopoulos, Patrick M Sexton, Denise Wootten  (2018)  Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex Nature. 555 :7694,  121-125 DOI:10.1038/nature25773 PMID:29466332 
Toshihiko Sugiki, Naohiro Kobayashi, Toshimichi Fujiwara (2017)  Modern Technologies of Solution Nuclear Magnetic Resonance Spectroscopy for Three-dimensional Structure Determination of Proteins Open Avenues for Life Scientists Computational and structural biotechnology journal. 15 328-339 DOI:10.1016/j.csbj.2017.04.001 PMID:28487762 
Eiryo Kawakami,Naruhiko Adachi, Toshiya Senda, Masami Horikoshi  (2017)  Leading role of TBP in the establishment of complexity in eukaryotic transcription initiation systems. Cell Reports . 21 :13,  3941-3956 DOI:10.1016/j.celrep.2017.12.034 PMID:29281839 
Atsuko Shirai, Takayuki Kawaguchi, Hideaki Shimojo, Daisuke Muramatsu, Mayumi Ishida-Yonetani, Yoshifumi Nishimura, Hiroshi Kimura, Jun-ichi Nakayama, Yoichi Shinkai  (2017)  Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly. eLife. 6 e25317- DOI:10.7554/eLife.25317 PMID:28760201 
Shuji Akai (2017)  加水分解酵素と金属の触媒集積型動的光学分割:ラセミ体アルコールを光学的に純粋な化合物に収率100% で変換する新手法 有機合成化学協会誌. 75 441-448 DOI:10.5059/yukigoseikyokaishi.75.441
Jun Hirabayashi, Dan Hu, Hiroaki Tateno, Naoyuki Kuwabara, Ryuichi Kato, Fumio Yagi (2018)  Carbohydrate Recognition Mechanism of the Mushroom Galectin ACG. Trends in Glycoscience and Glycotechnology. 30 :172,  SE75-SE88 DOI:10.4052/tigg.1736.1SE
Shuang Liu, Hitoshi Hasegawa, Erika Takemasa, Yasuyuki Suzuki, Keizou Oka, Takeshi Kiyoi, Hiroyuki Takeda, Tomio Ogasawara, Tatsuya Sawasaki, Masaki Yasukawa and Kazutaka Maeyama (2017)  Efficiency and Safety of CRAC Inhibitors in Human Rheumatoid Arthritis Xenograft Models. Journal of Immunology. 199 :5,  1584-1595 DOI:10.4049/jimmunol.1700192 PMID:28716825 
Kimiko Kuroki, Kazuhiro Mio, Ami Takahashi, Haruki Matsubara, Yoshiyuki Kasai, Sachie Manaka, Masahide Kikkawa, Daizo Hamada, Chikara Sato and Katsumi Maenaka (2017)  Cutting Edge: Class II-like Structural Features and Strong Receptor Binding of the Nonclassical HLA-G2 Isoform Homodimer Journal of Immunology. 198 3399-3403 DOI:10.4049/jimmunol.1601296 PMID:28348268 
Mieko Arisawa, Saori Tanii, Takeru Tazawa, and Masahiko Yamaguchi (2017)  Synthesis of Unsymmetric HetArXHetAr’ Compounds by Rhodium-Catalyzed Heteroaryl Exchange Reaction Heterocycles. 94 2179-2207 DOI:10.3987/REV-17-869
Soichiro Sato, Azusa Hirayama, Tohma Adachi, Daichi Kawauchi, Hirofumi Ueda, Hidetoshi Tokuyama (2017)  AgNTf2-Mediated Arylation of Bromopyrroloindolines Heterocycles. 94 1940-1957 DOI:10.3987/COM-17-13777
Takafumi Ide, Kazunori Shimizu, Yuji Kawato, Hiromichi Egami, and Yoshitaka Hamashima (2017)  α-Functionalization of TetrahHeterocyclesydroisoquinolines with Activated Alkyl Bromides under Photoredox Catalysis Heterocycles. 95 738-747 DOI:10.3987/COM-16-S(S)73
Yoshihiko Yamamoto, Yusuke Takamizu, Takashi Kurohara, Masatoshi Shibuya (2017)  Synthesis of g-Trifluoromethyl Tetronate Derivatives from Squarates Heterocycles. 95 525-539 DOI:10.3987/COM-16-S(S)12
Naoyoshi Maeda and Katsumi Maenaka (2017)  The Roles of Matricellular Proteins in Oncogenic Virus-Induced Cancers and Their Potential Utilities as Therapeutic Targets International Journal of Molecular Sciences. 18 2198- DOI:10.3390/ijms18102198 PMID:29065446 
Hideyuki Konishi,Masataka Fukuda,Tsuyoshi Ueda,Kei Manabe (2017)  Palladium-Catalyzed External-CO-Free Reductive Carbonylation of Bromoarenes Organic Syntheses. 94 66-76 DOI:10.15227/orgsyn.094.0066
大木規央,伊関峰生,朴三用 (2017)  光活性化アデニル酸シクラーゼ合成酵素OaPACの活性化機構解明 Journal of Japanese Biochemical Society.. 89 458-462 DOI:10.14952/SEIKAGAKU.2017.890458
宮地弘幸、小島宏建、一條秀憲 (2017)  アカデミア創薬を牽引する東京大学創薬機構のさらなる基盤構築:東京大学創薬機構構造展開ユニット設立 MEDCHEM NEWS . 27 178-183 DOI:10.14894/medchem.27.4_178
Yuri Shibata, Fuminori Tokunaga, Eiji Goto, Ginga Komatsu, Jin Gohda, Yasushi Saeki, Keiji Tanaka, Hirotaka Takahashi, Tatsuya Sawasaki, Satoshi Inoue, Hiroyuki Oshiumi, Tsukasa Seya, Hiroyasu Nakano, Yuetsu Tanaka, Kazuhiro Iwai, Jun-ichiro Inoue  (2017)  HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains. PLOS Pathogens. 13 :1,  e1006162- DOI:10.1371/journal.ppat.1006162 PMID:28103322 
Kazuhisa Honma, Satoshi Abe, Takeshi Endo, Narumi Uno, Mitsuo Oshimura, Tetsuya Ohbayashi, Yasuhiro Kazuki (2018)  Development of a multiple-gene-loading method by combining multi-integration system-equipped mouse artificial chromosome vector and CRISPR-Cas9 PLOS One. 13 :3,  e0193642- DOI:10.1371/journal.pone.0193642 PMID:29505588 
Daisuke Satoh, Satoru Iwado, Satoshi Abe, Kanako Kazuki, Shinobu Wakuri, Mitsuo Oshimura, Yasuhiro Kazuki (2017)  Establishment of a novel hepatocyte model that expresses four cytochrome P450 genes stably via mammalian-derived artificial chromosome for pharmacokinetics and toxicity studies PLOS One. 12 :10,  e0187072- DOI:10.1371/journal.pone.0187072 PMID:29065189 
Yeondae Kwon, Yukikazu Natori, Masaru Tanokura  (2017)  New approach to generating insights for aging research based on literature mining and knowledge integration PLOS One. 12 e0183534- DOI:10.1371/journal.pone.0183534 PMID:28817730 
Hiroyuki Takeda, Wei Zhou, Kohki Kido, Ryoji Suno, Takahiro Iwasaki, Takuya Kobayashi, Tatsuya Sawasaki  (2017)  CP5 system, for simple and highly efficient protein purification with a C-terminal designed mini tag PLOS One. 12 :5,  e0178246- DOI:10.1371/journal.pone.0178246 PMID:28542437 
Satoru Nagatoishi, Jose M M Caaveiro, Kouhei Tsumoto  (2017)  Biophysical Analysis of the Protein-Small Molecule Interactions to Develop Small Molecule Drug Discovery Yakugaku Zasshi. 138 1033-1041 DOI:10.1248/yakushi.17-00211-2 PMID:30068844 
大江 知之, 高橋 恭子, 中村 成夫, 増野 匡彦 (2017)  肝毒性を示す医薬品の代謝活性化機構の解析とそれに基づいた創薬戦略 薬学雑誌. 137 249-255 DOI:10.1248/yakushi.16-00230-1 PMID:28250317 
Hideyuki Konishi  (2017)  Creation of Novel Toxic Gas Surrogates and the Development of Safe and Facile Catalytic Reactions. Advanced Synthesis & Catalysis. 359 3592-3601 DOI:10.1248/cpb.c17-00795 PMID:29311504 
Shuichi Mori, Ryohei Takagaki, Shinya Fujii, Ko Urushibara, Aya Tanatani, Hiroyuki Kagechika (2017)  Novel non-steroidal progesterone receptor ligands based on m-carborane containing a secondary alcohol: Effect of chirality on ligand activity. Chemical and Pharmaceutical Bulletin. 65 :11,  1051-1057 DOI:10.1248/cpb.c17-00544 PMID:29093292 
Shun-ichiro Uesugi, Yusuke Sasano, Shogo Matsui, Naoki Kanoh, Yoshiharu Iwabuchi (2017)  Concise, Protecting-Group-Free Synthesis of (+)-Nemonapride via Eu(OTf)3-Catalyzed Aminolysis of 3,4-Epoxy Alcohol Chemical and Pharmaceutical Bulletin. 65 22-24 DOI:10.1248/cpb.c16-00568 PMID:28049911 
Katsunori Takahashi, Haruhisa Kikuchi, Van Hai Nguyen, Yoshiteru Oshima, Hirotaka Ishigaki, Junko Nakajima-Shimada, Yuzuru Kubohara (2017)  Biological activities of novel derivatives of differentiation-inducing factor 3 from Dictyostelium discoideum Biological and Pharmaceutical Bulletin. 40 1941-1947 DOI:10.1248/bpb.b17-00484 PMID:29093342 
Takashi Niwa, Hidenori Ochiai, Motoyuki Isoda, Takamitsu Hosoya (2017)  Facile Transformation of α,β-Unsaturated Carboxylic Acids to Alkenylboronic Esters via Rhodium-Catalyzed Decarbonylative Borylation of α,β-Unsaturated Thioesters Chemistry Letters. 46 :9,  1315-1318 DOI:10.1246/cl.170549
Tomohiro Meguro ,Suguru Yoshida , and Takamitsu Hosoya  (2017)  Sequential Molecular Conjugation using Thiophene S,S-Dioxides Bearing a Clickable Functional Group Chemistry Letters. 46 :8,  1137-1140 DOI:10.1246/cl.170426
Shota Mori, Masatoshi Shibuya, Yoshihiko Yamamoto  (2017)  Ruthenium-catalyzed Hydrocarbamoylative Cyclization of 1,6-Diynes with Formamides Chemistry Letters. 46 207-210 DOI:10.1246/cl.160961
Masahito Yoshida, Koji Umeda, Takayuki Doi  (2017)  Stereoselective Synthesis of β-Amino Acid Derivatives by Asymmetric Mannich Reaction in Flow Bulletin of the Chemical Society of Japan. 90 1157-1163 DOI:10.1246/bcsj.20170194
木村 宏 、 佐藤 優子  (2017)  ゲノム,エピゲノムからヌクレオームへ 遺伝情報発現制御機構の包括的理解に向けて 情報管理 . 60 :8,  555-563 DOI:10.1241/johokanri.60.555
Hisashi Mizutani, Hideaki Sugawara, Ashley M. Buckle, Takeshi Sangawa, Ken-ichi Miyazono, Jun Ohtsuka, Koji Nagata, Tomoki Shojima, Shohei Nosaki, Yuqun Xu, Delong Wang, Xiao Hu, Masaru Tanokura & Kei Yura  (2017)  REFOLDdb: a new and sustainable gateway to experimental protocols for protein refolding BMC Structural Biology. 17 4- DOI:10.1186/s12900-017-0074-z PMID:28438161 
Kazunori D. Yamada, Satoshi Omori, Hafumi Nishi & Masaru Miyagi (2017)  Identification of the sequence determinants of protein N-terminal acetylation through a decision tree approach. BMC Bioinformatics. . 18 289- DOI:10.1186/s12859-017-1699-4 PMID:28578658 
Toshiyuki Oda, Kyungtaek Lim, and Kentaro Tomii  (2017)  Simple adjustment of the sequence weight algorithm remarkably enhances PSI-BLAST performance BMC Bioinformatics. 18 288- DOI:10.1186/s12859-017-1686-9 PMID:28578660 
Kentaro Kamiya, Masayoshi Arai, Andi Setiawan, Motomasa Kobayashi (2017)  Anti-dormant Mycobacterial Activity of Viomellein and Xanthomegnin, Naphthoquinone Dimers Produced by Marine-derived Aspergillus sp Natural Product Communications. 12 579-581 DOI:10.1177/1934578X1701200428 PMID:30520600 
Akihiro Ito, Mitsuhiko Ohta, Yukinari Kato, Shunko Inada, Toshio Kato, Susumu Nakata,Yasushi Yatabe, Mitsuo Goto, Norio Kaneda, Kenichi Kurita, Hayao Nakanishi,and Kenji Yoshida (2018)  A Real-Time Near-Infrared Fluorescence Imaging Method for the Detection of Oral Cancers in Mice Using an Indocyanine Green-Labeled Podoplanin Antibody. Technology in Cancer Research & Treatment. 17 DOI:10.1177/1533033818767936 PMID:29649929 
Ikuo Hirano, Norio Suzuki, Shun Yamazaki, Hiroki Sekine, Naoko Minegishi,Ritsuko Shimizu, Masayuki Yamamoto (2017)  Renal Anemia Model Mouse Establishedby Transgenic Rescue with anErythropoietin Gene Lacking KidneySpecific Regulatory Elements Molecular and Cellular Biology. 37 e00451-16- DOI:10.1128/MCB.00451-16 PMID:27920250 
Lei Yu, Takashi Moriguchi, Hiroshi Kaneko, Makiko Hayashi, Atsushi Hasegawa, Masahiro Nezu, Hideyuki Saya, Masayuki Yamamoto, Ritsuko Shimizu (2017)  Reducing Inflammatory Cytokine Production from Renal Collecting Duct Cells by Inhibiting GATA2 Ameliorates Acute Kidney Injury Molecular and Cellular Biology. 37 e00211-17- DOI:10.1128/MCB.00211-17 PMID:28807932 
Haruhiko Ehara, Takeshi Yokoyama, Hideki Shigematsu, Shigeyuki Yokoyama, Mikako Shirouzu, Shun-ichi Sekine (2017)  Structure of the complete elongation complex of RNA polymerase II with basal factors Science. 357 :6354,  921-924 DOI:10.1126/science.aan8552 PMID:28775211 
Hiroshi Kaneko,Takehide Katoh, Ikuo Hirano, Atsushi Hasegawa, Tadayuki Tsujita, Masayuki Yamamoto, Ritsuko Shimizu (2017)  Induction of erythropoietin gene expression in epithelial cells by chemicals identified in GATA inhibitor screenings Genes to Cells. 22 939-952 DOI:10.1111/gtc.12537 PMID:29044949 
Keitaro Yamashita, Naoyuki Kuwabara, Takanori Nakane, Tomohiro Murai, Eiichi Mizohata, Michihiro Sugahara, Dongqing Pan, Tetsuya Masuda, Mamoru Suzuki, Tomomi Sato, Atsushi Kodan, Tomohiro Yamaguchi, Eriko Nango, Tomoyuki Tanaka, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Hiroshi Manya, Tamao Endo, Ryuichi Kato, Toshiya Senda, Hiroaki Kato, So Iwata, Hideo Ago, Masaki Yamamoto, Fumiaki Yumoto, and Toru Nakatsua, (2017)  Experimental phase determination with seleno- methionine or mercury-derivatization in serial femtosecond crystallography IUCrJ. 4 639-647 DOI:10.1107/S2052252517008557 PMID:28989719 
Masaki Yamamoto, Kunio Hirata, Keitaro Yamashita, Kazuya Hasegawa, Go Ueno, Hideo Ago and Takashi Kumasaka,  (2017)  Protein microcrystallography using synchrotron radiation IUCr Journals. 4 529-539 DOI:10.1107/S2052252517008193 PMID:28989710 
Minoru Kubo, Eriko Nango, Kensuke Tono, Tetsunari Kimura, Shigeki Owada, Changyong Song, Fumitaka Mafun, Ken Miyajima, Yoshihiro Takeda, Jun-ya Kohnoi Naoya Miyauchi, Takanori Nakane, Tomoyuki Tanaka, Takashi Nomura, Jan Davidsson, Rie Tanaka, Michio Murata, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Richard Neutze, Makina Yabashi, and So Iwata, (2017)  Nanosecond pump-probe device for time-resolved serial femtosecond crystallography developed at SACLA Journal of Synchrotron Radiation. 24 1086-1091 DOI:10.1107/S160057751701030X PMID:28862633 
Yoshinori Fukasawa, Toshiyuki Oda, Kentaro Tomii, Kenichiro Imai  (2017)  Origin and Evolutionary Alteration of the Mitochondrial Import System in Eukaryotic Lineages Molecular Biology and Evolution. 34 1574-1586 DOI:10.1093/molbev/msx096 PMID:28369657 
Atsunori Oshima  (2017)  Structure of an innexin gap junction channel and cryo-EM sample preparation Microscopy. 66 :6,  371-379 DOI:10.1093/jmicro/dfx035 PMID:29036409 
Shinji Yamada, Shunsuke Itai, Takuro Nakamura, Yao-Wen Chang, Hiroyuki Harada, Hiroyoshi Suzuki, Mika K. Kaneko, Yukinari Kato. (2017)  Establishment of H2Mab-119, an anti-human epidermal growth factor receptor 2 monoclonal antibody against pancreatic cancer Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 36 :6,  287-290 DOI:10.1089/mab.2017.0050 PMID:29172998 
Yao-Wen Chang, Shinji Yamada, Mika K. Kaneko, Yukinari Kato. (2017)  Epitope mapping of monoclonal antibody PMab-38 against dog podoplanin Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 36 :6,  291-295 DOI:10.1089/mab.2017.0048 PMID:29161183 
Itai Shunsuke, Yamada Shinji, Kaneko Mika K., Harada Hiroyuki, Kagawa Yumiko, Konnai Satoru, Kato Yukinari (2017)  Expression of cat podoplanin in feline squamous cell carcinomas Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 36 :6,  243-250 DOI:10.1089/mab.2017.0046 PMID:29090969 
Itai Shunsuke, Yamada Shinji, Kaneko Mika K., Chang Yao-Wen, Harada Hiroyuki, Kato Yukinari (2017)  Establishment of EMab-134, a sensitive and specific anti-epidermal growth factor receptor monoclonal antibody for detecting squamous cell carcinoma cells of the oral cavity Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 36 :6,  272-281 DOI:10.1089/mab.2017.0042 PMID:29090976 
Shunsuke Itai, Yuki Fujii, Mika K. Kaneko, Shinji Yamada, Takuro Nakamura, Miyuki Yanaka, Noriko Saidoh, Yao-Wen Chang, Saori Handa, Maki Takahashi, Hiroyoshi Suzuki, Hiroyuki Harada, Yukinari Kato. (2017)  Establishment of CMab-43, a sensitive and specific anti-CD133 monoclonal antibody for immunohistochemistry Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 36 :5,  231-235 DOI:10.1089/mab.2017.0031 PMID:28910211 
Shunsuke Itai, Shinji Yamada, Mika K. Kaneko, Hiroyuki Harada, Yukinari Kato (2017)  Immunohistochemical analysis using antipodocalyxin monoclonal antibody PcMab-47 demonstrates podocalyxin expression in oral squamous cell carcinomas. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 36 :5,  220-223 DOI:10.1089/mab.2017.0030 PMID:28873000 
Shunsuke Itai, Mika K. Kaneko, Yuki Fujii, Shinji Yamada, Takuro Nakamura, Miyuki Yanaka, Noriko Saidoh, Saori Handa, Yao-Wen Chang, Hiroyoshi Suzuki, Hiroyuki Harada, Yukinari Kato (2017)  Development of EMab-51, a sensitive and specific anti-epidermal growth factor receptor monoclonal antibody in flow cytometry, western blot, and immunohistochemistry Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 36 :5,  214-219 DOI:10.1089/mab.2017.0028 PMID:28891752 
Shinji Yamada, Shunsuke Itai, Takuro Nakamura, Miyuki Yanaka, Noriko Saidoh, Yao-Wen Chang, Saori Handa, Hiroyuki Harada, Yumiko Kagawa, Osamu Ichii, Satoru Konnai, Mika K. Kaneko, Yukinari Kato. (2017)  PMab-52: Specific and sensitive monoclonal antibody against cat podoplanin for immunohistochemistry Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 36 :5,  224-230 DOI:10.1089/mab.2017.0027 PMID:28737447 
Shunsuke Itai, Yuki Fujii, Mika K. Kaneko, Shinji Yamada, Takuro Nakamura, Miyuki Yanaka, Noriko Saidoh, Yao-Wen Chang, Saori Handa, Maki Takahashi, Hiroyoshi Suzuki, Hiroyuki Harada, Yukinari Kato. (2017)  H2Mab-77 is a Sensitive and Specific Anti-HER2 Monoclonal Antibody Against Breast Cancer Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 36 :4,  143-148 DOI:10.1089/mab.2017.0026 PMID:28700270 
Mika K. Kaneko, Akiko Kunita, Shinji Yamada, Takuro Nakamura, Miyuki Yanaka, Noriko Saidoh, Yao-Wen Chang, Saori Handa, Satoshi Ogasawara, Tomokazu Ohishi, Shinji Abe, Shunsuke Itai, Hiroyuki Harada, Manabu Kawada, Yasuhiko Nishioka, Masashi Fukayama, Yukinari Kato. (2017)  Antipodocalyxin antibody chPcMab-47 exerts antitumor activity in mouse xenograft models of colorectal adenocarcinomas Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 36 :4,  157-162 DOI:10.1089/mab.2017.0020 PMID:28665782 
Taishi Yonezawa, Hirotaka Takahashi, Shiori Shikata, Xiaoxiao Liu, Moe Tamura, Shuhei Asada, Tsuyoshi Fukushima, Tomofusa Fukuyama, Yosuke Tanaka, Tatsuya Sawasaki, Toshio Kitamura and Susumu Goyama (2017)  The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1. Journal of Biological Chemistry. 292 :30,  12528-12541 DOI:10.1074/jbc.M117.785675 PMID:28536267 
Mio Ohki, Ayana Sato-Tomita, Shigeru Matsunaga, Mineo Iseki, Jeremy R. H. Tame, Naoya Shibayama, and Sam-Yong Park (2017)  Molecular mechanism of photoactivation of a light-regulated adenylate cyclase Proceedings of the National Academy of Sciences of the United States of America. 114 :32,  8562-8567 DOI:10.1073/pnas.1704391114 PMID:28739908 
Alvaro Sanchez-Gonzalez, Allan S. Johnson, Ann Fitzpatrick, Christopher D. M. Hutchison, Clyde Fare, Violeta Cordon-Preciado, Gabriel Dorlhiac, Josie L. Ferreira, Rhodri M. Morgan, Jon P. Marangos, Shigeki Owada, Takanori Nakane, Rie Tanaka, Kensuke Tono, So Iwata, and Jasper J. van Thor (2017)  Coincidence timing of femtosecond optical pulses in an X-ray free electron laser Journal of Applied Physics. 122 :20,  203105- DOI:10.1063/1.5012749
Nobuhiro Obara, Takeshi Watanabe, Tomohiro Asakawa, Toshiyuki Kan, Takao Tanaka (2017)  Efficient synthesis of 3-amino-1,5-benzodiazepine-2-one derivatives. Synlett. 28 1183-1186 DOI:10.1055/s-0036-1588954
Saori Tanii, Mieko Arisawa, Takaya Tougo, Kiyofumi Horiuchi, Masahiko Yamaguchi (2017)  Rhodium-Catalyzed Synthesis of Unsymmetric Di(heteroaryl) Ethers Using Heteroaryl Exchange Reaction Synlett. 28 1601-1607 DOI:10.1055/s-0036-1588801
Yoshihiko Yamamoto  (2017)  Synthesis of Fused Furans and Thiophenes via Ruthenium-Catalyzed Atom-Transfer [2+2+1] Cycloadditions of α,ω-Diynes Synlett. 28 1250-1257 DOI:10.1055/s-0036-1588767
Yuya Ota, Yuji Kawato, Hiromichi Egami, Yoshitaka Hamashima (2017)  Enantioselective Allyl-, and Allenylboration of Aldehydes Catalyzed by Chiral Hydroxyl Carboxylic Acid Synlett. 28 976-980 DOI:10.1055/s-0036-1588690
Shoji Fujita, Masatoshi Shibuya,Yoshihiko Yamamoto  (2017)  Intramolecular Hydroalkoxylation/Reduction and Hydroamination/Reduction of Unactivated Alkynes Using a Silane-Iodine Catalytic System Synthesis. 49 4199-4204 DOI:10.1055/s-0036-1588436
Shohei Mori, Kunihiko Morihiro, Takumi Okuda, Yuuya Kasahara, Satoshi Obika (2017)  Hydrogen peroxide-triggered gene silencing in mammalian cells through boronated antisense oligonucleotides Chemical Science. 9 1112-1118 DOI:10.1039/c7sc04318j PMID:29629168 
Y Yamamoto, T Murayama, J Jiang, T Yasui, M Shibuya  (2017)  The vinylogous Catellani reaction: A combined computational and experimental study Chemical Science. 9 1191-1199 DOI:10.1039/c7sc04265e PMID:29675164 
Yuki Kishimoto, Akane Fujii, Osamu Nakagawa, Tetsuya Nagata, Takanori Yokota, Yoshiyuki Hari, Satoshi Obika (2017)  Synthesis and thermal stabilities of oligonucleotides containing 2’-O,4’-C-methylene bridged nucleic acid with a phenoxazine base Organic and Biomolecular Chemistry. 15 8145-8152 DOI:10.1039/c7ob01874f PMID:28920119 
Naoki Kanoh, Toshitaka Okamura, Takahiro Suzuki, Yoshiharu Iwabuchi (2017)  A Mild Two-Step Propargylation of Aromatic Bioactive Small Molecules Organic and Biomolecular Chemistry. 15 7190-7195 DOI:10.1039/C7OB01587A PMID:28812777 
Miyuki Yamaguchia and Kei Manabe (2017)  Three-Step Synthesis of 2,5,7-Trisubstituted Indoles from N-Acetyl-2,4,6-trichloroaniline Using Pd-Catalyzed Site-Selective Cross-Coupling Organic & Biomolecular Chemistry. 15 6645-6655 DOI:10.1039/C7OB01547J PMID:28752876 
Toshiki Akiyama, Takahisa Taniguchi, Nozomi Saito, Ryohei Doi, Tetsuo Honma, Yusuke Tamenori, Yuuta Ohki, Naoyuki Takahashi, Hiromichi Fujioka, Yoshihiro Sato, Mitsuhiro Arisawa (2017)  Ligand-Free Suzuki-Miyaura Coupling Using Ruthenium(0) Nanoparticles and a Continuously Irradiating Microwave System Green Chemistry. 19 3357-3369 DOI:10.1039/C7GC01166K
Yuka Kobayashi, Tomoshi Kameda, Masaru Hoshino, Nobutaka Fujii, Hiroaki Ohno, Shinya Oishi (2017)  Fe(II)-Complexation of Tripodal Hexapeptide Ligands with Three Bidentate Triazolylpyridines: Induction of Metal-Centred Chirality by Peptide Macrocyclization. Dalton Transactions. 46 13673-13676 DOI:10.1039/c7dt02739g PMID:28951936 
Kazuma Matsui,Yoshifumi Maegawa,Minoru Waki,Shinji Inagaki and Yoshihiko Yamamoto (2017)  Transfer hydrogenation of nitrogen heterocycles using recyclable rhodium catalyst immobilized on bipyridine-periodic mesoporous organosilica Catalysis Science & Technology. 8 534-539 DOI:10.1039/C7CY02167D
Kazuya Kanemoto, Yasuyuki Sugimura, Shigeomi Shimizu, Suguru Yoshida and Takamitsu Hosoya  (2017)  Rhodium-catalyzed odorless synthesis of diaryl sulfides from borylarenes and S-aryl thiosulfonates Chemical Communications. 53 :77,  10640-10643 DOI:10.1039/C7CC05868C PMID:28920976 
Kenta Morita, Reiya Ohta, Hiroshi Aoyama, Kenzo Yahata, Mitsuhiro Arisawa, Hiromichi Fujioka (2017)  Concise synthesis of oxacyclic compounds using highly discriminative two-way transformations of α,β-unsaturated esters in the presence of enones Chemical Communications. 53 6605-6608 DOI:10.1039/C7CC03287K PMID:28580473 
Shohei Yoshioka, Yuki Fujii, Hirofumi Tsujino, Tadayuki Uno, Hiromichi Fujioka, Mitsuhiro Arisawa (2017)  One-pot Enyne Metathesis/Diels-Alder/Oxidation to Six-membered Silacycles with a Multi-ring Core: Discovery of Novel Fluorophores Chemical Communications. 53 5970-5973 DOI:10.1039/C7CC02788E PMID:28480459 
Kazuhiro Morisaki, Hiroyuki Morimoto, Takashi Ohshima (2017)  Direct access to N-unprotected tetrasubstituted propargylamines via direct catalytic alkynylation of N-unprotected trifluoromethyl ketimines Chemical Communications. 53 6319-6322 DOI:10.1039/C7CC02194A PMID:28447089 
Shinji Kawanishi, Koji Sugiyama, Yasuhiro Oki, Takashi Ikawa, Shuji Akai (2017)  Preparation of optically active cycloalkenes bearing all-carbon quaternary stereogenic centres via lipase-oxovanadium combo-catalysed dynamic kinetic resolution Green Chemistry. 19 411-417 DOI:10.1039/C6GC01995A
Nami Ohashi and Hirokazu Tamamura (2017)  Peptide-derived mid-sized anti-HIV Amino Acids, Peptides and Proteins. 41 1-29 DOI:10.1039/9781782626619-00001
Kyoko Shirakabe, Takuya Omura, Yoshio Shibagaki, Emiko Mihara, Keiichi Homma, Yukinari Kato, Akihiko Yoshimura, Yoshinori Murakami, Junichi Takagi, Seisuke Hattori & Yoshihiro Ogawa  (2017)  Mechanistic insights into ectodomain shedding: susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation Scientific Reports. 7 46174- DOI:10.1038/srep46174 PMID:28393893 
Satoshi Abe, Kaoru Kobayashi, Asami Oji, Tetsushi Sakuma, Kanako Kazuki, Shoko Takehara, Kazuomi Nakamura, Azusa Okada, Yasuko Tsukazaki, Naoto Senda, Kazuhisa Honma, Takashi Yamamoto, Masahito Ikawa, Kan Chiba, Mitsuo Oshimura, Yasuhiro Kazuki (2017)  Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology Scientific Reports. 7 :1,  15189- DOI:10.1038/s41598-017-15033-0 PMID:29123154 
Shingo Nojima, Ayumi Fujishima, Koji Kato, Kayoko Ohuchi, Nobutaka Shimizu, Kento Yonezawa, Kenji Tajima & Min Yao (2017)  Crystal structure of the flexible tandem repeat domain of bacterial cellulose synthesis subunit C Scientific Reports. 7 :1,  13018- DOI:10.1038/s41598-017-12530-0 PMID:29026093 
Suofeng Sun, Kenji Nakashima, Masahiko Ito, Yuan Li, Takeshi Chida, Hirotaka Takahashi, Koichi Watashi, Tatsuya Sawasaki, Takaji Wakita & Tetsuro Suzuki (2017)  Involvement of PUF60 in Transcriptional and Post-transcriptional Regulation of Hepatitis B Virus Pregenomic RNA Expression. Scientific Reports . 7 :1,  12874- DOI:10.1038/s41598-017-12497-y PMID:28993636 
Atsushi Hijikata,Toshiyuki Tsuji,Masafumi Shionyu,Tsuyoshi Shirai (2017)  Decoding disease-causing mechanisms of missense mutations from supramolecular structures Scientific Reports. 7 8541- DOI:10.1038/s41598-017-08902-1 PMID:28819267 
Kazuhiro Abe, Jun Shimokawa, Mao Naito, Keith Munson, Olga Vagin, George Sachs, Hiroshi Suzuki, Kazutoshi Tani & Yoshinori Fujiyoshi  (2017)  The cryo-EM structure of gastric H+,K+-ATPase with bound BYK99, a high-affinity member of K+-competitive, imidazo[1,2-a]pyridine inhibitors. Scientific Reports. 7 :1,  6632- DOI:10.1038/s41598-017-06698-8 PMID:28747707 
Rebecka Andersson, Cecilia Safari, Robert Dods, Eriko Nango, Rie Tanaka, Ayumi Yamashita, Takanori Nakane, Kensuke Tono, Yasumasa Joti, Petra B?th, Elin Dunevall, Robert Bosman, Osamu Nureki, So Iwata, Richard Neutze & Gisela Branden (2017)  Serial femtosecond crystallography structure of cytochrome c oxidase at room temperature Scientific Reports. 7 :1,  4518- DOI:10.1038/s41598-017-04817-z PMID:28674417 
Christopher J Draper-Joyce, Maryam Khoshouei, David M Thal, Yi-Lynn Liang, Anh T N Nguyen, Sebastian G B Furness, Hariprasad Venugopal, Jo-Anne Baltos, J?rgen M Plitzko, Radostin Danev, Wolfgang Baumeister, Lauren T May, Denise Wootten, Patrick M Sexton, Alisa Glukhova, Arthur Christopoulos  (2018)  Structure of the adenosine-bound human adenosine A1 receptor-Gi complex Nature. 558 :7711,  559-563 DOI:10.1038/s41586-018-0236-6 PMID:29925945 
Takehiko Tosha, Takashi Nomura, Takuma Nishida, Naoya Saeki, Kouta Okubayashi, Raika Yamagiwa, Michihiro Sugahara, Takanori Nakane, Keitaro Yamashita, Kunio Hirata, Go Ueno, Tetsunari Kimura, Tamao Hisano, Kazumasa Muramoto, Hitomi Sawai, Hanae Takeda, Eiichi Mizohata, Ayumi Yamashita, Yusuke Kanematsu, Yu Takano, Eriko Nango, Rie Tanaka, Osamu Nureki, Osami Shoji, Yuka Ikemoto, Hironori Murakami, Shigeki Owada, Kensuke Tono, Makina Yabashi, Masaki Yamamoto, Hideo Ago, So Iwata, Hiroshi Sugimoto, Yoshitsugu Shiro& Minoru Kubo (2017)  Capturing an initial intermediate during the P450nor enzymatic reaction using time-resolved XFEL crystallography and caged-substrate Nature Communications. 8 1585- DOI:10.1038/s41467-017-01702-1 PMID:29147002 
Meirong Chen, Koji Kato, Yume Kubo, Yoshikazu Tanaka, Yuchen Liu, Feng Long, William B. Whitman, Pascal Lill, Christos Gatsogiannis, Stefan Raunser, Nobutaka Shimizu, Akira Shinoda, Akiyoshi Nakamura, Isao Tanaka & Min Yao (2017)  Structural basis for tRNA-dependent cysteine biosynthesis Nature Communications. 8 :1,  1521- DOI:10.1038/s41467-017-01543-y PMID:29142195 
Ui Okada, Eiki Yamashita, Arthur Neuberger, Mayu Morimoto, Hendrik W. van Veen & Satoshi Murakami (2017)  Crystal structure of tripartite-type ABC transporter MacB from Acinetobacter baumannii. Nature communications. 8 :1,  1336- DOI:10.1038/s41467-017-01399-2 PMID:29109439 
Alexander Gorel, Koji Motomura, Hironobu Fukuzawa, R. Bruce Doak, Marie Luise Grnbein, Mario Hilpert, Ichiro Inoue, Marco Kloos, Gabriela Kovcsov, Eriko Nango, Karol Nass, Christopher M. Roome, Robert L. Shoeman, Rie Tanaka, Kensuke Tono, Yasumasa Joti, Makina Yabashi, So Iwata, Lutz Foucar, Kiyoshi Ueda, Thomas R. M. Barends & Ilme Schlichting (2017)  Multi-wavelength anomalous diffraction de novo phasing using a two-colour X-ray free-electron laser with wide tunability Nature Communications. 8 1170- DOI:10.1038/s41467-017-00754-7 PMID:29079797 
Naoki Hosen, Yukiko Matsunaga, Kana Hasegawa, Hiroshi Matsuno, Yuki Nakamura, Mio Makita, Kouki Watanabe, Mikako Yoshida, Kei Satoh, Soyoko Morimoto, Fumihiro Fujiki, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Masahiro Manabe, Hiroyoshi Ichihara, Yasutaka Aoyama, Atsuko Mugitani, Takafumi Nakao, Masayuki Hino, Ryosuke Uchibori, Keiya Ozawa, Yoshihiro Baba, Seitaro Terakura, Naoki Wada, Eiichi Morii, Junichi Nishimura, Kiyoshi Takeda, Yusuke Oji, Haruo Sugiyama, Junichi Takagi & Atsushi Kumanogoh  (2017)  The activated conformation of integrin β7 is a novel multiple myeloma-specific target for CAR T cell therapy. Nature Medicine. 23 1436-1443 DOI:10.1038/nm.4431 PMID:29106400 
Tadato Ban, Takaya Ishihara, Hiroto Kohno, Shotaro Saita, Ayaka Ichimura, Katsumi Maenaka, Toshihiko Oka, Katsuyoshi Mihara & Naotada Ishihara (2017)  Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin Nature Cell Biology. 19 856-863 DOI:10.1038/ncb3560 PMID:28628083 
Hironobu Sakaguchi, Yuta Uetake, Masato Ohashi, Takashi Niwa, Sensuke Ogoshi, Takamitsu Hosoya (2017)  Copper-Catalyzed Regioselective Monodefluoroborylation of Polyfluoroalkenes en Route to Diverse Fluoroalkenes Journal of the American Chemical Society. 139 :36,  12855-12862 DOI:10.1021/jacs.7b08343 PMID:28849929 
Takuya Hidaka, Ganesh N. Pandian, Junichi Taniguchi, Tomohiro Nobeyama, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama (2017)  Creation of a Synthetic Ligand for Mitochondrial DNA Sequence Recognition and Promoter-Specific Transcription Suppression Journal of the American Chemical Society . 139 8444-8447 DOI:10.1021/jacs.7b05230 PMID:28614654 
Takashi Niwa, Hidenori Ochiai, Takamitsu Hosoya (2017)  Copper-Catalyzed ipso-Borylation of Fluoroarenes ACS Catalysis. 7 :7,  4535-4541 DOI:10.1021/acscatal.7b01448
Masatoshi Shibuya, Shoji Fujita, Masanori Abe, Yoshihiko Yamamoto  (2017)  Brnsted Acid/Silane Catalytic System for Intramolecular Hydroalkoxylation and Hydroamination of Unactivated Alkynes ACS Catalysis. 7 2848-2852 DOI:10.1021/acscatal.7b00403
Yoshihiko Yamamoto, Kei-ichiro Nishimura, Masatoshi Shibuya (2017)  Ruthenium-Catalyzed Cycloisomerization of 1,6-Diynes with Styryl Terminals Leading to Indenylidene Cycloalkenes ACS Catalysis. 7 1101-1107 DOI:10.1021/acscatal.6b03322
Toshimune Nomura, Satoshi Yokoshima, Tohru Fukuyama (2017)  Total synthesis of huperzine R Organic letters. 20 119-121 DOI:10.1021/acs.orglett.7b03555 PMID:29219324 
Yoshitake Nishiyama, Satoshi Yokoshima, Tohru Fukuyama (2017)  Synthesis of Cardiopetaline via a Wagner_Meerwein Rearrangement without Preactivation of the Pivotal Hydroxy Group Organic Letters. 19 5833-5835 DOI:10.1021/acs.orglett.7b02812 PMID:29039205 
Miyuki Yamaguchi, Kohei Suzuki, Yusuke Sato, Kei Manabe (2017)  Palladium-Catalyzed Direct C3-Selective Arylation of N-Unsubstituted Indoles with Aryl Chlorides and Triflates Organic Letters. 19 5388-5391 DOI:10.1021/acs.orglett.7b02669 PMID:28898099 
Hiroyuki Hakamata, Soichiro Sato, Hirofumi Ueda, Hidetoshi Tokuyama (2017)  AgNTf2-Mediated Allylation with Allylsilanes at C3a-Position of Hexahydropyrroloindoles: Application to Total Syntheses of Amauromine Alkaloids Organic Letters. 19 5308-5311 DOI:10.1021/acs.orglett.7b02602 PMID:28926277 
Tsubasa Matsuzawa, Keisuke Uchida, Suguru Yoshida, Takamitsu Hosoya (2017)  Synthesis of Diverse o-Arylthio-Substituted Diaryl Ethers by Direct Oxythiolation of Arynes with Diaryl Sulfoxides Involving Migratory O-Arylation Organic Letters. 19 :20,  5521-5524 DOI:10.1021/acs.orglett.7b02599 PMID:28984457 
Keisuke Morisaki, Yusuke Sasano, Takahiro Koseki, Takuro Shibuta, Naoki Kanoh, Wen-Hua Chiou, Yoshiharu Iwabuchi (2017)  Nazarov Cyclization Entry to Chiral Bicyclo[5.3.0]decanoid Building Blocks and Its Application to Formal Synthesis of (-)-Englerin A Organic Letters. 19 5142-5145 DOI:10.1021/acs.orglett.7b02428 PMID:28952739 
Takafumi Ide, Shuya Masuda, Yuji Kawato, Hiromichi Egami, Yoshitaka Hamashima (2017)  Benzylic C-H Trifluoromethylation via Photoenol Organic Letters. 19 4452-4455 DOI:10.1021/acs.orglett.7b01971 PMID:28799765 
Yoshitake Nishiyama, Yuki Hazama, Suguru Yoshida, Takamitsu Hosoya (2017)  Synthesis of Unsymmetrical Tertiary Phosphine Oxides via Sequential Substitution Reaction of Phosphonic Acid Dithioesters with Grignard Reagents Organic Letters. 19 :14,  3899-3902 DOI:10.1021/acs.orglett.7b01796 PMID:28696122 
Yosuke Nagasaka, Sayaka Shinta, kuKosuke Matsumura, Akitaka Masuda, Tomohiro Asakawa, Makoto Inai, Masahiro Egi, Yoshitaka Hamashima, Yoshinobu Ishikawa, Toshiyuki Kan (2017)  Total Synthesis of TAN1251C via Diastereoselective Construction of the Azaspiro Skeleton Organic Letters. 19 3839-3842 DOI:10.1021/acs.orglett.7b01718 PMID:28661151 
Shun Tanimura, Satoshi Yokoshima, Tohru Fukuyama (2017)  Total Synthesis of Huperzine Q Organic Letters. 19 3684-3686 DOI:10.1021/acs.orglett.7b01633 PMID:28640635 
Naoki Ogawa, Yousuke Yamaoka, Ken-Ichi Yamada, Kiyosei Takasu  (2017)  Synthesis of Extended Fluoranthenes via a KHMDS-Promoted Anion and Radical Reaction Cascade. Organic Letters.. 19 3327-3330 DOI:10.1021/acs.orglett.7b01538 PMID:28590747 
Atsumi Goto, Satoshi Yoshimura, Yuta Nakao, Makoto Inai, Tomohiro Asakawa, Masahiro Egi, Yoshitaka Hamashima, Mitsuru Kondo, Toshiyuki Kan (2017)  Synthetic Study on Pactamycin: Stereoselective Synthesis of the Cyclopentane Core Framework Organic Letters. 19 3358-3361 DOI:10.1021/acs.orglett.7b01257 PMID:28604005 
Shohei Ohno, Kohei Takamoto, Hiromichi Fujioka, Mitsuhiro Arisawa (2017)  Cycloisomerization between Aryl Enol Ether and Silylalkynes under Ruthenium Hydride Catalysis: Synthesis of 2,3-Disubstituted Benzofurans Organic Letters. 19 2422-2425 DOI:10.1021/acs.orglett.7b00985 PMID:28436668 
Yoshihiko Yamamoto (2017)  Theoretical Study on Ruthenium-Catalyzed Hydrocarbamoylative Cyclization of 1,-Diyne with Dimethylformamide Organometallics. 36 1154-1163 DOI:10.1021/acs.organomet.7b00026
Satoshi Yasuda, Yuta Kajiwara, Yosuke Toyoda, Kazushi Morimoto Ryoji Suno, So Iwata, Takuya Kobayashi, Takeshi Murata, Masahiro Kinoshita  (2017)  Hot-Spot Residues to be Mutated Common in G Protein-Coupled Receptors of Class A: Identification of Thermostabilizing Mutations Followed by Determination of Three-Dimensional Structures for Two Example Receptors The Journal of Physical Chemistry B. 121 :26,  6341-6350 DOI:10.1021/acs.jpcb.7b02997 PMID:28644022 
Masato Kaneda, Shinsuke Inuki, Hiroaki Ohno, Shinya Oishi  (2018)  Total Synthesis and Stereochemical Revision of Stereocalpin A: Mirror-Image Approach for Stereochemical Assignments of the Peptide-Polyketide Macrocycle. The Journal of Organic Chemistry. 83 3047-3060 DOI:10.1021/acs.joc.8b00118 PMID:29470088 
Keita Takubo, Ahmed A.B. Mohamed, Takafumi Ide, Kazuyuki Saito, Takashi Ikawa, Takehiko Yoshimitsu and Shuji Akai (2017)  Regioselective Rearrangement of 4,4-Disubstituted2-Hydroxycyclohexa-2,5-Dienones under Deoxyfluorination The Journal of Organic Chemistry. 82 13141-13151 DOI:10.1021/acs.joc.7b02208 PMID:29099595 
Kanako Nozawa-Kumada, Sayuri Osawa, Midori Sasaki, Isabelle Chataigner, Masanori Shigeno, and Yoshinori Kondo (2017)  Deprotonative Silylation of Aromatic C-H Bonds Mediated by a Combination of Trifluoromethyltrialkylsilane and Fluoride The Journal of Organic Chemistry. 82 9487-9496 DOI:10.1021/acs.joc.7b01525 PMID:28809110 
Kohei Takamoto, Shohei Ohno, Norimichi Hyogo, Hiromichi Fujioka, Mitsuhiro Arisawa (2017)  Ruthenium-Catalyzed 1,6-Aromatic Enamide-Silylalkyne Cycloisomerization: Approach to 2,3-Disubstituted Indoles The Journal of Organic Chemistry. 82 8733-8742 DOI:10.1021/acs.joc.7b01288 PMID:28730809 
Yoshihiko Yamamoto, Yuta Okude, Shota Mori, Masatoshi Shibuya (2017)  Combined Experimental and Computational Study on Ruthenium(II)-Catalyzed Reactions of Diynes with Aldehydes and N,N-Dimethylformamide The Journal of Organic Chemistry. 82 7964-7973 DOI:10.1021/acs.joc.7b01229 PMID:28682074 
Takashi Ikawa, Shigeaki Masuda, Hiroki Nakajima, Shuji Akai (2017)  2-(Trimethylsilyl)phenyl Trimethylsilyl Ethers as Stable and Readily Accessible Benzyne Precursors The Journal of Organic Chemistry. 82 4242-4253 DOI:10.1021/acs.joc.7b00238 PMID:28247765 
Naoyuki Kotoku, Ryosuke Ishida, Hirokazu Matsumoto, Masayoshi Arai, Kazunari Toda, Andi Setiawan, Osamu Muraoka, Motomasa Kobayashi (2017)  Biakamides A-D, Unique Polyketides from a Marine Sponge, Act as Selective Growth Inhibitors of Tumor Cells Adapted to Nutrient Starvation The Journal of Organic Chemistry. 82 1705-1718 DOI:10.1021/acs.joc.6b02948 PMID:28090774 
Hikaru Takano, Tetsuo Narumi, Wataru Nomura, Hirokazu Tamamura (2017)  Microwave-Assisted Synthesis of Azacoumarin Fluorophores and the Fluorescence Characterization The Journal of Organic Chemistry. 82 :5,  2739-2744 DOI:10.1021/acs.joc.6b02656 PMID:28150494 
Mieko Arisawa, Takeru Tazawa, Saori Tanii, Kiyofumi Horiuchi, Masahiko Yamaguchi (2017)  Rhodium-Catalyzed Synthesis of Unsymmetric Di(heteroaryl) Sulfides Using Heteroaryl Ethers and S‐Heteroaryl Thioesters via Heteroarylthio Exchange The Journal of Organic Chemistry. 82 804-810 DOI:10.1021/acs.joc.6b02585 PMID:27936692 
Hidetoshi Tokuyama,Kaori Yamada, Hideto Fujiwara, Juri Sakata, Kentaro Okano, Malipan Sappan, and Masahiko Isaka (2017)  Structural Determination of (-)-SCH 64874 and Hirsutellomycin by Semisynthesis The Journal of organic chemistry. 82 353-371 DOI:10.1021/acs.joc.6b02452 PMID:27966974 
Haruhisa Kikuchi, Ikuko Ito, Katsunori Takahashi, Hirotaka Ishigaki, Kyoichi Iizumi, Yuzuru Kubohara, Yoshiteru Oshima (2017)  Isolation, Synthsis, and Biological Activity of Chlorinated Alkylresorcinols from Dictyostelium Cellular Slime Molds. Journal of Natural Products. 80 2716-2722 DOI:10.1021/acs.jnatprod.7b00456 PMID:28921976 
Yuichi Onda, Yuichi Masuda, Masahito Yoshida, Takayuki Doi (2017)  Conformation-Based Design and Synthesis of Apratoxin A Mimetics Modified at the α,β-Unsaturated Thiazoline Moiety Journal of Medicinal Chemistry. 60 6751-6765 DOI:10.1021/acs.jmedchem.7b00833 PMID:28682609 
Chiduru Watanabe, Hirofumi Watanabe, Kaori Fukuzawa, Lorien J Parker, Yoshio Okiyama, Hitomi Yuki, Shigeyuki Yokoyama, Hirofumi Nakano, Shigenori Tanaka, Teruki Honma  (2017)  Theoretical Analysis of Activity Cliffs among Benzofuranone-Class Pim1 Inhibitors Using the Fragment Molecular Orbital Method with Molecular Mechanics Poisson-Boltzmann Surface Area (FMO+MM-PBSA) Approach Journal of Chemical Information and Modeling. 57 2996-3010 DOI:10.1021/acs.jcim.7b00110 PMID:29111719 
Nami Ohashi, Ryosuke Kobayashi, Wataru Nomura, Takuya Kobayakawa, Agnes Czikora, Brienna K. Herold, Nancy E. Lewin, Peter M. Blumberg, and Hirokazu Tamamura (2017)  Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol-Lactones as Protein Kinase C Ligands Bioconjugate Chemistry. 28 :8,  2135-2144 DOI:10.1021/acs.bioconjchem.7b00299 PMID:28671468 
Hiroyuki Taguchi, Yan Xie, Naoki Horikoshi, Kazumitsu Maehara, Akihito Harada, Jumpei Nogami, Koichi Sato, Yasuhiro Arimura, Akihisa Osakabe, Tomoya Kujirai, Takeshi Iwasaki, Yuichiro Semba, Taro Tachibana, Hiroshi Kimura, Yasuyuki Ohkawa, Hitoshi Kurumizaka (2017)  Crystal structure and characterization of novel human histone H3 variants, H3.6, H3.7, and H3.8 Biochemistry. 56 :16,  2184-2196 DOI:10.1021/acs.biochem.6b01098 PMID:28374988 
Tomoyo Mohri, Yusuke Ogura, Ryo Towada, Shigefumi Kuwahara (2017)  Enantioselective total synthesis of sacrolide A Tetrahedron Letters.. 58 4011-4013 DOI:10.1016/j.tetlet.2017.09.017
YoshihikoYamamoto (2017)  Recent Topics of Cp RuCl-Catalyzed Annulation Reactions Tetrahedron Letters. 58 3787-3794 DOI:10.1016/j.tetlet.2017.08.040
Takuya Kobayakawa, Hirokazu Tamamura (2017)  Stereoselective Synthesis of Xaa-Yaa Type (Z)-Chloroalkene Dipeptide Isosteres via Efficient Utilization of Organocopper Reagents Mediated Allylic Alkylation Tetrahedron . 73 :30,  4464-4471 DOI:10.1016/j.tet.2017.06.003
Van Hai Nguyen, Haruhisa Kikuchi, Hiraku Sasaki, Kyoichi Iizumi, Yuzuru Kubohara, Yoshiteru Oshima (2017)  Production of novel bispyrone metabolites in the cellular slime mold Dictyostelium giganteum induced by zinc(II) ion Tetrahedron. 73 583-588 DOI:10.1016/j.tet.2016.12.040
Ryoji Suno, Kanako Terakado Kimura, Takanori Nakane, Keitaro Yamashita, Junmei Wang, Takaaki Fujiwara, Yasuaki Yamanaka, Dohyun Im, Shoichiro Horita, Hirokazu Tsujimoto, Maki S. Tawaramoto, Takatsugu Hirokawa, Eriko Nango, Kensuke Tono, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Makina Yabashi, Keiko Shimamoto, Masaki Yamamoto, Daniel M. Rosenbaum,So Iwata, Tatsuro Shimamura, Takuya Kobayashi  (2018)  Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA Structure. 26 :1,  7-19 DOI:10.1016/j.str.2017.11.005 PMID:29225076 
Takao Arimori, Yu Kitago, Masataka Umitsu, Yuki Fujii, Ryoko Asaki, Keiko Tamura-Kawakami, Junichi Takagi (2017)  Fv-clasp: An artificially designed small antibody fragment with improved production compatibility, stability, and crystallizability Structure. 25 :10,  1611-1622 DOI:10.1016/j.str.2017.08.011 PMID:28919443 
Stephen K.Burley, GenjiKurisu, John L.Markley, Haruki Nakamura, Sameer Velankar, Helen M.Berman, Andrej Sali, Torsten Schwede, Jill Trewhella (2017)  PDB-Dev: a Prototype System for Depositing Integrative/Hybrid Structural Models Structure. 25 1317-1318 DOI:10.1016/j.str.2017.08.001 PMID:28877501 
Naruhiko Adachi, Kyohe iAizawa, Yuka Kratzer, Shinya Saijo, Nobutaka Shimizu, Toshiya Senda (2017)  Improved method for soluble expression and rapid purification of yeast TFIIA. Protein expression and purification. 133 50-56 DOI:10.1016/j.pep.2017.02.013 PMID:28259734 
Camilla Frattini, Sara Villa-Hernndez, Grazia Pellican, Rachel Jossen, Yuki Katou, Katsuhiko Shirahige, Rodrigo Bermejo (2017)  Cohesin Ubiquitylation and Mobilization Facilitate Stalled Replication Fork Dynamics molecular cell. 68 :4,  758-772 DOI:10.1016/j.molcel.2017.10.012 PMID:29129641 
Ottilie von Loeffelholz, Gabor Papai, Radostin Danev, Alexander G Myasnikov, S Kundhavai Natchiar, Isabelle Hazemann, Jean-Francois Menetret, Bruno P Klaholz (2018)  Volta phase plate data collection facilitates image processing and cryo-EM structure determination Journal of Structural Biology. 202 :3,  191-199 DOI:10.1016/j.jsb.2018.01.003 PMID:29337113 
Rubbiya A.Ali, Ahmed M.Mehdi, RosalbaRothnagel,Nicholas A.Hamilton, ChristophGerle, Michael J.Landsberg, BenHankamer  (2017)  RAZA: A Rapid 3D z-crossings Algorithm to segment electron tomograms and extract organelles and macromolecules. Journal of Structural Biology. 200 :2,  73-86 DOI:10.1016/j.jsb.2017.10.002 PMID:29032142 
Reiya Ohta, Yuichi Kuboki, Yuki Yoshikawa, Yasuyuki Koutani, Tomohiro Maegawa, Hiromichi Fujioka (2017)  Versatile and chemoselective synthesis of fluorinated methyl ethers from methoxymethyl ethers Journal of Fluorine Chemistry. 201 1-6 DOI:10.1016/j.jfluchem.2017.07.007
NaoyoshiMaeda, ChisatoYamada, AmiTakahashi, KimikoKuroki, KatsumiMaenaka (2017)  Therapeutic application of human leukocyte antigen-G1 improves atopic dermatitis-like skin lesions in mice International Immunopharmacology. 50 202-207 DOI:10.1016/j.intimp.2017.06.026 PMID:28675838 
Kouhei Tsuchida, Tadayuki Tsujita, Makiko Hayashi, Asaka Ojima, Nadine Keleku-Lukwete, Fumiki Katsuoka, Akihito Otsuki, Haruhisa Kikuchi, Yoshiteru,Oshima,Mikiko Suzuki, Masayuki Yamamoto (2017)  Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation Free Radical Biology & Medicine. 103 236-247 DOI:10.1016/j.freeradbiomed.2016.12.041 PMID:28039084 
Yasuhiko Izumi, Harue Kataoka, Yuri Inose, Akinori Akaike, Yutaka Koyama, Toshiaki Kume (2018)  Neuroprotective Effect of an Nrf2-ARE Activator Identified from a Chemical Library on Dopaminergic Neurons European Journal of Pharmacology. 818 470-479 DOI:10.1016/j.ejphar.2017.11.023 PMID:29154837 
Chika Higashi, Atsuko Kawaji, Naoto Tsuda, Makiko Hayashi, Ryota Saito, Yoko Yagishita,Takafumi Suzuki, Akira Uruno, Masaki Nakamura, Kazunari Nakao, Shoji Furusako, Masayuki Yamamoto (2017)  The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice European Journal of Pharmacology. 802 76-84 DOI:10.1016/j.ejphar.2017.02.044 PMID:28246026 
ZutaoYu, JunichiTaniguchi, YuleiWei, Ganesh N.Pandian, KaoriHashiya, ToshikazuBando, HiroshiSugiyama (2017)  Antiproliferative and Apoptotic Activities of Sequence-Specific Histone Acetyltransferase Inhibitors European Journal of Medicinal Chemistry . 138 320-327 DOI:10.1016/j.ejmech.2017.06.037 PMID:28686912 
Daisuke Satoh, Satoshi Abe, Kaoru Kobayashi, Yoshihiro Nakajima, Mitsuo Oshimura, Yasuhiro Kazuki (2018)  Human and mouse artificial chromosome technologies for studies of pharmacokinetics and toxicokinetics Drug Metabolism and Pharmacokinetics . 33 :1,  17-30 DOI:10.1016/j.dmpk.2018.01.002 PMID:29398301 
Masaki Banno, Yusuke Komiyama, Cao Wei, Yuya Oku, Kokoro Ueki, Kazuya Sumikoshi, Shugo Nakamura, Tohru Terada, Kentaro Shimizu (2017)  Development of a sugar-binding residue prediction system from protein sequences using support vector machine Computational Biology and Chemistry. 66 36-43 DOI:10.1016/j.compbiolchem.2016.10.009 PMID:27889654 
Adam H Tencer , Khan L Cox , Luo Di , Joseph B Bridgers , Jie Lyu , Xiaodong Wang , Jennifer K Sims , Tyler M Weaver , Hillary F Allen , Yi Zhang , Jovylyn Gatchalian , Michael A Darcy , Matthew D Gibson , Jinzen Ikebe , Wei Li , Paul A Wade , Jeffrey J Hayes , Brian D Strahl , Hidetoshi Kono , Michael G Poirier , Catherine A Musselman , Tatiana G Kutateladze  (2017)  Covalent modifications of histone H3K9 promote binding of CHD3 Cell Reports. 21 455-466 DOI:10.1016/j.celrep.2017.09.054 PMID:29020631 
Yoko Yagishita, Akira Uruno, Toshiaki Fukutomi, Ritsumi Saito, Daisuke Saigusa, Jingbo Pi, Akiyoshi Fukamizu, Fumihiro Sugiyama, Satoru Takahashi, Masayuki Yamamoto (2017)  Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress Cell Reports. 18 2030-2044 DOI:10.1016/j.celrep.2017.01.064 PMID:28228267 
Norihito Arichi, Shinichi Fujiwara, Michiyasu Ishizawa, Makoto Makishima, Duy H Hua, Ken-Ichi Yamada, Yousuke Yamaoka, Kiyosei Takasu  (2017)  Synthesis and Biological Evaluation of Steroidal Derivatives Bearing a Small Ring as Vitamin D Receptor Agonists. Bioorganic Medicinal Chemistry Letters. 27 3408-3411 DOI:10.1016/j.bmcl.2017.05.089 PMID:28610979 
Hitomi Yuki, Ko Kikuzato, Yasuko Koda, Junko Mikuni, Yuri Tomabechi, Mutsuko Kukimoto-Niino, Akiko Tanaka, Fumiyuki Shirai, Mikako Shirouzu, Hiroo Koyama, Teruki Honma (2017)  Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen Bioorganic & Medicinal Chemistry. 25 4259-4260 DOI:10.1016/j.bmc.2017.05.053 PMID:28662963 
HiromasaYoshioka, AyumiYamada, YukoNishiyama, HiroyukiKagechika, YuichiHashimoto, ShinyaFujii (2017)  Development of nonsteroidal glucocorticoid receptor modulators based on N-benzyl-N-(4-phenoxyphenyl)benzenesulfonamide scaffold Bioorganic & Medicinal Chemistry. 25 :13,  3461-3470 DOI:10.1016/j.bmc.2017.04.032 PMID:28506584 
Asako Kikuchi, Masayuki Okuyama, Koji Kato, Shohei Osaki, Min Ma, Yuya Kumagai, Kana Matsunaga, Patcharapa Klahan, Takayoshi Tagami, Min Yao, Atsuo Kimura (2017)  A novel glycoside hydrolase family 97 enzyme: bifunctional β-l-arabinopyranosidase/α-galactosidase from Bacteroides thetaiotaomicron. Biochimie. 142 41-50 DOI:10.1016/j.biochi.2017.08.003 PMID:28804002 
Taiki Shimizu, Chiyoko Uchida, Ritsuko Shimizu, Hozumi Motohashi, Takafumi Uchida (2017)  Prolyl Isomerase Pin1 Promotes Proplatelet Formation of Megakaryocytes via Tau Biochemical and Biophysical Research Communications. 493 946-951 DOI:10.1016/j.bbrc.2017.09.115 PMID:28943044 
Masato Hoshino, Makoto Nakakido, Satoru Nagatoishi, Chihiro Aikawa, Ichiro Nakagawa, Kouhei Tsumotoa (2017)  Biophysical characterization of the interaction between heme and proteins responsible for heme transfer in Streptococcus pyogenes Biochemical and Biophysical Research Communications. 493 1109-1114 DOI:10.1016/j.bbrc.2017.09.055 PMID:28919415 
Pau Bernado, Nobutaka Shimizu, Giuseppe Zaccai, Hironari Kamikubo, Masaaki Sugiyama  (2017)  Solution scattering approaches to dynamical ordering in biomolecular systems biochimica et-biophysica-acta, general subjects. 1862 :2,  253-274 DOI:10.1016/j.bbagen.2017.10.015 PMID:29107147 
Masayoshi Arai, Dayoung Shin, Kentaro Kamiya, Ryosuke Ishida, Andi Setiawan, Naoyuki Kotoku, Motomasa Kobayashi (2017)  Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II Journal of Natural Medicines . 71 44-49 DOI:10.1007/s11418-016-1025-x PMID:27449332 
Tomohiro Tanaka, Toru Aoki, Wataru Nomura, Hirokazu Tamamura (2017)  Bivalent 14-mer Peptide Ligands of CXCR4 with Polyproline Linkers with Anti-Chemotactic Activity against Jurkat Cells Journal of Peptide Science. 23 :7月8日,  574-580 DOI:10.1002/psc.2946 PMID:28078743 
Masamichi Nagae,Dorothee Liebschner,Yusuke Yamada,Kana Morita‐Matsumoto,Naohiro Matsugaki,Toshiya Senda,Morihisa Fujita,Taroh Kinoshita,Yoshiki Yamaguchi (2017)  Crystallographic analysis of murine p24γ2 Golgi dynamics domain. Proteins. 85 :4,  764-770 DOI:10.1002/prot.25242 PMID:28066915 
Shuichi Mori, Tomoya Hirano, Asuka Takaguchi, Takashi Fujiwara, Yusuke Okazaki, Hiroyuki Kagechika (2017)  Selective Reagent for Detection of N-ε-Monomethylation of a Peptide Lysine Residue through SNAr Reaction European Journal of Organic Chemistry. 2017 3606-3611 DOI:10.1002/ejoc.201700488
Yusuke Yoshikawa, Maki Yamakawa,Tetsuya Kobayashi,Kenichi Murai,Mitsuhiro Arisawa,Michinori Sumimoto,Hiromichi Fujioka (2017)  First Asymmetric Total Synthesis and Insight into the Structure of Laurenidificin European Journal of Organic Chemistry. 2017 2715-2718 DOI:10.1002/ejoc.201700321
Yoshihiro Nagao, Tatsunari Hisanaga, Hiromichi Egami, Yuji Kawato, Yoshitaka Hamashima (2017)  Desymmetrization of Bisallylic Amides through Catalytic Enantioselective Bromocyclization with BINAP Monoxide Chemistry - A European Journal. 23 16758-16762 DOI:10.1002/chem.201704847 PMID:29044749 
Suguru Yoshida, Keita Shimizu, Keisuke Uchida, Yuki Hazama, Kazunobu Igawa, Katsuhiko Tomooka, Takamitsu Hosoya (2017)  Construction of Condensed Polycyclic Aromatic Frameworks through Intramolecular Cycloaddition Reactions Involving Arynes Bearing an Internal Alkyne Moiety Chemistry - A European Journal. 23 15332-15335 DOI:10.1002/chem.201704345 PMID:28921682 
Masanao Sawa, Kazuhiro Morisaki, Yuta Kondo, Hiroyuki Morimoto, Takashi Ohshima (2017)  Direct Access to N‐Unprotected α‐ and/or β‐Tetrasubstituted Amino Acid Esters via Direct Catalytic Mannich‐Type Reactions Using N‐Unprotected Trifluoromethyl Ketimines Chemistry - A European Journal. 23 17022-17028 DOI:10.1002/chem.201703516 PMID:28950035 
Haruhiko Hattori, Satoshi Yokoshima, Tohru Fukuyama (2017)  Total Syntheses of Aurachins_A and B Angewandte Chemie International Edition . 56 6980-6983 DOI:10.1002/anie.201702204 PMID:28471077 
Yoshihiko Yamamoto, Kei‐ichiro Nishimura, Shota Mori, Masatoshi Shibuya (2017)  Assembly of a Benzo-Fused Bridged Ketone Scaffold from 1,5,10-Enediynes through One-Pot Ruthenium-Catalyzed Cyclization/Iodine-Mediated Oxidative Ring Expansion Angewandte Chemie International Edition. 56 5494-5497 DOI:10.1002/anie.201700493 PMID:28418229 
Hidenori Ochiai, Yuta Uetake, Takashi Niwa, Takamitsu Hosoya (2017)  Rhodium-Catalyzed Decarbonylative Borylation of Aromatic Thioesters for Facile Diversification of Aromatic Carboxylic Acids Angewandte Chemie International Edition. 56 2482-2486 DOI:10.1002/anie.201611974 PMID:28124826 
Kanako Nozawa-Kumada, Moeto Inagi, and Yoshinori Kondo (2017)  Highly chemoselective DMPU-mediated trialkylsilylation of terminal alkynes using trifluoromethyltrialkylsilane Asian Journal of Organic Chemistry. 6 63-66 DOI:10.1002/ajoc.201600472
Yoshihiko Yamamoto, Erina Ohkubo, Masatoshi Shibuya  (2017)  Synthesis of 3-Aryl-2-(trifluoromethyl)indoles via Copper-Catalyzed Hydroarylation and Subsequent Cadogan Cyclization Advanced Synthesis & Catalysis. 359 1747-1751 DOI:10.1002/adsc.201700122
Takashi Kurohara, Masatoshi Shibuya, Yoshihiko Yamamoto (2017)  Electrophilic Derivatization of Trifluoromethyl-Substituted Semisquarate Using Unsaturated Organosilanes and Subsequent Ring Transformations Advanced Synthesis & Catalysis. 359 1413-1419 DOI:10.1002/adsc.201601297
Soichiro Sato,Azusa Hirayama,Dr. Hirofumi Ueda,Prof.Dr. Hidetoshi Tokuyama (2017)  Total Syntheses of (+)-T988 B and C via AgNTf2-Mediated Coupling of Bromopyrroloindoline with Indole Asian Journal of Organic Chemistry . 6 54-58 DOI:10.1002/1joc.201600474
Yoshito Abe Seijiro Shioi,Shunsuke Kita,Hikaru Nakata,Katsumi Maenaka, Daisuke Kohda,Tsutomu Katayama,Tadashi Ued (2017)  X-ray crystal structure of Escherichia coli HspQ, a protein involved in the retardation of replication initiation FEBS Letters. 591 3805-3816 DOI:10.1002/1873-3468.12892 PMID:29083032 

BINDSの支援を受けた研究成果(論文)

Roppongi S, Tateoka C, Fujimoto M, Iizuka I, Morisawa S, Nakamura A, Honma N, Suzuki Y, Shida Y, Ogasawara W, Tanaka N, Sakamoto Y and Nonaka T (2017)  Periplasmic form of dipeptidyl aminopeptidase IV from Pseudoxanthomonas mexicana WO24: purification, kinetic characterization, crystallization and X-ray crystallographic analysis Acta Crystallogr F Struct Biol Commun. 73 :11,  601-606 DOI:10.1107/S2053230X17014911 PMID:29095153 
S. Sakurai, T. Tomita, T. Shimizu and U. Ohto (2017)  The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif Acta Crystallogr F Struct Biol Commun. 73 :3,  130-137 DOI:10.1107/S2053230X17001911 PMID:28291748 
K. Murakami, K. Nakano, T. Shimizu and U. Ohto  (2017)  The crystal structure of human DEAH-box RNA helicase 15 reveals a domain organization of the mammalian DEAH/RHA family Acta Crystallogr F Struct Biol Commun. 73 :6,  347-355 DOI:10.1107/S2053230X17007336 PMID:28580923 
Shunya Sakurai, Toshiyuki Shimizu, Umeharu Ohto  (2017)  The crystal structure of the AhRR-ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription J. Biol. Chem. 292 :43,  17609-17616 DOI:10.1074/jbc.M117.812974 PMID:28904176 
Hanaoka, K., Sasakura, K., Suwanai, Y., Toma-Fukai, S., Shimamoto, K., Takano, Y., Shibuya, N., Terai, T., Komatsu, T., Ueno, T., Ogasawara, Y., Tsuchiya, Y., Watanabe, Y., Kimura, H., Wang, C., Uchiyama, M., Kojima, H., Okabe, T., Urano, Y., Shimizu, T., Nagano, T (2017)  Discovery and Mechanistic Characterization of Selective Inhibitors of H 2 S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide Sci Rep. 7 40227- DOI:10.1038/srep40227 PMID:28079151 
Kohki Yamamoto, Toshifumi Suzuki, Riyo Imamura, Tetsuo Nagano, Takayoshi Okabe, Hiroyuki Miyachi (2017)  Synthesis of both enantiomers of 1,2,3,4-tetrahydroisoquinoline derivative IPPAM-1 and enantio-dependency of its positive allosteric modulation of prostacyclin receptor. Bioorganic & Medicinal Chemistry Letters. 27 :11,  2567-2570 DOI:10.1016/j.bmcl.2017.03.083 PMID:28462839 
Yoshimasa Takizawa, Hiroki Tanaka, Shinichi Machida, Masako Koyama, Kazumitsu Maehara, Yasuyuki Ohkawa, Paul A Wade, Matthias Wolf, Hitoshi Kurumizaka (2018)  Cryo-EM structure of the nucleosome containing the ALB1 enhancer DNA sequence Open Biology. 8 :3,  170255- DOI:10.1098/rsob.170255 PMID:29563192 
Daiki Kato, Akihisa Osakabe, Yasuhiro Arimura, Yuka Mizukami, Naoki Horikoshi, Kazumi Saikusa, Satoko Akashi, Yoshifumi Nishimura, Sam-Yong Park, Jumpei Nogami, Kazumitsu Maehara, Yasuyuki Ohkawa, Atsushi Matsumoto, Hidetoshi Kono, Rintaro Inoue, Masaaki Sugiyama, Hitoshi Kurumizaka (2017)  Crystal structure of the overlapping dinucleosome composed of hexasome and octasome. Science. 356 :6334,  205-208 DOI:10.1126/science.aak9867 PMID:28408607 
Hiroshi Ueda, Jun-ichi Kurita, Hiroyuki Neyama, Yuuka Hirao, Hiroyuki Kouji, Tadashi Mishina, Masaji Kasai, Hirofumi Nakano, Atsushi Yoshimori, Yoshifumi Nishimura  (2017)  A mimetic of the mSin3-binding helix of NRSF/REST ameliorates abnormal pain behavior in chronic pain models. Bioorganic & Medicinal Chemistry Letters. 27 :20,  4705-4709 DOI:10.1016/j.bmcl.2017.09.006 PMID:28927787 
Masayuki Oda, Satomi Inaba, Narutoshi Kamiya, Gert-Jan Bekker, Bunzo Mikami (2017)  Structural and thermodynamic characterization of endo-1,3-β-glucanase: Insights into the substrate recognition mechanism Biochimica et Biophysica Acta. 1866 :3,  415-425 DOI:10.1016/j.bbapap.2017.12.004 PMID:29246508 
Toshihiko Sugiki, Kyoko Furuita, Toshimichi Fujiwara, Chojiro Kojima (2018)  Current NMR Techniques for Structure-Based Drug Discovery Molecules. 1 :23,  148- DOI:10.3390/molecules23010148 PMID:29329228 
Natsuki Fukuda, Kentaro Noi, Lidong Weng, Yoshihiro Kobashigawa, Hiromi Miyazaki, Yukari Wakeyama, Michiyo Takaki, Yusuke Nakahara, Yuka Tatsuno, Makiyo Uchida-Kamekura, Yoshiaki Suwa, Takashi Sato, Naoki Ichikawa-Tomikawa, Motoyoshi Nomizu, Yukio Fujiwara, Fumina Ohsaka, Takashi Saitoh, Katsumi Maenaka, Hiroyuki Kumeta, Shoko Shinya, Chojiro Kojima, Teru Ogura and Hiroshi Morioka (2017)  Production of Single-Chain Fv Antibodies Specific for GA-Pyridine, an Advanced Glycation End-Product (AGE), with Reduced Inter-Domain Motion Molecules.. :22,  1695- DOI:10.3390/molecules22101695 PMID:28994732 
Yoko Tabe, Shinichi Yamamoto, Kaori Saitoh, Kazumasa Sekihara, Norikazu Monma, Kazuho Ikeo, Kaoru Mogushi, Masato Shikami, Vivian Ruvolo, Jo Ishizawa, Numsen Hail Jr, Saiko Kazuno, Mamoru Igarashi, Hiromichi Matsushita, Yasunari Yamanaka, Hajime Arai, Isao Nagaoka, Takashi Miida, Yoshihide Hayashizaki, Marina Konopleva and Michael Andreeff  (2017)  Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells. Cancer Research. 6 :77,  1453-1464 DOI:10.1158/0008-5472.CAN-16-1645 PMID:28108519 
Y Shomura, M Taketa, H Nakashima, H Tai, H Nakagawa, Y Ikeda, M Ishii, Y Igarashi, H Nishihara, K-S Yoon, S Ogo, S Hirota, Y Higuchi (2017)  Structural basis of the redox switches in the NAD+-reducing soluble [NiFe]-hydrogenase Science. 6354 :357,  928-932 DOI:10.1126/science.aan4497 PMID:28860386 
Tomohiro Kubo, Toshiyuki Oda  (2017)  Electrostatic interaction between polyglutamylated tubulin and the nexin-dynein regulatory complex regulates flagellar motility Molecular biology of the cell. 17 :28,  2260-2266 DOI:10.1091/mbc.e17-05-0285 PMID:28637765 
Atsushi Furukawa, Kosuke Kakita, Tomoki Yamada, Mikihiro Ishizuka, Jiro Sakamoto, Nanao Hatori, Naoyoshi Maeda, Fumina Ohsaka, Takashi Saitoh, Takao Nomura, Kimiko Kuroki, Hisanori Nambu, Hisashi Arase, Shigeki Matsunaga, Masahiro Anada, Toyoyuki Ose, Shunichi Hashimoto, and Katsumi Maenaka  (2017)  Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILRホア immune cell receptor Journal of Biological Chemistry. 51 :292,  21128-21136 DOI:10.1074/jbc.M117.799239 PMID:29046357 
Alexander Holm Viborg, Takane Katayama, Takatoshi Arakawa, Maher Abou Hachem, Leila Lo Leggio, Motomitsu Kitaoka, Birte Svensson, Shinya Fushinobu  (2017)  Discovery of α-L-arabinopyranosidases from human gut microbiome expands the diversity within glycoside hydrolase family 42. The Journal of biological Chemistry. 51 :292,  21092-21101 DOI:10.1074/jbc.M117.792598 PMID:29061847 
Satoshi Watanabe, Manami Harayama, Shingo Kanemura, Roberto Sitia, Kenji Inaba (2017)  Structural basis of pH-dependent client binding by ERp44, a key regulator of protein secretion at the ER-Golgi interface Proceedings of the National Academy of Sciences of the United States of America. 16 :114,  E3224-E3232 DOI:10.1073/pnas.1621426114 PMID:28373561 
Minghao Chen, Shin-Ichi Asai, Shun Narai, Shusuke Nambu, Naoki Omura, Yuriko Sakaguchi, Tsutomu Suzuki, Masao Ikeda-Saito, Kimitsuna Watanabe, Min Yao, Naoki Shigi, Yoshikazu Tanaka  (2017)  Biochemical and structural characterization of oxygen-sensitive 2-thiouridine synthesis catalyzed by an iron-sulfur protein TtuA Proceedings of the National Academy of Sciences of the United States of America. 19 :114,  4954-4959 DOI:10.1073/pnas.1615585114 PMID:28439027 
Jun-ichi Kurita, Yuuka Hirao, Hirofumi Nakano, Yoshifumi Fukunishi & Yoshifumi Nishimura  (2017)  Sertraline, chlorprothixene, and chlorpromazine characteristically interact with the REST-binding site of the corepressor mSin3, showing medulloblastoma cell growth inhibitory activities Scientific Reports. 1 :8,  13763- DOI:10.1038/s41598-018-31852-1 PMID:30213984 
Hirotake Miyauchi, Satomi Moriyama, Tsukasa Kusakizako, Kaoru Kumazaki, Takanori Nakane, Keitaro Yamashita, Kunio Hirata, Naoshi Dohmae, Tomohiro Nishizawa, Koichi Ito, Takaaki Miyaji, Yoshinori Moriyama, Ryuichiro Ishitani& Osamu Nureki  (2017)  Structural basis for xenobiotic extrusion by eukaryotic MATE transporter. Nature Communications. :8,  1633- DOI:10.1038/s41467-017-01541-0 PMID:29158478 
Wataru Shihoya, Tomohiro Nishizawa, Keitaro Yamashita, Asuka Inoue, Kunio Hirata, Francois Marie Ngako Kadji, Akiko Okuta, Kazutoshi Tani, Junken Aoki, Yoshinori Fujiyoshi, Tomoko Doi& Osamu Nureki  (2017)  X-ray Structures of Endothelin ET B Receptor Bound to Clinical Antagonist Bosentan and Its Analog Nature Structural & Molecular Biology. 9 :24,  758-764 DOI:10.1038/nsmb.3450 PMID:28805809 
Reiya Taniguchi, Asuka Inoue, Misa Sayama, Akiharu Uwamizu, Keitaro Yamashita, Kunio Hirata, Masahito Yoshida, Yoshiki Tanaka, Hideaki E. Kato, Yoshiko Nakada-Nakura, Yuko Otani, Tomohiro Nishizawa, Takayuki Doi, Tomohiko Ohwada, Ryuichiro Ishitani, Junken Aoki & Osamu Nureki  (2017)  Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6 Nature. 548 :7767,  356-360 DOI:10.1038/nature23448 PMID:28792932 
Su-Hee Cho, Seung-Young Kim, Takeo Tomita, Taro Shiraishi, Jin-Soo Park, Shusuke Sato, Fumitaka Kudo, Tadashi Eguchi, Nobutaka Funa, Makoto Nishiyama, Tomohisa Kuzuyama  (2017)  Fosfomycin Biosynthesis via Transient Cytidylylation of 2-Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme. ACS Chemical Biology. 8 :12,  2209-2215 DOI:10.1021/acschembio.7b00419 PMID:28727444 
Yuki Kanai, Ayaka Harada, Tomokazu Shibata, Ryu Nishimura, Kosuke Namiki, Miho Watanabe, Shunpei Nakamura, Fumiaki Yumoto, Toshiya Senda, Akihiro Suzuki, Saburo Neya, Yasuhiko Yamamoto (2017)  Characterization of Heme Orientational Disorder in a Myoglobin Reconstituted with a Trifluoromethyl-Group-Substituted Heme Cofactor Biochemistry. 34 :56,  4500-4508 DOI:10.1021/acs.biochem.7b00457 PMID:28758387 
Yoshiki Tanaka, Shigehiro Iwaki, Tomoya Tsukazaki (2017)  Crystal Structure of a Plant Multidrug and Toxic Compound Extrusion Family Protein Structure. 9 :25,  1455-1460 DOI:10.1016/j.str.2017.07.009 PMID:28877507 
Tadayuki Ogawa, Shinya Saijo, Nobutaka Shimizu, Xuguang Jiang, Nobutaka Hirokawa (2017)  Mechanism of Catalytic Microtubule Depolymerization via KIF2-Tubulin Transitional Conformation Cell Reports. 11 :20,  2626-2638 DOI:10.1016/j.celrep.2017.08.067 PMID:28903043 
Haruhiko Ehara, Takashi Umehara, Shun-ichi Sekine, Shigeyuki Yokoyama  (2017)  Crystal structure of RNA polymerase II from Komagataella pastoris Biochemical and biophysical research communications. 2 :487,  230-235 DOI:10.1016/j.bbrc.2017.04.039 PMID:28412353 
Akito Kawai, Victor T G Chuang, Yosuke Kouno, Keishi Yamasaki, Shuichi Miyamoto, Makoto Anraku, Masaki Otagiri  (2017)  Crystallographic analysis of the ternary complex of octanoate and N-acetyl-l-methionine with human serum albumin reveals the mode of their stabilizing interactions. Biochim Biophys Acta Proteins Proteomics. 8 :1865,  979-984 DOI:10.1016/j.bbapap.2017.04.004 PMID:28473296 
Shoko Shinya, Mariana G. Ghinet, Ryszard Brzezinski, Kyoko Furuita, Chojiro Kojima, Sneha Shah, Evgenii L. Kovrigin & Tamo Fukamizo (2017)  NMR line shape analysis of a multi-state ligand binding mechanism in chitosanase Journal of Biomolecular NMR. 4 :67,  309-319 DOI:10.1007/s10858-017-0109-6 PMID:28393280 
Toshihiko Sugiki, Toshimichi Fujiwara, Chojiro Kojima (2017)  Cold-Shock Expression System in E. coli for Protein NMR Studies Methods in Molecular Biology. :1586,  345-357 DOI:10.1007/978-1-4939-6887-9_23 PMID:28470617 
Yukiya Sako, Kensuke Ninomiya, Yukiko Okuno, Masayasu Toyomoto, Atsushi Nishida, Yuka Koike, Kenji Ohe, Isao Kii, Suguru Yoshida, Naohiro Hashimoto, Takamitsu Hosoya, Masafumi Matsuo, Masatoshi Hagiwara (2022)  Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy Scientific Reports. 7 46126- DOI:10.1038/srep46126 PMID:28555643 
Yuma Yamada, Reina Munechika, Eriko Kawamura, Yu Sakurai, Yusuke Sato, Hideyoshi Harashima  (2017)  Mitochondrial delivery of Doxorubicin using MITO-Porter kills drug-resistant renal cancer cells via mitochondrial toxicity Journal of Pharmaceutical Sciences. 106 :9,  2428-2437 DOI:10.1016/j.xphs.2017.04.058 PMID:28478130 
"Kazunori D. Yamada, Naoki Kunishima, Yoshinori Matsuura, Koshiro Nakai, Hisashi Naitow, Yoshinori Fukasawa and Kentaro Tomii " (2017)  Designing better diffracting crystals of biotin carboxyl carrier protein from Pyrococcus horikoshii by a mutation based on the crystal-packing propensity of amino acids Acta crystallographica. Section D, Structural biology. 73 757-766 DOI:10.1107/S2059798317010932 PMID:28876239 
Satoshi Ishiyama, Atsuya Nishiyama, Yasushi Saeki, Kei Moritsugu, Daichi Morimoto, Luna Yamaguchi, Naoko Arai, Rumie Matsumura, Toru Kawakami, Yuichi Mishima, Hironobu Hojo, Shintaro Shimamura, Fuyuki Ishikawa, Shoji Tajima, Keiji Tanaka, Mariko Ariyoshi, Masahiro Shirakawa, Mitsunori Ikeguchi, Akinori Kidera, Isao Suetake, Kyohei Arita (2017)  Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance Molecular Cell. 68 :2,  350-360 DOI:10.1016/j.molcel.2017.09.037 PMID:29053958 
佐分利亘、加藤公児、姚閔、松井博和、森春英 (2017)  βマンナン分解に寄与するセロビオース2-エピメラーゼとβ-マンノシドホスホリラーゼの構造と機能 応用糖質科学会誌. 7 69- DOI:ISSN:2185-6427
清水伸隆、浴本 亨、穴見康昭、伊藤俊将、池口満徳、山本恵子 (2017)  MD-SAXS法によるビタミンD受容体リガンド結合ドメインの不活性型および活性阻害型の溶液構造解析 放射光. 30 :6,  264-274 DOI:ISSN:0914-9287
Kuwabara N, Kato R (2017)  Structural biology of muscular dystrophy by X-ray crystallography PF Highlights 2016. 46- DOI:https://www2.kek.jp/imss/pf/science/publ/pfhl/2016/16hl5_3.pdf
Lu Guo, Xin Sun, Zhichao Hao, Jingjing Huang, Xiaojian Han, Yajie You, Yaying Li, Meiying Shen, Tatsuhiko Ozawa, Hiroyuki Kishi, Atsushi Muraguchi, and Aishun Jin (2017)  Identification of novel epitopes with agonistic activity for the development of tumor immunotherapy targeting TRAIL-R1 Journal of Cancer. 8 :13,  2542-2553 DOI:10.7150/jca.19918 PMID:28900492 
桑原直之, 加藤龍一, 萬谷博, 遠藤玉夫 (2017)  POMGnT1の構造解析による筋ジストロフィー疾患発症機序解明 日本結晶学会誌. 59 :2月3日,  114-120 DOI:10.5940/jcrsj.59.114
Keimei Oh, Tomoki Hoshi, Sumiya Tomio, Kenji Ueda and Kojiro Hara  (2017)  A Chemical Genetics Strategy That Identifies Small Molecules Which Induce the Triple Response in Arabidopsis Molecules . 22 2270- DOI:10.3390/molecules22122270 PMID:29257123 
Masaru Yokoyama, Tomoichiro Oka, Hirotaka Takagi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Yukinobu Tohya and Hironori Sato (2017)  A Proposal for a Structural Model of the Feline Calicivirus Protease Bound to the Substrate Peptide under Physiological Conditions Frontiers in Microbiology. 8 1383- DOI:10.3389/fmicb.2017.01383 PMID:28790989 
Bakhtiyor Nosirov , Joel Billaud , Alexis Vandenbon , Diego Diez , Edward Wijaya , Ken J Ishii , Shunsuke Teraguchi , Daron M Standley (2017)  Mapping circulating serum miRNAs to their immune-related target mRNAs. Adv Appl Bioinform Chem. 10 1-9 DOI:10.2147/AABC.S121598 PMID:28203094 
Hiroshi Ohta , Kazuki Kurimoto , Ikuhiro Okamoto , Tomonori Nakamura , Yukihiro Yabuta , Hidetaka Miyauchi , Takuya Yamamoto , Yukiko Okuno , Masatoshi Hagiwara , Kenjiro Shirane, Hiroyuki Sasaki , Mitinori Saitou (2017)  In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate. The EMBO journal. 36 1888-1907 DOI:10.15252/embj.201695862 PMID:28559416 
Takeda H, Sawasaki T (2017)  AGIAタグシステム:細胞生物学研究に最適な高感度検出およびキャプチャー用ペプチドタグ [AGIA tag system: a super-sensitive detection and capture peptide tag suitable for cell biology] 生化学. 89 302-307 DOI:10.14952/SEIKAGAKU.2017.890302
Kenji Ohe, Mayumi Yoshida, Akiko Nakano-Kobayashi, Motoyasu Hosokawa, Yukiya Sako, Maki Sakuma, Yukiko Okuno, Tomomi Usui, Kensuke Ninomiya, Takayuki Nojima, Naoyuki Kataoka, Masatoshi Hagiwara  (2017)  RBM24 promotes U1 snRNP recognition of the mutated 5' splice site in the IKBKAP gene of familial dysautonomia. RNA. 23 1393-1403 DOI:10.1261/rna.059428.116 PMID:28592461 
Naoe Kaneko, Tomoyuki Iwasaki, Yuki Ito, Hiroyuki Takeda, Tatsuya Sawasaki, Shinnosuke Morikawa, Naoko Nakano, Mie Kurata, and Junya Masumoto (2017)  Applications of reconstituted inflammasomes in a cell-free system to drug discovery and elucidation of the pathogenesis of autoinflammatory diseases Inflammation and Regeneration. 37 9- DOI:10.1186/s41232-017-0040-y PMID:29259708 
Yoshitaka Zaimoku, Hiroyuki Takamatsu, Kazuyoshi Hosomichi, Tatsuhiko Ozawa, Noriharu Nakagawa, Tatsuya Imi, Hiroyuki Maruyama, Takamasa Katagiri, Hiroyuki Kishi, Atsushi Tajima, Atsushi Muraguchi, Koichi Kashiwase, Shinji Nakao  (2017)  Identification of an HLA class I allele closely involved in the autoantigen presentation in acquired aplastic anemia. Blood. 129 :21,  2908-2916 DOI:10.1182/blood-2016-11-752378 PMID:28232583 
Naoe Kaneko, Yuki Ito, Tomoyuki Iwasaki, Hiroyuki Takeda, Tatsuya Sawasaki, Kiyoshi Migita, Kazunaga Agematsu, Tomohiro Koga, Atsushi Kawakami, Akihiro Yachie,Koh-ichiro Yoshiura, Shinnosuke Morikawa, Mie Kurata and Junya Masumoto (2017)  Poly (I:C) and hyaluronic acid directly interact with NLRP3, resulting in the assembly of NLRP3 and ASC in a cell-free system. European Journal of Inflammation. European Journal of Inflammation. 15 :2,  85-97 DOI:10.1177/1721727X17711047
Toru Tamahara, Kyoko Ochiai, Akihiko Muto, Yukinari Kato, Nicolas Sax, Mitsuyo Matsumoto, Takeyoshi Koseki, Kazuhiko Igarashi (2017)  The mTOR-Bach2 cascade controls cell cycle and class switch recombination during B cell differentiation Moledular and Cellular Biology. 37 :24,  e00418-17- DOI:10.1128/MCB.00418-17 PMID:28993481 
Yosuke Hashimoto, Keisuke Shirakura, Yoshiaki Okada, Hiroyuki Takeda, Kohki Endo, Maki Tamura, Akihiro Watari, Yoshifusa Sadamura, Tatsuya Sawasaki, Takefumi Doi, Kiyohito Yagi and Masuo Kondoh (2017)  Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model The Journal of Pharmacology and Experimental Therapeutics. 363 :2,  275-283 DOI:10.1124/jpet.117.243014 PMID:28819070 
Atsumi Tsuji-Hosokawa,Kei Takasawa,Risa Nomura,Yuichi Miyakawa,Chikahiko Numakura,Atsushi Hijikata,Tsuyoshi Shirai ,Yoshihiro Ogawa,Kenichi Kashimada,Tomohiro Morio (2017)  Molecular Mechanisms of Insulin Resistance in 2 Cases of Primary Insulin Receptor Defect-Associated Diseases Pediatr Diabetes. 18 917-924 DOI:10.1111/pedi.12508 PMID:28181734 
Maharani Pertiwi Koentjoro, Naruhiko Adachi, Miki Senda, Naoto Ogawa, Toshiya Senda (2018)  Crystal structure of the DNA-binding domain of the LysR-type transcriptional regulator CbnR in complex with a DNA fragment of the recognition binding site in the promoter region The FEBS Journal. 285 :5,  977-989 DOI:10.1111/febs.14380 PMID:29323785 
Yosuke Ohno, Yujiro Toyoshima, Hideaki Yurin, Norikazu Monma, Huihui Xiang, Kentaro Sumida, Shun Kaneumi, Satoshi Terada, Shinichi Hashimoto, Kazuho Ikeo, Shigenori Homma? Hideki Kawamura, Norihiko Takahashi, Akinobu Taketomi, Hidemitsu Kitamura  (2017)  Lack of interleukin-6 in the tumor microenvironment augments type-1 immunity and increases the efficacy of cancer immunotherapy. Cancer Science. 108 :10,  1959-1966 DOI:10.1111/cas.13330 PMID:28746799 
Kumar Nagarathinam, Frank Jaenecke, Yoshiko Nakada-Nakura, Yunhon Hotta, Kehong Liu, So Iwata, Milton T Stubbs, Norimichi Nomura, Mikio Tanabe (2017)  The multidrug-resistance transporter MdfA from Escherichia coli: crystallization and X-ray diffraction analysis. Acta Crystallographica Section F, Structural bilogy of commuinications. 73 423-430 DOI:10.1107/S2053230X17008500 PMID:28695852 
Shuichiro Nakabo,Motomu Hashimoto,Shinji Ito,Moritoshi Furu,Hiromu Ito,Takao Fujii,Hajime Yoshifuji,Yoshitaka Imura,Ran Nakashima,Kosaku Murakami,Nobuo Kuramoto,Masao Tanaka,Junko Satoh,Akihito Ishigami,Satoshi Morita,Tsuneyo Mimori,Koichiro Ohmura (2017)  Carbamylated albumin is one of the target antigens of anti-carbamylated protein antibodies. Rheumatology. 56 1217-1226 DOI:10.1093/rheumatology/kex088 PMID:28398552 
Masahiko Okuda, Yuka Nakazawa, Chaowan Guo, Tomoo Ogi, and Yoshifumi Nishimura  (2017)  CommonTFIIH recruitment mechanism in global genome and transcription-coupled repair subpathways Nucleic Acids Research. 45 :22,  13043-13055 DOI:10.1093/nar/gkx970 PMID:29069470 
Kishan K Nyati , Kazuya Masuda , Mohammad Mahabub-Uz Zaman , Praveen K Dubey , David Millrine , Jaya P Chalise , Mitsuru Higa , Songling Li , Daron M Standley , Kazunobu Saito , Hamza Hanieh , Tadamitsu Kishimoto  (2017)  TLR4-induced NF-kappaB and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a. Nucleic Acids Research. 45 :5,  2687-2703 DOI:10.1093/nar/gkx064 PMID:28168301 
Ryota Moriuchi, Kaori Takada, Masae Takabayashi, Yuko Yamamoto, Jun Shimodaira, Naoko Kuroda, Emiko Akiyama, Mayumi Udagawa, Ryoichi Minai, Masao Fukuda, Toshiya Senda, Naoto Ogawa (2017)  Amino acid residues critical for DNA binding and inducer recognition in CbnR, a LysR-type transcriptional regulator from Cupriavidus necator NH9 Bioscience Biotechnol Biochem.. 81 :11,  2119-2129 DOI:10.1080/09168451.2017.1373592 PMID:28936918 
Shiro Fukuda, Shunbun Kita, Yoshinari Obata, Yuya Fujishima, Hirofumi Nagao, Shigeki Masuda, Yoshimitsu Tanaka, Hitoshi Nishizawa, Tohru Funahashi, Junichi Takagi, Norikazu Maeda, Iichiro Shimomura (2017)  The unique prodomain of T-cadherin plays a key role in adiponectin binding with the essential extracellular cadherin repeats 1 and 2 Journal of Biological Chemistry. 292 :19,  7840-7849 DOI:10.1074/jbc.M117.780734 PMID:28325833 
Masaki Inoue, Daisuke Ando, Haruhiko Kamada, Shintaro Taki, Mayumi Niiyama, Yohei Mukai, Takashi Tadokoro, Katsumi Maenaka, Taisuke Nakayama, Yuji Kado, Tsuyoshi Inoue, Yasuo Tsutsumi and Shin-ichi Tsunoda (2017)  A trimeric structural fusion of an antagonistic tumor necrosis factor-α mutant enhances molecular stability and enables facile modification Journal of Biological Chemistry. . 292 6438-6451 DOI:10.1074/jbc.M117.779686 PMID:28235800 
Akiko Nakano-Kobayashi, Tomonari Awaya, Isao Kii, Yuto Sumida, Yukiko Okuno, Suguru Yoshida, Tomoe Sumida, Haruhisa Inoue, Takamitsu Hosoya, Masatoshi Hagiwara (2017)  Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice Proceedings of the National Academy of Sciences of the United States of America. 114 :38,  10268-10273 DOI:10.1073/pnas.1704143114 PMID:28874550 
Kentaro Matsuura, Hiromi Sawai, Kazuho Ikeo, Shintaro Ogawa, Etsuko Iio, Masanori Isogawa, Noritomo Shimada, Atsumasa Komori, Hidenori Toyoda, Takashi Kumada, Tadashi Namisaki, Hitoshi Yoshiji, Naoya Sakamoto, Mina Nakagawa, Yasuhiro Asahina, Masayuki Kurosaki, Namiki Izumi, Nobuyuki Enomoto, Atsunori Kusakabe, Eiji Kajiwara, Yoshito Itoh, Tatsuya Ide, Akihiro Tamori, Misako Matsubara, Norifumi Kawada, Ken Shirabe, Eiichi Tomita, Masao Honda, Shuichi Kaneko, Sohji Nishina, Atsushi Suetsugu, Yoichi Hiasa, Hisayoshi Watanabe, Takuya Genda, Isao Sakaida, Shuhei Nishiguchi, Koichi Takaguchi, Eiji Tanaka, Junichi Sugihara, Mitsuo Shimada, Yasuteru Kondo, Yosuke Kawai, Kaname Kojima, Masao Nagasaki, Katsushi Tokunaga, Yasuhito Tanaka (2017)  Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection. Gastroenterology. 152 :6,  1383-1394 DOI:10.1053/j.gastro.2017.01.041 PMID:28163062 
K Ishizuka, Y Fujita, T Kawabata, H Kimura, Y Iwayama, T Inada, Y Okahisa, J Egawa, M Usami, I Kushima, Y Uno, T Okada, M Ikeda, B Aleksic, D Mori, To Someya, T Yoshikawa, N Iwata, H Nakamura, T Yamashita & N Ozaki  (2017)  Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders Translational Psychiatry. 7 e1184-e1184 DOI:10.1038/tp.2017.173 PMID:28763059 
H Kimura, Y Fujita, T Kawabata, K Ishizuka, C Wang, Y Iwayama, Y Okahisa, I Kushima, M Morikawa, Y Uno, T Okada, M Ikeda, T Inada, A Branko, D Mori, T Yoshikawa, N Iwata, H Nakamura, T Yamashita & N Ozaki  (2017)  A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility Translational Psychiatry. 7 e1214-e1214 DOI:10.1038/tp.2017.170 PMID:28892071 
Mohamad Alaa Terkawi, Ryo Takano, Atsushi Furukawa, Fumi Murakoshi, and Kentaro Kato. (2017)  Involvement of β-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum Scientific Reports. 7 41772- DOI:10.1038/srep41772 PMID:28181499 
Satoshi Ogawa, Koji Miyamoto, Keiichirou Nemoto, Tatsuya Sawasaki, Hisakazu Yamane, Hideaki Nojiri & Kazunori Okada (2017)  OsMYC2, an essential factor for JA-inductive sakuranetin production in rice, interacts with MYC2-like proteins that enhance its transactivation ability. Scientific Reports . 7 40175- DOI:10.1038/srep40175 PMID:28067270 
Yumi Inoue, Yusuke V Morimoto, Keiichi Namba, Tohru Minamino (2018)  Novel insights into the mechanism of well-ordered assembly of bacterial flagellar proteins in Salmonella. Science Reports. 8 :1,  1787- DOI:10.1038/s41598-018-20209-3 PMID:29379125 
Soh Yamazaki, Yoshihiko Tanaka, Hiromitsu Araki, Akira Kohda, Fumiyuki Sanematsu, Tomoko Arasaki, Xuefeng Duan, Fumihito Miura, Takaharu Katagiri, Ryodai Shindo, Hiroyasu Nakano, Takashi Ito, Yoshinori Fukui, Shogo Endo, Hideki Sumimoto (2017)  The AP-1 transcription factor JunB is required for Th17 cell differentiation. Scientific Reports. 7 :1,  17402- DOI:10.1038/s41598-017-17597-3 PMID:29234109 
Shuhei Sakakibara, Takao Arimori, Kazuo Yamashita, Hideyuki Jinzai, Daisuke Motooka, Shota Nakamura, Songling Li, Kazuya Takeda, Jun Katayama, Marwa Ali El Hussien, Masashi Narazaki, Toshio Tanaka, Daron M. Standley, Junichi Takagi & Hitoshi Kikutani  (2017)  Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus Scietific Reports. 7 16428- DOI:10.1038/s41598-017-16681-y PMID:29180749 
Akihiro Watari, Miki Kodaka, Koji Matsuhisa, Yuta Sakamoto, Kota Hisaie, Norihito Kawashita, Tatsuya Takagi, Yoshiaki Yamagishi, Hidehiko Suzuki, Hirofumi Tsujino, Kiyohito Yagi, Masuo Kondoh (2017)  Identification of claudin-4 binder that attenuates tight junction barrier function by TR-FRET-based screening assay Scientific Reports. 7 14514- DOI:10.1038/s41598-017-15108-y PMID:29109448 
Shinichi Hashimoto, Yuta Tabuchi, Hideaki Yurino, Yoshihiko Hirohashi, Shungo Deshimaru, Takuya Asano, Tasuku Mariya, Kenshiro Oshima, Yuzuru Takamura, Yoshiaki Ukita, Akio Ametani, Naoto Kondo, Norikazu Monma, Tadayuki Takeda, Sadahiko Misu, Toshitugu Okayama, Kazuho Ikeo, Tsuyoshi Saito, Shuich Kaneko, Yutaka Suzuki, Masahira Hattori, Kouji Matsushima & Toshihiko Torigoe  (2017)  Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues. Scientific Reports. 7 :1,  14225- DOI:10.1038/s41598-017-14676-3 PMID:29079795 
Emiko Yoshida, Yasuhisa Terao, Noriko Hayashi, Kaoru Mogushi, Atsushi Arakawa, Yuji Tanaka, Yosuke Ito, Hiroko Ohmiya, Yoshihide Hayashizaki, Satoru Takeda, Masayoshi Itoh & Hideya Kawaji  (2017)  Promoter-level transcriptome in primary lesions of endometrial cancer identified biomarkers associated with lymph node metastasis. Scientific Reports. 7 :1,  14160- DOI:10.1038/s41598-017-14418-5 PMID:29074988 
Xuan Shi, Takuya Miyakawa, Akira Nakamura, Feng Hou, Makoto Hibi, Jun Ogawa, Yeondae Kwon & Masaru Tanokura (2017)  Engineering a short-chain dehydrogenase/reductase for the stereoselective production of (2S,3R,4S)-4-hydroxyisoleucine with three asymmetric centers Scientific reports. 7 :1,  13703- DOI:10.1038/s41598-017-13978-w PMID:29057974 
Hui-Min Qin, Takuya Miyakawa, Akira Inoue, Akira Nakamura, Ryuji Nishiyama, Takao Ojima & Masaru Tanokura (2017)  Laminarinase from Flavobacterium sp. reveals the structural basis of thermostability and substrate specificity Scientific reports. 7 11425- DOI:10.1038/s41598-017-11542-0 PMID:28900273 
Yuqun Xu, Lingwen Liu, Akira Nakamura, Shinichi Someya, Takuya Miyakawa & Masaru Tanokura (2017)  Studies on the regulatory mechanism of isocitrate dehydrogenase 2 using acetylation mimics Scientific reports. 7 :1,  9785- DOI:10.1038/s41598-017-10337-7 PMID:28852116 
Naoya Maekawa, Satoru Konnai, Satoshi Takagi, Yumiko Kagawa, Tomohiro Okagawa, Asami Nishimori, Ryoyo Ikebuchi, Yusuke Izumi, Tatsuya Deguchi, Chie Nakajima, Yukinari Kato, Keiichi Yamamoto, Hidetoshi Uemura, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi.  (2017)  A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma Scientific Reports. 7 :1,  8951- DOI:10.1038/s41598-017-09444-2 PMID:28827658 
Munazah Andrabi, Andrew Paul Hutchins, Diego Miranda-Saavedra, Hidetoshi Kono, Ruth Nussinov, Kenji Mizuguchi, Shandar Ahmad (2017)  Predicting conformational ensembles and genome-wide transcription factor binding sites from DNA sequences. Scientific Reports. 7 4071- DOI:10.1038/s41598-017-03199-6 PMID:28642456 
Atsushi Matsumoto, Naoyuki Miyazaki, Junichi Takagi, Kenji Iwasaki (2017)  2D hybrid analysis: Approach for building three-dimensional atomic model by electron microscopy image matching. Scientific Reports. 7 377- DOI:10.1038/s41598-017-00337-y PMID:28336911 
Yutaka Yoshii, Ken-ichi Okuda, Satomi Yamada, Mari Nagakura, Shinya Sugimoto, Tetsuo Nagano, Takayoshi Okabe,Hirotatsu Kojima, Takeo Iwamoto, Kazuyoshi Kuwano, and Yoshimitsu Mizunoe (2017)  Norgestimate inhibits staphylococcal biofilm formation and resensitizes methicillin-resistant Staphylococcus aureus to β-lactam antibiotics. npj Biofilms and Microbiomes. 3 18- DOI:10.1038/s41522-017-0026-1 PMID:28758016 
Yongchan Lee, Tomohiro Nishizawa, Mizuki Takemoto, Kaoru Kumazaki, Keitaro Yamashita, Kunio Hirata, Ayumi Minoda, Satoru Nagatoishi, Kouhei Tsumoto, Ryuichiro Ishitani & Osamu Nureki (2017)  Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity Nature Plants. 3 :10,  825-832 DOI:10.1038/s41477-017-0022-8 PMID:28970497 
Katharina E J Jungnickel, Joanne L Parker, Simon Newstead (2018)  Structural basis for amino acid transport by the CAT family of SLC7 transporters. Nature Communications. 9 :1,  550- DOI:10.1038/s41467-018-03066-6 PMID:29416041 
Takashi Nakaoku, Takashi Kohno, Mitsugu Araki, Seiji Niho, Rakhee Chauhan, Phillip P. Knowles, Katsuya Tsuchihara, Shingo Matsumoto, Yoko Shimada, Sachiyo Mimaki, Genichiro Ishii, Hitoshi Ichikawa, Satoru Nagatoishi, Kouhei Tsumoto, Yasushi Okuno, Kiyotaka Yoh, Neil Q. McDonald & Koichi Goto  (2018)  A secondary RET mutation in the activation loop conferring resistance to vandetanib Nature Communications. 9 625- DOI:10.1038/s41467-018-02994-7 PMID:29434222 
Yu Nakashima, Takahiro Mori, Hitomi Nakamura, Takayoshi Awakawa, Shotaro Hoshino, Miki Senda, Toshiya Senda, Ikuro Abe (2017)  Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis Nature Communications. 9 :1,  104- DOI:10.1038/s41467-017-02371-w PMID:29317628 
Mitsuaki Fujimoto, Ryosuke Takii, Eiichi Takaki, Arpit Katiyar, Ryuichiro Nakato, Katsuhiko Shirahige, Akira Nakai (2017)  The HSF1-PARP13-PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis nature communications. 8 :1,  1638- DOI:10.1038/s41467-017-01807-7 PMID:29158484 
Ryo Yonehara, Shigeyuki Nada, Tomokazu Nakai, Masahiro Nakai, Ayaka Kitamura, Akira Ogawa, Hirokazu Nakatsumi, Keiichi I. Nakayama, Songling Li, Daron M. Standley, Eiki Yamashita, Atsushi Nakagawa, Masato Okada (2017)  Structural basis for the assembly of the Ragulator- Rag GTPase complex Nature communications. 8 :1,  1625- DOI:10.1038/s41467-017-01762-3 PMID:29158492 
Keiichirou Nemoto, Abdelaziz Ramadan, Gen-ichiro Arimura, Kenichiro Imai, Kentaro Tomii, Kazuo Shinozaki & Tatsuya Sawasaki (2017)  Tyrosine phosphorylation of the GARU E3 ubiquitin ligase promotes gibberellin signalling by preventing GID1 degradation Nature Communications. 8 :1,  1004- DOI:10.1038/s41467-017-01005-5 PMID:29042542 
Miwa Sasai, Naoya Sakaguchi, Ji Su Ma, Shuhei Nakamura, Tsuyoshi Kawabata, Hironori Bando, Youngae Lee, Tatsuya Saitoh, Shizuo Akira, Akiko Iwasaki, Daron M Standley, Tamotsu Yoshimori & Masahiro Yamamoto (2017)  Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense Nature Immunology. 18 :8,  899-910 DOI:10.1038/ni.3767 PMID:28604719 
Nipawan Nuemket, Norihisa Yasui, Yuko Kusakabe, Yukiyo Nomura, Nanako Atsumi, Shuji Akiyama, Eriko Nango, Yukinari Kato, Mika K. Kaneko, Junichi Takagi, Maiko Hosotani & Atsuko Yamashita (2017)  Structural basis for perception of diverse chemical substances by T1r taste receptors Nature Communications. 8 15530- DOI:10.1038/ncomms15530 PMID:28534491 
Hongrui Meng, Chikara Yamashita, Kahori Shiba-Fukushima, Tsuyoshi Inoshita, Manabu Funayama, Shigeto Sato, Tomohisa Hatta, Tohru Natsume, Masataka Umitsu, Junichi Takagi, Yuzuru Imai & Nobutaka Hattori (2017)  Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c Nature Communications. 8 15500- DOI:10.1038/ncomms15500 PMID:28589937 
Fumiji Saito, Kouyuki Hirayasu, Takeshi Satoh, Christian W. Wang, John Lusingu, Takao Arimori, Kyoko Shida, Nirianne Marie Q. Palacpac, Sawako Itagaki, Shiroh Iwanaga, Eizo Takashima, Takafumi Tsuboi, Masako Kohyama, Tadahiro Suenaga, Marco Colonna, Junichi Takagi, Thomas Lavstsen, Toshihiro Horii & Hisashi Arase (2017)  Immune Evasion of Plasmodium Falciparum by RIFIN via Inhibitory Receptors Nature. 552 :7683,  101-105 DOI:10.1038/nature24994 PMID:29186116 
Yoshifumi Amamoto, Yuki Aoi, Nozomu Nagashima, Hiroki Suto, Daisuke Yoshidome, Yasuhiro Arimura, Akihisa Osakabe, Daiki Kato, Hitoshi Kurumizaka, Shigehiro A. Kawashima, Kenzo Yamatsugu (2017)  Synthetic posttranslational modifications: chemical catalyst-driven regioselective histone acylation of native chromatin Journal of the American Chemical Society . 139 :22,  7568-7576 DOI:10.1021/jacs.7b02138 PMID:28534629 
Satoshi Abe, Hiroyasu Tabe, Hiroshi Ijiri, Keitaro Yamashita, Kunio Hirata, Kohei Atsumi, Takuya Shimoi, Masaki Akai, Hajime Mori, Susumu Kitagawa, Takafumi Ueno (2017)  Crystal Engineering of Self-Assembled Porous Protein Materials in Living Cells ACS Nano. 11 :3,  2410-2419 DOI:10.1021/acsnano.6b06099 PMID:28094987 
Yuki Shiga, Daisuke Murata, Akinori Sugimoto, Yuta Oshima, Minoru Tada, Akiko Ishii-Watabe, Kenichiro Imai, Kentaro Tomii, Takashi Takeuchi, Shinji Kagaya, Atsushi Sato (2017)  Hinge-Deficient IgG1 Fc Fusion: Application to Human Lactoferrin Molecular Pharmaceutics. 14 :9,  3025-3035 DOI:10.1021/acs.molpharmaceut.7b00221 PMID:28763236 
Misa Sayama,Asuka Inoue,Sho Nakamura,Sejin Jung,Masaya Ikubo,Yuko Otani,Akiharu Uwamizu,Takayuki Kishi,Kumiko Makide,Junken Aoki,Takatsugu Hirokawa,Tomohiko Ohwada (2017)  Probing the Hydrophobic Binding Pocket of G-Protein-Coupled Lysophosphatidylserine Receptor GPR34/LPS1by Docking-Aided Structure-Activity Analysis Journal of Medicinal Chemistry. 60 6384-6399 DOI:10.1021/acs.jmedchem.7b00693 PMID:28715213 
Yasuhiro Wada,Seiji Nakano,Akifumi Morimoto,Ken-Ichi Kasahara,Takahiko Hayashi,Yoshio Takada,Hiroko Suzuki,Michiko Niwa-Sakai,Shigeki Ohashi,Mutsuhiro Mori,Takatsugu Hirokawa,Satoshi Shuto (2017)  Discovery of Novel Indazole Derivatives as Orally Available β3-Adrenergic Receptor Agonists Lacking Off-Target-Based Cardiovascular Side Effects Journal of Medicinal Chemistry. 60 3252-3265 DOI:10.1021/acs.jmedchem.6b01197 PMID:28355078 
Yohei Miyanoiri, Atsushi Hijikata, Yuuki Nishino, Mizuki Gohara, Yasuhiro Onoue, Seiji Kojima, Chojiro Kojima, Tsuyoshi Shirai, Masatsune Kainosho, Michio Homma, (2017)  Structural and functional analysis of the C-terminal region of FliG, an essential motor component of vibrio Na+-driven flagella. Structure. 25 :10,  1540-1548 DOI:10.1016/j.str.2017.08.010 PMID:28919442 
Masaaki Ito, Shin-ichiro Egashira, Kazuki Yoshida, Tomoko Mineno, Kazuo Kumagai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Michio Ui, Isao Matsuoka (2017)  Identification of novel selective P2Y6 receptor antagonists by high-throughput screening assay Life Sciences. 180 137-142 DOI:10.1016/j.lfs.2017.05.017 PMID:28527783 
Susanne M.Krug, Tomohiro Hayaishi, Daisuke Iguchi, Akihiro Watari, Azusa Takahashi, Michael Fromm, Masahiro Nagahama, Hiroyuki Takeda, Yoshiaki Okada, Tatsuya Sawasaki, Takefumi Doi, Kiyohito Yagi, Masuo Kondoh (2017)  Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction Journal of Controlled Release. 260 1-11 DOI:10.1016/j.jconrel.2017.05.024 PMID:28528740 
Takeshi Kawabata, Masayuki Oda, Fusako Kawai (2017)  Mutational analysis of cutinase-like enzyme, Cut190, based on the 3D docking structure with model compounds of polyethylene terephthalate Journal of Bioscience and Bioengineering. 124 28-35 DOI:10.1016/j.jbiosc.2017.02.007 PMID:28259444 
Kosuke Yamaguchi, Masashi Hada, Yuko Fukuda, Erina Inoue, Yoshinori Makino, Yuki Katou, Katsuhiko Shirahige, Yuki Okada  (2018)  Re-evaluating the Localization of Sperm-Retained Histones Revealed the Modification-Dependent Accumulation in Specific Genome Regions Cell Reports. 23 :13,  3920-3932 DOI:10.1016/j.celrep.2018.05.094 PMID:29949774 
Takeru Hayashi, Miki Senda, Nobuhiro Suzuki, Hiroko Nishikawa, Chi Ben, Chao Tang, Lisa Nagase, Kaori Inoue, Toshiya Senda, Masanori Hatakeyama  (2017)  Differential Mechanisms for SHP2 binding and activation are exploited by geographically distinct Helicobacter pylori CagA oncoproteins Cell Reports.. 20 :12,  2876-2890 DOI:10.1016/j.celrep.2017.08.080 PMID:28930683 
Daisuke Yasuda, Akihiro Yuasa, Rika Obata, Mao Nakajima, Kyoko Takahashi, Tomoyuki Ohe, Yoshinobu Ichimura, Masaaki Komatsu, Masayuki Yamamoto RiyoImamuraHirotatsuKojimaTakayoshiOkabeTetsuoNaganoTadahikoMashino (2017)  Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor Bioorganic & Medicinal Chemistry Letters. 27 5006-5009 DOI:10.1016/j.bmcl.2017.10.008 PMID:29037947 
Saki Matsumoto, Kei Iida, Asako Murata, Masatsugu Denawa, Masatoshi Hagiwara, Kazuhiko Nakatani  (2017)  Synthetic ligand promotes gene expression by affecting GC sequence in promoter. Bioorganic & Medicinal Chemistry Letters. 27 3391-3394 DOI:10.1016/j.bmcl.2017.06.006 PMID:28610980 
HiroyukiMiyachi, ToshifumiSuzuki, RiyoImamura, TetsuoNagano, TakayoshiOkabe (2017)  Structural development of 1,2,3,4-tetrahydroisoquinoline-type positive allosteric modulators of prostacyclin receptor (IPPAMs) to improve metabolic stability, and investigation of metabolic fate. Bioorganic & Medicinal Chemistry Letters. 27 3572-3575 DOI:10.1016/j.bmcl.2017.05.040 PMID:28587821 
Takanori Matsumaru, Makoto Inai, KanaIshigami, Toshiki Iwamatsu, Hiroshi Maita, Satoko Otsuguro, Takao Nomura, Akira Matsuda, Satoshi Ichikawa, Masahiro Sakaitani, Satoshi Shuto, Katsumi Maenaka, Toshiyuki Kan (2017)  Divergent synthesis of kinase inhibitor derivatives, leading to discovery of selective Gck inhibitors Bioorganic & Medicinal Chemistry Letters. 27 2144-2147 DOI:10.1016/j.bmcl.2017.03.055 PMID:28385506 
MariIshigami-Yuasa, YukoWatanabe, TakayasuMori, HiroyukiMasuno, ShinyaFujii, ErikoKikuchi, ShinichiUchida, HiroyukiKagechika (2017)  Development of WNK signaling inhibitors as a new class of antihypertensive drugs Bioorganic & Medicinal Chemistry. 25 :14,  3845-3852 DOI:10.1016/j.bmc.2017.05.034 PMID:28566208 
Yuma Yamada, Takuya Ishikawa, Hideyoshi Harashima (2017)  Validation of the use of an artificial mitochondrial reporter DNA vector containing a Cytomegalovirus promoter for mitochondrial transgene expression Biomaterials. 136 56-66 DOI:10.1016/j.biomaterials.2017.05.016 PMID:28521201 
Tomofumi Sakai, Yumi Inoue, Naoya Terahara, Keiichi Namba, Tohru Minamino (2018)  A triangular loop of domain D1 of FlgE is essential for hook assembly but not for the mechanical function. Biochemical and Biophysical Research Communications. 495 :2,  1789-1794 DOI:10.1016/j.bbrc.2017.12.037 PMID:29229393 
Keisuke Shirakura, Ryosuke Ishiba, Taito Kashio, Miki Sakai, Yu Fukushima, Nana Yamamoto, Shiori Manabe, Naoya Shigesada, Toru Tanaka, Nobumasa Hino, William C Aird, Takefumi Doi, Yoshiaki Okada (2017)  Endothelial Robo4 regulates IL-6 production by endothelial cells and monocytes via a crosstalk mechanism in inflammation Biochemical and Biophysical Research Communications. 495 801-806 DOI:10.1016/j.bbrc.2017.11.067 PMID:29137978 
HiromiYoshida, NozomuNishi, KenjiWada, TakanoriNakamura, MitsuomiHirashima,Naoyuki Kuwabara, RyuichiKato, ShigehiroKamitori (2017)  X-ray structure of a protease-resistant mutant form of human galectin-9 having two carbohydrate recognition domains with a metal-binding site. Biochemical and Biophysical Research Communications. 490 :4,  1287-1293 DOI:10.1016/j.bbrc.2017.07.009 PMID:28687490 
Ryo Ito, Ikuko Sato, Tadayuki Tsujita, Atsushi Yokoyama, Akira Sugawara (2017)  A ubiquitin-proteasome inhibitor bortezomib suppresses the expression of CYP11B2, a key enzyme of aldosterone synthesis Biochemical and Biophysical Research Communications. 489 21-28 DOI:10.1016/j.bbrc.2017.05.109 PMID:28533088 
Thittaya Kunthic, Hirokazu Watanabe, Ryuji Kawano, Yoshikazu Tanaka, Boonhiang Promdonkoy, Min Yao, Panadda Boonserm (2017)  pH Regulates Pore Formation of a Protease Activated Vip3Aa from Bacillus thuringiensis. Biochimica et Biophysica Acta-Biomembranes. 1859 :11,  2234-2241 DOI:10.1016/j.bbamem.2017.08.018 PMID:28865796 
Toshiya Senda, Miki Senda (2017)  An Introduction to the crystallographic study of enzymes for organic chemists, with a sample analysis pf extradiol ring-cleavage dioxygenases. Future directions in biocatalysis (Second Edition). 399-421 DOI:10.1016/B978-0-444-63743-7.00020-2
Yoshikazu Hattori, David Heidenreich, Yuki Ono, Toshihiko Sugiki, Kei-ichi Yokoyama, Ei-ichiro Suzuki, Toshimichi Fujiwara, Chojiro Kojima (2017)  Protein 19 F-labeling Using Transglutaminase for the NMR Study of Intermolecular Interactions Journal of Biomolecular NMR. 68 :4,  271-279 DOI:10.1007/s10858-017-0125-6 PMID:28756478 
Bao Ngoc Nguyen, Yukiko Okuno, Masahiko Ajiro, Kei Iida, Masatsugu Denawa, Makoto Yamamoto, Naoya Sakamoto, Hiroyuki Kagechika, Masatoshi Hagiwara  (2017)  Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression. Journal of medical virology. 89 1224-1234 DOI:10.1002/jmv.24739 PMID:27922182 
Takenori Yamamoto, Naoe Taira Nihira, Satomi Yogosawa, Katsuhiko Aoki, Hiroyuki Takeda, Tatsuya Sawasaki, Kiyotsugu Yoshida (2017)  Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks FEBS Letters. 591 :6,  842-853 DOI:10.1002/1873-3468.12596 PMID:28194753